ATE87503T1 - Liposomes praeparat und antibiotikum. - Google Patents

Liposomes praeparat und antibiotikum.

Info

Publication number
ATE87503T1
ATE87503T1 AT87901176T AT87901176T ATE87503T1 AT E87503 T1 ATE87503 T1 AT E87503T1 AT 87901176 T AT87901176 T AT 87901176T AT 87901176 T AT87901176 T AT 87901176T AT E87503 T1 ATE87503 T1 AT E87503T1
Authority
AT
Austria
Prior art keywords
liposomes
preparative
antibiotic
aminoglycoside
phosphate
Prior art date
Application number
AT87901176T
Other languages
English (en)
Inventor
Marcel B Bally
Lois E Bolcsak
Pieter R Cullis
Andrew S Janoff
Lawrence D Mayer
Robert P Lenk
Jo Ann Jedrusiak
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27130236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE87503(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ATE87503T1 publication Critical patent/ATE87503T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Saccharide Compounds (AREA)
AT87901176T 1986-12-23 1987-01-13 Liposomes praeparat und antibiotikum. ATE87503T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94639186A 1986-12-23 1986-12-23
US94639886A 1986-12-23 1986-12-23
PCT/US1987/000077 WO1988004573A1 (en) 1986-12-23 1987-01-13 Liposome preparation and antibiotic
EP87901176A EP0295248B2 (de) 1986-12-23 1987-01-13 Liposomes präparat und antibiotikum

Publications (1)

Publication Number Publication Date
ATE87503T1 true ATE87503T1 (de) 1993-04-15

Family

ID=27130236

Family Applications (2)

Application Number Title Priority Date Filing Date
AT87901176T ATE87503T1 (de) 1986-12-23 1987-01-13 Liposomes praeparat und antibiotikum.
AT92106331T ATE141166T1 (de) 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende liposome

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT92106331T ATE141166T1 (de) 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende liposome

Country Status (8)

Country Link
EP (3) EP0295248B2 (de)
JP (1) JP2528153B2 (de)
AT (2) ATE87503T1 (de)
AU (1) AU609711B2 (de)
CA (1) CA1314481C (de)
DE (3) DE3785198T3 (de)
IL (2) IL97538A (de)
WO (1) WO1988004573A1 (de)

Families Citing this family (46)

