CA3053010A1 - Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer - Google Patents

Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer Download PDF

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Publication number
CA3053010A1
CA3053010A1 CA3053010A CA3053010A CA3053010A1 CA 3053010 A1 CA3053010 A1 CA 3053010A1 CA 3053010 A CA3053010 A CA 3053010A CA 3053010 A CA3053010 A CA 3053010A CA 3053010 A1 CA3053010 A1 CA 3053010A1
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Prior art keywords
cells
cancer
antigen
tumor
binding
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Pending
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CA3053010A
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English (en)
French (fr)
Inventor
Gregory P. CHANG
Ann F. CHEUNG
William Haney
Asya Grinberg
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Dragonfly Therapeutics Inc
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Dragonfly Therapeutics Inc
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Publication date
Application filed by Dragonfly Therapeutics Inc filed Critical Dragonfly Therapeutics Inc
Priority to CA3221995A priority Critical patent/CA3221995C/en
Publication of CA3053010A1 publication Critical patent/CA3053010A1/en
Pending legal-status Critical Current

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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CA3053010A 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer Pending CA3053010A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3221995A CA3221995C (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762456535P 2017-02-08 2017-02-08
US62/456,535 2017-02-08
PCT/US2018/017470 WO2018148445A1 (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3221995A Division CA3221995C (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Publications (1)

Publication Number Publication Date
CA3053010A1 true CA3053010A1 (en) 2018-08-16

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CA3053010A Pending CA3053010A1 (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CA3221995A Active CA3221995C (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

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Application Number Title Priority Date Filing Date
CA3221995A Active CA3221995C (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

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US (2) US11834506B2 (https=)
EP (2) EP4491234A3 (https=)
JP (3) JP2020506971A (https=)
KR (3) KR20240023449A (https=)
CN (1) CN110944651A (https=)
AU (1) AU2018219887B2 (https=)
CA (2) CA3053010A1 (https=)
DK (1) DK3579848T3 (https=)
ES (1) ES3005783T3 (https=)
FI (1) FI3579848T3 (https=)
IL (1) IL268554B2 (https=)
MX (1) MX2019009468A (https=)
PT (1) PT3579848T (https=)
RS (1) RS66445B1 (https=)
SG (1) SG11201907299XA (https=)
WO (1) WO2018148445A1 (https=)

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SG11201907299XA (en) 2017-02-08 2019-09-27 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
MA47465A (fr) * 2017-02-10 2019-12-18 Dragonfly Therapeutics Inc Protéines fixant le bcma, le nkg2d et le cd16
IL268755B2 (en) * 2017-02-20 2025-12-01 Dragonfly Therapeutics Inc Proteins that bind her2, nkg2d, and cd16
CA3054078A1 (en) * 2017-02-20 2018-08-23 Dragonfly Therapeutics, Inc. Proteins binding cd33, nkg2d and cd16
BR112019017256A2 (pt) * 2017-02-20 2020-04-14 Dragonfly Therapeutics Inc proteínas de ligação gd2, nkg2d e cd16
CN120173123A (zh) * 2017-02-27 2025-06-20 蜻蜓疗法股份有限公司 靶向caix、ano1、间皮素、trop2、cea或紧密连接蛋白-18.2的多特异性结合蛋白
KR20200010430A (ko) * 2017-05-23 2020-01-30 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질
AU2018273250A1 (en) * 2017-05-23 2019-12-12 Dragonfly Therapeutics, Inc. A protein binding NKG2D, CD16 and a tumor-associated antigen
SG10202102502VA (en) * 2017-09-07 2021-04-29 Dragonfly Therapeutics Inc Proteins binding nkg2d, cd16 and a tumor-associated antigen
EA202091887A1 (ru) 2018-02-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры
DK3749346T3 (da) 2018-02-08 2024-09-09 Dragonfly Therapeutics Inc Antistof variable domænekombinationer rettet mod nkg2d-receptoren
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
WO2019222449A1 (en) * 2018-05-16 2019-11-21 Dragonfly Therapeutics, Inc. Protein binding nkg2d, cd16 and a fibroblast activation protein
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