CA2969242A1 - Enzymatically produced cellulose - Google Patents
Enzymatically produced cellulose Download PDFInfo
- Publication number
- CA2969242A1 CA2969242A1 CA2969242A CA2969242A CA2969242A1 CA 2969242 A1 CA2969242 A1 CA 2969242A1 CA 2969242 A CA2969242 A CA 2969242A CA 2969242 A CA2969242 A CA 2969242A CA 2969242 A1 CA2969242 A1 CA 2969242A1
- Authority
- CA
- Canada
- Prior art keywords
- cellulose
- cellodextrin
- reaction
- enzyme
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920002678 cellulose Polymers 0.000 title claims abstract description 281
- 239000001913 cellulose Substances 0.000 title claims abstract description 281
- 108010077004 Cellodextrin phosphorylase Proteins 0.000 claims abstract description 152
- 238000006243 chemical reaction Methods 0.000 claims abstract description 87
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 57
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 47
- FYGDTMLNYKFZSV-ZWSAEMDYSA-N cellotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-ZWSAEMDYSA-N 0.000 claims abstract description 44
- 229920002299 Cellodextrin Polymers 0.000 claims abstract description 43
- HXXFSFRBOHSIMQ-VFUOTHLCSA-N alpha-D-glucose 1-phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O HXXFSFRBOHSIMQ-VFUOTHLCSA-N 0.000 claims abstract description 43
- 238000006911 enzymatic reaction Methods 0.000 claims abstract description 40
- 229950010772 glucose-1-phosphate Drugs 0.000 claims abstract description 39
- 102000004190 Enzymes Human genes 0.000 claims description 60
- 108090000790 Enzymes Proteins 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 49
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims description 26
- 239000013078 crystal Substances 0.000 claims description 26
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 229910052816 inorganic phosphate Inorganic materials 0.000 claims description 15
- 229920002472 Starch Polymers 0.000 claims description 13
- 238000006116 polymerization reaction Methods 0.000 claims description 13
- 239000008107 starch Substances 0.000 claims description 13
- 235000019698 starch Nutrition 0.000 claims description 13
- 108020000005 Sucrose phosphorylase Proteins 0.000 claims description 12
- 108010059892 Cellulase Proteins 0.000 claims description 11
- 108010043943 Starch Phosphorylase Proteins 0.000 claims description 11
- 108090000637 alpha-Amylases Proteins 0.000 claims description 10
- 108010028688 Isoamylase Proteins 0.000 claims description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 9
- 239000005720 sucrose Substances 0.000 claims description 8
- 239000002028 Biomass Substances 0.000 claims description 7
- 101710154526 Lytic chitin monooxygenase Proteins 0.000 claims description 5
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 description 269
- 239000000203 mixture Substances 0.000 description 67
- 229940088598 enzyme Drugs 0.000 description 57
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 42
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 38
- 239000000463 material Substances 0.000 description 32
- 108090000623 proteins and genes Proteins 0.000 description 32
- 230000000694 effects Effects 0.000 description 31
- 108091033319 polynucleotide Proteins 0.000 description 29
- 102000040430 polynucleotide Human genes 0.000 description 29
- 239000002157 polynucleotide Substances 0.000 description 29
- 230000014509 gene expression Effects 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 18
- 229920001282 polysaccharide Polymers 0.000 description 18
- 150000004676 glycans Chemical class 0.000 description 17
- 239000005017 polysaccharide Substances 0.000 description 17
- 239000000758 substrate Substances 0.000 description 17
- 239000000047 product Substances 0.000 description 16
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 15
- 241001086881 Vibrio ruber Species 0.000 description 15
- 238000000576 coating method Methods 0.000 description 15
- 238000001246 colloidal dispersion Methods 0.000 description 15
- 239000010408 film Substances 0.000 description 15
- 238000004458 analytical method Methods 0.000 description 14
- 239000002904 solvent Substances 0.000 description 14
- 150000007523 nucleic acids Chemical class 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 108091028043 Nucleic acid sequence Proteins 0.000 description 12
- 229910019142 PO4 Inorganic materials 0.000 description 12
- 241000061145 Ruminococcus champanellensis Species 0.000 description 12
- 238000001212 derivatisation Methods 0.000 description 12
- 239000008103 glucose Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 239000011248 coating agent Substances 0.000 description 11
- 230000002255 enzymatic effect Effects 0.000 description 11
- 239000010452 phosphate Substances 0.000 description 11
- 235000021317 phosphate Nutrition 0.000 description 11
- 229920001184 polypeptide Polymers 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 11
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 108091026890 Coding region Proteins 0.000 description 10
- 241000196324 Embryophyta Species 0.000 description 10
- 150000001413 amino acids Chemical group 0.000 description 10
- 230000000813 microbial effect Effects 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 10
- 108010076504 Protein Sorting Signals Proteins 0.000 description 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 9
- 239000002585 base Substances 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 239000002773 nucleotide Substances 0.000 description 9
- 125000003729 nucleotide group Chemical group 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 8
- 239000000872 buffer Substances 0.000 description 8
- 238000005517 mercerization Methods 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 7
- 108700026244 Open Reading Frames Proteins 0.000 description 7
- 239000007983 Tris buffer Substances 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 239000000178 monomer Substances 0.000 description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 6
- 238000004630 atomic force microscopy Methods 0.000 description 6
