CA2895172C - Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process - Google Patents
Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process Download PDFInfo
- Publication number
- CA2895172C CA2895172C CA2895172A CA2895172A CA2895172C CA 2895172 C CA2895172 C CA 2895172C CA 2895172 A CA2895172 A CA 2895172A CA 2895172 A CA2895172 A CA 2895172A CA 2895172 C CA2895172 C CA 2895172C
- Authority
- CA
- Canada
- Prior art keywords
- chloro
- dihydroxypropoxy
- 5uppdwo3
- tolyl
- propylimino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/77—Preparation of chelates of aldehydes or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12180920 | 2012-08-17 | ||
| EP12180920.6 | 2012-08-17 | ||
| PCT/IB2013/056662 WO2014027330A1 (en) | 2012-08-17 | 2013-08-15 | Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2895172A1 CA2895172A1 (en) | 2014-02-20 |
| CA2895172C true CA2895172C (en) | 2020-08-18 |
Family
ID=46940231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2895172A Active CA2895172C (en) | 2012-08-17 | 2013-08-15 | Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9340518B2 (ja) |
| EP (1) | EP2885266B1 (ja) |
| JP (2) | JP6322630B2 (ja) |
| KR (1) | KR101731739B1 (ja) |
| CN (1) | CN104540800B (ja) |
| CA (1) | CA2895172C (ja) |
| CY (1) | CY1123300T1 (ja) |
| DK (1) | DK2885266T3 (ja) |
| ES (1) | ES2795105T3 (ja) |
| HR (1) | HRP20200883T1 (ja) |
| HU (1) | HUE050733T2 (ja) |
| IL (1) | IL237198A (ja) |
| LT (1) | LT2885266T (ja) |
| MX (1) | MX350891B (ja) |
| PL (1) | PL2885266T3 (ja) |
| PT (1) | PT2885266T (ja) |
| RS (1) | RS60408B1 (ja) |
| SI (1) | SI2885266T1 (ja) |
| TW (1) | TWI606036B (ja) |
| WO (1) | WO2014027330A1 (ja) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2519660C2 (ru) | 2008-03-17 | 2014-06-20 | Актелион Фармасьютиклз Лтд | Режим дозировки селективного агониста рецептора s1p1 |
| MX350891B (es) * | 2012-08-17 | 2017-09-22 | Actelion Pharmaceuticals Ltd | Proceso para la preparacion de (2z,5z)-5-(3-cloro-4-((r)-2,3-dihid roxipropoxi) bencilideno)-2-(propilimino)-3-(o-tolil) tiazolidin-4-ona y el intermediario usado en dicho proceso. |
| MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
| MX2020011182A (es) | 2014-12-11 | 2022-10-03 | Actelion Pharmaceuticals Ltd | Regimen de dosificacion para un agonista selectivo de receptor s1p1. |
| MX2018007887A (es) * | 2015-12-25 | 2019-02-20 | Crystal Pharmatech Co Ltd | Formas cristalinas de modulador selectivo del receptor s1p1 y método de preparación del mismo. |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| US11220488B2 (en) | 2017-09-19 | 2022-01-11 | Teva Pharmaceuticals International Gmbh | Crystalline polymorph of Ponesimod |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| KR102365655B1 (ko) | 2018-11-29 | 2022-02-22 | 원광대학교 산학협력단 | 콩 발효 추출물을 유효성분으로 포함하는 피부 주름 예방 또는 개선용 조성물 |
| EP4051250A1 (en) | 2019-10-31 | 2022-09-07 | Idorsia Pharmaceuticals Ltd | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
| WO2023022896A1 (en) | 2021-08-17 | 2023-02-23 | Teva Czech Industries S.R.O | Polymorphs of ponesimod |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023152691A1 (en) * | 2022-02-10 | 2023-08-17 | Metrochem Api Pvt Ltd | Process for the preparation of ponesimod and its intermediates thereof |
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| US3077402A (en) | 1954-12-06 | 1963-02-12 | Polaroid Corp | Photographic color processes, products, and compositions |
