CA3005238A1 - Porous structures for extended release drug delivery devices - Google Patents

Porous structures for extended release drug delivery devices Download PDF

Info

Publication number
CA3005238A1
CA3005238A1 CA3005238A CA3005238A CA3005238A1 CA 3005238 A1 CA3005238 A1 CA 3005238A1 CA 3005238 A CA3005238 A CA 3005238A CA 3005238 A CA3005238 A CA 3005238A CA 3005238 A1 CA3005238 A1 CA 3005238A1
Authority
CA
Canada
Prior art keywords
porous structure
barrier layer
reservoir
therapeutic
porous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3005238A
Other languages
English (en)
French (fr)
Inventor
Randolph E. Campbell
Kevin W. Sacherman
Kathleen Cogan Farinas
Signe R. Erickson
Jeremy BOYETTE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ForSight Vision4 Inc
Original Assignee
ForSight Vision4 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ForSight Vision4 Inc filed Critical ForSight Vision4 Inc
Publication of CA3005238A1 publication Critical patent/CA3005238A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/04—General characteristics of the apparatus implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/125—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CA3005238A 2015-11-20 2016-11-18 Porous structures for extended release drug delivery devices Abandoned CA3005238A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562258054P 2015-11-20 2015-11-20
US201562258127P 2015-11-20 2015-11-20
US62/258,054 2015-11-20
US62/258,127 2015-11-20
PCT/US2016/062944 WO2017087902A1 (en) 2015-11-20 2016-11-18 Porous structures for extended release drug delivery devices

Publications (1)

Publication Number Publication Date
CA3005238A1 true CA3005238A1 (en) 2017-05-26

Family

ID=58719280

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3005238A Abandoned CA3005238A1 (en) 2015-11-20 2016-11-18 Porous structures for extended release drug delivery devices

Country Status (11)

Country Link
US (2) US11432959B2 (enExample)
EP (1) EP3377009B1 (enExample)
JP (2) JP6912475B2 (enExample)
KR (1) KR20180084104A (enExample)
CN (2) CN113069681B (enExample)
AU (1) AU2016355345A1 (enExample)
BR (1) BR112018010063A2 (enExample)
CA (1) CA3005238A1 (enExample)
IL (1) IL259273A (enExample)
MX (1) MX2018006234A (enExample)
WO (1) WO2017087902A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2992100T3 (es) 2014-07-15 2024-12-09 Forsight Vision4 Inc Dispositivo de administración de implante ocular
CN113069681B (zh) * 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 制造用于缓释药物递送的治疗装置的方法
CN109195556B (zh) 2016-04-05 2021-03-26 弗赛特影像4股份有限公司 可植入眼睛药物递送装置
KR20190106996A (ko) 2016-11-03 2019-09-18 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 외부 산소 전달을 수반 또는 비-수반하는 산소 센서가 구비된 캡슐화 장치 시스템
BR112020010053A2 (pt) 2017-11-21 2020-11-03 Forsight Vision4, Inc. aparelho para troca de fluido para sistema de liberação de porta expansível e métodos de uso do mesmo
KR102168759B1 (ko) 2018-11-01 2020-10-22 주식회사 에스티엔 약액 주입기
CN109596791B (zh) * 2018-11-12 2021-08-10 禄根仪器(镇江)有限公司 一种栓剂测试装置
CN110171814B (zh) * 2019-05-13 2022-07-29 电子科技大学 水溶性KCl催化合成碳纳米片的方法及储能、缓释应用
JP2022541847A (ja) * 2019-07-24 2022-09-27 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド インプラント可能なカテーテル
CA3160807A1 (en) * 2019-12-05 2021-06-10 Antons SIZOVS Stabilized drug formulations and methods of loading drug delivery implants
CN112107742B (zh) * 2020-10-22 2024-05-14 南京佑羲医药科技有限公司 一种长效智能植入式载药装置及其制造方法
US20220378611A1 (en) * 2021-05-27 2022-12-01 W. L. Gore & Associates, Inc. Drug therapy delivery systems and methods
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
CN114849034B (zh) * 2022-01-29 2025-05-02 优畅达(武汉)医疗科技有限公司 一种控制给药时间的方法
US20230355271A1 (en) * 2022-05-02 2023-11-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for therapeutic molecule delivery to subcutaneous or intraperitoneal sites
USD1101145S1 (en) 2022-08-11 2025-11-04 Genentech, Inc. Ocular incision guide tool
KR102806740B1 (ko) 2024-01-19 2025-05-12 포항공과대학교 산학협력단 마이크로 및 나노 스케일의 요철 채널 구조를 갖는 고속 유기 전기화학 트랜지스터 및 그의 제조방법
WO2026050299A1 (en) * 2024-08-27 2026-03-05 Glaukos Corporation Drug delivery implants as intraocular drug depots
KR20260031485A (ko) * 2024-08-29 2026-03-09 조철민 골시멘트 주입 장치

Family Cites Families (434)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1747814A (en) 1927-10-03 1930-02-18 Gulf Production Company Automatic switcher device for oil-storage tanks
US2585815A (en) 1947-01-16 1952-02-12 Mclintock Duncan Menzies Injection syringe
US2564977A (en) 1949-01-19 1951-08-21 Hu Quang Hsi Medical injecting apparatus
US2886497A (en) 1957-04-12 1959-05-12 United States Steel Corp Method for determining the permeability of steel to hydrogen
US3232117A (en) 1962-09-14 1966-02-01 Roger Gilmont Instr Inc Micrometer buret
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3641237A (en) 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3831583A (en) 1971-03-05 1974-08-27 Univ California Implantable bulb for inflation of surgical implements