- -1 cellobiose) Chemical compound 0.000 description 6
- 230000002538 fungal effect Effects 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 229930027917 kanamycin Natural products 0.000 description 6
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 6
- 229960000318 kanamycin Drugs 0.000 description 6
- 229930182823 kanamycin A Natural products 0.000 description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 6
- 239000008108 microcrystalline cellulose Substances 0.000 description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 description 6
- 238000001542 size-exclusion chromatography Methods 0.000 description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
- 229920001503 Glucan Polymers 0.000 description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- 238000007792 addition Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000003125 aqueous solvent Substances 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 239000000416 hydrocolloid Substances 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 239000006166 lysate Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000011574 phosphorus Substances 0.000 description 5
- 229910052698 phosphorus Inorganic materials 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000013592 cell lysate Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000006167 equilibration buffer Substances 0.000 description 4
- 239000002198 insoluble material Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 235000014469 Bacillus subtilis Nutrition 0.000 description 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 3
- 108090000604 Hydrolases Proteins 0.000 description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- 241001570530 Ruminococcus champanellensis 18P13 = JCM 17042 Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 238000004166 bioassay Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 125000003147 glycosyl group Chemical group 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 229930182817 methionine Natural products 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 239000004627 regenerated cellulose Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000010409 thin film Substances 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 2
- 108700010070 Codon Usage Proteins 0.000 description 2
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
- 241001198387 Escherichia coli BL21(DE3) Species 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 2
- NFNVDJGXRFEYTK-YUMQZZPRSA-N Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O NFNVDJGXRFEYTK-YUMQZZPRSA-N 0.000 description 2
- 239000006142 Luria-Bertani Agar Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 229920001131 Pulp (paper) Polymers 0.000 description 2
- 241000192031 Ruminococcus Species 0.000 description 2
- 229920002305 Schizophyllan Polymers 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- LUEWUZLMQUOBSB-ZLBHSGTGSA-N alpha-maltotetraose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](O[C@H](O[C@@H]3[C@H](O[C@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-ZLBHSGTGSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000002869 basic local alignment search tool Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- OCIBBXPLUVYKCH-FYTDUCIRSA-N beta-D-cellohexaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3[C@H](O[C@@H](O[C@@H]4[C@H](O[C@@H](O[C@@H]5[C@H](O[C@@H](O)[C@H](O)[C@H]5O)CO)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O OCIBBXPLUVYKCH-FYTDUCIRSA-N 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- OCIBBXPLUVYKCH-UHFFFAOYSA-N cellopentanose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(OC4C(OC(OC5C(OC(O)C(O)C5O)CO)C(O)C4O)CO)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O OCIBBXPLUVYKCH-UHFFFAOYSA-N 0.000 description 2
- FTNIPWXXIGNQQF-XHCCAYEESA-N cellopentaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3[C@H](O[C@@H](O[C@@H]4[C@H](OC(O)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FTNIPWXXIGNQQF-XHCCAYEESA-N 0.000 description 2
- 229940106157 cellulase Drugs 0.000 description 2
- 238000012993 chemical processing Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 239000013256 coordination polymer Substances 0.000 description 2
- YWAUQXHOCBBYLP-FBNUBEQJSA-L disodium;[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate;hydrate Chemical compound O.[Na+].[Na+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@@H]1O YWAUQXHOCBBYLP-FBNUBEQJSA-L 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 238000010353 genetic engineering Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
- 239000012139 lysis buffer Substances 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 125000001360 methionine group Chemical class N[C@@H](CCSC)C(=O)* 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000009877 rendering Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000013341 scale-up Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000002525 ultrasonication Methods 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 238000004736 wide-angle X-ray diffraction Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 description 1
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241001513093 Aspergillus awamori Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 241000123777 Blautia obeum Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000252867 Cupriavidus metallidurans Species 0.000 description 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108700007698 Genetic Terminator Regions Proteins 0.000 description 1
- 101710179023 Glucose-1-phosphatase Proteins 0.000 description 1
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241000235058 Komagataella pastoris Species 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 238000006957 Michael reaction Methods 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- 101100329574 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) csn-5 gene Proteins 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 241000320412 Ogataea angusta Species 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
- 108010073135 Phosphorylases Proteins 0.000 description 1