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US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5269979A (en) * 1988-06-08 1993-12-14 Fountain Pharmaceuticals, Inc. Method for making solvent dilution microcarriers
IL90561A (en) * 1988-06-08 1993-08-18 Fountain Pharm Inc Method for making solvent dilution microcarriers
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US5843473A (en) * 1989-10-20 1998-12-01 Sequus Pharmaceuticals, Inc. Method of treatment of infected tissues
CA2046997C (en) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomal products
US6060080A (en) * 1990-07-16 2000-05-09 Daiichi Pharmaceutical Co., Ltd. Liposomal products
PT100486B (pt) * 1992-05-14 1999-07-30 Ineti Inst Nac Engenh E Tecnol Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao
US5958449A (en) * 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
AU3244393A (en) * 1992-12-02 1994-06-22 Vestar, Inc. Antibiotic formulation and process
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
KR100241300B1 (ko) * 1993-11-16 2000-03-02 Sheldon A. Schaffer 활성물질의 조절된 방출성을 갖는 소포
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
US7883717B2 (en) 2001-06-12 2011-02-08 Johns Hopkins University Reservoir device for intraocular drug delivery
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
EP2823820B1 (de) * 2002-10-29 2018-06-06 Insmed Incorporated Aminoglycosid enthaltende Liposome zur Behandlung von pulmonaren Infektionen
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
CA2896083A1 (en) 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
AU2010208046B2 (en) 2009-01-29 2014-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
HUE054113T2 (hu) 2010-08-05 2021-08-30 Forsight Vision4 Inc Injekciós készülék gyógyszerbejuttatáshoz
EP2600876B1 (de) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Verfahren und vorrichtung zur verabreichung kombinierter arzneimittel
HRP20211909T1 (hr) 2010-08-05 2022-03-18 Forsight Vision4, Inc. Uređaj za liječenja oka
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
EP2739252A4 (de) 2011-08-05 2015-08-12 Forsight Vision4 Inc Abgabe kleiner moleküle über eine implantierbare therapeutische vorrichtung
EP4643921A2 (de) 2011-09-16 2025-11-05 ForSight Vision4, Inc. Flüssigkeitsaustauschvorrichtung
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
CN104349783B (zh) 2012-05-21 2018-07-13 英斯麦德公司 治疗肺部感染的系统
WO2014085526A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
EP2968113B8 (de) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systeme zur verzögerten intraokularen abgabe schwerlöslicher verbindungen aus einem implantat mit einem portabgabesystem
CN105246438B (zh) 2013-03-28 2018-01-26 弗赛特影像4股份有限公司 用于输送治疗物质的眼科植入物
KR102447412B1 (ko) 2014-05-15 2022-09-23 인스메드 인코포레이티드 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
EP3169289B1 (de) 2014-07-15 2020-04-15 ForSight Vision4, Inc. Augenimplantateinführungssystem
MX2017001818A (es) 2014-08-08 2017-05-30 Forsight Vision4 Inc Formulaciones estables y solubles de inhibidores de receptor de quinasa tirosina y metodos de preparacion de los mismos.
MX383085B (es) 2014-11-10 2025-03-13 Forsight Vision4 Inc Dispositivo de entrega de fármacos expandibles y método de uso.
CA3005238A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
KR20180133440A (ko) 2016-04-05 2018-12-14 포사이트 비젼4, 인크. 이식 가능한 안구 약물 전달 장치
AU2018372806B2 (en) 2017-11-21 2024-05-30 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
JP7460534B2 (ja) 2018-03-30 2024-04-02 インスメッド インコーポレイテッド リポソーム医薬品の連続製造方法
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4397846A (en) * 1981-05-15 1983-08-09 Murray Weiner Storage-stable lipid vesicles and method of preparation
JPS59500952A (ja) * 1982-03-29 1984-05-31 ザ　リポソ−ム　カンパニ−、インコ−ポレ−テッド 安定なプルリラメラベシクル類
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
WO1985001103A1 (en) * 1983-08-31 1985-03-14 Diagraph Corporation Ink jet printing apparatus
US4532089A (en) * 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
JPH0655676B2 (ja) * 1984-07-26 1994-07-27 ザ リポソ−ム カンパニ−、インコ−ポレ−テツド 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高
JPH0680767A (ja) * 1992-09-03 1994-03-22 Matsushita Electric Ind Co Ltd 電子・電気機器用エポキシ樹脂組成物

Also Published As

Publication number Publication date
DE3785198T3 (de) 1999-09-02
DE3751871T2 (de) 1997-03-13
EP0498471B1 (de) 1996-08-14
AU6934587A (en) 1988-07-15
WO1988004573A1 (en) 1988-06-30
DE3785198T2 (de) 1993-07-15
DE3751871T4 (de) 1998-03-26
DE3751871D1 (de) 1996-09-19
EP0498471A2 (de) 1992-08-12
JP2528153B2 (ja) 1996-08-28
EP0295248B2 (de) 1999-04-28
JPH01501619A (ja) 1989-06-08
CA1314481C (en) 1993-03-16
EP0295248A1 (de) 1988-12-21
IL97538A (en) 1995-03-15
DE3785198D1 (de) 1993-05-06
EP0295248B1 (de) 1993-03-31
EP0295248A4 (de) 1988-12-19
ATE141166T1 (de) 1996-08-15
EP0498471A3 (en) 1993-03-03
EP0500143A3 (en) 1993-03-03
AU609711B2 (en) 1991-05-09
EP0500143A2 (de) 1992-08-26
IL97538A0 (en) 1992-06-21

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