US3986510A (en) 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3995635A (en) 1971-09-09 1976-12-07 Alza Corporation Ocular insert
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3826258A (en) 1972-02-07 1974-07-30 S Abraham Gradual release medicine carrier
US3845201A (en) 1972-04-24 1974-10-29 S Loucas Solid state ophthalmic medication delivery method
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3914402A (en) 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US4179497A (en) 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
US3902495A (en) 1974-01-28 1975-09-02 Cavitron Corp Flow control system
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949748A (en) 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US3926188A (en) 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4142526A (en) 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
NL188266C (nl) 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US3977404A (en) 1975-09-08 1976-08-31 Alza Corporation Osmotic device having microporous reservoir
US4014333A (en) 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4111201A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for delivering selected beneficial agents having varying degrees of solubility
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4186184A (en) 1977-12-27 1980-01-29 Alza Corporation Selective administration of drug with ocular therapeutic system
US4220152A (en) 1978-05-08 1980-09-02 Pfizer Inc. Delivery system
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
DE3068986D1 (en) 1980-01-28 1984-09-27 Merck & Co Inc Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors
US4309776A (en) 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4439198A (en) 1981-07-09 1984-03-27 University Of Illinois Foundation Biodegradable ocular insert for controlled delivery of ophthalmic medication
US4730013A (en) 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4475916A (en) 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4673405A (en) 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4883459A (en) 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4774091A (en) 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
US4634427A (en) 1984-09-04 1987-01-06 American Hospital Supply Company Implantable demand medication delivery assembly
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4577642A (en) * 1985-02-27 1986-03-25 Medtronic, Inc. Drug dispensing body implantable lead employing molecular sieves and methods of fabrication
US4712550A (en) 1985-04-08 1987-12-15 Sinnett Kevin B Retinal tack
US4693886A (en) 1985-04-22 1987-09-15 Alza Corporation Osmotic device with inert core
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
EP0201611A1 (de) 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
FR2582221B1 (fr) 1985-05-21 1987-09-25 Applied Precision Ltd Dispositif implantable d'injection chronique d'une substance, notamment therapeutique
US4840615A (en) 1985-09-30 1989-06-20 Mcghan Medical Corporation Self-sealing injection reservoir
US4781675A (en) 1985-11-27 1988-11-01 White Thomas C Infusion cannula
DE3672981D1 (de) 1985-11-27 1990-08-30 Thomas C White Gewebeimplantierbare fluessigkeitsverteileinrichtung.
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
IL97538A (en) 1986-12-23 1995-03-15 Liposome Co Inc Multilamellar liposomes containing nonphosphate guanindino aminoglycosides and their preparation.
US4781680A (en) 1987-03-02 1988-11-01 Vir Engineering Resealable injection site
US4853229A (en) 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
US4865846A (en) 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US5174999A (en) 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
WO1990007575A1 (en) 1988-12-30 1990-07-12 Anderson David M Stabilized microporous materials and hydrogel materials
US5141748A (en) 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US4979938A (en) 1989-05-11 1990-12-25 Iomed, Inc. Method of iontophoretically treating acne, furuncles and like skin disorders
US5219101A (en) * 1989-06-01 1993-06-15 Pall Corporation Contamination-resistant dispensing and metering drop forming device
US5013459A (en) * 1989-11-09 1991-05-07 Dow Corning Corporation Opthalmic fluid dispensing method
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5197882A (en) * 1990-05-14 1993-03-30 Gary R. Jernberg Periodontal barrier and method for aiding periodontal tissue regeneration agents
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5238687A (en) 1990-07-11 1993-08-24 Alza Corporation Delivery device with a protective sleeve
US5084021A (en) 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
AU650113B2 (en) 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5334189A (en) 1991-06-03 1994-08-02 Wade Stephen E Device for controlled diffusion of a chemical substance
US5282829A (en) 1991-08-15 1994-02-01 United States Surgical Corporation Hollow body implants
FR2682090B1 (fr) 1991-10-03 1993-12-31 Holzstoff Holding Sa Systeme-reservoir pour diffusion prolongee d'un principe actif.
