DE3751871T4 - Guanidinaminoglycosid enthaltende Liposome - Google Patents

Guanidinaminoglycosid enthaltende Liposome

Info

Publication number
DE3751871T4
DE3751871T4 DE3751871T DE3751871T DE3751871T4 DE 3751871 T4 DE3751871 T4 DE 3751871T4 DE 3751871 T DE3751871 T DE 3751871T DE 3751871 T DE3751871 T DE 3751871T DE 3751871 T4 DE3751871 T4 DE 3751871T4
Authority
DE
Germany
Prior art keywords
aminoglycoside
liposomes containing
containing guanidine
liposomes
guanidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751871T
Other languages
English (en)
Other versions
DE3751871T2 (de
DE3751871D1 (de
Inventor
Marcel B Bally
Lois E Bolcsak
Pieter R Cullis Pieter Cullis
Andrew S Janoff Andrew Janoff
Lawrence D Mayer
Robert P Lenk
Jo Ann Jedrusiak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27130236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3751871(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of DE3751871T2 publication Critical patent/DE3751871T2/de
Publication of DE3751871T4 publication Critical patent/DE3751871T4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE3751871T 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende Liposome Expired - Lifetime DE3751871T4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94639886A 1986-12-23 1986-12-23
US94639186A 1986-12-23 1986-12-23

Publications (2)

Publication Number Publication Date
DE3751871T2 DE3751871T2 (de) 1997-03-13
DE3751871T4 true DE3751871T4 (de) 1998-03-26

Family

ID=27130236

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3785198T Expired - Lifetime DE3785198T3 (de) 1986-12-23 1987-01-13 Liposomes präparat und antibiotikum.
DE3751871T Expired - Lifetime DE3751871T4 (de) 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende Liposome
DE3751871A Expired - Fee Related DE3751871D1 (de) 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende Liposome

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3785198T Expired - Lifetime DE3785198T3 (de) 1986-12-23 1987-01-13 Liposomes präparat und antibiotikum.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3751871A Expired - Fee Related DE3751871D1 (de) 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende Liposome

Country Status (8)

Country Link
EP (3) EP0295248B2 (de)
JP (1) JP2528153B2 (de)
AT (2) ATE141166T1 (de)
AU (1) AU609711B2 (de)
CA (1) CA1314481C (de)
DE (3) DE3785198T3 (de)
IL (2) IL97538A (de)
WO (1) WO1988004573A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013796A1 (en) * 1993-11-16 1995-05-26 Depotech Corporation Vesicles with controlled release of actives
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
IL90561A (en) * 1988-06-08 1993-08-18 Fountain Pharm Inc Method for making solvent dilution microcarriers
US5269979A (en) * 1988-06-08 1993-12-14 Fountain Pharmaceuticals, Inc. Method for making solvent dilution microcarriers
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US5843473A (en) * 1989-10-20 1998-12-01 Sequus Pharmaceuticals, Inc. Method of treatment of infected tissues
US6060080A (en) * 1990-07-16 2000-05-09 Daiichi Pharmaceutical Co., Ltd. Liposomal products
CA2046997C (en) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomal products
PT100486B (pt) * 1992-05-14 1999-07-30 Ineti Inst Nac Engenh E Tecnol Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao
WO1994012155A1 (en) * 1992-12-02 1994-06-09 Vestar, Inc. Antibiotic formulation and process
US5958449A (en) * 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
PT1581236E (pt) * 2002-10-29 2013-12-24 Insmed Inc Libertação prolongada de anti-infecciosos
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
EP3067046B1 (de) 2005-12-08 2020-03-25 Insmed Incorporated Antiinfektive zusammensetzungen auf lipidbasis zur behandlung von lungeninfekten
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CA3045436A1 (en) 2009-01-29 2010-08-05 Forsight Vision4, Inc. Posterior segment drug delivery
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
WO2012019139A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
JP5907966B2 (ja) 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
EP2640360A2 (de) 2010-11-19 2013-09-25 Forsight Vision4, Inc. Therapeutische wirkstoffformulierungen für implantierte vorrichtungen
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
EP3903733A1 (de) 2011-09-16 2021-11-03 ForSight Vision4, Inc. Flüssigkeitsaustauschvorrichtung
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
SI2852391T1 (sl) 2012-05-21 2022-04-29 Insmed Incorporated Sistemi za obravnavo pljučnih infekcij
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
EP2968113B8 (de) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systeme zur verzögerten intraokularen abgabe schwerlöslicher verbindungen aus einem implantat mit einem portabgabesystem
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
DK3466432T3 (da) 2014-05-15 2020-09-28 Insmed Inc Fremgangsmåder til behandling af pulmonale non-tuberkuløse mykobakterielle infektioner
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CN114587774A (zh) 2014-11-10 2022-06-07 弗赛特影像4股份有限公司 治疗眼睛的系统
KR20180084104A (ko) 2015-11-20 2018-07-24 포사이트 비젼4, 인크. 연장 방출 약물 전달 장치를 위한 다공성 구조물
AR108177A1 (es) 2016-04-05 2018-07-25 Forsight Vision4 Inc Dispositivos de suministro de fármacos oculares implantables
BR112020010053A2 (pt) 2017-11-21 2020-11-03 Forsight Vision4, Inc. aparelho para troca de fluido para sistema de liberação de porta expansível e métodos de uso do mesmo
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4397846A (en) * 1981-05-15 1983-08-09 Murray Weiner Storage-stable lipid vesicles and method of preparation
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
JPS59500952A (ja) * 1982-03-29 1984-05-31 ザ　リポソ−ム　カンパニ−、インコ−ポレ−テッド 安定なプルリラメラベシクル類
SU1123697A1 (ru) * 1982-08-18 1984-11-15 Всесоюзный научно-исследовательский институт фармации Способ получени липосомальной формы антибиотиков стрептомицинового р да
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
JPS59210013A (ja) * 1983-05-04 1984-11-28 Ajinomoto Co Inc 活性物質含有リポソ−ム
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
MX160365A (es) * 1983-08-31 1990-02-12 Rockwell International Corp Mejoras a metodo para formar un piston de frenado para freno de disco
US4532089A (en) * 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
JPH0655676B2 (ja) * 1984-07-26 1994-07-27 ザ リポソ−ム カンパニ−、インコ−ポレ−テツド 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高
JPH0680767A (ja) * 1992-09-03 1994-03-22 Matsushita Electric Ind Co Ltd 電子・電気機器用エポキシ樹脂組成物

