CH623812A5 - Process for the preparation of 6,7-benzomorphane derivatives - Google Patents

Process for the preparation of 6,7-benzomorphane derivatives Download PDF

Info

Publication number
CH623812A5
CH623812A5 CH502175A CH502175A CH623812A5 CH 623812 A5 CH623812 A5 CH 623812A5 CH 502175 A CH502175 A CH 502175A CH 502175 A CH502175 A CH 502175A CH 623812 A5 CH623812 A5 CH 623812A5
Authority
CH
Switzerland
Prior art keywords
compound
formula
methyl
lower alkyl
hydrogen
Prior art date
Application number
CH502175A
Other languages
German (de)
English (en)
Inventor
Thomas Alfred Montzka
John Daniel Matiskella
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CH623812A5 publication Critical patent/CH623812A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH502175A 1974-04-18 1975-04-18 Process for the preparation of 6,7-benzomorphane derivatives CH623812A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46200774A 1974-04-18 1974-04-18

Publications (1)

Publication Number Publication Date
CH623812A5 true CH623812A5 (en) 1981-06-30

Family

ID=23834846

Family Applications (1)

Application Number Title Priority Date Filing Date
CH502175A CH623812A5 (en) 1974-04-18 1975-04-18 Process for the preparation of 6,7-benzomorphane derivatives

Country Status (23)

Country Link
JP (3) JPS6218552B2 (ja)
BE (1) BE828054A (ja)
CA (1) CA1040630A (ja)
CH (1) CH623812A5 (ja)
CS (1) CS199586B2 (ja)
DD (1) DD119787A5 (ja)
DE (1) DE2517220A1 (ja)
DK (2) DK155999C (ja)
FI (1) FI60564C (ja)
FR (1) FR2267774B1 (ja)
GB (1) GB1493420A (ja)
HU (1) HU173039B (ja)
IE (1) IE41003B1 (ja)
IL (1) IL47114A (ja)
LU (1) LU72315A1 (ja)
NL (1) NL159971C (ja)
NO (1) NO143155C (ja)
OA (1) OA04983A (ja)
PH (1) PH12067A (ja)
SE (1) SE427181B (ja)
SU (1) SU721002A3 (ja)
YU (1) YU93275A (ja)
ZA (1) ZA752471B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01179624A (ja) * 1988-01-12 1989-07-17 Matsushita Refrig Co Ltd 生鮮物貯蔵装置
GB2442535B (en) 2006-10-05 2011-07-13 Ngf Europ Ltd Method and articles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation

Also Published As

Publication number Publication date
JPS6127390B2 (ja) 1986-06-25
HU173039B (hu) 1979-02-28
FR2267774B1 (ja) 1978-08-04
IL47114A (en) 1979-01-31
FR2267774A1 (ja) 1975-11-14
DK155999B (da) 1989-06-12
FI60564C (fi) 1982-02-10
ZA752471B (en) 1976-03-31
JPS50142568A (ja) 1975-11-17
NO143155B (no) 1980-09-15
PH12067A (en) 1978-10-30
IE41003L (en) 1975-10-18
SE427181B (sv) 1983-03-14
OA04983A (fr) 1980-11-30
DE2517220A1 (de) 1975-11-06
CS199586B2 (en) 1980-07-31
JPS6218552B2 (ja) 1987-04-23
JPS60120868A (ja) 1985-06-28
JPH0119387B2 (ja) 1989-04-11
SE7504469L (sv) 1975-10-20
IE41003B1 (en) 1979-09-26
CA1040630A (en) 1978-10-17
NL7504648A (nl) 1975-10-21
NO143155C (no) 1980-12-29
AU8025875A (en) 1976-10-21
IL47114A0 (en) 1975-06-25
DK166375A (da) 1975-10-19
FI60564B (fi) 1981-10-30
DD119787A5 (ja) 1976-05-12
NL159971C (nl) 1979-09-17
NO751371L (ja) 1975-10-21
SU721002A3 (ru) 1980-03-05
DK155999C (da) 1989-11-06
DE2517220C2 (ja) 1990-04-19
GB1493420A (en) 1977-11-30
DK194088D0 (da) 1988-04-08
FI751106A (ja) 1975-10-19
LU72315A1 (ja) 1976-03-17
BE828054A (fr) 1975-10-17
YU93275A (en) 1982-02-28
DK194088A (da) 1988-04-08
JPS60142964A (ja) 1985-07-29

Similar Documents

Publication Publication Date Title
DE1670616C3 (de) 14-Hydroxydihydronormorphinverbindungen und Verfahren zu ihrer Herstellung
DE2243961C2 (ja)
DE69630772T2 (de) Neue polycyclische aminopyridine als acetylcholinesterase hemmer, verfahren zur herstellung und deren verwendung
EP0882021A1 (de) Neue phenanthridine
DE9290063U1 (de) Chinuclidin-Derivate
DE2828039A1 (de) 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
DE69929173T2 (de) Therapeutische verbindungen
US3853889A (en) 3,14-substituted-8-oxamorphinans
US4272540A (en) 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE2305092A1 (de) Alpha-aminomethylbenzylalkoholderivate
DE3790166C2 (de) Verbindungen auf der Basis von Normorphin- und Norcodein-Derivaten sowie Analoga, diese enthaltende pharmazeutische Zusammensetzungen sowie Verfahren zur Herstellung solcher und Verfahren zum Trennen diastereomerer Gemische von N-sek.-Alkyl-Derivaten von Normorphin
DE2524054A1 (de) 1-cycloalkylmethyl-3a-(substituiertes-phenyl)-decahydroisochinoline
DE112010001980T5 (de) Synthese von Morphin und Verwandten Derivaten
DE69002474T2 (de) Carboxyalkyl-ether von 2-Amino-7-hydroxytetralin.
DE69628543T2 (de) Indolderivate und ihre medizinische verwendung
EP0064685A1 (de) Dibenzo(de,g)chinolin-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE1695416A1 (de) Benzomorphan-derivate und Verfahren zu deren Herstellung
CH623812A5 (en) Process for the preparation of 6,7-benzomorphane derivatives
DE2649172C2 (ja)
DE2841126A1 (de) Pyrimido eckige klammer auf 2,1-a eckige klammer zu isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
DE2748466A1 (de) 4a-aryloctahydro-1h-2-pyrindine
EP0068384B1 (en) 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one
EP0068382B1 (en) N-cyclopropylmethyl-14-ethoxymorphinan-6-one compounds exhibiting mixed analgesic/narcotic antagonist activity and precursors therefore
DE2132810A1 (de) Indenopyrrolderivate und ihre Salze,Verfahren zu ihrer Herstellung und Arzneipraeparate
DE2857122C2 (ja)

Legal Events

Date Code Title Description
PL Patent ceased