IE810326L - Preparing flumequine. - Google Patents

Preparing flumequine.

Info

Publication number
IE810326L
IE810326L IE810326A IE32681A IE810326L IE 810326 L IE810326 L IE 810326L IE 810326 A IE810326 A IE 810326A IE 32681 A IE32681 A IE 32681A IE 810326 L IE810326 L IE 810326L
Authority
IE
Ireland
Prior art keywords
flumequine
preparing
formula
image
gb2069498a
Prior art date
Application number
IE810326A
Other versions
IE50928B1 (en
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/122,599 external-priority patent/US4301288A/en
Priority claimed from US06/122,657 external-priority patent/US4301289A/en
Priority claimed from US06/122,470 external-priority patent/US4301291A/en
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of IE810326L publication Critical patent/IE810326L/en
Publication of IE50928B1 publication Critical patent/IE50928B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the formula: <IMAGE> wherein R is hydrogen or alkyl having 1-3 carbon atoms, and acid addition salts thereof, are useful intermediates in the preparation of 6- fluorotetrahydroquinaldine and flumequine which has the formula: <IMAGE> [GB2069498A]
IE326/81A 1980-02-19 1981-02-18 Substituted tetrahydroquinaldines and their use in the preparation of flumequine IE50928B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/122,599 US4301288A (en) 1980-02-19 1980-02-19 Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
US06/122,657 US4301289A (en) 1980-02-19 1980-02-19 Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
US06/122,470 US4301291A (en) 1980-02-19 1980-02-19 Intermediates for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid

Publications (2)

Publication Number Publication Date
IE810326L true IE810326L (en) 1981-08-19
IE50928B1 IE50928B1 (en) 1986-08-20

Family

ID=27382802

Family Applications (1)

Application Number Title Priority Date Filing Date
IE326/81A IE50928B1 (en) 1980-02-19 1981-02-18 Substituted tetrahydroquinaldines and their use in the preparation of flumequine

Country Status (6)

Country Link
JP (2) JPH0215077A (en)
AU (1) AU524459B2 (en)
FR (1) FR2476079A1 (en)
GB (1) GB2069498B (en)
IE (1) IE50928B1 (en)
NZ (1) NZ196293A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400386A (en) * 1981-11-06 1983-08-23 Riker Laboratories, Inc. Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine
US4472407A (en) * 1983-03-17 1984-09-18 Riker Laboratories, Inc. Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
DE3413693A1 (en) * 1984-04-11 1985-10-17 Boehringer Mannheim Gmbh, 6800 Mannheim FLUORINATED ANILINE DERIVATIVES AND THEIR USE
IT1231425B (en) * 1987-10-05 1991-12-04 Prodotti Antibiotici Spa PROCEDURE FOR THE SYNTHESIS OF A BENZO (IJ) QUINOLIZIN-2-CARBOXYLIC ACID DERIVATIVE
CA2009664A1 (en) * 1989-02-27 1990-08-27 Philip Thiam Shin Lau Tetrahydroquinolines and method of preparation
US5043469A (en) * 1989-07-17 1991-08-27 Eastman Kodak Company Process for preparing 5-substituted aminophenols
CA2422137A1 (en) * 2000-09-14 2003-03-13 Kaken Pharmaceutical Co., Ltd. Tetrahydroquinoline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793524A (en) * 1971-12-30 1973-06-29 Riker Laboratories Inc BENZOQUINOLIZINE-CARBOXYLIC ACIDS AND THEIR DERIVATIVES
ZA728444B (en) * 1971-12-30 1973-10-31 Riker Laboratories Inc Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof

Also Published As

Publication number Publication date
GB2069498A (en) 1981-08-26
JPH0215066A (en) 1990-01-18
JPH0416474B2 (en) 1992-03-24
AU524459B2 (en) 1982-09-16
NZ196293A (en) 1983-09-02
GB2069498B (en) 1984-02-08
FR2476079A1 (en) 1981-08-21
JPH0215077A (en) 1990-01-18
AU6742581A (en) 1981-09-24
FR2476079B1 (en) 1984-04-20
IE50928B1 (en) 1986-08-20
JPH0375541B2 (en) 1991-12-02

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Legal Events

Date Code Title Description
MM4A Patent lapsed