JPS5780317A - Preparation of pharmaceutical composition for injection - Google Patents
Preparation of pharmaceutical composition for injectionInfo
- Publication number
- JPS5780317A JPS5780317A JP15617380A JP15617380A JPS5780317A JP S5780317 A JPS5780317 A JP S5780317A JP 15617380 A JP15617380 A JP 15617380A JP 15617380 A JP15617380 A JP 15617380A JP S5780317 A JPS5780317 A JP S5780317A
- Authority
- JP
- Japan
- Prior art keywords
- basic substance
- injection
- compound
- solubility
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To prepare the titled composition having remarkably improved solubility of the active drug component, by compounding a basic substance to 4- carbamoyl-imidazolium-5-oleate having strong carcinostatic effect to hard cancer.
CONSTITUTION: The compound of formula which is a carcinostatic agent having high safety and low side effects, or its salt, or their hydrate, is compounded with a basic substance to obtain a pharmaceutical composition for injection. The basic substance is pref. an organic amine, esp. L-arginine in view of the solubility, safety, handleability, etc. The amount of the basic substance is pref. 0.9W8mol per 1mol of the principal drug. The addition of the basic substance remarkably improves the solubility of the compound of formula, and enables the administration of a high dosage of the compound by injection.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15617380A JPS5780317A (en) | 1980-11-05 | 1980-11-05 | Preparation of pharmaceutical composition for injection |
| DE8181305148T DE3176849D1 (en) | 1980-11-05 | 1981-10-29 | Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate |
| EP81305148A EP0051962B1 (en) | 1980-11-05 | 1981-10-29 | Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate |
| CA000389484A CA1186999A (en) | 1980-11-05 | 1981-11-05 | Pharmaceutical composition for injection |
| CA000442797A CA1186227A (en) | 1980-11-05 | 1983-12-07 | Pharmaceutical composition for injection |
| US06/667,385 US4582845A (en) | 1980-11-05 | 1984-11-02 | Pharmaceutical composition for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15617380A JPS5780317A (en) | 1980-11-05 | 1980-11-05 | Preparation of pharmaceutical composition for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5780317A true JPS5780317A (en) | 1982-05-19 |
Family
ID=15621942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15617380A Pending JPS5780317A (en) | 1980-11-05 | 1980-11-05 | Preparation of pharmaceutical composition for injection |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5780317A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61172821A (en) * | 1984-12-12 | 1986-08-04 | メデイカ・フア−マシユ−テイカル・カンパニ−・リミテツド | Manufacture of novel hemine complex compound for medicinal use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5332124A (en) * | 1976-09-07 | 1978-03-27 | Sumitomo Chem Co Ltd | Carcinostatic agent |
-
1980
- 1980-11-05 JP JP15617380A patent/JPS5780317A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5332124A (en) * | 1976-09-07 | 1978-03-27 | Sumitomo Chem Co Ltd | Carcinostatic agent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61172821A (en) * | 1984-12-12 | 1986-08-04 | メデイカ・フア−マシユ−テイカル・カンパニ−・リミテツド | Manufacture of novel hemine complex compound for medicinal use |
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