- 102000009097 Phosphorylases Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000589540 Pseudomonas fluorescens Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241000192029 Ruminococcus albus Species 0.000 description 1
- 241000123753 Ruminococcus bromii Species 0.000 description 1
- 241000192026 Ruminococcus flavefaciens Species 0.000 description 1
- 241000202356 Ruminococcus lactaris Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 108700009124 Transcription Initiation Site Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 241000223259 Trichoderma Species 0.000 description 1
- 241000499912 Trichoderma reesei Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000607281 Vibrio adaptatus Species 0.000 description 1
- 241000607594 Vibrio alginolyticus Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 241000607253 Vibrio mimicus Species 0.000 description 1
- 241000607272 Vibrio parahaemolyticus Species 0.000 description 1
- 241000607269 Vibrio proteolyticus Species 0.000 description 1
- 241000607265 Vibrio vulnificus Species 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 241001464867 [Ruminococcus] gnavus Species 0.000 description 1
- 241001464870 [Ruminococcus] torques Species 0.000 description 1
- KWVFUTDPKIKVQW-UHFFFAOYSA-N [Sr].[Na] Chemical compound [Sr].[Na] KWVFUTDPKIKVQW-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 101150009206 aprE gene Proteins 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 229910001919 chlorite Inorganic materials 0.000 description 1
- 229910052619 chlorite group Inorganic materials 0.000 description 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000000109 continuous material Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- KYRUBSWVBPYWEF-UHFFFAOYSA-N copper;iron;sulfane;tin Chemical compound S.S.S.S.[Fe].[Cu].[Cu].[Sn] KYRUBSWVBPYWEF-UHFFFAOYSA-N 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 1
- 235000013681 dietary sucrose Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000001476 gene delivery Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 229940079826 hydrogen sulfite Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- UCNNJGDEJXIUCC-UHFFFAOYSA-L hydroxy(oxo)iron;iron Chemical compound [Fe].O[Fe]=O.O[Fe]=O UCNNJGDEJXIUCC-UHFFFAOYSA-L 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 1
- 239000002029 lignocellulosic biomass Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 150000002840 non-reducing disaccharides Chemical class 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000014493 regulation of gene expression Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 229940071182 stannate Drugs 0.000 description 1
- 125000005402 stannate group Chemical group 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 229940006486 zinc cation Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/02—Cellulose; Modified cellulose
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D101/00—Coating compositions based on cellulose, modified cellulose, or cellulose derivatives
- C09D101/02—Cellulose; Modified cellulose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01049—Cellodextrin phosphorylase (2.4.1.49)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Jellies, Jams, And Syrups (AREA)
- Storage Of Fruits Or Vegetables (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014094594 | 2014-12-23 | ||
| CNPCT/CN2014/094593 | 2014-12-23 | ||
| CN2014094593 | 2014-12-23 | ||
| CNPCT/CN2014/094594 | 2014-12-23 | ||
| PCT/US2015/065707 WO2016106013A1 (en) | 2014-12-23 | 2015-12-15 | Enzymatically produced cellulose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2969242A1 true CA2969242A1 (en) | 2016-06-30 |
Family
ID=55069158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2969242A Abandoned CA2969242A1 (en) | 2014-12-23 | 2015-12-15 | Enzymatically produced cellulose |
| CA2969241A Abandoned CA2969241A1 (en) | 2014-12-23 | 2015-12-15 | Enzymatically produced cellulose |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2969241A Abandoned CA2969241A1 (en) | 2014-12-23 | 2015-12-15 | Enzymatically produced cellulose |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20180334696A1 (enExample) |
| EP (2) | EP3237632B8 (enExample) |
| JP (2) | JP2018512109A (enExample) |
| CN (2) | CN108064306B (enExample) |
| AU (2) | AU2015369967B2 (enExample) |
| CA (2) | CA2969242A1 (enExample) |
| WO (2) | WO2016106013A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015369929B2 (en) | 2014-12-22 | 2020-08-20 | Nutrition & Biosciences USA 4, Inc. | Polymeric blend containing poly alpha-1,3-glucan |
| US20180334696A1 (en) * | 2014-12-23 | 2018-11-22 | E I Du Pont De Nemours And Company | Enzymatically produced cellulose |
| WO2016126685A1 (en) | 2015-02-06 | 2016-08-11 | E. I. Du Pont De Nemours And Company | Colloidal dispersions of poly alpha-1,3-glucan based polymers |
| CN107995923B (zh) | 2015-06-01 | 2021-11-02 | 营养与生物科学美国4公司 | 包含聚α-1,3-葡聚糖的胶体分散体的结构化的液体组合物 |
| KR102746152B1 (ko) | 2015-10-26 | 2024-12-26 | 뉴트리션 앤드 바이오사이언시스 유에스에이 4, 인크. | 수불용성 알파-(1,3-글루칸) 조성물 |
| KR102745257B1 (ko) | 2015-10-26 | 2024-12-23 | 뉴트리션 앤드 바이오사이언시스 유에스에이 4, 인크. | 종이용 다당류 코팅 |
| JP7045313B2 (ja) | 2015-11-13 | 2022-03-31 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー,インコーポレイテッド | 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物 |
| JP2019504932A (ja) | 2015-11-13 | 2019-02-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company | 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物 |
| WO2017083226A1 (en) | 2015-11-13 | 2017-05-18 | E. I. Du Pont De Nemours And Company | Glucan fiber compositions for use in laundry care and fabric care |
| US10895028B2 (en) | 2015-12-14 | 2021-01-19 | Dupont Industrial Biosciences Usa, Llc | Nonwoven glucan webs |
| EP3494173B1 (en) | 2016-10-28 | 2021-06-23 | Nutrition & Biosciences USA 4, Inc. | Rubber compositions comprising polysaccharides |
| JP2020506279A (ja) | 2016-11-16 | 2020-02-27 | デュポン・インダストリアル・バイオサイエンシーズ・ユーエスエイ・エルエルシー | 多糖を含む成形物品 |
| CN109983067B (zh) * | 2016-11-16 | 2022-11-15 | 营养与生物科学美国4公司 | 纤维素/多糖复合材料 |