| NL270002A (ja) | 1960-10-08 | |||
| GB1001479A (en) | 1962-10-10 | 1965-08-18 | Angeli Inst Spa | Glycerol ethers |
| OA03835A (fr) | 1970-07-17 | 1971-12-24 | Rhone Poulenc Sa | Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent. |
| PL166269B1 (pl) | 1990-04-27 | 1995-04-28 | Orion Yh Tyma Oy | Sposób wytwarzania nowych farmakologicznie aktywnych pochodnych katecholul PL PL PL PL PL |
| TW221689B (ja) | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd | |
| EP0638075B1 (en) | 1993-02-26 | 2002-01-16 | Otsuka Pharmaceutical Co., Ltd. | Thiazole or imidazole derivatives as maillard reaction inhibitors |
| KR960022486A (ko) | 1994-12-29 | 1996-07-18 | 김준웅 | 신규 티아졸리딘-4-온 유도체 |
| WO2001036402A1 (fr) | 1998-07-14 | 2001-05-25 | Fujimoto Brothers Co., Ltd. | Nouveaux derives de 2-(n-cyano-imino)thiazolidin-4-one |
| US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
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| US20050019825A9 (en) | 2002-03-15 | 2005-01-27 | Qing Dong | Common ligand mimics: pseudothiohydantoins |
| BR0312650A (pt) | 2002-07-10 | 2005-05-03 | Applied Research Systems | Derivados de benzeno fundido azolidinona-vinila |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| AU2003261434A1 (en) | 2002-08-12 | 2004-02-25 | Bristol-Myers Squibb Company | Iminothiazolidinones as inhibitors of hcv replication |
| AP1967A (en) | 2002-11-22 | 2009-03-10 | Smithkline Beecham Corp | Thiazolidinone compounds as inhibitors of Hyak3 |
| US20040167192A1 (en) | 2003-01-16 | 2004-08-26 | David Solow-Cordero | Methods of treating conditions associated with an Edg-7 receptor |
| EP1667791A1 (en) | 2003-10-06 | 2006-06-14 | Solvias AG | Process for the parallel detection of crystalline forms of molecular solids |
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| SI1689726T1 (sl) * | 2003-11-21 | 2011-01-31 | Actelion Pharmaceuticals Ltd | Derivati 5-(benz-(z)-iliden)-tiazolidin-4-ona kot imunosupresivna sredstva |
| US20070249599A1 (en) | 2004-02-25 | 2007-10-25 | Duffy Kevin J | Novel Chemical Compounds |
| WO2005123677A1 (en) | 2004-06-16 | 2005-12-29 | Actelion Pharmaceuticals Ltd | 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents |
| WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| RU2478384C2 (ru) | 2004-11-29 | 2013-04-10 | Новартис Аг | Курс лечения с использованием агониста рецептора s1p |
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| US7879821B2 (en) | 2006-01-26 | 2011-02-01 | University Of Medicine And Dentistry Of New Jersey | Method for modulating inflammatory responses by altering plasma lipid levels |
| JP5253401B2 (ja) | 2006-09-07 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節薬としてのピリジン−４−イル誘導体 |
| TWI408139B (zh) | 2006-09-07 | 2013-09-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
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| WO2008035239A1 (en) | 2006-09-21 | 2008-03-27 | Actelion Pharmaceuticals Ltd | Phenyl derivatives and their use as immunomodulators |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| TWI460166B (zh) * | 2006-11-23 | 2014-11-11 | Actelion Pharmaceuticals Ltd | 製備２-亞胺基-四氫噻唑-４-酮衍生物之新穎方法 |
| KR101454944B1 (ko) | 2007-03-16 | 2014-10-27 | 액테리온 파마슈티칼 리미티드 | Ｓ1ｐ1/ｅｄｇ 수용체 작동약으로서 아미노-피리딘 유도체 |
