IE41003L - N-substituted -9- alkoxy -5- methyl -6, 7-benzomorphans - Google Patents

N-substituted -9- alkoxy -5- methyl -6, 7-benzomorphans

Info

Publication number
IE41003L
IE41003L IE750877A IE87775A IE41003L IE 41003 L IE41003 L IE 41003L IE 750877 A IE750877 A IE 750877A IE 87775 A IE87775 A IE 87775A IE 41003 L IE41003 L IE 41003L
Authority
IE
Ireland
Prior art keywords
compounds
substituted
group
treatment
benzomorphans
Prior art date
Application number
IE750877A
Other versions
IE41003B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE41003L publication Critical patent/IE41003L/en
Publication of IE41003B1 publication Critical patent/IE41003B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds of formula L <IMAGE> wherein the substituents are defined in Claim 1, are prepared from corresponding 9 alpha -hydroxy compounds, in which the 2'-hydroxy group and the amino group are protected, by treatment with a strong base and subsequent alkylation to give a 9-OR<5> compound or by treatment of the blocked compound with a diazo(lower)alkane or tri(lower)alkyloxonium fluoroborate and subsequent alkylation, resulting in 9-OR<5>-substituted compounds. After cleaving off the protective groups and conversion to the 2'-OR<2> and 2-R<1> group, the compounds L are obtained. Compounds L with R<2>=H are converted to compounds with R<2>=lower alkyl by etherification. The compounds prepared are used as analgesics and/or as antagonists of narcotics and are non-addictive. [GB1493420A]
IE877/75A 1974-04-18 1975-04-18 N-substituted-9-alkoxy-5-methyl-6,7-benzomorphans IE41003B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46200774A 1974-04-18 1974-04-18

Publications (2)

Publication Number Publication Date
IE41003L true IE41003L (en) 1975-10-18
IE41003B1 IE41003B1 (en) 1979-09-26

Family

ID=23834846

Family Applications (1)

Application Number Title Priority Date Filing Date
IE877/75A IE41003B1 (en) 1974-04-18 1975-04-18 N-substituted-9-alkoxy-5-methyl-6,7-benzomorphans

Country Status (23)

Country Link
JP (3) JPS6218552B2 (en)
BE (1) BE828054A (en)
CA (1) CA1040630A (en)
CH (1) CH623812A5 (en)
CS (1) CS199586B2 (en)
DD (1) DD119787A5 (en)
DE (1) DE2517220A1 (en)
DK (2) DK155999C (en)
FI (1) FI60564C (en)
FR (1) FR2267774B1 (en)
GB (1) GB1493420A (en)
HU (1) HU173039B (en)
IE (1) IE41003B1 (en)
IL (1) IL47114A (en)
LU (1) LU72315A1 (en)
NL (1) NL159971C (en)
NO (1) NO143155C (en)
OA (1) OA04983A (en)
PH (1) PH12067A (en)
SE (1) SE427181B (en)
SU (1) SU721002A3 (en)
YU (1) YU93275A (en)
ZA (1) ZA752471B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01179624A (en) * 1988-01-12 1989-07-17 Matsushita Refrig Co Ltd Apparatus for preservation of perishable material
GB2442535B (en) 2006-10-05 2011-07-13 Ngf Europ Ltd Method and articles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation

Also Published As

Publication number Publication date
CA1040630A (en) 1978-10-17
DE2517220A1 (en) 1975-11-06
FR2267774B1 (en) 1978-08-04
NO143155C (en) 1980-12-29
LU72315A1 (en) 1976-03-17
JPS60120868A (en) 1985-06-28
FI60564B (en) 1981-10-30
YU93275A (en) 1982-02-28
DK194088A (en) 1988-04-08
CS199586B2 (en) 1980-07-31
IL47114A0 (en) 1975-06-25
NO751371L (en) 1975-10-21
BE828054A (en) 1975-10-17
PH12067A (en) 1978-10-30
NO143155B (en) 1980-09-15
JPH0119387B2 (en) 1989-04-11
DK166375A (en) 1975-10-19
NL159971C (en) 1979-09-17
JPS6218552B2 (en) 1987-04-23
AU8025875A (en) 1976-10-21
FI751106A (en) 1975-10-19
DK155999C (en) 1989-11-06
HU173039B (en) 1979-02-28
NL7504648A (en) 1975-10-21
DE2517220C2 (en) 1990-04-19
DK194088D0 (en) 1988-04-08
FR2267774A1 (en) 1975-11-14
CH623812A5 (en) 1981-06-30
JPS6127390B2 (en) 1986-06-25
JPS50142568A (en) 1975-11-17
DK155999B (en) 1989-06-12
FI60564C (en) 1982-02-10
SU721002A3 (en) 1980-03-05
DD119787A5 (en) 1976-05-12
GB1493420A (en) 1977-11-30
JPS60142964A (en) 1985-07-29
SE427181B (en) 1983-03-14
OA04983A (en) 1980-11-30
ZA752471B (en) 1976-03-31
IE41003B1 (en) 1979-09-26
SE7504469L (en) 1975-10-20
IL47114A (en) 1979-01-31

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