CH395124A - Verfahren zur Herstellung von Halogenalkylaminen - Google Patents
Verfahren zur Herstellung von HalogenalkylaminenInfo
- Publication number
- CH395124A CH395124A CH715965A CH715965A CH395124A CH 395124 A CH395124 A CH 395124A CH 715965 A CH715965 A CH 715965A CH 715965 A CH715965 A CH 715965A CH 395124 A CH395124 A CH 395124A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- formula
- hydrogen
- phenyl
- halogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 125000005843 halogen group Chemical group 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 238000009833 condensation Methods 0.000 claims description 6
- 230000005494 condensation Effects 0.000 claims description 6
- 239000007858 starting material Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 239000003054 catalyst Substances 0.000 claims description 5
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 claims description 5
- 229910003446 platinum oxide Inorganic materials 0.000 claims description 5
- KWTSXDURSIMDCE-UHFFFAOYSA-N 1-phenylpropan-2-amine Chemical compound CC(N)CC1=CC=CC=C1 KWTSXDURSIMDCE-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 150000001728 carbonyl compounds Chemical class 0.000 claims description 3
- 150000002431 hydrogen Chemical group 0.000 claims description 3
- FFDNRFMIOVQZMT-UHFFFAOYSA-N 3-chloropropanal Chemical compound ClCCC=O FFDNRFMIOVQZMT-UHFFFAOYSA-N 0.000 claims description 2
- 241000272525 Anas platyrhynchos Species 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 230000036528 appetite Effects 0.000 claims description 2
- 235000019789 appetite Nutrition 0.000 claims description 2
- 239000002830 appetite depressant Substances 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 210000000653 nervous system Anatomy 0.000 claims description 2
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 239000001294 propane Substances 0.000 claims description 2
- UMSVPCYSAUKCAZ-UHFFFAOYSA-N propane;hydrochloride Chemical compound Cl.CCC UMSVPCYSAUKCAZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims 2
- UAARVZGODBESIF-UHFFFAOYSA-N 2-chloropropanal Chemical compound CC(Cl)C=O UAARVZGODBESIF-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED30233A DE1210873B (de) | 1959-03-18 | 1959-03-18 | Verfahren zur Herstellung von Halogenalkylaminen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH395124A true CH395124A (de) | 1965-07-15 |
Family
ID=7040409
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH715965A CH395124A (de) | 1959-03-18 | 1960-02-12 | Verfahren zur Herstellung von Halogenalkylaminen |
| CH157660A CH396026A (de) | 1959-03-18 | 1960-02-12 | Verfahren zur Herstellung von Halogenalkylaminen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH157660A CH396026A (de) | 1959-03-18 | 1960-02-12 | Verfahren zur Herstellung von Halogenalkylaminen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3485926A (enEXAMPLES) |
| BE (1) | BE588736A (enEXAMPLES) |
| CH (2) | CH395124A (enEXAMPLES) |
| DE (1) | DE1210873B (enEXAMPLES) |
| FR (1) | FR628M (enEXAMPLES) |
| GB (1) | GB917099A (enEXAMPLES) |
| SE (1) | SE300621B (enEXAMPLES) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1443735B1 (de) * | 1961-03-29 | 1970-03-12 | Degussa | Verfahren zur Herstellung von substituierten Halogenalkylaminen |
| CH483390A (de) * | 1966-10-28 | 1969-12-31 | Hoffmann La Roche | Verfahren zur Herstellung eines Phenäthylamins |
| HU193662B (en) * | 1983-12-20 | 1987-11-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing synergetic pharmaceutical composition of antidepressive aktivity |
| US5220068A (en) * | 1986-09-25 | 1993-06-15 | Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt. | Psychostimulant agent |
| HU207280B (en) | 1986-09-25 | 1993-03-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them |
| LV5226A3 (lv) * | 1986-09-25 | 1993-10-10 | Chinoin Gyogyszer Es Vegyeszet | Fenilalkilaminu vai to farmakologiski pienemamu saju iegusanas panemiens |
-
1959
- 1959-03-18 DE DED30233A patent/DE1210873B/de active Pending
-
1960
- 1960-02-12 CH CH715965A patent/CH395124A/de unknown
- 1960-02-12 CH CH157660A patent/CH396026A/de unknown
- 1960-02-17 SE SE1601/60A patent/SE300621B/xx unknown
- 1960-02-24 GB GB6512/60A patent/GB917099A/en not_active Expired
- 1960-03-16 BE BE588736A patent/BE588736A/fr unknown
- 1960-08-31 FR FR820583A patent/FR628M/fr active Active
-
1966
- 1966-03-01 US US538464A patent/US3485926A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE1210873B (de) | 1966-02-17 |
| US3485926A (en) | 1969-12-23 |
| FR628M (enEXAMPLES) | 1961-06-26 |
| CH396026A (de) | 1965-07-31 |
| GB917099A (en) | 1963-01-30 |
| SE300621B (enEXAMPLES) | 1968-05-06 |
| BE588736A (fr) | 1960-07-18 |
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