| EP3609949A1 (en) | 2017-06-30 | 2020-02-19 | DuPont Industrial Biosciences USA, LLC | Polysaccharide-elastomer masterbatch compositions |
| CN107584138B (zh) * | 2017-09-17 | 2019-05-24 | 赵兵 | 基于海绵模板的石墨烯/纳米银纳米复合材料 |
| CN111566128B (zh) | 2017-11-10 | 2022-06-21 | 营养与生物科学美国4公司 | 独特形态的多糖 |
| JP7431172B2 (ja) * | 2018-04-23 | 2024-02-14 | ダニスコ・ユーエス・インク | ホスホリラーゼ酵素を用いたβ-1,3グリコシド結合を含むグルカンの合成 |
| JP7076098B2 (ja) * | 2018-05-02 | 2022-05-27 | 国立大学法人東京工業大学 | セロオリゴ糖の製造方法 |
| WO2020023278A1 (en) | 2018-07-23 | 2020-01-30 | Danisco Us Inc | Alpha-glucose-1 -phosphate synthesis from sucrose and glucan synthesis using glucan phosphorylases |
| US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
| CN110194446B (zh) * | 2019-06-10 | 2022-05-13 | 广西科学院 | 一种以纤维素深度水解得到的2d纤维素为原料的石墨烯2d粉体的制备方法 |
| US20230052291A1 (en) * | 2019-12-12 | 2023-02-16 | Sun Chemical Colors & Effects Gmbh | Cellulose nanocrystal effect pigments for cosmetic applications |
| CN112753843A (zh) * | 2021-02-04 | 2021-05-07 | 海南华研胶原科技股份有限公司 | 一种组合酶解法提取牡蛎肽的方法 |
| US20240190785A1 (en) * | 2021-03-23 | 2024-06-13 | Resonac Corporation | Spreading agent, fertilizer composition and agricultural chemical composition |
| JP2024525685A (ja) | 2021-07-13 | 2024-07-12 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー,インコーポレイテッド | カチオン性グルカンエステル誘導体 |
| CN114031912A (zh) * | 2021-12-01 | 2022-02-11 | 宁波大学 | 一种酶合成纳米纤维素/phbv复合材料及其制备方法 |
| CN114847338B (zh) * | 2022-06-06 | 2023-10-24 | 河北天农农业科技有限公司 | 一种绿原酸保鲜膜的成膜方法及其在蛋品保鲜中的应用 |
| WO2024015769A1 (en) | 2022-07-11 | 2024-01-18 | Nutrition & Biosciences USA 4, Inc. | Amphiphilic glucan ester derivatives |
| EP4339228A1 (en) * | 2022-09-13 | 2024-03-20 | Lanbiotic GmbH | Storage stable microbial composition |
| JP2024137125A (ja) * | 2023-03-24 | 2024-10-07 | 国立大学法人東京工業大学 | ゲル化剤、液体組成物及びハイドロゲル |
| WO2025072416A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives |
| WO2025072417A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives |
Family Cites Families (203)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1296839A (enExample) | 1969-05-29 | 1972-11-22 | ||
| GB1372034A (en) | 1970-12-31 | 1974-10-30 | Unilever Ltd | Detergent compositions |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5972682A (en) | 1984-05-29 | 1999-10-26 | Genencor International, Inc. | Enzymatically active modified subtilisins |
| US5801038A (en) | 1984-05-29 | 1998-09-01 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| US4933287A (en) | 1985-08-09 | 1990-06-12 | Gist-Brocades N.V. | Novel lipolytic enzymes and their use in detergent compositions |
| US4810414A (en) | 1986-08-29 | 1989-03-07 | Novo Industri A/S | Enzymatic detergent additive |
| NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
| US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
| ATE113070T1 (de) | 1987-05-29 | 1994-11-15 | Genencor Int | Cutinase haltige reinigungsmittelzusammensetzungen. |
| EP0305216B1 (en) | 1987-08-28 | 1995-08-02 | Novo Nordisk A/S | Recombinant Humicola lipase and process for the production of recombinant humicola lipases |
| JPS6474992A (en) | 1987-09-16 | 1989-03-20 | Fuji Oil Co Ltd | Dna sequence, plasmid and production of lipase |
| DE68924654T2 (de) | 1988-01-07 | 1996-04-04 | Novonordisk As | Spezifische Protease. |
| JP3079276B2 (ja) | 1988-02-28 | 2000-08-21 | 天野製薬株式会社 | 組換え体dna、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法 |
| US5648263A (en) | 1988-03-24 | 1997-07-15 | Novo Nordisk A/S | Methods for reducing the harshness of a cotton-containing fabric |
| WO1990009446A1 (en) | 1989-02-17 | 1990-08-23 | Plant Genetic Systems N.V. | Cutinase |
| KR0165550B1 (ko) | 1989-06-29 | 1999-01-15 | 마가렛트 에이. 호른 | 온도, 산 및/또는 알칼리에 대한 안정성이 증가된 변이체 미생물 알파-아밀라아제 |
| GB8915658D0 (en) | 1989-07-07 | 1989-08-23 | Unilever Plc | Enzymes,their production and use |
| JP2848861B2 (ja) * | 1989-09-14 | 1999-01-20 | ダイセル化学工業株式会社 | オリゴマー及びその製造方法 |
| WO1991016422A1 (de) | 1990-04-14 | 1991-10-31 | Kali-Chemie Aktiengesellschaft | Alkalische bacillus-lipasen, hierfür codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren |
| BR9106839A (pt) | 1990-09-13 | 1993-07-20 | Novo Nordisk As | Variante de lipase,construcao de dna,vetor de expressao de recombinante,celula,planta,processo para produzir uma variante de lipase,aditivo e composicao de detergente |
| ATE155521T1 (de) | 1990-09-28 | 1997-08-15 | Procter & Gamble | Polyhydroxyfettsäureamidtenside zur erhöhung der enzymleistung |
| US5340735A (en) | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
| JPH05236958A (ja) | 1992-02-28 | 1993-09-17 | Amano Pharmaceut Co Ltd | 新規イソアミラーゼ及びその製造法 |
| DK72992D0 (da) | 1992-06-01 | 1992-06-01 | Novo Nordisk As | Enzym |
| DK88892D0 (da) | 1992-07-06 | 1992-07-06 | Novo Nordisk As | Forbindelse |
| KR100294361B1 (ko) | 1992-07-23 | 2001-09-17 | 피아 스타르 | 돌연변이체알파-아밀라제,세정제,접시세척제,및액화제 |
| KR100303620B1 (ko) | 1992-12-01 | 2001-11-22 | 피아 스타르 | 효소반응의증강법 |
| KR100322793B1 (ko) | 1993-02-11 | 2002-06-20 | 마가렛 에이.혼 | 산화안정성알파-아밀라아제 |
| DK0652946T3 (da) | 1993-04-27 | 2005-05-30 | Genencor Int | Nye lipase-varianter til anvendelse i detergenter |
| DK77393D0 (da) | 1993-06-29 | 1993-06-29 | Novo Nordisk As | Aktivering af enzymer |
| JP2859520B2 (ja) | 1993-08-30 | 1999-02-17 | ノボ ノルディスク アクティーゼルスカブ | リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物 |
| BR9407767A (pt) | 1993-10-08 | 1997-03-18 | Novo Nordisk As | Variante de enzima &-amilase uso da mesma construção de DNA vetor de express o recombinante célula processos para produzir uma &-amilase hibrida e para preparar uma variante de uma &-amilase aditivo detergente e composições detergentes |
| CA2173946A1 (en) | 1993-10-13 | 1995-04-20 | Anders Hjelholt Pedersen | H2o2-stable peroxidase variants |
| JPH07143883A (ja) | 1993-11-24 | 1995-06-06 | Showa Denko Kk | リパーゼ遺伝子及び変異体リパーゼ |
| WO1995022615A1 (en) | 1994-02-22 | 1995-08-24 | Novo Nordisk A/S | A method of preparing a variant of a lipolytic enzyme |
| ES2364776T3 (es) | 1994-02-24 | 2011-09-14 | HENKEL AG & CO. KGAA | Enzimas mejoradas y detergentes que las contienen. |
| US5691295A (en) | 1995-01-17 | 1997-11-25 | Cognis Gesellschaft Fuer Biotechnologie Mbh | Detergent compositions |