US5681572A (en) 1991-10-18 1997-10-28 Seare, Jr.; William J. Porous material product and process
US5830492A (en) 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5576480A (en) 1992-11-06 1996-11-19 Pall Corporation System and method for testing the integrity of porous elements
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5770076A (en) 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
AU708529B2 (en) 1994-11-10 1999-08-05 University Of Kentucky Research Foundation, The Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5704915A (en) 1995-02-14 1998-01-06 Therex Limited Partnership Hemodialysis access device
US5554132A (en) 1995-03-30 1996-09-10 Abbott Laboratories Hand grip for use with syringe
ATE272414T1 (de) 1995-05-14 2004-08-15 Optonol Ltd Intraokulares implantat, einführgerät sowie implantierungsverfahren
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5989216A (en) 1995-06-29 1999-11-23 Sims Deltec, Inc. Access portal and method
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB2310149A (en) 1996-02-15 1997-08-20 Nomix Chipman Ltd Spray gun
US20090005864A1 (en) 1996-03-18 2009-01-01 Eggleston Harry C Modular intraocular implant
US5951512A (en) 1996-05-28 1999-09-14 Horizon Medical Products, Inc. Infusion port with modified drug reservoir
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
AU7533696A (en) 1996-12-13 1998-06-18 Ciba-Geigy Ag New materials
DE69835305T2 (de) 1997-03-31 2007-07-19 Alza Corp., Mountain View Diffusionsgesteuertes implantierbares Verabreichungssystem
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5968008A (en) 1997-08-04 1999-10-19 Grams; Guenter A. Cannula with parallel channels and sliding sheath
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6331523B1 (en) 1998-03-12 2001-12-18 Genentech, Inc. Method of enhancing the survival of retinal neurons and treating ocular diseases using FGF-5
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
FR2784296B1 (fr) 1998-09-18 2001-01-05 Imedex Biomateriaux Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US6361780B1 (en) 1998-11-12 2002-03-26 Cardiac Pacemakers, Inc. Microporous drug delivery system
WO2000035531A1 (en) 1998-12-14 2000-06-22 Tre Esse Progettazione Biomedica S.R.L. Catheter system for performing intramyocardiac therapeutic treatment
DE19948783C2 (de) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implantat
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US20050119601A9 (en) 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US6420399B1 (en) 1999-06-18 2002-07-16 Alcon Manufacturing, Ltd. Topical ophthalmic mast cell stabilizers for treating allergic eye disease
US6638263B1 (en) 1999-10-12 2003-10-28 Durect Corporation Regulation of drug delivery through flow diversion
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
DE60040876D1 (de) 1999-10-21 2009-01-02 Alcon Inc Medikamentenzuführeinrichtung
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
CN100408118C (zh) 2000-01-12 2008-08-06 贝克顿迪肯森公司 降低眼内压力的系统和方法
US20030212383A1 (en) 2001-01-05 2003-11-13 Dana Cote System and methods for reducing intraocular pressure
DE10008826C2 (de) 2000-02-25 2002-03-14 Disetronic Licensing Ag Mikroperfusionsvorrichtung mit Sammelbehältnis
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
EP1186439A4 (en) 2000-03-13 2004-12-08 Seiko Epson Corp METHOD FOR SURFACE TREATMENT, ITEMS PRODUCED THEREOF AND DEVICE FOR SURFACE TREATMENT
US7141152B2 (en) 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US6945969B1 (en) 2000-03-31 2005-09-20 Medtronic, Inc. Catheter for target specific drug delivery
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
ATE404140T1 (de) 2000-08-30 2008-08-15 Univ Johns Hopkins Vorrichtung zur intraokularen wirkstoffverabreichung
WO2002019992A2 (en) 2000-09-06 2002-03-14 Alcon, Inc. Switchable tackiness coating compositions for ophthalmic implants
US6303290B1 (en) 2000-09-13 2001-10-16 The Trustees Of The University Of Pennsylvania Encapsulation of biomaterials in porous glass-like matrices prepared via an aqueous colloidal sol-gel process
WO2002056863A2 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
DE60137542D1 (de) 2001-01-03 2009-03-12 Bausch & Lomb Wirkstoffabgabevorrichtungen mit verzögerter freisetzung mehrere stoffe enthaltend
CA2433032C (en) 2001-01-03 2008-11-25 Bausch & Lomb Incorporated Sustained release drug delivery devices with coated drug cores
WO2002053129A1 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with prefabricated permeable plugs
EP1372602B1 (en) 2001-01-09 2007-04-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6872198B1 (en) 2001-01-24 2005-03-29 Arrow International, Inc. Double-y-shaped multi-lumen catheter with selectively attachable hubs
WO2002058667A2 (en) 2001-01-26 2002-08-01 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
FR2821672B1 (fr) 2001-03-02 2003-05-02 Scp Dosagene R & D Moyens pour l'extraction de produits a analyser et leurs applications en diagnostic et analyse
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
IL159715A0 (en) 2001-07-10 2004-06-20 Teva Pharma Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
ES2271301T3 (es) 2001-07-23 2007-04-16 Alcon, Inc. Dispositivo de suministro de farmaco oftalmico.
