CH623307A5 - - Google Patents

Download PDF

Info

Publication number
CH623307A5
CH623307A5 CH345680A CH345680A CH623307A5 CH 623307 A5 CH623307 A5 CH 623307A5 CH 345680 A CH345680 A CH 345680A CH 345680 A CH345680 A CH 345680A CH 623307 A5 CH623307 A5 CH 623307A5
Authority
CH
Switzerland
Prior art keywords
methyl
indole
propoxy
hydroxy
methylmercapto
Prior art date
Application number
CH345680A
Other languages
German (de)
English (en)
Inventor
Wolfgang Dr Rer Nat Kampe
Kurt Dr Ing Stach
Max Dr Rer Nat Thiel
Vet Wolfgang Dr Med Bartsch
Karl Dr Med Dietmann
Egon Dr Med Roesch
Wolfgang Prof Dr Med Schaumann
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742454406 external-priority patent/DE2454406A1/de
Priority claimed from DE19752505681 external-priority patent/DE2505681A1/de
Priority claimed from DE19752508251 external-priority patent/DE2508251C2/de
Priority claimed from DE19752528771 external-priority patent/DE2528771A1/de
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of CH623307A5 publication Critical patent/CH623307A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
CH345680A 1974-11-16 1980-05-05 CH623307A5 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19742454406 DE2454406A1 (de) 1974-11-16 1974-11-16 Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE19752505681 DE2505681A1 (de) 1975-02-11 1975-02-11 Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE19752508251 DE2508251C2 (de) 1975-02-26 1975-02-26 Derivate des Indols, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
DE19752528771 DE2528771A1 (de) 1975-06-27 1975-06-27 Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
CH623307A5 true CH623307A5 (fi) 1981-05-29

Family

ID=27431915

Family Applications (3)

Application Number Title Priority Date Filing Date
CH1473575A CH622248A5 (fi) 1974-11-16 1975-11-13
CH345780A CH623308A5 (fi) 1974-11-16 1980-05-05
CH345680A CH623307A5 (fi) 1974-11-16 1980-05-05

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CH1473575A CH622248A5 (fi) 1974-11-16 1975-11-13
CH345780A CH623308A5 (fi) 1974-11-16 1980-05-05

Country Status (21)

Country Link
US (2) US4076829A (fi)
JP (1) JPS5845423B2 (fi)
AR (3) AR208570A1 (fi)
AT (1) AT349004B (fi)
AU (1) AU473145B2 (fi)
CA (1) CA1051002A (fi)
CH (3) CH622248A5 (fi)
CS (1) CS199604B2 (fi)
DD (1) DD123460A5 (fi)
DK (1) DK140985C (fi)
ES (1) ES442648A1 (fi)
FI (1) FI61693C (fi)
FR (1) FR2290897A1 (fi)
GB (1) GB1471636A (fi)
HU (1) HU173308B (fi)
IE (1) IE42286B1 (fi)
LU (1) LU73808A1 (fi)
NL (1) NL7513336A (fi)
PL (1) PL100799B1 (fi)
SE (1) SE405598B (fi)
SU (2) SU649314A3 (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
DE2830211A1 (de) * 1977-07-21 1979-02-01 Sandoz Ag Substituierte indol-derivate, ihre herstellung und verwendung
WO1980000152A1 (en) * 1978-07-03 1980-02-07 Sandoz Ag 3-aminopropoxy-aryl derivates,preparation and use thereof
US4495352A (en) * 1979-02-13 1985-01-22 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
EP0025111B1 (en) * 1979-08-10 1984-07-25 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE3030047A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3115993A1 (de) * 1981-04-13 1982-11-11 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue indol-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten
US5013732A (en) * 1984-08-06 1991-05-07 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471515A (en) * 1965-02-01 1969-10-07 Sandoz Ag (2-hydroxy-3-substituted aminopropoxy)indoles
CH475981A (de) * 1966-12-13 1969-07-31 Sandoz Ag Verfahren zur Herstellung neuer Indol-Derivate
GB1308029A (en) * 1969-07-25 1973-02-21 Sandoz Ltd Indole derivatives
BE754360A (fr) * 1969-08-05 1971-02-03 Sandoz Sa Nouveaux derives de l'indole, leur preparation et medicaments contenantdes derives
US3705907A (en) * 1970-02-19 1972-12-12 Sandoz Ltd 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
US3751429A (en) * 1970-03-24 1973-08-07 Sandoz Ltd 4-(3-amino-2-substituted propoxy)indole derivatives
CH535762A (de) * 1970-09-30 1973-04-15 Sandoz Ag Verfahren zur Herstellung neuer Indolderivate
CH540253A (de) * 1971-01-07 1973-08-15 Sandoz Ag Verfahren zur Herstellung neuer Indole