| DK1921147T3 (da) | 1994-02-24 | 2011-09-19 | Henkel Ag & Co Kgaa | Forbedrede enzymer og detergenter indeholdende disse |
| EP1637596B1 (en) | 1994-03-29 | 2011-05-18 | Novozymes A/S | Alkaline bacillus amylase |
| AU2524695A (en) | 1994-05-04 | 1995-11-29 | Genencor International, Inc. | Lipases with improved surfactant resistance |
| WO1995035382A2 (en) | 1994-06-17 | 1995-12-28 | Genecor International Inc. | NOVEL AMYLOLYTIC ENZYMES DERIVED FROM THE B. LICHENIFORMIS α-AMYLASE, HAVING IMPROVED CHARACTERISTICS |
| ATE222286T1 (de) | 1994-06-17 | 2002-08-15 | Genencor Int | Reinigungsverfahren mit pflanzenzellwände abbauendes hemicellulase enzym enthaltender zusammensetzung und deren verwendung in reinigungsverfahren |
| WO1995035381A1 (en) | 1994-06-20 | 1995-12-28 | Unilever N.V. | Modified pseudomonas lipases and their use |
| WO1996000292A1 (en) | 1994-06-23 | 1996-01-04 | Unilever N.V. | Modified pseudomonas lipases and their use |
| FI970563L (fi) | 1994-08-11 | 1997-02-10 | Genencor Int | Parannettu puhdistuskoostumus |
| BE1008998A3 (fr) | 1994-10-14 | 1996-10-01 | Solvay | Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci. |
| CA2203398A1 (en) | 1994-10-26 | 1996-05-09 | Thomas Sandal | An enzyme with lipolytic activity |
| AR000862A1 (es) | 1995-02-03 | 1997-08-06 | Novozymes As | Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del |
| EP0808363B1 (en) | 1995-02-03 | 2009-05-27 | Novozymes A/S | A method of designing alpha-amylase mutants with predetermined properties |
| US5716837A (en) | 1995-02-10 | 1998-02-10 | Monsanto Company | Expression of sucrose phosphorylase in plants |
| US5811277A (en) | 1995-02-21 | 1998-09-22 | Food Industry Research And Development Institute | Method for recovery and purification of isoamylase by adsorption on raw starch |
| JPH08228778A (ja) | 1995-02-27 | 1996-09-10 | Showa Denko Kk | 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法 |
| CA2216316A1 (en) | 1995-03-24 | 1996-10-03 | Genencor International, Inc. | An improved laundry detergent composition comprising amylase |
| DE69633825T2 (de) | 1995-07-14 | 2005-11-10 | Novozymes A/S | Modifiziertes enzym mit lipolytischer aktivität |
| EP0851913B1 (en) | 1995-08-11 | 2004-05-19 | Novozymes A/S | Novel lipolytic enzymes |
| EP0850307B1 (en) | 1995-09-13 | 2005-11-09 | Genencor International, Inc. | Alkaliphilic and thermophilic microorganisms and enzymes obtained therefrom |
| ES2432519T3 (es) | 1996-04-30 | 2013-12-04 | Novozymes A/S | Mutantes de alfa-amilasa |
| US6211134B1 (en) | 1996-05-14 | 2001-04-03 | Genecor International, Inc. | Mutant α-amylase |
| US5763385A (en) | 1996-05-14 | 1998-06-09 | Genencor International, Inc. | Modified α-amylases having altered calcium binding properties |
| CA2265734A1 (en) | 1996-10-08 | 1998-04-16 | Novo Nordisk A/S | Diaminobenzoic acid derivatives as dye precursors |
| ATE293696T1 (de) | 1996-12-09 | 2005-05-15 | Genencor Int | Mutierte alpha-amylase enzyme mit erhöhter stabilität |
| DE19709775A1 (de) | 1997-03-10 | 1998-09-17 | Planttec Biotechnologie Gmbh | Nucleinsäuremoleküle codierend Stärkephosphorylase aus Mais |
| US6008026A (en) | 1997-07-11 | 1999-12-28 | Genencor International, Inc. | Mutant α-amylase having introduced therein a disulfide bond |
| JP2995289B2 (ja) * | 1997-08-04 | 1999-12-27 | 農林水産省食品総合研究所長 | セロビオースフォスフォリラーゼ遺伝子、該遺伝子を含むベクター及び形質転換体 |
| US6080568A (en) | 1997-08-19 | 2000-06-27 | Genencor International, Inc. | Mutant α-amylase comprising modification at residues corresponding to A210, H405 and/or T412 in Bacillus licheniformis |
| GB9719637D0 (en) | 1997-09-15 | 1997-11-19 | Genencor Int Bv | Proteases from gram-positive organisms |
| GB9719636D0 (en) | 1997-09-15 | 1997-11-19 | Genencor Int Bv | Proteases from gram-positive organisms |
| KR20010015754A (ko) | 1997-10-13 | 2001-02-26 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | α-아밀라제 변이체 |
| AR015977A1 (es) | 1997-10-23 | 2001-05-30 | Genencor Int | Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes |
| EP2386568B1 (en) | 1997-10-30 | 2014-08-06 | Novozymes A/S | Alpha-amylase mutants |
| CN1174999C (zh) * | 1997-12-04 | 2004-11-10 | 旭化成株式会社 | 纤维素分散体 |
| GB9727471D0 (en) | 1997-12-30 | 1998-02-25 | Genencor Int Bv | Proteases from gram positive organisms |
| GB9727464D0 (en) | 1997-12-30 | 1998-02-25 | Genencor Int Bv | Proteases from gram positive organisms |
| KR20010040517A (ko) | 1998-02-18 | 2001-05-15 | 피아 스타르 | 알칼리성 bacillus 아밀라제 |
| DK1066374T3 (da) | 1998-02-27 | 2006-09-18 | Novozymes As | Amylolytiske enzymvarianter |
| DK2305799T3 (en) | 1998-02-27 | 2016-07-25 | Novozymes As | Maltogenic alpha-amylase variants |
| WO1999045124A2 (en) | 1998-03-04 | 1999-09-10 | Genencor International, Inc. | Modified forms of pullulanase |
| JP2002505885A (ja) | 1998-03-09 | 2002-02-26 | ノボザイムス アクティーゼルスカブ | デンプンからのグルコースシロップの酵素的調製 |
| ATE528394T1 (de) | 1998-06-10 | 2011-10-15 | Novozymes As | Neuartige mannasen |
| DE19834180A1 (de) | 1998-07-29 | 2000-02-03 | Benckiser Nv | Zusammensetzung zur Verwendung in einer Geschirrspülmaschine |
| US6197565B1 (en) | 1998-11-16 | 2001-03-06 | Novo-Nordisk A/S | α-Amylase variants |
| KR19990068298A (ko) | 1999-03-12 | 1999-09-06 | 정명우 | 장미씨기름을함유하는치약조성물 |
| US6596303B1 (en) | 1999-03-22 | 2003-07-22 | Mars Incorporated | Pet food for maintenance of joint health and alleviation of arthritic symptoms in companion animals |
| JP4668426B2 (ja) | 1999-03-30 | 2011-04-13 | ノボザイムス アクティーゼルスカブ | α−アミラーゼ変異体 |
| ES2322426T3 (es) | 1999-03-31 | 2009-06-22 | Novozymes A/S | Polipeptidos con actividad alfa-amilasa y acidos nucleicos que codifican a los mismos. |
| WO2000060060A2 (en) | 1999-03-31 | 2000-10-12 | Novozymes A/S | Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same |
| US6387495B1 (en) * | 1999-04-16 | 2002-05-14 | Kimberly-Clark Worldwide, Inc. | Superabsorbent-containing composites |
| CN1240832C (zh) | 1999-08-20 | 2006-02-08 | 诺维信公司 | 碱性芽孢杆菌淀粉酶 |
| US6254645B1 (en) | 1999-08-20 | 2001-07-03 | Genencor International, Inc. | Enzymatic modification of the surface of a polyester fiber or article |
