JPS57156418A - Carcinostatic - Google Patents
CarcinostaticInfo
- Publication number
- JPS57156418A JPS57156418A JP4110981A JP4110981A JPS57156418A JP S57156418 A JPS57156418 A JP S57156418A JP 4110981 A JP4110981 A JP 4110981A JP 4110981 A JP4110981 A JP 4110981A JP S57156418 A JPS57156418 A JP S57156418A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- medication
- bone marrow
- tumor
- main ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: A carcinostatic having low side effects such as bone marrow suppression, etc., exhibiting a carcinostatic action in a wide range, easily water-soluble, capable of being processed into various kinds of drug forms, having low toxicity, comprising bredinin, a nucleotide antibiotic, as a main ingredient.
CONSTITUTION: A carcinostatic comprising 4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-oleate shown by the formula or its salt as main ingredient. The compound shown by the formula exhibits a carcinostatic action not only on a heterotypic tumor such as Ehrlich carcinoma but also on a homotypic tumor such as mouse leukemia p 388, Lewis lung cancer, etc. which has been regarded as a slightly curable disease, by inventing a medication merhod such as oral medication or frequent continuous medication. High safety is observed by acute toxic test, the carcinostatic can stand a long-term use since it has very low bone marrow suppression which is found in a carcinostatic in wide use. In medication, a proper period of the stop of administration is provided, and continuous medication is carried out, to reduce the disorder degree of a host and to exhibit an extremely carcinostatic effect.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4110981A JPS57156418A (en) | 1981-03-19 | 1981-03-19 | Carcinostatic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4110981A JPS57156418A (en) | 1981-03-19 | 1981-03-19 | Carcinostatic |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57156418A true JPS57156418A (en) | 1982-09-27 |
Family
ID=12599301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4110981A Pending JPS57156418A (en) | 1981-03-19 | 1981-03-19 | Carcinostatic |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57156418A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227817A (en) * | 1983-06-07 | 1984-12-21 | Toyo Jozo Co Ltd | Long-acting bredinin preparation for oral administration |
WO1993002683A1 (en) * | 1991-08-06 | 1993-02-18 | Asahi Kasei Kogyo Kabushiki Kaisha | Composition for curing proliferative skin diseases |
US5472947A (en) * | 1990-05-17 | 1995-12-05 | Asahi Kasei Kogyo Kabushiki Kaisha | Application of 4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-olate to the treatment of multiple sclerosis |
EP0712629A1 (en) * | 1987-10-28 | 1996-05-22 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
JP2007269814A (en) * | 2000-01-26 | 2007-10-18 | Asahi Kasei Pharma Kk | Mizoribine tablet with improved color tone change |
JP2011190282A (en) * | 2000-01-26 | 2011-09-29 | Asahi Kasei Pharma Kk | Mizoribine tablet with improved color tone change |
-
1981
- 1981-03-19 JP JP4110981A patent/JPS57156418A/en active Pending
Non-Patent Citations (1)
Title |
---|
THE JOURNAL OF ANTIBIOTICS28 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227817A (en) * | 1983-06-07 | 1984-12-21 | Toyo Jozo Co Ltd | Long-acting bredinin preparation for oral administration |
JPH0530810B2 (en) * | 1983-06-07 | 1993-05-11 | Asahi Chemical Ind | |
EP0712629A1 (en) * | 1987-10-28 | 1996-05-22 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
US5472947A (en) * | 1990-05-17 | 1995-12-05 | Asahi Kasei Kogyo Kabushiki Kaisha | Application of 4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-olate to the treatment of multiple sclerosis |
WO1993002683A1 (en) * | 1991-08-06 | 1993-02-18 | Asahi Kasei Kogyo Kabushiki Kaisha | Composition for curing proliferative skin diseases |
US5462929A (en) * | 1991-08-06 | 1995-10-31 | Asahi Kasei Kogyo Kabushiki Kaisha | Treatment of psoriasis by administration of 4-carbamoyl-1-β-D-ribofuranosylimidszolium-5-oleate |
JP2007269814A (en) * | 2000-01-26 | 2007-10-18 | Asahi Kasei Pharma Kk | Mizoribine tablet with improved color tone change |
JP2011190282A (en) * | 2000-01-26 | 2011-09-29 | Asahi Kasei Pharma Kk | Mizoribine tablet with improved color tone change |
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