FI893100A - Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi - Google Patents

Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi Download PDF

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Publication number
FI893100A
FI893100A FI893100A FI893100A FI893100A FI 893100 A FI893100 A FI 893100A FI 893100 A FI893100 A FI 893100A FI 893100 A FI893100 A FI 893100A FI 893100 A FI893100 A FI 893100A
Authority
FI
Finland
Prior art keywords
acyldoxy
preparation
analogous process
ribonucleoside derivatives
derivatives
Prior art date
Application number
FI893100A
Other languages
English (en)
Swedish (sv)
Other versions
FI91764B (fi
FI893100A0 (fi
FI91764C (fi
Inventor
Borstel Reid Warren Von
Michael Kevin Bamat
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of FI893100A publication Critical patent/FI893100A/fi
Publication of FI893100A0 publication Critical patent/FI893100A0/fi
Priority to FI941245A priority Critical patent/FI97891C/fi
Publication of FI91764B publication Critical patent/FI91764B/fi
Application granted granted Critical
Publication of FI91764C publication Critical patent/FI91764C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
FI893100A 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi FI91764C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI941245A FI97891C (fi) 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11592387A 1987-10-28 1987-10-28
US11592387 1987-10-28
PCT/US1988/003824 WO1989003838A1 (en) 1987-10-28 1988-10-27 Acyl deoxyribonucleoside derivatives and uses thereof
US8803824 1988-10-27

Publications (4)

Publication Number Publication Date
FI893100A true FI893100A (fi) 1989-06-26
FI893100A0 FI893100A0 (fi) 1989-06-26
FI91764B FI91764B (fi) 1994-04-29
FI91764C FI91764C (fi) 1994-08-10

Family

ID=22364166

Family Applications (2)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
FI941245A FI97891C (fi) 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI941245A FI97891C (fi) 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (1) US6020320A (fi)
EP (2) EP0355131B1 (fi)
JP (2) JP2637534B2 (fi)
KR (1) KR890701609A (fi)
AT (2) ATE243039T1 (fi)
CA (1) CA1329932C (fi)
DE (2) DE3855513T2 (fi)
DK (1) DK174400B1 (fi)
FI (2) FI91764C (fi)
HK (1) HK1004854A1 (fi)
IL (1) IL88204A (fi)
IN (1) IN167609B (fi)
NO (1) NO174392C (fi)
WO (1) WO1989003838A1 (fi)
ZA (1) ZA888083B (fi)

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US7307166B1 (en) 1987-10-28 2007-12-11 Wellstat Therapeutics Corporation Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US6329350B1 (en) * 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US6743782B1 (en) * 1987-10-28 2004-06-01 Wellstat Therapeutics Corporation Acyl deoxyribonucleoside derivatives and uses thereof
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
ATE179615T1 (de) * 1991-02-08 1999-05-15 Pro Neuron Inc Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese
AU667676B2 (en) * 1991-07-05 1996-04-04 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
CA2150940C (en) * 1992-12-08 2007-08-21 Reid Warren Von Borstel Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
KR100290132B1 (ko) 1994-07-01 2001-05-15 마이클 바마트 전신 염증 및 염증성 간염 치료용 피리미딘 누클레오티드 전구체
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AU5475799A (en) 1998-08-10 2000-03-06 Centre National De La Recherche Scientifique Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
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US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
DE10117615A1 (de) * 2001-04-07 2002-10-10 Max Delbrueck Centrum Verwendung von Nucleosiden, Nucleobasen und deren Derivaten zur verbesserten Gewinnung von adulten Stammzellen
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
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EP2187894B1 (en) 2007-08-16 2020-03-18 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. D. radiodurans extract containing nucleosides and manganese
CA2751563A1 (en) * 2009-02-04 2010-08-12 Jelena Mann Methods of inhibiting fibrogenesis and treating fibrotic disease
ES2647584T3 (es) 2010-04-29 2017-12-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Método para producir vacunas que comprende la irradiación de microorganismos en una composición que comprende aminoácidos y ortofosfato de manganeso
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Also Published As

Publication number Publication date
DK318089D0 (da) 1989-06-27
NO174392B (no) 1994-01-17
HK1004854A1 (en) 1998-12-11
IL88204A (en) 1996-06-18
JPH07267981A (ja) 1995-10-17
CA1329932C (en) 1994-05-31
EP0355131A1 (en) 1990-02-28
US6020320A (en) 2000-02-01
FI91764B (fi) 1994-04-29
FI941245A (fi) 1994-03-16
KR890701609A (ko) 1989-12-21
ATE142221T1 (de) 1996-09-15
WO1989003838A1 (en) 1989-05-05
IL88204A0 (en) 1989-06-30
DE3856557D1 (de) 2003-07-24
DK174400B1 (da) 2003-02-10
DK318089A (da) 1989-08-28
EP0355131A4 (en) 1990-12-05
JPH02500373A (ja) 1990-02-08
EP0712629B1 (en) 2003-06-18
EP0712629A1 (en) 1996-05-22
DE3855513T2 (de) 1997-01-09
NO892642L (no) 1989-08-24
JP2637534B2 (ja) 1997-08-06
IN167609B (fi) 1990-11-24
ZA888083B (en) 1990-06-27
FI97891B (fi) 1996-11-29
FI893100A0 (fi) 1989-06-26
DE3855513D1 (de) 1996-10-10
EP0355131B1 (en) 1996-09-04
DE3856557T2 (de) 2004-06-03
FI91764C (fi) 1994-08-10
JP2764014B2 (ja) 1998-06-11
FI97891C (fi) 1997-03-10
NO892642D0 (no) 1989-06-26
NO174392C (no) 1994-04-27
ATE243039T1 (de) 2003-07-15
FI941245A0 (fi) 1994-03-16

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