| US6933140B1 (en) | 1999-11-05 | 2005-08-23 | Genencor International, Inc. | Enzymes useful for changing the properties of polyester |
| AR026433A1 (es) | 1999-11-10 | 2003-02-12 | Novozymes As | Variantes de alfa-amilasa tipo fungamyl |
| US6350599B1 (en) | 2000-01-12 | 2002-02-26 | Novozymes A/S | Pullulanase variants and methods for preparing such variants with predetermined properties |
| AU3724801A (en) | 2000-03-03 | 2001-09-12 | Novozymes A/S | Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same |
| EP3594334A3 (en) | 2000-03-08 | 2020-03-18 | Novozymes A/S | Variants with altered properties |
| US20030104969A1 (en) | 2000-05-11 | 2003-06-05 | Caswell Debra Sue | Laundry system having unitized dosing |
| AU2001258229A1 (en) | 2000-05-12 | 2001-11-26 | Novozymes A/S | Alpha-amylase variants with altered 1,6-activity |
| WO2001096537A2 (en) | 2000-06-14 | 2001-12-20 | Novozymes A/S | Pre-oxidized alpha-amylase |
| JP4083374B2 (ja) * | 2000-07-11 | 2008-04-30 | トヨタ自動車株式会社 | セルロースの生成方法 |
| CA2702204C (en) | 2000-08-01 | 2011-09-06 | Novozymes A/S | Alpha-amylase mutants with altered properties |
| US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
| WO2002031124A2 (en) | 2000-10-13 | 2002-04-18 | Novozymes A/S | Alpha-amylase variant with altered properties |
| AU2002232435A1 (en) | 2000-11-27 | 2002-06-03 | The Procter & Gamble Company | Dishwashing method |
| CA2592612C (en) | 2000-11-27 | 2008-07-29 | The Procter & Gamble Company | Detergent pouch comprising superposed or superposable compartments |
| DE60234523D1 (de) | 2001-05-15 | 2010-01-07 | Novozymes As | Alpha-amylasevariante mit veränderten eigenschaften |
| DK2135957T3 (da) | 2001-05-28 | 2019-05-13 | Ezaki Glico Co | Fremgangsmåde til fremstilling af glucaner |
| US7666459B2 (en) | 2001-09-12 | 2010-02-23 | The Procter & Gamble Company | Pet food compositions |
| JP3998477B2 (ja) * | 2002-01-18 | 2007-10-24 | 旭化成ケミカルズ株式会社 | セルロース複合体とその製造方法 |
| EP1354939A1 (en) | 2002-04-19 | 2003-10-22 | The Procter & Gamble Company | Pouched cleaning compositions |
| MXPA05002116A (es) | 2002-08-23 | 2005-06-03 | Du Pont | Utilizacion de productos de almidon para produccion biologica por fermentacion. |
| ES2530518T3 (es) | 2003-04-29 | 2015-03-03 | Danisco Us Inc | Nueva celulasa 029cel de Bacillus |
| CA2538349C (en) | 2003-06-25 | 2014-08-12 | Novozymes A/S | Polypeptides having alpha-amylase activity and polynucleotides encoding same |
| JP2007526748A (ja) | 2003-06-25 | 2007-09-20 | ノボザイムス アクティーゼルスカブ | 澱粉加工用酵素 |
| WO2004113551A1 (en) | 2003-06-25 | 2004-12-29 | Novozymes A/S | Process for the hydrolysis of starch |
| EP1664285A2 (en) | 2003-08-22 | 2006-06-07 | Novozymes A/S | Fungal alpha-amylase variants |
| US20080124427A1 (en) | 2003-08-22 | 2008-05-29 | Novozymes A/S | Process for preparing a dough comprising a starch-degrading glucogenic exo-amy-lase of family 13 |
| CN1845990B (zh) * | 2003-09-04 | 2012-03-21 | 江崎格力高株式会社 | 耐热化蔗糖磷酸化酶(sp)的方法 |
| ES2269907T3 (es) | 2003-09-22 | 2007-04-01 | THE PROCTER & GAMBLE COMPANY | Composicion detergente en dosis unitaria liquida. |
| US7754460B2 (en) | 2003-12-03 | 2010-07-13 | Danisco Us Inc. | Enzyme for the production of long chain peracid |
| ES2361838T3 (es) | 2003-12-03 | 2011-06-22 | Danisco Us Inc. | Perhidrolasa. |
| US8703459B2 (en) | 2003-12-05 | 2014-04-22 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity |
| AU2004312117B2 (en) | 2004-01-08 | 2011-09-15 | Novozymes A/S | Amylase |
| DE102004020720A1 (de) | 2004-04-28 | 2005-12-01 | Henkel Kgaa | Verfahren zur Herstellung von Wasch- oder Reinigungsmitteln |
| GB0416155D0 (en) | 2004-07-20 | 2004-08-18 | Unilever Plc | Laundry product |
| CA2575878A1 (en) | 2004-08-02 | 2006-02-09 | Novozymes A/S | Creation of diversity in polypeptides |
| EP1797179A1 (en) | 2004-08-02 | 2007-06-20 | Novozymes A/S | Maltogenic alpha-amylase variants |
| US20060045854A1 (en) | 2004-08-27 | 2006-03-02 | Lynette Zaidel | Oral care composition with cross-linked polymer peroxide |
| US20080248558A1 (en) | 2004-09-10 | 2008-10-09 | Novozymes A/S | Methods For Preventing, Removing, Reducing, or Disrupting Biofilm |
| GB0423986D0 (en) | 2004-10-29 | 2004-12-01 | Unilever Plc | Method of preparing a laundry product |
| WO2006063594A1 (en) | 2004-12-15 | 2006-06-22 | Novozymes A/S | Alkaline bacillus amylase |
| US20060134025A1 (en) | 2004-12-17 | 2006-06-22 | Colgate-Palmolive Company | Oral compositions containing extracts of Rosmarinus and related methods |
| AU2005318698A1 (en) | 2004-12-22 | 2006-06-29 | Novozymes A/S | Hybrid enzymes consisting of an endo-amylase first amino acid sequence and a carbohydrate -binding module as second amino acid sequence |
| AU2005318696B2 (en) | 2004-12-23 | 2010-12-16 | Novozymes A/S | Alpha-amylase variants |
| US7625441B2 (en) | 2005-02-09 | 2009-12-01 | Solae, Llc | Paper coating formulation having a reduced level of binder |
| EP1896057A2 (en) | 2005-06-24 | 2008-03-12 | Novozymes A/S | Amylases for pharmaceutical use |
| RU2433182C2 (ru) | 2005-10-12 | 2011-11-10 | Джененкор Интернэшнл, Инк. | Применение и получение стабильной при хранении нейтральной металлопротеиназы |
| US20080057007A1 (en) | 2006-03-01 | 2008-03-06 | Dentech, Inc. | Oral hygiene products containing ascorbic acid and method of using the same |
| EP1991651B2 (en) | 2006-03-02 | 2022-07-06 | The Procter & Gamble Company | Surface active bleach at dynamic ph |
| WO2007111899A2 (en) | 2006-03-22 | 2007-10-04 | The Procter & Gamble Company | Liquid treatment composition |
| GB0613069D0 (en) | 2006-06-30 | 2006-08-09 | Unilever Plc | Laundry articles |
| WO2008000825A1 (en) | 2006-06-30 | 2008-01-03 | Novozymes A/S | Bacterial alpha-amylase variants |
| JP2009543577A (ja) | 2006-07-18 | 2009-12-10 | ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン | 幅広い温度におけるプロテアーゼ変異体の活性 |
| US7968691B2 (en) | 2006-08-23 | 2011-06-28 | Danisco Us Inc. | Pullulanase variants with increased productivity |
| US8017373B2 (en) * | 2006-08-31 | 2011-09-13 | Iogen Energy Corporation | Process for enzymatic hydrolysis of pretreated lignocellulosic feedstocks |