Also Published As

Publication number Publication date
EP0295248A1 (de) 1988-12-21
WO1988004573A1 (en) 1988-06-30
EP0500143A3 (en) 1993-03-03
ATE87503T1 (de) 1993-04-15
EP0498471B1 (de) 1996-08-14
DE3785198D1 (de) 1993-05-06
EP0500143A2 (de) 1992-08-26
DE3751871T2 (de) 1997-03-13
EP0498471A3 (en) 1993-03-03
JP2528153B2 (ja) 1996-08-28
EP0295248B2 (de) 1999-04-28
CA1314481C (en) 1993-03-16
DE3785198T2 (de) 1993-07-15
EP0295248A4 (de) 1988-12-19
JPH01501619A (ja) 1989-06-08
IL97538A0 (en) 1992-06-21
IL97538A (en) 1995-03-15
ATE141166T1 (de) 1996-08-15
EP0498471A2 (de) 1992-08-12
EP0295248B1 (de) 1993-03-31
AU609711B2 (en) 1991-05-09
DE3751871D1 (de) 1996-09-19
AU6934587A (en) 1988-07-15
DE3785198T3 (de) 1999-09-02

Similar Documents

Publication Publication Date Title
DE3751871T4 (de) Guanidinaminoglycosid enthaltende Liposome
ES8703876A1 (es) Un procedimiento para la preparacion de derivados de purina.
FI941245A (fi) Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi
ES492400A0 (es) Procedimiento para la preparacion de derivados de (ergo- lin-il)-n',n'-dietilurea
ES8201581A1 (es) Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES8704491A1 (es) Procedimiento para la obtencion de nuevas piridopirimidinas
BE886370A (fr) Derives de l'acide 16-hydroxy-prostanoique 4,5-insatures
MX161397A (es) Procedimiento para preparar derivados de 1,3 oxazolidin-2-ona
SE8700555L (sv) Purinderivat, deras framstellning och lekemedel innehallande dessa
ES551485A0 (es) Procedimiento para la preparacion de derivados de all-cis-1,3,5-triamino-2,4,6-trihidrociclohexano
IT1173473B (it) Procedimento per la preparazione di 1,8-diidrossi-10-acil-9-antroni,in particolare per l'uso nel trattamento di psoriasi
RO80112A (ro) Procedeu pentru prepararea de acid 1,1-dioxopenicilic
ES493931A0 (es) Procedimiento de preparacion de nuevos derivados de la 3,4,5-trimetoxi-cinamoil-piperazina
ES557647A0 (es) Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo
ZA83856B (en) Thiazaspirane derivatives,processes for their preparation,and medicaments
ES544772A0 (es) Procedimiento para preparar derivados de pirazol(1,5-a) pi- ridina
IL77009A0 (en) Biphenylyloxy and biphenylylalkoxy aryl acyl urea derivatives,processes for the preparation thereof and pesticidal compositions containing the same
MX9304133A (es) Nuevos derivados de los fosfolipidos.
MX159632A (es) Procedimiento para la preparacion de derivados de pirimidina 2,4,6,triona
ES2016651B3 (es) Proceso mejorado para la preparacion de n,n'tetratiodimorfolinas.
ES542379A0 (es) "procedimiento para preparar derivados de acido n-(fenilme- tiltio-3-oxo-1-propil)-aminoacetico".
ES549906A0 (es) Procedimiento para la preparacion de derivados de 1,4-dihi- dropiridina
ES510973A0 (es) "procedimiento para la preparacion de derivados c-glicosidicos de halometiltiazoles".
ES509891A0 (es) "procedimiento para la preparacion del acido 1,2,3,6-tetrahidro 2 6 dioxo 4 pirimidin carboxilico"
ES541884A0 (es) Procedimiento para la preparacion de derivados de 10-amino- tieno (3,2) (1,5) benzotiazepinas