CN1203814C (zh) 2001-07-23 2005-06-01 爱尔康公司 眼部药物输送装置
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
PT1420716E (pt) 2001-08-29 2012-11-21 Ricardo A P De Carvalho Um sistema implantável e selável destinado à administração unidireccional de agentes terapêuticos em tecidos-alvo
CA2460334A1 (en) 2001-09-14 2003-03-27 Francis J. Martin Microfabricated nanopore device for sustained release of therapeutic agent
US20040254197A1 (en) 2001-09-28 2004-12-16 Santen Pharmaceutical Co., Ltd. Injections for eye tissues containing drug bonded to polyethlene glycol
AU2002341959A1 (en) 2001-10-04 2003-04-14 Case Western Reserve University Drug delivery devices and methods
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20070088335A1 (en) * 2001-10-24 2007-04-19 Med-El Elektromedizinische Geraete Gmbh Implantable neuro-stimulation electrode with fluid reservoir
US7003405B1 (en) 2001-10-25 2006-02-21 Sandia Corporation Methods for characterizing subsurface volatile contaminants using in-situ sensors
EP1444338A4 (en) 2001-11-15 2007-07-04 Arryx Inc PASTILLE WITH SAMPLES
US7090888B2 (en) 2002-01-18 2006-08-15 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
BR0308482A (pt) 2002-03-11 2005-02-22 Alcon Inc Sistema de administração de droga implantável
US7074426B2 (en) 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
US8084054B2 (en) 2002-07-15 2011-12-27 Novartis Ag Bioerodible film for ophthalmic drug delivery
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US20040019325A1 (en) 2002-07-29 2004-01-29 Medrip Ltd. Syringe Pump
US20070219632A1 (en) 2002-08-02 2007-09-20 David Castillejos Method and intra-sclera implant for treatment of glaucoma and presbyopia
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
MXPA05002841A (es) 2002-09-18 2005-05-27 Oculex Pharm Inc Metodo y aparato de administracion de implantes oculares.
AU2003279055A1 (en) 2002-09-29 2004-04-19 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US7794437B2 (en) 2003-01-24 2010-09-14 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
US20060167435A1 (en) 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
WO2004076647A2 (en) 2003-02-26 2004-09-10 The Regents Of The University Of California Use of steady-state oxygen gradients to modulate animal cell functions
US20050255144A1 (en) 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US20050074497A1 (en) 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US7094222B1 (en) 2003-04-28 2006-08-22 The United States Of America As Represented By The Secretary Of Navy Syringe device for simultaneous infusion and withdrawal
AU2004237774B2 (en) 2003-05-02 2009-09-10 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
EP1671624B1 (en) 2003-05-02 2010-08-11 SurModics, Inc. Delivery device for a controlled drug release of an active agent into the posterior section of the eye
AU2004264839B2 (en) 2003-06-13 2009-06-04 Becton, Dickinson And Company Improved intra-dermal delivery of biologically active agents
US20040260380A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices for delivering multiple stenting structures in situ
WO2004112653A2 (en) 2003-06-18 2004-12-29 D-Crown Ltd. Devices and methods for delivering and forming single and multiple stenting structures in situ
US20040260381A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices and methods for forming stenting structures in situ
WO2005007233A2 (en) 2003-06-20 2005-01-27 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
JP2007526019A (ja) 2003-07-10 2007-09-13 アルコン，インコーポレイティド 眼科用薬物送達デバイス
FI120333B (fi) 2003-08-20 2009-09-30 Bioretec Oy Huokoinen lääketieteellinen väline ja menetelmä sen valmistamiseksi
AU2004274026A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
AU2006225241B2 (en) 2003-09-24 2008-07-17 Tianda Pharmaceuticals (Australia) Pty Limited Medication Holder
JP4445966B2 (ja) 2003-09-24 2010-04-07 メディ−ストリーム プロプライエタリィ リミティッド 薬物ホルダー
US7615141B2 (en) 2003-10-03 2009-11-10 University Of Washington Electrochemical micromanufacturing system and method
WO2005039668A2 (en) * 2003-10-21 2005-05-06 Boiarski Anthony A Implantable drug delivery device for sustained release of therapeutic agent
US7211272B2 (en) 2003-12-22 2007-05-01 Bausch & Lomb Incorporated Drug delivery device
US7744520B2 (en) 2004-02-12 2010-06-29 Neovista, Inc. Method and apparatus for intraocular brachytherapy
US7276050B2 (en) 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