| EP2097519A2 (en) | 2006-12-21 | 2009-09-09 | Danisco US, INC., Genencor Division | Compositions and uses for an alpha-amylase polypeptide of bacillus species 195 |
| GB0700931D0 (en) | 2007-01-18 | 2007-02-28 | Reckitt Benckiser Nv | Dosage element and a method of manufacturing a dosage element |
| US20100112637A1 (en) | 2007-02-01 | 2010-05-06 | Novozymes A/S | Polypeptides Having Alpha-Amylase Activity and Polynucleotides Encoding Same |
| SE0700404L (sv) * | 2007-02-19 | 2008-08-20 | Xylophane Ab | Polymerfilm eller -beläggning innefattande hemicellulosa |
| US8021863B2 (en) | 2007-02-19 | 2011-09-20 | Novozymes A/S | Polypeptides with starch debranching activity |
| WO2008106214A1 (en) | 2007-02-27 | 2008-09-04 | Danisco Us Inc. | Cleaning enzymes and fragrance production |
| CN102604753A (zh) | 2007-02-27 | 2012-07-25 | 丹尼斯科美国公司 | 清洁用酶和臭味预防 |
| WO2009058661A1 (en) | 2007-10-31 | 2009-05-07 | Danisco Us Inc., Genencor Division | Use and production of citrate-stable neutral metalloproteases |
| EP2205732A2 (en) | 2007-11-01 | 2010-07-14 | Danisco US Inc. | Production of thermolysin and variants thereof and use in liquid detergents |
| CA2704745C (en) | 2007-11-05 | 2019-01-15 | Danisco Us Inc. | Alpha-amylase variants with altered properties |
| DK2245130T3 (da) | 2008-02-04 | 2021-01-18 | Danisco Us Inc | Ts23 -alpha-amylasevarianter med ændrede egenskaber |
| PL2088187T3 (pl) | 2008-02-08 | 2013-01-31 | Procter & Gamble | Sposób otrzymywania rozpuszczalnej w wodzie saszetki |
| US8066818B2 (en) | 2008-02-08 | 2011-11-29 | The Procter & Gamble Company | Water-soluble pouch |
| EP2098123A1 (de) | 2008-03-07 | 2009-09-09 | Bayer CropScience AG | Verwendung von Alternan als Verdickungsmittel und Verdickungsmittelzusammensetzungen enthaltend Alternan und ein weiteres Verdickungsmittel. |
| US20090233830A1 (en) | 2008-03-14 | 2009-09-17 | Penny Sue Dirr | Automatic detergent dishwashing composition |
| EP2100947A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| EP2107107A1 (en) | 2008-04-02 | 2009-10-07 | The Procter and Gamble Company | Water-soluble pouch comprising a detergent composition |
| CN102027004A (zh) | 2008-05-16 | 2011-04-20 | 诺维信公司 | 具有α-淀粉酶活性的多肽和编码该多肽的多核苷酸 |
| MX2010013121A (es) | 2008-06-06 | 2011-01-21 | Danisco Inc | Composiciones y metodos que comprenden proteasas microbianas variantes. |
| DK2297313T3 (en) | 2008-06-06 | 2015-06-08 | Danisco Us Inc | ALPHA AMYLASE VARIETIES OF BACILLUS SUBTILIS AND METHODS OF USING IT |
| EP2133410B1 (en) | 2008-06-13 | 2011-12-28 | The Procter & Gamble Company | Multi-compartment pouch |
| BR122013014156A2 (pt) | 2008-11-11 | 2015-07-14 | Danisco Us Inc | Composição de limpeza compreendendo variantes de subtilisina, bem como processo de limpeza |
| JP2012508031A (ja) | 2008-11-11 | 2012-04-05 | ダニスコ・ユーエス・インク | 1以上の組み合わせ変異を含むプロテアーゼ |
| US8530219B2 (en) | 2008-11-11 | 2013-09-10 | Danisco Us Inc. | Compositions and methods comprising a subtilisin variant |
| CN102292444A (zh) | 2008-11-20 | 2011-12-21 | 诺维信股份有限公司 | 具有淀粉分解增强活性的多肽和编码该多肽的多核苷酸 |
| US20100125046A1 (en) | 2008-11-20 | 2010-05-20 | Denome Frank William | Cleaning products |
| ES2639442T3 (es) | 2009-01-28 | 2017-10-26 | The Procter And Gamble Company | Composición para lavado de ropa en bolsa multicompartimental |
| WO2010088447A1 (en) | 2009-01-30 | 2010-08-05 | Novozymes A/S | Polypeptides having alpha-amylase activity and polynucleotides encoding same |
| WO2010091221A1 (en) | 2009-02-06 | 2010-08-12 | Novozymes A/S | Polypeptides having alpha-amylase activity and polynucleotides encoding same |
| EP3998328A1 (en) | 2009-02-09 | 2022-05-18 | The Procter & Gamble Company | Detergent composition |
| EP2406373B1 (en) | 2009-03-10 | 2014-05-28 | Danisco US Inc. | Bacillus megaterium strain dsm90-related alpha-amylases, and methods of use, thereof |
| RU2011144134A (ru) | 2009-04-01 | 2013-05-10 | ДАНИСКО ЮЭс ИНК. | Композиции и способы, включающие варианты альфа-амилазы с измененными свойствами |
| EP2417254B1 (en) | 2009-04-08 | 2014-05-21 | Danisco US Inc. | Halomonas strain wdg195-related alpha-amylases, and methods of use, thereof |
| GB0906281D0 (en) | 2009-04-09 | 2009-05-20 | Reckitt Benckiser Nv | Detergent compositions |
| WO2010127451A1 (en) * | 2009-05-06 | 2010-11-11 | Fpinnovations | Crystalline sulphated cellulose ii and its production from sulphuric acid hydrolysis of celulose |
| EP2432699B1 (en) | 2009-05-19 | 2021-08-18 | The Procter & Gamble Company | A method for printing water-soluble film |
| EP2467476A1 (en) | 2009-08-21 | 2012-06-27 | Novozymes A/S | Polypeptides having isoamylase activity and polynucleotides encoding same |
| CN105368809A (zh) | 2009-12-09 | 2016-03-02 | 丹尼斯科美国公司 | 包含蛋白酶变体的组合物和方法 |
| WO2011076897A1 (en) | 2009-12-22 | 2011-06-30 | Novozymes A/S | Use of amylase variants at low temperature |
| CN102791854A (zh) | 2009-12-22 | 2012-11-21 | 诺维信公司 | 普鲁兰酶变体及其用途 |
| US9416355B2 (en) | 2010-01-04 | 2016-08-16 | Novozymes North America, Inc. | Alpha-amylase variants and polynucleotides encoding same |
| EP2528955B1 (en) | 2010-01-29 | 2019-05-15 | Monosol, LLC | Water-soluble film having improved dissolution and stress properties, and packets made therefrom |
| CN113186178A (zh) | 2010-02-10 | 2021-07-30 | 诺维信公司 | 在螯合剂存在下具有高稳定性的变体和包含变体的组合物 |
| US20110240510A1 (en) | 2010-04-06 | 2011-10-06 | Johan Maurice Theo De Poortere | Optimized release of bleaching systems in laundry detergents |
| PL3095861T3 (pl) | 2010-05-06 | 2020-04-30 | The Procter & Gamble Company | Produkty konsumenckie z odmianami proteaz |
| GB201008573D0 (en) | 2010-05-21 | 2010-07-07 | Univ Gent | Biocatalytic production of cellobiosides |
| JP5926245B2 (ja) * | 2010-06-17 | 2016-05-25 | ボルレガール アクティーゼルスカブ | セルロースの酵素的加水分解 |
| ES2527679T5 (es) | 2010-06-24 | 2022-04-19 | Procter & Gamble | Artículos solubles de dosis unitaria que comprenden un polímero catiónico |
| CA2808843C (en) | 2010-08-23 | 2018-05-01 | The Sun Products Corporation | Unit dose detergent compositions and methods of production and use thereof |
| WO2012059336A1 (en) | 2010-11-03 | 2012-05-10 | Henkel Ag & Co. Kgaa | Laundry article having cleaning properties |
