JPS5780317A - Preparation of pharmaceutical composition for injection - Google Patents

Preparation of pharmaceutical composition for injection

Info

Publication number
JPS5780317A
JPS5780317A JP15617380A JP15617380A JPS5780317A JP S5780317 A JPS5780317 A JP S5780317A JP 15617380 A JP15617380 A JP 15617380A JP 15617380 A JP15617380 A JP 15617380A JP S5780317 A JPS5780317 A JP S5780317A
Authority
JP
Japan
Prior art keywords
basic substance
injection
compound
solubility
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15617380A
Other languages
Japanese (ja)
Inventor
Yoshinari Yamahira
Takaharu Fujioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP15617380A priority Critical patent/JPS5780317A/en
Priority to DE8181305148T priority patent/DE3176849D1/en
Priority to EP81305148A priority patent/EP0051962B1/en
Priority to CA000389484A priority patent/CA1186999A/en
Publication of JPS5780317A publication Critical patent/JPS5780317A/en
Priority to CA000442797A priority patent/CA1186227A/en
Priority to US06/667,385 priority patent/US4582845A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To prepare the titled composition having remarkably improved solubility of the active drug component, by compounding a basic substance to 4- carbamoyl-imidazolium-5-oleate having strong carcinostatic effect to hard cancer.
CONSTITUTION: The compound of formula which is a carcinostatic agent having high safety and low side effects, or its salt, or their hydrate, is compounded with a basic substance to obtain a pharmaceutical composition for injection. The basic substance is pref. an organic amine, esp. L-arginine in view of the solubility, safety, handleability, etc. The amount of the basic substance is pref. 0.9W8mol per 1mol of the principal drug. The addition of the basic substance remarkably improves the solubility of the compound of formula, and enables the administration of a high dosage of the compound by injection.
COPYRIGHT: (C)1982,JPO&Japio
JP15617380A 1980-11-05 1980-11-05 Preparation of pharmaceutical composition for injection Pending JPS5780317A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP15617380A JPS5780317A (en) 1980-11-05 1980-11-05 Preparation of pharmaceutical composition for injection
DE8181305148T DE3176849D1 (en) 1980-11-05 1981-10-29 Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate
EP81305148A EP0051962B1 (en) 1980-11-05 1981-10-29 Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate
CA000389484A CA1186999A (en) 1980-11-05 1981-11-05 Pharmaceutical composition for injection
CA000442797A CA1186227A (en) 1980-11-05 1983-12-07 Pharmaceutical composition for injection
US06/667,385 US4582845A (en) 1980-11-05 1984-11-02 Pharmaceutical composition for injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15617380A JPS5780317A (en) 1980-11-05 1980-11-05 Preparation of pharmaceutical composition for injection

Publications (1)

Publication Number Publication Date
JPS5780317A true JPS5780317A (en) 1982-05-19

Family

ID=15621942

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15617380A Pending JPS5780317A (en) 1980-11-05 1980-11-05 Preparation of pharmaceutical composition for injection

Country Status (1)

Country Link
JP (1) JPS5780317A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172821A (en) * 1984-12-12 1986-08-04 メデイカ・フア−マシユ−テイカル・カンパニ−・リミテツド Manufacture of novel hemine complex compound for medicinal use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5332124A (en) * 1976-09-07 1978-03-27 Sumitomo Chem Co Ltd Carcinostatic agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5332124A (en) * 1976-09-07 1978-03-27 Sumitomo Chem Co Ltd Carcinostatic agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172821A (en) * 1984-12-12 1986-08-04 メデイカ・フア−マシユ−テイカル・カンパニ−・リミテツド Manufacture of novel hemine complex compound for medicinal use

Similar Documents

Publication Publication Date Title
IL102814A0 (en) Pyrazine derivatives,their preparation and pharmaceutical compositions comprising them
HUP0402549A2 (en) Parenteral composition of paracetamol
JPS5551020A (en) Remedy for rheumatism
EP0647616A4 (en) Zinc tranexamate compound.
IL47937A (en) Pharmaceutical compositions containing 6,8-diethyl-5-hydroxy-4-oxo-4h-1-benzopyran-2-carboxylic acid or a salt thereof
JPS5780317A (en) Preparation of pharmaceutical composition for injection
JPS56138110A (en) Suppository containing citric acid or salt thereof
JPS5630917A (en) Preventive and remedy for hepatitis
JPS57156418A (en) Carcinostatic
JPS56115715A (en) Physiologically active agent containing (3- dimethylcarbam-oxyphenyl) trimethyl ammonium derivative
NZ505080A (en) Pharmaceutical formulations containing a compound having an amidine group stabilized by an acid
JPS54132239A (en) Anti-tumor agent
JPS5569510A (en) Carcinostatic agent
JPS54125663A (en) Carcinostatic agent and novel compound having carcinostatic activity
JPS5634624A (en) Central nervous system depressant
JPS54105237A (en) Analgesic agent containing nalorphine-6-glucuronide
JPS5695114A (en) Carcinostatic agent
ES481792A1 (en) N1-Benzoyl-N2-phenyl-1,3-diaminopropane-2-ols and their salts, process for their preparation and medicaments containing them.
KR920011486A (en) Antitumor agents
JPS5634625A (en) Antitumorigenic agent
JPS5742620A (en) Novel antiulcer agent
JPS57128625A (en) Carcinostatic
JPS57114517A (en) Antidiabetic agent
JPS57171989A (en) Aminometyl-secalonic acid and its preparation
JPS57108014A (en) Antithrombotic agent