CA2948080A1 - Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection - Google Patents

Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection Download PDF

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Publication number
CA2948080A1
CA2948080A1 CA2948080A CA2948080A CA2948080A1 CA 2948080 A1 CA2948080 A1 CA 2948080A1 CA 2948080 A CA2948080 A CA 2948080A CA 2948080 A CA2948080 A CA 2948080A CA 2948080 A1 CA2948080 A1 CA 2948080A1
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CA
Canada
Prior art keywords
methoxy
dihydrobenzo
ethyl
oxo
quinolizine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA2948080A
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English (en)
French (fr)
Inventor
Song Yang
Xingchun Han
Zhanguo Wang
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2948080A1 publication Critical patent/CA2948080A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2948080A 2014-05-13 2015-05-11 Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection Abandoned CA2948080A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2014077354 2014-05-13
CNPCT/CN2014/077354 2014-05-13
CN2015074462 2015-03-18
CNPCT/CN2015/074462 2015-03-18
PCT/EP2015/060284 WO2015173164A1 (en) 2014-05-13 2015-05-11 Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection

Publications (1)

Publication Number Publication Date
CA2948080A1 true CA2948080A1 (en) 2015-11-19

Family

ID=53055057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2948080A Abandoned CA2948080A1 (en) 2014-05-13 2015-05-11 Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection

Country Status (9)

Country Link
US (1) US9920049B2 (sv)
EP (1) EP3143020B1 (sv)
JP (1) JP6568106B2 (sv)
KR (1) KR20160148715A (sv)
CN (1) CN106459032B (sv)
CA (1) CA2948080A1 (sv)
MX (1) MX2016014728A (sv)
RU (1) RU2016146365A (sv)
WO (1) WO2015173164A1 (sv)

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