CA2931641C - Fabs d'immunoglobuline en tandem et leurs utilisations - Google Patents

Fabs d'immunoglobuline en tandem et leurs utilisations Download PDF

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Publication number
CA2931641C
CA2931641C CA2931641A CA2931641A CA2931641C CA 2931641 C CA2931641 C CA 2931641C CA 2931641 A CA2931641 A CA 2931641A CA 2931641 A CA2931641 A CA 2931641A CA 2931641 C CA2931641 C CA 2931641C
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binding protein
binding
disease
seq
cell
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CA2931641A1 (fr
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Chengbin Wu
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Epimab Biotherapeutics Inc
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Epimab Biotherapeutics Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K—PEPTIDES
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C07K2319/00—Fusion polypeptide

Abstract

La présente invention concerne des protéines de liaison multivalente et multispécifique capables de liaison à deux antigènes ou plus, ou deux épitopes ou plus. La présente invention concerne également des procédés de fabrication et d'utilisation de telles protéines de liaison multivalente et multispécifique, comprenant des procédés d'utilisation de telles protéines de liaison pour la prévention et le traitement de diverses maladies, ou pour la détection d'antigènes spécifiques in vitro ou in vivo.
CA2931641A 2013-12-30 2014-12-24 Fabs d'immunoglobuline en tandem et leurs utilisations Active CA2931641C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2013/090923 2013-12-30
CN2013090923 2013-12-30
PCT/US2014/072336 WO2015103072A1 (fr) 2013-12-30 2014-12-24 Fabs d'immunoglobuline en tandem et leurs utilisations

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CA2931641A1 CA2931641A1 (fr) 2015-07-09
CA2931641C true CA2931641C (fr) 2022-05-10

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CA2931641A Active CA2931641C (fr) 2013-12-30 2014-12-24 Fabs d'immunoglobuline en tandem et leurs utilisations

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US (4) US10519251B2 (fr)
EP (2) EP3089994B1 (fr)
JP (2) JP6706578B2 (fr)
KR (1) KR102056963B1 (fr)
CN (1) CN106459182B (fr)
AR (1) AR098979A1 (fr)
AU (1) AU2014374055B2 (fr)
BR (1) BR112016015140A2 (fr)
CA (1) CA2931641C (fr)
CU (1) CU20160101A7 (fr)
DK (1) DK3089994T3 (fr)
ES (1) ES2923641T3 (fr)
IL (1) IL246287B (fr)
MX (1) MX2016008667A (fr)
NZ (1) NZ720353A (fr)
RU (2) RU2016129959A (fr)
TW (1) TWI672316B (fr)
WO (1) WO2015103072A1 (fr)

Families Citing this family (209)

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US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
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