WO2005091922A2 (en) 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20060182783A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Sustained release intraocular drug delivery systems
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
EP1765455A2 (en) * 2004-06-01 2007-03-28 Microchips, Inc. Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
DK1765454T3 (en) 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
CA2575622A1 (en) 2004-08-06 2006-02-09 Sopherion Therapeutics, Inc. Anti-angiogenic peptides and methods of use thereof
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
US20060104969A1 (en) 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US20060052754A1 (en) 2004-09-04 2006-03-09 Fields Douglas W Thumb trigger syringe pole
US7709049B2 (en) 2004-09-10 2010-05-04 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
CN101890167B (zh) 2004-10-01 2017-03-01 拉姆斯科股份有限公司 可方便植入的缓释药物组合物
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
CN101437478A (zh) * 2004-10-04 2009-05-20 Qlt美国有限公司 聚合送递制剂的眼部送递
CA2583399A1 (en) 2004-10-14 2006-04-27 Sopherion Therapeutics, Inc. Anti-angiogenic peptides and methods of use thereof
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
ES2669585T3 (es) 2004-10-29 2018-05-28 The Regents Of The University Of California Micropartículas porosas de silicio para la entrega de fármaco para el ojo
US20060129215A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060154981A1 (en) 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
US20080233053A1 (en) 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
AU2006227116A1 (en) 2005-03-21 2006-09-28 Santen Pharmaceutical Co., Ltd. Drug delivery systems for treatment of diseases or conditions
US20070077270A1 (en) 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
WO2006108054A2 (en) 2005-04-05 2006-10-12 The Ohio State University Diffusion delivery system and methods of fabrication
US20100168535A1 (en) 2006-04-12 2010-07-01 Mark Ries Robinson Methods and apparatuses related to blood analyte measurement system
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
WO2006127962A2 (en) 2005-05-25 2006-11-30 Becton, Dickinson And Comapny Particulate formulations for intradermal delivery of biologically active agents
US20070021357A1 (en) 2005-06-17 2007-01-25 Dynamis Therapeutics, Inc. Treatment of inflammatory conditions
WO2007002184A1 (en) 2005-06-21 2007-01-04 Bausch & Lomb Incorporated Drug delivery device having zero or near zero-order release kinetics
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
WO2007016656A2 (en) 2005-08-02 2007-02-08 Btg International Limited Modulators of hypoxia inducible factor-1 and related uses for the treatment of ocular disorders
WO2007021671A2 (en) 2005-08-10 2007-02-22 Insight Instruments, Inc. Tool for extracting vitreous samples from an eye
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
CA2622573A1 (en) 2005-09-16 2007-03-29 (Osi) Eyetech, Inc. Ophthalmic syringe
WO2007035356A2 (en) * 2005-09-16 2007-03-29 Bg Implant, Inc. Glaucoma treatment devices and methods
US20070071756A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation
US20070072933A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an ocular agent
US20080003219A1 (en) 2005-09-26 2008-01-03 Minu, L.L.C. Delivery of an ocular agent
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
WO2007038453A2 (en) 2005-09-26 2007-04-05 Advanced Ocular Systems Limited Use of an anti-vascular endothelial growth factor (vegf) agent to ameliorate inflammation
TW200732347A (en) 2005-10-06 2007-09-01 Trophogen Inc VEGF analogs and methods of use
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
EP1948112A4 (en) 2005-10-11 2011-04-13 Podaima Blake SMART MEDICAL COMPLIANCE PROCESS AND SYSTEM
US20080125406A1 (en) 2005-10-14 2008-05-29 Robin Alan L Method for Treating Primary and Secondary Forms of Glaucoma
KR20080059280A (ko) 2005-10-14 2008-06-26 알콘, 인코퍼레이티드 녹내장의 원발성 및 ２차 형태의 치료 방법
JP4721425B2 (ja) 2005-12-01 2011-07-13 キヤノン株式会社 流体移動方法および流体移動装置
EP1957695B1 (en) 2005-12-07 2011-02-09 Ramot at Tel-Aviv University Ltd. Drug-delivering composite structures
US20070131610A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based apparatus and associated method
US20070131611A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based article and associated method
JP5388582B2 (ja) 2006-01-17 2014-01-15 トランセンド・メディカル・インコーポレイテッド 薬剤投与処置装置
EP3005996B1 (en) 2006-01-17 2019-12-04 Novartis Ag Glaucoma treatment device
US20080216736A1 (en) 2006-01-19 2008-09-11 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