| EP3036999B1 (en) | 2010-12-20 | 2019-04-24 | Hill's Pet Nutrition, Inc. | Pet food compositions for inducing a satiety response |
| GB201101536D0 (en) | 2011-01-31 | 2011-03-16 | Reckitt Benckiser Nv | Cleaning article |
| AU2012214520A1 (en) | 2011-02-07 | 2013-08-22 | The Board Of Trustees Of The University Of Illinois | Enhanced cellodextrin metabolism |
| EP4230735A1 (en) | 2011-05-05 | 2023-08-23 | Danisco US Inc. | Compositions and methods comprising serine protease variants |
| US20140087435A1 (en) | 2012-08-13 | 2014-03-27 | Georgia Tech Research Corporation | Novel Microbial Biocatalysts That Enables Use Of Cellodextrin As Biofuel |
| JP6236859B2 (ja) * | 2013-05-08 | 2017-11-29 | 凸版印刷株式会社 | ガスバリア層形成用の塗工液の製造方法 |
| HRP20200170T1 (hr) * | 2014-09-10 | 2020-05-15 | Pfeifer & Langen GmbH & Co. KG | Celobioza fosforilaza |
| US20180334696A1 (en) * | 2014-12-23 | 2018-11-22 | E I Du Pont De Nemours And Company | Enzymatically produced cellulose |
-
2015
- 2015-12-15 US US15/532,635 patent/US20180334696A1/en not_active Abandoned
- 2015-12-15 EP EP15820010.5A patent/EP3237632B8/en active Active
- 2015-12-15 JP JP2017533754A patent/JP2018512109A/ja active Pending
- 2015-12-15 EP EP15820007.1A patent/EP3237631A1/en not_active Withdrawn
- 2015-12-15 CA CA2969242A patent/CA2969242A1/en not_active Abandoned
- 2015-12-15 AU AU2015369967A patent/AU2015369967B2/en not_active Ceased
- 2015-12-15 CA CA2969241A patent/CA2969241A1/en not_active Abandoned
- 2015-12-15 CN CN201580070420.XA patent/CN108064306B/zh not_active Expired - Fee Related
- 2015-12-15 WO PCT/US2015/065707 patent/WO2016106013A1/en not_active Ceased
- 2015-12-15 JP JP2017533766A patent/JP6770519B2/ja active Active
- 2015-12-15 AU AU2015369965A patent/AU2015369965B2/en not_active Ceased
- 2015-12-15 US US15/532,550 patent/US10131929B2/en active Active
- 2015-12-15 WO PCT/US2015/065699 patent/WO2016106011A1/en not_active Ceased
- 2015-12-15 CN CN201580070778.2A patent/CN107109450A/zh active Pending
-
2018
- 2018-11-15 US US16/191,483 patent/US10392641B2/en active Active
-
2019
- 2019-08-23 US US16/549,092 patent/US10927392B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180334696A1 (en) | 2018-11-22 |
| EP3237632A1 (en) | 2017-11-01 |
| WO2016106013A1 (en) | 2016-06-30 |
| EP3237631A1 (en) | 2017-11-01 |
| WO2016106011A1 (en) | 2016-06-30 |
| JP2018512109A (ja) | 2018-05-17 |
| EP3237632B8 (en) | 2019-03-13 |
| JP6770519B2 (ja) | 2020-10-14 |
| AU2015369965A1 (en) | 2017-06-15 |
| US20170327857A1 (en) | 2017-11-16 |
| AU2015369967B2 (en) | 2019-06-27 |
| US20190100782A1 (en) | 2019-04-04 |
| CN108064306A (zh) | 2018-05-22 |
| AU2015369965B2 (en) | 2020-01-30 |
| US10131929B2 (en) | 2018-11-20 |
| EP3237632B1 (en) | 2018-10-24 |
| CN107109450A (zh) | 2017-08-29 |
| US10927392B2 (en) | 2021-02-23 |
| US20200080121A1 (en) | 2020-03-12 |
| CA2969241A1 (en) | 2016-06-30 |
| US10392641B2 (en) | 2019-08-27 |
| JP2018512040A (ja) | 2018-05-10 |
| CN108064306B (zh) | 2022-11-01 |
| AU2015369967A1 (en) | 2017-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10927392B2 (en) | Enzymatically produced cellulose | |
| Gao et al. | Cloning, characterization and substrate degradation mode of a novel chitinase from Streptomyces albolongus ATCC 27414 | |
| US10988789B2 (en) | Glucosyltransferase enzymes for production of glucan polymers | |
| Luo et al. | High level production of a Bacillus amlyoliquefaciens chitosanase in Pichia pastoris suitable for chitooligosaccharides preparation | |
| CN105821020B (zh) | 一种β-甘露聚糖酶mRmMan5A及其编码基因与应用 | |
| Purushotham et al. | Multiple chitinases of an endophytic Serratia proteamaculans 568 generate chitin oligomers | |
| KR20190054187A (ko) | D-타가토스의 효소적 생산 | |
| Li et al. | Biochemical characterization of two β-N-acetylglucosaminidases from Streptomyces violascens for efficient production of N-acetyl-d-glucosamine | |
| US11180740B2 (en) | Synthesis of glucan comprising beta-1,3 glycosidic linkages with beta-1,3-glucan phosphorylase enzymes | |
| Vaikuntapu et al. | Applicability of endochitinase of Flavobacterium johnsoniae with transglycosylation activity in generating long-chain chitooligosaccharides | |
| Hobel et al. | Cloning, expression, and characterization of a highly thermostable family 18 chitinase from Rhodothermus marinus | |
| CN109072270B (zh) | 用于产生低聚糖或葡萄糖的组合物及其产生的方法 | |
| CN111836900A (zh) | 从海藻生产葡萄糖及昆布多糖寡糖的新型β-葡萄糖苷酶 | |
| Wang et al. | Characterization of a thermostable PL-31 family alginate lyase from Paenibacillus ehimensis and its application for alginate oligosaccharides bioproduction | |
| Guo et al. | Gene cloning, functional expression, and characterization of a novel GH46 chitosanase from Streptomyces avermitilis (SaCsn46A) | |
| CN112795556A (zh) | 一种β-N-乙酰氨基葡萄糖苷酶159及其克隆表达与应用 | |
| CN116262925A (zh) | 一种β-1,3-葡聚糖酶及其制备方法和应用 | |
| Ju et al. | Efficient expression and characterization of an endo-type lyase HCLase_M28 and its gradual scale-up fermentation for the preparation of chondroitin sulfate oligosaccharides | |
| Ramakrishna et al. | Carboxy-terminal glycosyl hydrolase 18 domain of a carbohydrate active protein of Chitinophaga pinensis is a non-processive exochitinase | |
| Armenova et al. | Direct microbial production of 2, 3-Butanediol from inulin by Bacillus velezensis R22 through the synergistic action of membrane and cytoplasmic inulinases | |
| TW201943854A (zh) | D-阿洛酮糖之酶促產生 | |
| Suresh | Enzymatic production of different types of chitooligosaccharides | |
| Ismail et al. | Characterization of thermostable beta-1, 4-galactanase and its application in hydrolysis of pectin from sweet potato (Ipomoea batatas (L.) Lam) peels | |
| Cheng Gong et al. | Expression of chitosanase from Bacillus amyloliquefaciens in Pichia pastoris and its application in preparation of chitooligosaccharides with controllable structure. | |
| Sun et al. | Preparation of various aminooligosaccharides using a novel chitinase and its CBM fusion mutants |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20220307 |
|
| FZDE | Discontinued |
Effective date: 20220307 |