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| RU2519660C2 (ru) | 2008-03-17 | 2014-06-20 | Актелион Фармасьютиклз Лтд | Режим дозировки селективного агониста рецептора s1p1 |
| GB0819182D0 (en) | 2008-10-20 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Crystalline forms |
| US20100160369A1 (en) * | 2008-12-04 | 2010-06-24 | Exelixis, Inc. | S1P1 Agonists and Methods of Making And Using |
| ES2810823T3 (es) | 2008-12-22 | 2021-03-09 | Novartis Ag | Régimen de dosificación para un agonista del receptor S1P |
| KR101660555B1 (ko) | 2008-12-22 | 2016-09-27 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 요법 |
| MX350891B (es) * | 2012-08-17 | 2017-09-22 | Actelion Pharmaceuticals Ltd | Proceso para la preparacion de (2z,5z)-5-(3-cloro-4-((r)-2,3-dihid roxipropoxi) bencilideno)-2-(propilimino)-3-(o-tolil) tiazolidin-4-ona y el intermediario usado en dicho proceso. |
-
2013
- 2013-08-15 MX MX2015002127A patent/MX350891B/es active IP Right Grant
- 2013-08-15 KR KR1020157006474A patent/KR101731739B1/ko active IP Right Grant
- 2013-08-15 WO PCT/IB2013/056662 patent/WO2014027330A1/en active Application Filing
- 2013-08-15 US US14/422,167 patent/US9340518B2/en active Active
- 2013-08-15 JP JP2015527061A patent/JP6322630B2/ja active Active
- 2013-08-15 LT LTEP13779378.2T patent/LT2885266T/lt unknown
- 2013-08-15 CN CN201380042658.2A patent/CN104540800B/zh active Active
- 2013-08-15 DK DK13779378.2T patent/DK2885266T3/da active
- 2013-08-15 SI SI201331742T patent/SI2885266T1/sl unknown
- 2013-08-15 RS RS20200642A patent/RS60408B1/sr unknown
- 2013-08-15 HU HUE13779378A patent/HUE050733T2/hu unknown
- 2013-08-15 EP EP13779378.2A patent/EP2885266B1/en active Active
- 2013-08-15 CA CA2895172A patent/CA2895172C/en active Active
- 2013-08-15 PT PT137793782T patent/PT2885266T/pt unknown
- 2013-08-15 ES ES13779378T patent/ES2795105T3/es active Active
- 2013-08-15 PL PL13779378T patent/PL2885266T3/pl unknown
- 2013-08-16 TW TW102129570A patent/TWI606036B/zh active
-
2015
- 2015-02-12 IL IL237198A patent/IL237198A/en active IP Right Grant
-
2017
- 2017-04-13 JP JP2017079804A patent/JP6424250B2/ja active Active
-
2020
- 2020-06-02 HR HRP20200883TT patent/HRP20200883T1/hr unknown
- 2020-06-11 CY CY20201100532T patent/CY1123300T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104540800A (zh) | 2015-04-22 |
| JP2017160223A (ja) | 2017-09-14 |
| PL2885266T3 (pl) | 2020-11-16 |
| MX2015002127A (es) | 2015-05-11 |
| IL237198A (en) | 2017-12-31 |
| MX350891B (es) | 2017-09-22 |
| HUE050733T2 (hu) | 2021-01-28 |
| EP2885266A1 (en) | 2015-06-24 |
| US20150203459A1 (en) | 2015-07-23 |
| DK2885266T3 (da) | 2020-06-08 |
| RS60408B1 (sr) | 2020-07-31 |
| PT2885266T (pt) | 2020-05-29 |
| US9340518B2 (en) | 2016-05-17 |
| CA2895172A1 (en) | 2014-02-20 |
| TWI606036B (zh) | 2017-11-21 |
| JP6424250B2 (ja) | 2018-11-14 |
| TW201408634A (zh) | 2014-03-01 |
| CN104540800B (zh) | 2017-05-10 |
| KR101731739B1 (ko) | 2017-05-11 |
| HRP20200883T1 (hr) | 2020-09-04 |
| EP2885266B1 (en) | 2020-03-18 |
| IL237198A0 (en) | 2015-04-30 |
| ES2795105T3 (es) | 2020-11-20 |
| CY1123300T1 (el) | 2021-12-31 |
| KR20150042277A (ko) | 2015-04-20 |
| JP2015530373A (ja) | 2015-10-15 |
| SI2885266T1 (sl) | 2020-10-30 |
| JP6322630B2 (ja) | 2018-05-09 |
| WO2014027330A1 (en) | 2014-02-20 |
| LT2885266T (lt) | 2020-07-10 |
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