WO2007100986A2 (en) 2006-02-24 2007-09-07 Rosetta Inpharmatics Llc Extraction and diagnostic fluid devices, systems and methods of use
WO2007101204A1 (en) 2006-02-27 2007-09-07 Alcon Research, Ltd. Method of treating glaucoma
EP1834636A1 (en) 2006-03-08 2007-09-19 Sahajanand Medical Technologies PVT. ltd Compositions comprising porous articles and uses in implantable medical devices
US20100297046A1 (en) 2006-03-31 2010-11-25 Dynamis Therapeutics, Inc. Compositions and Methods Related to Fructosamine-3-Kinase Inhibitors
NZ572193A (en) 2006-03-31 2011-10-28 Quadra Logic Tech Inc Nasolacrimal drainage system implants for drug therapy with non-fluid swellable retention structure around drug core
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
US20080027304A1 (en) 2006-04-18 2008-01-31 Pardo Geoffrey B Intraocular pressure attenuation device
US8007461B2 (en) 2006-04-18 2011-08-30 Pingan Huo Sterile drug-mixing syringe
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US7981096B2 (en) 2006-05-12 2011-07-19 David Castillejos Optic nerve head implant and medication delivery system
CN101448534B (zh) * 2006-05-17 2012-10-03 生物技术公司 用于医疗植入物的各向异性纳米多孔涂层
US20070270750A1 (en) 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US20080124372A1 (en) 2006-06-06 2008-05-29 Hossainy Syed F A Morphology profiles for control of agent release rates from polymer matrices
EP2037882B1 (en) 2006-06-28 2014-12-10 SurModics, Inc. Combination degradable and non-degradable matrices for active agent delivery
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
CA2657064C (en) 2006-07-19 2014-09-23 Noab Biodiscoveries Inc. Method and device to extract components contained in a fluid
EP2046437A2 (en) 2006-07-20 2009-04-15 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
US20080069854A1 (en) 2006-08-02 2008-03-20 Inframat Corporation Medical devices and methods of making and using
US9039761B2 (en) 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
JP2008054521A (ja) 2006-08-29 2008-03-13 Canon Inc 細胞培養処理装置及び細胞培養処理方法
US8821943B2 (en) 2006-09-12 2014-09-02 Board Of Regents Of The University Of Nebraska Methods and compositions for targeted delivery of therapeutic agents
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
JP5694664B2 (ja) 2006-09-29 2015-04-01 サーモディクス，インコーポレイティド 生分解性眼用インプラント及び眼の病気を治療する方法
US9149750B2 (en) 2006-09-29 2015-10-06 Mott Corporation Sinter bonded porous metallic coatings
WO2008045272A2 (en) 2006-10-06 2008-04-17 Dynamis Therapeutics, Inc. Compositions and methods for skin lightening
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
CA2667791A1 (en) 2006-10-25 2008-05-02 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
WO2008115290A2 (en) 2006-10-25 2008-09-25 Revalesio Corporation Methods of wound care and treatment
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US20080111282A1 (en) 2006-11-10 2008-05-15 Baojun Xie Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles
CA2668954C (en) 2006-11-10 2020-09-08 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20100286791A1 (en) 2006-11-21 2010-11-11 Goldsmith David S Integrated system for the ballistic and nonballistic infixion and retrieval of implants
US20090263346A1 (en) 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US20100210792A1 (en) 2006-12-05 2010-08-19 David Taft Drug delivery
WO2008073295A2 (en) 2006-12-07 2008-06-19 Surmodics, Inc. Latent stabilization of bioactive agents releasable from implantable medical articles
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
EP2091481A2 (en) 2006-12-18 2009-08-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
RU2009128703A (ru) 2006-12-26 2011-02-10 Клт Плаг Диливери, Инк. (Us) Имплантаты, доставляющие лекарства, для уменьшения оптических дефектов
JP5201744B2 (ja) 2007-01-09 2013-06-05 フォヴェア ファルマシューティカル 眼内注射装置
CN101646402A (zh) 2007-01-19 2010-02-10 金文申有限公司 用粉末模塑法制成的多孔、不可降解植入物
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
GB0702864D0 (en) 2007-02-14 2007-03-28 Benoist Girard Sas Prosthetic implant for use without bone cement
WO2008116165A2 (en) 2007-03-21 2008-09-25 Next Safety, Inc. Methods and systems of delivering medication via inhalation
US20080249501A1 (en) 2007-04-09 2008-10-09 Medtronic Vascular, Inc. Methods for Simultaneous Injection and Aspiration of Fluids During a Medical Procedure
EP2139471A2 (en) 2007-04-30 2010-01-06 Alcon Research, Ltd. Treatment of age-related macular degeneration using inhibitors of complement factor d
