GB1493420A - N-substituted-9-alkoxy-5-methyl-6,7-benzomorphans - Google Patents
N-substituted-9-alkoxy-5-methyl-6,7-benzomorphansInfo
- Publication number
- GB1493420A GB1493420A GB15925/75A GB1592575A GB1493420A GB 1493420 A GB1493420 A GB 1493420A GB 15925/75 A GB15925/75 A GB 15925/75A GB 1592575 A GB1592575 A GB 1592575A GB 1493420 A GB1493420 A GB 1493420A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- substituted
- group
- treatment
- benzomorphans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of formula L <IMAGE> wherein the substituents are defined in Claim 1, are prepared from corresponding 9 alpha -hydroxy compounds, in which the 2'-hydroxy group and the amino group are protected, by treatment with a strong base and subsequent alkylation to give a 9-OR<5> compound or by treatment of the blocked compound with a diazo(lower)alkane or tri(lower)alkyloxonium fluoroborate and subsequent alkylation, resulting in 9-OR<5>-substituted compounds. After cleaving off the protective groups and conversion to the 2'-OR<2> and 2-R<1> group, the compounds L are obtained. Compounds L with R<2>=H are converted to compounds with R<2>=lower alkyl by etherification. The compounds prepared are used as analgesics and/or as antagonists of narcotics and are non-addictive.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46200774A | 1974-04-18 | 1974-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1493420A true GB1493420A (en) | 1977-11-30 |
Family
ID=23834846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15925/75A Expired GB1493420A (en) | 1974-04-18 | 1975-04-17 | N-substituted-9-alkoxy-5-methyl-6,7-benzomorphans |
Country Status (23)
| Country | Link |
|---|---|
| JP (3) | JPS6218552B2 (en) |
| BE (1) | BE828054A (en) |
| CA (1) | CA1040630A (en) |
| CH (1) | CH623812A5 (en) |
| CS (1) | CS199586B2 (en) |
| DD (1) | DD119787A5 (en) |
| DE (1) | DE2517220A1 (en) |
| DK (2) | DK155999C (en) |
| FI (1) | FI60564C (en) |
| FR (1) | FR2267774B1 (en) |
| GB (1) | GB1493420A (en) |
| HU (1) | HU173039B (en) |
| IE (1) | IE41003B1 (en) |
| IL (1) | IL47114A (en) |
| LU (1) | LU72315A1 (en) |
| NL (1) | NL159971C (en) |
| NO (1) | NO143155C (en) |
| OA (1) | OA04983A (en) |
| PH (1) | PH12067A (en) |
| SE (1) | SE427181B (en) |
| SU (1) | SU721002A3 (en) |
| YU (1) | YU93275A (en) |
| ZA (1) | ZA752471B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01179624A (en) * | 1988-01-12 | 1989-07-17 | Matsushita Refrig Co Ltd | Apparatus for preservation of perishable material |
| GB2442535B (en) | 2006-10-05 | 2011-07-13 | Ngf Europ Ltd | Method and articles |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE34235B1 (en) * | 1969-06-04 | 1975-03-19 | Acf Chemiefarma Nv | 6,7-benzomorphans and their preparation |
-
1975
- 1975-04-14 YU YU00932/75A patent/YU93275A/en unknown
- 1975-04-15 FI FI751106A patent/FI60564C/en not_active IP Right Cessation
- 1975-04-15 FR FR7511646A patent/FR2267774B1/fr not_active Expired
- 1975-04-16 OA OA55477A patent/OA04983A/en unknown
- 1975-04-17 ZA ZA00752471A patent/ZA752471B/en unknown
- 1975-04-17 SE SE7504469A patent/SE427181B/en not_active IP Right Cessation
- 1975-04-17 NO NO751371A patent/NO143155C/en unknown