Also Published As

Publication number Publication date
CH623308A5 (fi) 1981-05-29
CH622248A5 (fi) 1981-03-31
US4229464A (en) 1980-10-21
DK140985B (da) 1979-12-17
ES442648A1 (es) 1977-04-16
CS199604B2 (en) 1980-07-31
IE42286L (en) 1976-05-16
DD123460A5 (fi) 1976-12-20
SE405598B (sv) 1978-12-18
AR211268A1 (es) 1977-11-15
LU73808A1 (fi) 1976-06-11
ATA870975A (de) 1978-08-15
PL100799B1 (pl) 1978-11-30
AU8669275A (en) 1976-06-17
GB1471636A (en) 1977-04-27
AT349004B (de) 1979-03-12
AR213287A1 (es) 1979-01-15
SU679135A3 (ru) 1979-08-05
FI61693B (fi) 1982-05-31
FR2290897B1 (fi) 1978-11-10
JPS5175059A (fi) 1976-06-29
AR208570A1 (es) 1977-02-15
NL7513336A (nl) 1976-05-18
IE42286B1 (en) 1980-07-16
CA1051002A (en) 1979-03-20
SE7512823L (sv) 1976-05-17
DK140985C (da) 1980-06-02
JPS5845423B2 (ja) 1983-10-08
FI753219A (fi) 1976-05-17
SU649314A3 (ru) 1979-02-25
FR2290897A1 (fr) 1976-06-11
HU173308B (hu) 1979-04-28
US4076829A (en) 1978-02-28
DK513575A (da) 1976-05-17
FI61693C (fi) 1982-09-10
AU473145B2 (en) 1976-06-17

Similar Documents

Publication Publication Date Title
DE2335943C3 (de) Tricyclisch substituierte Aminoalkohole und ihre nichttoxischen Salze, Verfahren zu deren Herstellung und deren Verwendung bei der Bekämpfung von Herz- und Kreislauferkrankungen
CH623307A5 (fi)
CH629190A5 (en) Process for the preparation of 1-(triarylalkyl)-4-phenylpiperidine derivatives
DE1237574B (de) Verfahren zur Herstellung von Piperazinderivaten
DE2427272C3 (de) 1-(2-(β-Naphthyloxy)-äthyl)-3-methyl -pyrazolon-(5), Verfahren sowie Verwendung als Antithrombotikum
DE2549568A1 (de) 2,6-dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsaeureisobutylester, mehrere verfahren zu seiner herstellung sowie seine verwendung als coronartherapeutikum
EP0045911B1 (de) Neue Aminopropanol-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0003298B1 (de) 4-Hydroxy-2-benzimidazolin-thion-Derivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE3414801A1 (de) 4-(nitrophenyl)-tetrahydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2403786A1 (de) Neue derivate der cumarine
CH630919A5 (de) Verfahren zur herstellung von aminopropanol-derivaten.
DE2235114A1 (de) Neue dioxocincarboxamidderivate
AT360515B (de) Verfahren zur herstellung von neuen 4-hydroxy- indol-derivaten und ihren salzen
DE2356005A1 (de) Neue 7-amino-imidazo eckige klammer auf 1,2-a eckige klammer zu pyrimidine, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
DE1670143C3 (fi)
DE1545786A1 (de) Verfahren zur Herstellung von Carbonsaeure-N-methylpiperaziden
AT360514B (de) Verfahren zur herstellung von neuen 4-hydroxy- indol-derivaten und ihren salzen
AT334339B (de) Verfahren zur herstellung von neuen alpha- (1-bis-arylalkylaminoalkyl) -aralkoxybenzylalkoholen
DE2626890A1 (de) Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
AT315870B (de) Verfahren zur Herstellung von neuen Adenin-Derivaten und von deren Salzen
AT375650B (de) Verfahren zur herstellung von neuen 4-hydroxy-2 -benzimidazolinon-derivaten und von deren salzen, razematen und optisch aktiven formen
AT247345B (de) Verfahren zur Herstellung von neuen Piperazinverbindungen
DE2166258C3 (de) Aminoalkohole, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate
AT276372B (de) Verfahren zur Herstellung von neuen N-(tert.-Aminoalkyl)-amidderivaten und deren Säureadditionssalzen
AT235280B (de) Verfahren zur Herstellung neuer Indolderivate

Legal Events

Date Code Title Description
PL Patent ceased