ATE205850T1 - Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden - Google Patents

Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden

Info

Publication number
ATE205850T1
ATE205850T1 AT92914215T AT92914215T ATE205850T1 AT E205850 T1 ATE205850 T1 AT E205850T1 AT 92914215 T AT92914215 T AT 92914215T AT 92914215 T AT92914215 T AT 92914215T AT E205850 T1 ATE205850 T1 AT E205850T1
Authority
AT
Austria
Prior art keywords
treatment
chemotherapeutic
antiviral agents
pyrimidine nucleosides
toxic effects
Prior art date
Application number
AT92914215T
Other languages
English (en)
Inventor
Borstel Reid W Von
Michael K Bamat
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Application granted granted Critical
Publication of ATE205850T1 publication Critical patent/ATE205850T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
AT92914215T 1991-07-05 1992-06-25 Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden ATE205850T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72434091A 1991-07-05 1991-07-05
PCT/US1992/005324 WO1993001202A1 (en) 1991-07-05 1992-06-25 Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Publications (1)

Publication Number Publication Date
ATE205850T1 true ATE205850T1 (de) 2001-10-15

Family

ID=24910042

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92914215T ATE205850T1 (de) 1991-07-05 1992-06-25 Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden

Country Status (13)

Country Link
EP (1) EP0594667B1 (de)
JP (1) JP2584947B2 (de)
KR (1) KR100256144B1 (de)
AT (1) ATE205850T1 (de)
AU (1) AU667676B2 (de)
CA (2) CA2504078C (de)
DE (1) DE69232070T2 (de)
DK (1) DK0594667T3 (de)
ES (1) ES2160579T3 (de)
GR (1) GR3036749T3 (de)
HK (1) HK1003424A1 (de)
WO (1) WO1993001202A1 (de)
ZA (1) ZA924975B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329350B1 (en) 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5691320A (en) 1987-10-28 1997-11-25 Pro-Neuron, Inc. Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
MX9700109A (es) 1994-07-01 1997-04-30 Pro Neuron Inc Precursores nucleotidos de pirimidina para el tratamiento de inflamaciones sistemicas y hepatitis inflamatoria.
CA2189097A1 (en) * 1995-11-15 1997-05-16 Pin-Fang Lin Composition and method of treating retroviral infection
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
DE10110355A1 (de) * 2001-03-03 2002-09-12 Ulrich Walker Bekämpfung von Nebenwirkungen
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
WO2009114325A2 (en) 2008-03-03 2009-09-17 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same
KR102004559B1 (ko) 2011-08-30 2019-07-26 아스텍스 파마수티컬스, 인크. 데시타빈 유도체 제제
CN104114570B (zh) * 2011-10-14 2016-08-31 齐多夫定生产和商业协会封闭式股份公司 作为人免疫缺陷病毒hiv-1产生的选择性抑制剂的氨基甲酰基膦酸酯盐
BR112018000054A2 (pt) 2015-07-02 2018-09-04 Otsuka Pharmaceutical Co., Ltd. composições farmacêuticas liofilizadas
WO2017156380A1 (en) * 2016-03-10 2017-09-14 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
EP3538151A4 (de) * 2016-11-11 2020-06-10 Whitehead Institute for Biomedical Research Humanplasmaähnliches medium
SG11202000932XA (en) 2017-08-03 2020-02-27 Otsuka Pharma Co Ltd Drug compound and purification methods thereof
WO2020036975A1 (en) * 2018-08-14 2020-02-20 Tosk, Inc. Methods and compositions for reducing fluorouracil induced toxicity
CN112770760A (zh) * 2018-08-14 2021-05-07 托斯克公司 降低辐射诱发的毒性的方法和组合物
EP3836941A4 (de) * 2018-08-14 2022-05-18 Tosk, Inc. Verfahren und zusammensetzungen zur behandlung von mukositis
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
DE3481191D1 (de) * 1983-07-20 1990-03-08 Teijin Ltd Antineoplastisches mittel.
JP2894610B2 (ja) * 1987-10-28 1999-05-24 プロ−ニューロン，インコーポレーテッド アシル化ウリジンおよびシチジンならびにその使用
DE3856557T2 (de) * 1987-10-28 2004-06-03 Wellstat Therapeutics Corp. Acyldeoxyribonukleosid-Derivate und Verwendungen davon
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
CA2100655C (en) * 1991-02-08 2004-02-03 Reid W. Von Borstel Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis

Also Published As

Publication number Publication date
CA2504078C (en) 2007-08-28
DE69232070T2 (de) 2002-06-06
GR3036749T3 (en) 2001-12-31
HK1003424A1 (en) 1998-10-30
JPH06508846A (ja) 1994-10-06
ES2160579T3 (es) 2001-11-16
CA2111571A1 (en) 1993-01-21
JP2584947B2 (ja) 1997-02-26
EP0594667A1 (de) 1994-05-04
AU667676B2 (en) 1996-04-04
WO1993001202A1 (en) 1993-01-21
CA2504078A1 (en) 1993-01-21
AU2254492A (en) 1993-02-11
EP0594667A4 (en) 1996-01-10
CA2111571C (en) 2005-08-23
DK0594667T3 (da) 2001-11-12
ZA924975B (en) 1993-04-28
DE69232070D1 (de) 2001-10-25
EP0594667B1 (de) 2001-09-19
KR100256144B1 (ko) 2000-05-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee