CH621329A5 - - Google Patents

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Publication number
CH621329A5
CH621329A5 CH270775A CH270775A CH621329A5 CH 621329 A5 CH621329 A5 CH 621329A5 CH 270775 A CH270775 A CH 270775A CH 270775 A CH270775 A CH 270775A CH 621329 A5 CH621329 A5 CH 621329A5
Authority
CH
Switzerland
Prior art keywords
formula
carbon atoms
alkyl
compounds
hydrogen
Prior art date
Application number
CH270775A
Other languages
German (de)
English (en)
Inventor
Bola Vithal Shetty
Telfer Lawson Thomas
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of CH621329A5 publication Critical patent/CH621329A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CH270775A 1974-03-04 1975-03-04 CH621329A5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44780474A 1974-03-04 1974-03-04
US05/545,074 US3974157A (en) 1974-03-04 1975-01-29 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters

Publications (1)

Publication Number Publication Date
CH621329A5 true CH621329A5 (es) 1981-01-30

Family

ID=27035098

Family Applications (4)

Application Number Title Priority Date Filing Date
CH270775A CH621329A5 (es) 1974-03-04 1975-03-04
CH1260378A CH617921A5 (en) 1974-03-04 1978-12-11 Process for the preparation of novel 1-aminoalkyl-2-aryl- cyclohexanol compounds
CH1260278A CH615413A5 (en) 1974-03-04 1978-12-11 Process for the preparation of novel 1-aminoalkyl-2-arylcyclohexanol compounds
CH657979A CH619207A5 (en) 1974-03-04 1979-07-13 Process for the preparation of novel 1-aminoalkyl-2-arylcyclohexanol compounds

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH1260378A CH617921A5 (en) 1974-03-04 1978-12-11 Process for the preparation of novel 1-aminoalkyl-2-aryl- cyclohexanol compounds
CH1260278A CH615413A5 (en) 1974-03-04 1978-12-11 Process for the preparation of novel 1-aminoalkyl-2-arylcyclohexanol compounds
CH657979A CH619207A5 (en) 1974-03-04 1979-07-13 Process for the preparation of novel 1-aminoalkyl-2-arylcyclohexanol compounds

Country Status (13)

Country Link
US (1) US3974157A (es)
JP (1) JPS50157342A (es)
BE (1) BE826260A (es)
CH (4) CH621329A5 (es)
DK (2) DK143698C (es)
FI (1) FI60205C (es)
FR (1) FR2262974B1 (es)
GB (1) GB1474004A (es)
IE (1) IE40733B1 (es)
LU (1) LU71964A1 (es)
NL (1) NL7502450A (es)
NO (1) NO140100C (es)
SE (2) SE7502407L (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4306097A (en) * 1977-09-13 1981-12-15 Pfizer Inc. 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
FR2472559A1 (fr) * 1979-12-31 1981-07-03 Cerm Cent Europ Rech Mauvernay Derives du 1-aminomethyl 2-phenoxy cyclohexanol, procede d'obtention, application en therapeutique et compositions les contenant
US4391827A (en) * 1980-09-08 1983-07-05 Pfizer Inc. 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor
US4933475A (en) * 1980-09-19 1990-06-12 Pfizer, Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4835192A (en) * 1980-09-19 1989-05-30 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4331602A (en) * 1980-09-19 1982-05-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted]phenyl)naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4921994A (en) * 1980-09-19 1990-05-01 Pfizer Inc. Pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes and derivatives thereof
US4486609A (en) * 1981-03-16 1984-12-04 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4593131A (en) * 1980-09-19 1986-06-03 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4371720A (en) * 1980-09-19 1983-02-01 Pfizer Inc. 2-Hydroxy-4-(substituted) phenyl cycloalkanes and derivatives
US4831059A (en) * 1980-09-19 1989-05-16 Pfizer Inc. Producing analgesia with pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes derivatives
US4739079A (en) * 1980-09-19 1988-04-19 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
JPS57122041A (en) * 1981-01-21 1982-07-29 Suntory Ltd Phenylclohexane derivative
US4847414A (en) * 1981-10-19 1989-07-11 Hoechst-Roussel Pharmaceuticals, Inc. 2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and intermediates thereof
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
ATE30715T1 (de) * 1983-08-19 1987-11-15 Pennwalt Corp Cyclohexancarbonsaeuren und deren derivate als mittel gegen arrhythmie.
GB8405112D0 (en) * 1984-02-28 1984-04-04 Akzo Nv Anti-arrhythmic amino-alcohols
US4760146A (en) * 1986-02-18 1988-07-26 Pennwalt Corporation Cyclohexene carboxylic esters and amides as antidysrhythmic agents
US5248830A (en) * 1989-08-24 1993-09-28 Rhone-Poulenc Rorer Pharmaceuticals Inc. Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydro-pyran-2-ones
AU2023292A (en) * 1991-02-11 1992-09-15 Rhone-Poulenc Rorer International (Holdings) Inc. Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydropyran-2-ones
NZ260408A (en) * 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
KR100354702B1 (ko) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
DE10000311A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Aminomethyl-Phonyl-Cyclohexanonderivate
DE10048714A1 (de) * 2000-09-30 2002-04-11 Gruenenthal Gmbh 5-Amino-1-penlen-3-ol-Derivate
US8669291B2 (en) * 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US10968209B2 (en) 2016-05-19 2021-04-06 Glaxosmithkline Intellectual Property (No.2) Limited TRPV4 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2586512A (en) * 1948-09-15 1952-02-19 Searle & Co Cyclohexyl-amino-alcohols
US2680115A (en) * 1949-01-28 1954-06-01 Maurice L Tainter Substituted tertiary-aminoalkyl carbinols
US2656386A (en) * 1951-02-24 1953-10-20 Upjohn Co Aminoethylhydrocarbonoxycyclohexenes
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols

Also Published As

Publication number Publication date
CH617921A5 (en) 1980-06-30
DK83575A (es) 1975-09-05
IE40733L (en) 1975-09-04
DK143698B (da) 1981-09-28
JPS50157342A (es) 1975-12-19
DK328479A (da) 1979-08-03
IE40733B1 (en) 1979-08-01
LU71964A1 (es) 1975-08-20
NO750706L (es) 1975-09-05
SE8203051L (sv) 1982-05-14
NL7502450A (nl) 1975-09-08
BE826260A (nl) 1975-06-30
CH615413A5 (en) 1980-01-31
CH619207A5 (en) 1980-09-15
US3974157A (en) 1976-08-10
FR2262974A1 (es) 1975-10-03
FI60205B (fi) 1981-08-31
DK143698C (da) 1982-03-08
AU7877375A (en) 1976-09-09
FI60205C (fi) 1981-12-10
FI750601A (es) 1975-09-05
FR2262974B1 (es) 1980-01-25
GB1474004A (en) 1977-05-18
NO140100B (no) 1979-03-26
SE7502407L (es) 1975-09-05
NO140100C (no) 1979-07-04

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PL Patent ceased