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CN101815724B (zh) 2007-05-29 2015-02-25 安吉奥开米公司 用于将轭合至其的试剂递送至组织的抑肽酶样多肽
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
WO2009023615A1 (en) 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
US7901726B2 (en) 2007-08-31 2011-03-08 Boston Scientific Scimed, Inc. Porous medical articles for therapeutic agent delivery
EP2205193A2 (en) 2007-09-07 2010-07-14 QLT Plug Delivery, Inc. Lacrimal implant detection
WO2009035567A2 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Insertion and extraction tools for lacrimal implants
ES2538838T3 (es) 2007-09-07 2015-06-24 Mati Therapeutics Inc. Método para preparar insertos de fármacos para liberación sostenida de agentes terapéuticos
US20090081272A1 (en) 2007-09-24 2009-03-26 John Clarke Medical devices having a metal particulate composition for controlled diffusion
US8308755B2 (en) 2007-09-24 2012-11-13 Ethicon Endo-Surgery, Inc. Elliptical retractor
US8974809B2 (en) 2007-09-24 2015-03-10 Boston Scientific Scimed, Inc. Medical devices having a filter insert for controlled diffusion
US20090214601A1 (en) 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
US20100100043A1 (en) 2007-10-05 2010-04-22 Racenet Danyel J Flexible Access Device For Use In Surgical Procedure
US20090093752A1 (en) 2007-10-05 2009-04-09 Tyco Healthcare Group Lp Seal anchor for use in surgical procedures
WO2009055620A1 (en) 2007-10-25 2009-04-30 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090263495A1 (en) 2007-10-25 2009-10-22 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20100008997A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100303918A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US20100009008A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20100004189A1 (en) 2007-10-25 2010-01-07 Revalesio Corporation Compositions and methods for treating cystic fibrosis
WO2010062628A1 (en) 2008-10-27 2010-06-03 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100303917A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20100310665A1 (en) 2007-10-25 2010-12-09 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
JP2011502990A (ja) 2007-11-05 2011-01-27 ボーシュ アンド ローム インコーポレイティド 薬物送達用ビヒクルとしての水非混和性物質
US8114883B2 (en) 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
ES2425769T5 (es) 2007-12-20 2017-07-28 University Of Southern California Aparato para la administración de agentes terapéuticos
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
DK2240220T3 (en) 2008-01-03 2016-08-01 Univ Southern California Implantable devices for drug AND APPARATUS FOR refilling DEVICES
WO2009089409A2 (en) 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009094466A2 (en) 2008-01-22 2009-07-30 University Of Florida Research Foundation, Inc. Contact lenses for extended release of bioactive agents containing diffusion attenuators
US8521273B2 (en) 2008-01-29 2013-08-27 Gilbert H. KLIMAN Drug delivery devices, kits and methods therefor
US8201752B2 (en) 2008-03-10 2012-06-19 Vapore, Inc. Low energy vaporization of liquids: apparatus and methods
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
US20090240208A1 (en) 2008-03-19 2009-09-24 Warsaw Orthopedic, Inc. Microparticle delivery syringe and needle for placing particle suspensions and removing vehicle fluid
EP2257326A2 (en) 2008-03-21 2010-12-08 Novartis AG Powder dispersion apparatus
ES2689420T3 (es) 2008-03-31 2018-11-14 Nitto Denko Corporation Sistema de administración de permeante y métodos para su uso
US8555874B2 (en) 2008-04-04 2013-10-15 Nektar Therapeutics Aerosolization device
US8801665B2 (en) 2008-04-10 2014-08-12 Henry Ford Health System Apparatus and method for controlled depth of injection into myocardial tissue
WO2009128932A1 (en) 2008-04-15 2009-10-22 Sarcode Corporation Delivery of lfa-1 antagonists to the gastrointestinal system
US9132088B2 (en) 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
CN103919804A (zh) 2008-05-01 2014-07-16 利发利希奥公司 治疗消化功能紊乱的组合物和方法
CA2723723C (en) 2008-05-08 2019-06-25 Replenish Pumps, Llc Implantable drug-delivery devices, and apparatus and methods for filling the devices
US20100197512A1 (en) 2008-07-11 2010-08-05 Intellicyt Multi-Sample Particle Analyzer and Method for High Throughput Screening
CN102159126A (zh) 2008-07-21 2011-08-17 阿尔斯塔西斯公司 在组织中形成管道的装置、方法和成套用具
US20100022943A1 (en) 2008-07-25 2010-01-28 Medtronic Vascular, Inc. Hydrodynamic Thrombectomy Catheter
US20100023033A1 (en) 2008-07-25 2010-01-28 Medtronic Vescular, Inc. Hydrodynamic Thrombectomy Catheter
