FI941245A - Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi - Google Patents

Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi Download PDF

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Publication number
FI941245A
FI941245A FI941245A FI941245A FI941245A FI 941245 A FI941245 A FI 941245A FI 941245 A FI941245 A FI 941245A FI 941245 A FI941245 A FI 941245A FI 941245 A FI941245 A FI 941245A
Authority
FI
Finland
Prior art keywords
acyl derivatives
deoxyguanosine
preparation
enhancing
haematopoesis
Prior art date
Application number
FI941245A
Other languages
English (en)
Swedish (sv)
Other versions
FI941245A0 (fi
FI97891C (fi
FI97891B (fi
Inventor
Borstel Reid Warren Von
Michael Kevin Bamat
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of FI941245A0 publication Critical patent/FI941245A0/fi
Publication of FI941245A publication Critical patent/FI941245A/fi
Application granted granted Critical
Publication of FI97891B publication Critical patent/FI97891B/fi
Publication of FI97891C publication Critical patent/FI97891C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
FI941245A 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi FI97891C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11592387A 1987-10-28 1987-10-28
US11592387 1987-10-28
PCT/US1988/003824 WO1989003838A1 (en) 1987-10-28 1988-10-27 Acyl deoxyribonucleoside derivatives and uses thereof
US8803824 1988-10-27
FI893100 1989-06-26
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi

Publications (4)

Publication Number Publication Date
FI941245A0 FI941245A0 (fi) 1994-03-16
FI941245A true FI941245A (fi) 1994-03-16
FI97891B FI97891B (fi) 1996-11-29
FI97891C FI97891C (fi) 1997-03-10

Family

ID=22364166

Family Applications (2)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
FI941245A FI97891C (fi) 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (1) US6020320A (fi)
EP (2) EP0712629B1 (fi)
JP (2) JP2637534B2 (fi)
KR (1) KR890701609A (fi)
AT (2) ATE142221T1 (fi)
CA (1) CA1329932C (fi)
DE (2) DE3855513T2 (fi)
DK (1) DK174400B1 (fi)
FI (2) FI91764C (fi)
HK (1) HK1004854A1 (fi)
IL (1) IL88204A (fi)
IN (1) IN167609B (fi)
NO (1) NO174392C (fi)
WO (1) WO1989003838A1 (fi)
ZA (1) ZA888083B (fi)

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US5968914A (en) 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6743782B1 (en) * 1987-10-28 2004-06-01 Wellstat Therapeutics Corporation Acyl deoxyribonucleoside derivatives and uses thereof
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US5691320A (en) * 1987-10-28 1997-11-25 Pro-Neuron, Inc. Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
US6060459A (en) 1987-10-28 2000-05-09 Pro-Neuron, Inc. Enhancing blood cell count with oxypurine nucleosides
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
IL100874A (en) * 1991-02-08 1996-01-19 Pro Neuron Inc Oxiforin nucleosides and their composition, for use as medicines, their preparation and pharmaceutical preparations containing them
ATE205850T1 (de) * 1991-07-05 2001-10-15 Pro Neuron Inc Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
CA2588495C (en) * 1992-12-08 2009-11-17 Wellstat Therapeutics Corporation The utility of uridine nucleosides in the treatment of cachexia
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
EP0768883A4 (en) 1994-07-01 2004-09-15 Wellstat Therapeutics Corp PYRIMIDINE NUCLEOTIDE PRECURSORS FOR THE TREATMENT OF SYSTEMIC INFLAMMATION AND INFLAMMATORY HEPATITIS
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US20020006913A1 (en) 1997-11-04 2002-01-17 Von Borstel Reid W. Antimutagenic compositions for treatment and prevention of photodamage to skin
WO1999030705A1 (en) * 1997-12-16 1999-06-24 William Darwin Garner Reduction of uv induced skin cancer by topical amines
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
AU5475799A (en) 1998-08-10 2000-03-06 Centre National De La Recherche Scientifique Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis
DE60037578T2 (de) 1999-02-23 2009-01-08 The Regents Of The University Of California, Oakland Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen
US6576619B2 (en) * 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
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TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
PT1572095E (pt) 2002-09-13 2015-10-13 Novartis Ag Β-l-2'-desoxinucleósidos para tratamento de estirpes resistentes de vhb
EP2187894B1 (en) 2007-08-16 2020-03-18 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. D. radiodurans extract containing nucleosides and manganese
CA2751563A1 (en) * 2009-02-04 2010-08-12 Jelena Mann Methods of inhibiting fibrogenesis and treating fibrotic disease
CA3012801A1 (en) 2010-04-29 2011-11-10 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions containing purine and pyrimidine nucleosides, peptides, and manganese and their uses
US9446064B2 (en) 2013-03-14 2016-09-20 Epizyme, Inc. Combination therapy for treating cancer
AU2021202658A1 (en) 2021-04-28 2022-11-17 Fondazione Telethon Gene therapy

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Also Published As

Publication number Publication date
FI941245A0 (fi) 1994-03-16
EP0712629B1 (en) 2003-06-18
IL88204A (en) 1996-06-18
CA1329932C (en) 1994-05-31
DE3855513T2 (de) 1997-01-09
EP0355131B1 (en) 1996-09-04
NO892642L (no) 1989-08-24
EP0712629A1 (en) 1996-05-22
DE3856557T2 (de) 2004-06-03
FI91764C (fi) 1994-08-10
ZA888083B (en) 1990-06-27
JPH07267981A (ja) 1995-10-17
FI97891C (fi) 1997-03-10
DK318089D0 (da) 1989-06-27
NO174392B (no) 1994-01-17
DE3856557D1 (de) 2003-07-24
NO174392C (no) 1994-04-27
EP0355131A4 (en) 1990-12-05
FI91764B (fi) 1994-04-29
IL88204A0 (en) 1989-06-30
HK1004854A1 (en) 1998-12-11
JP2764014B2 (ja) 1998-06-11
EP0355131A1 (en) 1990-02-28
DK174400B1 (da) 2003-02-10
KR890701609A (ko) 1989-12-21
ATE243039T1 (de) 2003-07-15
IN167609B (fi) 1990-11-24
JP2637534B2 (ja) 1997-08-06
WO1989003838A1 (en) 1989-05-05
FI893100A0 (fi) 1989-06-26
ATE142221T1 (de) 1996-09-15
JPH02500373A (ja) 1990-02-08
FI893100A (fi) 1989-06-26
US6020320A (en) 2000-02-01
DE3855513D1 (de) 1996-10-10
FI97891B (fi) 1996-11-29
DK318089A (da) 1989-08-28
NO892642D0 (no) 1989-06-26

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