CA3119773A1 - Irak degraders and uses thereof - Google Patents
Irak degraders and uses thereof Download PDFInfo
- Publication number
- CA3119773A1 CA3119773A1 CA3119773A CA3119773A CA3119773A1 CA 3119773 A1 CA3119773 A1 CA 3119773A1 CA 3119773 A CA3119773 A CA 3119773A CA 3119773 A CA3119773 A CA 3119773A CA 3119773 A1 CA3119773 A1 CA 3119773A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- nitrogen
- ring
- sulfur
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862774051P | 2018-11-30 | 2018-11-30 | |
| US62/774,051 | 2018-11-30 | ||
| US201962788460P | 2019-01-04 | 2019-01-04 | |
| US62/788,460 | 2019-01-04 | ||
| US201962793992P | 2019-01-18 | 2019-01-18 | |
| US62/793,992 | 2019-01-18 | ||
| US201962826743P | 2019-03-29 | 2019-03-29 | |
| US62/826,743 | 2019-03-29 | ||
| US201962831007P | 2019-04-08 | 2019-04-08 | |
| US62/831,007 | 2019-04-08 | ||
| US201962851427P | 2019-05-22 | 2019-05-22 | |
| US62/851,427 | 2019-05-22 | ||
| US201962868574P | 2019-06-28 | 2019-06-28 | |
| US62/868,574 | 2019-06-28 | ||
| US201962875347P | 2019-07-17 | 2019-07-17 | |
| US62/875,347 | 2019-07-17 | ||
| US201962879117P | 2019-07-26 | 2019-07-26 | |
| US62/879,117 | 2019-07-26 | ||
| PCT/US2019/064070 WO2020113233A1 (en) | 2018-11-30 | 2019-12-02 | Irak degraders and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3119773A1 true CA3119773A1 (en) | 2020-06-04 |
Family
ID=70853519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3119773A Pending CA3119773A1 (en) | 2018-11-30 | 2019-12-02 | Irak degraders and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US11352350B2 (enExample) |
| EP (1) | EP3886904B1 (enExample) |
| JP (2) | JP7623943B2 (enExample) |
| KR (2) | KR20250167680A (enExample) |
| CN (1) | CN113423427B (enExample) |
| AU (1) | AU2019389174A1 (enExample) |
| BR (1) | BR112021010484A2 (enExample) |
| CA (1) | CA3119773A1 (enExample) |
| CO (1) | CO2021007068A2 (enExample) |
| IL (1) | IL283471A (enExample) |
| MX (1) | MX2021006154A (enExample) |
| PH (1) | PH12021500026A1 (enExample) |
| SG (1) | SG11202105424PA (enExample) |
| WO (1) | WO2020113233A1 (enExample) |
Families Citing this family (90)
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|---|---|---|---|---|
| LT3466955T (lt) | 2014-01-13 | 2021-02-25 | Aurigene Discovery Technologies Limited | Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CN120574283A (zh) | 2019-04-05 | 2025-09-02 | 凯麦拉医疗公司 | Stat降解剂和其用途 |
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| US20240383887A1 (en) | 2021-05-07 | 2024-11-21 | Kymera Therapeutics, Inc. | Deuterated irak degraders and uses thereof |
| CA3236265A1 (en) | 2021-10-29 | 2023-05-04 | William Leong | Irak4 degraders and synthesis thereof |
| US20230277519A1 (en) | 2022-01-14 | 2023-09-07 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| CA3243560A1 (en) | 2022-01-31 | 2023-08-03 | Kymera Therapeutics, Inc. | Iraqi Degradation Agents and Their Uses |
| WO2023192586A1 (en) | 2022-03-31 | 2023-10-05 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CN120303270A (zh) | 2022-10-13 | 2025-07-11 | 凯麦拉医疗公司 | Irak4降解剂的盐形式 |
| AU2023398975A1 (en) | 2022-12-13 | 2025-06-12 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
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2019
- 2019-12-02 CA CA3119773A patent/CA3119773A1/en active Pending
- 2019-12-02 SG SG11202105424PA patent/SG11202105424PA/en unknown
- 2019-12-02 WO PCT/US2019/064070 patent/WO2020113233A1/en not_active Ceased
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- 2019-12-02 CN CN201980089596.8A patent/CN113423427B/zh active Active
- 2019-12-02 MX MX2021006154A patent/MX2021006154A/es unknown
- 2019-12-02 KR KR1020257039237A patent/KR20250167680A/ko active Pending
- 2019-12-02 PH PH1/2021/500026A patent/PH12021500026A1/en unknown
- 2019-12-02 KR KR1020217020350A patent/KR102891608B1/ko active Active
- 2019-12-02 JP JP2021530878A patent/JP7623943B2/ja active Active
- 2019-12-02 US US16/701,077 patent/US11352350B2/en active Active
- 2019-12-02 EP EP19891087.9A patent/EP3886904B1/en active Active
- 2019-12-02 AU AU2019389174A patent/AU2019389174A1/en active Pending
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2020
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2021
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2022
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2023
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2024
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2025
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Also Published As
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|---|---|
| JP2022516401A (ja) | 2022-02-28 |
| US20240239777A1 (en) | 2024-07-18 |
| BR112021010484A2 (pt) | 2021-08-24 |
| JP2025000987A (ja) | 2025-01-07 |
| MX2021006154A (es) | 2021-08-24 |
| US12258341B2 (en) | 2025-03-25 |
| US11807636B2 (en) | 2023-11-07 |
| EP3886904B1 (en) | 2026-04-22 |
| US11117889B1 (en) | 2021-09-14 |
| AU2019389174A1 (en) | 2021-07-01 |
| CO2021007068A2 (es) | 2021-09-30 |
| EP3886904A4 (en) | 2022-07-13 |
| US20220324854A1 (en) | 2022-10-13 |
| KR102891608B1 (ko) | 2025-11-28 |
| CN113423427B (zh) | 2026-03-13 |
| IL283471A (en) | 2021-07-29 |
| KR20250167680A (ko) | 2025-12-01 |
| JP7623943B2 (ja) | 2025-01-29 |
| EP3886904A1 (en) | 2021-10-06 |
| CN113423427A (zh) | 2021-09-21 |
| US20250163042A1 (en) | 2025-05-22 |
| KR20210111252A (ko) | 2021-09-10 |
| PH12021500026A1 (en) | 2022-05-11 |
| WO2020113233A1 (en) | 2020-06-04 |
| US11352350B2 (en) | 2022-06-07 |
| SG11202105424PA (en) | 2021-06-29 |
| US20210323952A1 (en) | 2021-10-21 |
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