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US20100075950A1 (en) 2008-08-26 2010-03-25 Auspex Pharmaceuticals, Inc. Phenylpropanone modulators of dopamine receptor
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
AT507187B1 (de) 2008-10-23 2010-03-15 Helmut Dr Buchberger Inhalator
WO2010062394A2 (en) 2008-11-26 2010-06-03 Surmodics, Inc. Implantable ocular drug delivery device and methods
DE102008054431B3 (de) 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents
WO2010078063A1 (en) 2009-01-02 2010-07-08 Alcon Research, Ltd. In-situ refillable ophthalmic implant
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
CN104887389B (zh) 2009-01-29 2017-06-23 弗赛特影像4股份有限公司 后段给药
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
TW201043211A (en) 2009-03-31 2010-12-16 Johnson & Johnson Vision Care Inc Punctal plugs
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
WO2010125416A1 (en) 2009-04-27 2010-11-04 Raouf Rekik Drug delivery to the anterior and posterior segments of the eye
BRPI1013992A2 (pt) 2009-04-27 2016-08-16 Revalesio Corp composições e métodos para o tratamento de resistência à insulina e diabetes melito
US20110125178A1 (en) 2009-05-15 2011-05-26 Michael Drews Devices, methods and kits for forming tracts in tissue
CA2762536C (en) 2009-05-18 2019-05-21 Dose Medical Corporation Drug eluting ocular implant
AU2010256558B2 (en) 2009-06-03 2013-10-03 Forsight Labs, Llc Anterior segment drug delivery
WO2011008896A2 (en) 2009-07-14 2011-01-20 Board Of Regents, The University Of Texas System Therapeutic methods using controlled delivery devices having zero order kinetics
WO2011008986A2 (en) 2009-07-15 2011-01-20 California Institute Of Technology A method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves
AT516600B1 (de) 2009-07-23 2016-07-15 Baxter Int Herstellung von faktor h (fh) und fh-derivaten aus plasma
EP2464744A1 (en) 2009-08-14 2012-06-20 F. Hoffmann-La Roche AG Biological markers for monitoring patient response to vegf antagonists
JP2013503885A (ja) 2009-09-01 2013-02-04 ノースウェスタン ユニバーシティ 担体としてオリゴヌクレオチド修飾されたナノ粒子を使用する治療薬の送達
EP2480270A4 (en) 2009-09-21 2015-07-08 Harvard Apparatus Regenerative Technology Inc METHOD AND DEVICE FOR INTRODUCING CELLS TO A TISSUE POSITION
CA2785468A1 (en) 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US8821474B2 (en) 2010-02-22 2014-09-02 Microsert Ltd. Slow release liquid drug delivery device
US8038650B2 (en) 2010-02-22 2011-10-18 Microsert Ltd. Slow release liquid drug delivery device
JP5729651B2 (ja) 2010-02-23 2015-06-03 ゴードン アトウッド，クリストファー 生体分子及びその相互作用特性の検出方法
EP2552349A4 (en) * 2010-03-31 2017-12-06 Ocuject, LLC Device and method for intraocular drug delivery
CA2807554C (en) * 2010-08-05 2021-10-26 Forsight Vision4 Inc. Implantable therapeutic device
WO2012019047A2 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Subconjunctival implant for posterior segment drug delivery
WO2012019136A2 (en) 2010-08-05 2012-02-09 Forsight Vision 4, Inc. Injector apparatus and method for drug delivery
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
WO2012065006A2 (en) 2010-11-11 2012-05-18 Forsight Vision4, Inc. Methods and apparatus to determine porous structures for drug delivery
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP4249059B1 (en) 2011-06-28 2025-07-30 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
EP4643921A3 (en) 2011-09-16 2026-01-07 ForSight Vision4, Inc. Fluid exchange apparatus
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
EP2968113B8 (en) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
WO2014160884A1 (en) 2013-03-28 2014-10-02 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
WO2015085234A1 (en) 2013-12-06 2015-06-11 Forsight Vision4, Inc. Implantable therapeutic devices
ES2992100T3 (es) 2014-07-15 2024-12-09 Forsight Vision4 Inc Dispositivo de administración de implante ocular
MX2017001818A (es) 2014-08-08 2017-05-30 Forsight Vision4 Inc Formulaciones estables y solubles de inhibidores de receptor de quinasa tirosina y metodos de preparacion de los mismos.
SG11201703726XA (en) 2014-11-10 2017-06-29 Forsight Vision4 Inc Expandable drug delivery devices and method of use
CN113069681B (zh) * 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 制造用于缓释药物递送的治疗装置的方法
CN109195556B (zh) 2016-04-05 2021-03-26 弗赛特影像4股份有限公司 可植入眼睛药物递送装置
BR112020010053A2 (pt) 2017-11-21 2020-11-03 Forsight Vision4, Inc. aparelho para troca de fluido para sistema de liberação de porta expansível e métodos de uso do mesmo

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