CA3203273A1 - Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same - Google Patents

Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same

Info

Publication number
CA3203273A1
CA3203273A1 CA3203273A CA3203273A CA3203273A1 CA 3203273 A1 CA3203273 A1 CA 3203273A1 CA 3203273 A CA3203273 A CA 3203273A CA 3203273 A CA3203273 A CA 3203273A CA 3203273 A1 CA3203273 A1 CA 3203273A1
Authority
CA
Canada
Prior art keywords
seq
catalytically active
variant
ada2 protein
active portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3203273A
Other languages
English (en)
French (fr)
Inventor
Christopher D. Thanos
Lin Wang
Michael H. Shepard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Halozyme Inc
Original Assignee
Halozyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halozyme Inc filed Critical Halozyme Inc
Publication of CA3203273A1 publication Critical patent/CA3203273A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004Adenosine deaminase (3.5.4.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3203273A 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same Pending CA3203273A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462063936P 2014-10-14 2014-10-14
US62/063,936 2014-10-14
CA3126536A CA3126536C (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3126536A Division CA3126536C (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same

Publications (1)

Publication Number Publication Date
CA3203273A1 true CA3203273A1 (en) 2016-04-21

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CA3203273A Pending CA3203273A1 (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
CA2964317A Active CA2964317C (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
CA3126536A Active CA3126536C (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same

Family Applications After (2)

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CA2964317A Active CA2964317C (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
CA3126536A Active CA3126536C (en) 2014-10-14 2015-10-14 Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same

Country Status (16)

Country Link
US (3) US9969998B2 (enExample)
EP (1) EP3207130B1 (enExample)
JP (1) JP6625627B2 (enExample)
KR (1) KR102122463B1 (enExample)
CN (1) CN108064282A (enExample)
AU (2) AU2015332533B2 (enExample)
BR (1) BR112017007765B1 (enExample)
CA (3) CA3203273A1 (enExample)
DK (1) DK3207130T3 (enExample)
EA (1) EA201700181A1 (enExample)
ES (1) ES2753391T3 (enExample)
IL (1) IL251527B (enExample)
NZ (2) NZ746680A (enExample)
PL (1) PL3207130T3 (enExample)
SG (1) SG11201702934TA (enExample)
WO (1) WO2016061286A2 (enExample)

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