JPS5695114A - Carcinostatic agent - Google Patents
Carcinostatic agentInfo
- Publication number
- JPS5695114A JPS5695114A JP17196979A JP17196979A JPS5695114A JP S5695114 A JPS5695114 A JP S5695114A JP 17196979 A JP17196979 A JP 17196979A JP 17196979 A JP17196979 A JP 17196979A JP S5695114 A JPS5695114 A JP S5695114A
- Authority
- JP
- Japan
- Prior art keywords
- pac
- carcinostatic agent
- protocatechuic aldehyde
- toxicity
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: A carcinostatic agent, having a selective inhibitory action on DNA synthesis of mammals with very low toxicity, and containing protocatechuic aldehyde. cyclic carbonate as an active constituent.
CONSTITUTION: A carcinostatic agent containing protocatechuic aldehyde.cyclic carbonate of formula I (referred to as PAC) as an active constituent. The mode of action of PAC is to have an inhibitory action on DNA synthesis, e.g. giantism of cells and nuclei, and act on cancer cells synthesizing DNA vigorously with the selective toxicity in the same way as the compound of formula II (common name: protocatechuic aldehyde, referred to as PA). The acute toxicity of PAC is about 1/8 that of PA, and the safe dose twice that of PA renders the carcinostatic agent clinically useful. The effective dose is 0.03W120mg/kg, preferably 0.1W60mg/kg, for oral administration and 0.001W20mg/kg for intravenous administration. The agent can be used extensively regardless of the dosage form if PAC is contained therein.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17196979A JPS5695114A (en) | 1979-12-28 | 1979-12-28 | Carcinostatic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17196979A JPS5695114A (en) | 1979-12-28 | 1979-12-28 | Carcinostatic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5695114A true JPS5695114A (en) | 1981-08-01 |
Family
ID=15933104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17196979A Pending JPS5695114A (en) | 1979-12-28 | 1979-12-28 | Carcinostatic agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5695114A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693862A (en) * | 2019-11-02 | 2020-01-17 | 上海中医药大学附属岳阳中西医结合医院 | Application of protocatechualdehyde in inhibiting CtBP1 |
-
1979
- 1979-12-28 JP JP17196979A patent/JPS5695114A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693862A (en) * | 2019-11-02 | 2020-01-17 | 上海中医药大学附属岳阳中西医结合医院 | Application of protocatechualdehyde in inhibiting CtBP1 |
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