- 1975-04-17 CA CA224,879A patent/CA1040630A/en not_active Expired
- 1975-04-17 HU HU75BI514A patent/HU173039B/en not_active IP Right Cessation
- 1975-04-17 BE BE155505A patent/BE828054A/en not_active IP Right Cessation
- 1975-04-17 PH PH17073A patent/PH12067A/en unknown
- 1975-04-17 DK DK166375A patent/DK155999C/en not_active IP Right Cessation
- 1975-04-17 GB GB15925/75A patent/GB1493420A/en not_active Expired
- 1975-04-17 LU LU72315A patent/LU72315A1/xx unknown
- 1975-04-18 JP JP50046634A patent/JPS6218552B2/ja not_active Expired
- 1975-04-18 IL IL47114A patent/IL47114A/en unknown
- 1975-04-18 DE DE19752517220 patent/DE2517220A1/en active Granted
- 1975-04-18 CS CS752714A patent/CS199586B2/en unknown
- 1975-04-18 IE IE877/75A patent/IE41003B1/en unknown
- 1975-04-18 SU SU752128785A patent/SU721002A3/en active
- 1975-04-18 NL NL7504648.A patent/NL159971C/en not_active IP Right Cessation
- 1975-04-18 DD DD185549A patent/DD119787A5/xx unknown
- 1975-04-18 CH CH502175A patent/CH623812A5/en not_active IP Right Cessation
-
1984
- 1984-10-11 JP JP59211573A patent/JPS60120868A/en active Granted
- 1984-10-11 JP JP59211572A patent/JPS60142964A/en active Granted
-
1988
- 1988-04-08 DK DK194088A patent/DK194088A/en not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3362784D1 (en) | Process for preparing free-flowing ethylcellulose microcapsules | |
| KR880012526A (en) | l-phenyl-3-naphthalenyloxypropanamine | |
| ES391497A1 (en) | 1,2,3,8-tetrahydrodibenzo(3,4:6,7)cyclohepta(1,2-c)pyrroles as cns-depressants | |
| GB1493420A (en) | N-substituted-9-alkoxy-5-methyl-6,7-benzomorphans | |
| ES493375A0 (en) | PROCEDURE FOR THE PREPARATION OF MIXTURES OF OPTICAL LIGHTENERS | |
| JPS57206686A (en) | Pyrrolo(2,3-d)carbazole derivative and manufacture | |
| KR850002253A (en) | Method for preparing pyridinium compound | |
| KR840005070A (en) | Method for preparing aminoalkadiene derivative | |
| ATE8649T1 (en) | POLYVINYL CHLORIDE MIXTURE CONTAINING A COPPER COMPOUND. | |
| ES376094A1 (en) | High molecular weight polyamides with an improved affinity for acid dyes modified with amino epoxy compound | |
| ES391524A1 (en) | 2,3 - dihydro - 5-trifluoromethyl-1h-di-benzo(2,3:6,7)thiepino(4,5-c)pyrroles as cns-depressants | |
| JPS5329387A (en) | Polymerizable composition | |
| KR840004720A (en) | Insecticide composition and preparation method thereof | |
| KR840007588A (en) | Method for preparing triazole antifungal agent | |
| GB1511949A (en) | Epoxy curing agents | |
| JPS57140729A (en) | Preparation of isobutene tetramer | |
| ES458733A1 (en) | Thioethers | |
| ES8403442A1 (en) | (Arylmethyl)aryl-amino-cyclohexanols, -cyclohexanes, -cyclohexenes and intermediates thereof, a process for preparing the same and their use as medicaments. | |
| JPS5211247A (en) | Flame-retarded resin composition | |
| JPS5263255A (en) | Flame-retarded polyester compositions | |
| CH612907A5 (en) | Process for the preparation of a new 1-aryloxy-4-amino-2-butanol | |
| JPS5432592A (en) | Preparation of aromatic polyester | |
| TH2193EX (en) | New types of tricyclic amines | |
| JPS5645418A (en) | Co-dimerization of isobutene and n-butene | |
| JPS5283829A (en) | Cyclic compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |