CA2881666A1 - Microorganisms and methods for the production of fatty acids and fatty acid derived products - Google Patents

Microorganisms and methods for the production of fatty acids and fatty acid derived products Download PDF

Info

Publication number
CA2881666A1
CA2881666A1 CA2881666A CA2881666A CA2881666A1 CA 2881666 A1 CA2881666 A1 CA 2881666A1 CA 2881666 A CA2881666 A CA 2881666A CA 2881666 A CA2881666 A CA 2881666A CA 2881666 A1 CA2881666 A1 CA 2881666A1
Authority
CA
Canada
Prior art keywords
fatty acid
coa
bxf
production
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2881666A
Other languages
English (en)
French (fr)
Inventor
Hans Liao
Eileen SPINDLER
Joseph R. Warner
Michael Louie
Wendy RIBBLE
Brittney PRATHER
Ron Evans
Tanya E. W. Lipscomb
Michael D. Lynch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cargill Inc
Original Assignee
OPX Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OPX Biotechnologies Inc filed Critical OPX Biotechnologies Inc
Publication of CA2881666A1 publication Critical patent/CA2881666A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/001Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/011573-Hydroxybutyryl-CoA dehydrogenase (1.1.1.157)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y103/00Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01009Enoyl-[acyl-carrier-protein] reductase (NADH) (1.3.1.9)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01194Acetoacetyl-CoA synthase (2.3.1.194)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185Escherichia
    • C12R2001/19Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2881666A 2012-08-10 2013-08-09 Microorganisms and methods for the production of fatty acids and fatty acid derived products Abandoned CA2881666A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682138P 2012-08-10 2012-08-10
US201261682127P 2012-08-10 2012-08-10
US61/682,138 2012-08-10
US61/682,127 2012-08-10
PCT/US2013/054422 WO2014026162A1 (en) 2012-08-10 2013-08-09 Microorganisms and methods for the production of fatty acids and fatty acid derived products

Publications (1)

Publication Number Publication Date
CA2881666A1 true CA2881666A1 (en) 2014-02-13

Family

ID=50068615

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2881666A Abandoned CA2881666A1 (en) 2012-08-10 2013-08-09 Microorganisms and methods for the production of fatty acids and fatty acid derived products

Country Status (12)

Country Link
US (2) US20140051136A1 (cg-RX-API-DMAC10.html)
EP (1) EP2882843A4 (cg-RX-API-DMAC10.html)
JP (1) JP2015524283A (cg-RX-API-DMAC10.html)
KR (1) KR20150040359A (cg-RX-API-DMAC10.html)
CN (2) CN109182238A (cg-RX-API-DMAC10.html)
AU (1) AU2013299414A1 (cg-RX-API-DMAC10.html)
BR (1) BR112015002940A2 (cg-RX-API-DMAC10.html)
CA (1) CA2881666A1 (cg-RX-API-DMAC10.html)
IN (1) IN2015DN01858A (cg-RX-API-DMAC10.html)
MX (1) MX2015001780A (cg-RX-API-DMAC10.html)
SG (1) SG11201501013PA (cg-RX-API-DMAC10.html)
WO (1) WO2014026162A1 (cg-RX-API-DMAC10.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
EP2843043A1 (en) 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids
WO2015077752A1 (en) * 2013-11-25 2015-05-28 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
WO2015173247A1 (en) * 2014-05-12 2015-11-19 Metabolic Explorer New microorganism and method for the production of 1.2-propanediol based on nadph dependent acetol reductase and improved nadph supply
EP2944697A1 (en) 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
EP2946764A1 (en) 2014-05-23 2015-11-25 Evonik Degussa GmbH Biosynthetic production of acyl amino acids
EP2975131A1 (en) 2014-07-17 2016-01-20 Evonik Degussa GmbH Synthesis of alkanes
KR20240023194A (ko) 2014-07-18 2024-02-20 게노마티카 인코포레이티드 지방 디올의 미생물 생산
EP2993228B1 (en) * 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3081639A1 (en) 2015-04-14 2016-10-19 Evonik Degussa GmbH Acyl amino acid production
EP3091080A1 (en) 2015-05-05 2016-11-09 Evonik Degussa GmbH Process for producing acyl amino acids employing lipases
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN108473967B (zh) 2015-12-17 2022-03-29 赢创运营有限公司 基因修饰的产乙酸细胞
MY187786A (en) 2016-07-27 2021-10-22 Evonik Operations Gmbh N-acetyl homoserine
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
WO2018157150A1 (en) * 2017-02-27 2018-08-30 Duke University In vivo protein n-acylation

Family Cites Families (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2406889A (en) 1942-12-14 1946-09-03 Manning Maxwell & Moore Inc Power unit for traveling cranes
US2469701A (en) 1946-02-13 1949-05-10 American Cyanamid Co Preparation of acrylic acid
US2464768A (en) 1946-02-13 1949-03-15 American Cyanamid Co Preparation of esters of acrylic acid
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US3687885A (en) 1970-04-15 1972-08-29 Du Pont Water base paints having an improved balance of anti-drip and leveling qualities
GB1349586A (en) 1970-12-11 1974-04-03 Polysar Ltd Latex composition and process for producing the same
US3872037A (en) 1970-12-11 1975-03-18 Polysar Ltd Improved carboxylic latex for paper coating utilizing butadiene-styrene-acrylic acid-acrolein tetrapolymers
US3904685A (en) 1973-07-20 1975-09-09 Celanese Corp Polyacrylic acid having high chelation value and its production
US3891591A (en) 1973-08-13 1975-06-24 Du Pont Coating compositions
US3915921A (en) 1974-07-02 1975-10-28 Goodrich Co B F Unsaturated carboxylic acid-long chain alkyl ester copolymers and tri-polymers water thickening agents and emulsifiers
US4029577A (en) 1975-11-17 1977-06-14 Betz Laboratories, Inc. Polymers for use in water treatment
DE2757329C2 (de) 1977-12-22 1980-02-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Polymerisaten der Acrylsäure oder Methacrylsäure
US4268641A (en) 1979-04-24 1981-05-19 Union Carbide Corporation Acrylic acid-acrylate copolymer thickening agents
US4431547A (en) 1981-08-24 1984-02-14 Nalco Chemical Company Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca3 (PO4)2
US4985518A (en) 1981-10-26 1991-01-15 American Colloid Company Process for preparing water-absorbing resins
JPS58180233A (ja) 1982-04-19 1983-10-21 Nippon Shokubai Kagaku Kogyo Co Ltd 吸収剤
US4685915A (en) 1984-04-06 1987-08-11 The Procter & Gamble Company Disposable diaper having density and basis weight profiled absorbent core
US4734478A (en) 1984-07-02 1988-03-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Water absorbing agent
US4708997A (en) 1985-07-22 1987-11-24 The Dow Chemical Company Suspending agent for the suspension polymerization of water-soluble monomers
DE3544770A1 (de) 1985-12-18 1987-06-19 Stockhausen Chem Fab Gmbh Verfahren und vorrichtung zum kontinuierlichen herstellen von polymerisaten und copolymerisaten der acrylsaeure und/oder methacrylsaeure
US5009653A (en) 1988-03-31 1991-04-23 The Procter & Gamble Company Thin, flexible sanitary napkin
US4952505A (en) 1988-08-08 1990-08-28 Florida State University Fermentation of trichoderma reesei and apparatus therefor
US5487989A (en) 1988-08-31 1996-01-30 Bioenergy International, L.C. Ethanol production by recombinant hosts
IT1229506B (it) 1989-01-26 1991-09-03 Sigma Prodotti Chimici Srl Polimero dell'acido acrilico esente da solventi residui e procedimento per la sua preparazione.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5145906A (en) 1989-09-28 1992-09-08 Hoechst Celanese Corporation Super-absorbent polymer having improved absorbency properties
JP2938920B2 (ja) 1990-01-31 1999-08-25 住友精化株式会社 吸水性樹脂の製造方法
US5350799A (en) 1990-05-31 1994-09-27 Hoechst Celanese Corporation Process for the conversion of fine superabsorbent polymer particles into larger particles
US5342899A (en) 1991-05-16 1994-08-30 The Dow Chemical Company Process for recycling aqueous fluid absorbents fines to a polymerizer
US5135617A (en) 1991-07-01 1992-08-04 Phillips Petroleum Company Separation of aromatic from olefinic hydrocarbons by extractive distillation
DE4138408A1 (de) 1991-11-22 1993-05-27 Cassella Ag Hydrophile, hochquellfaehige hydrogele
CA2083346A1 (en) 1991-12-13 1993-06-14 Eric G. Lundquist A catalyzed esterification process
US5142023A (en) 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5827255A (en) 1992-07-27 1998-10-27 The Procter & Gamble Company Sanitary napkin comprising an absorbent core having a density gradient
US5405913A (en) 1993-03-22 1995-04-11 The University Of Akron Free radical copper(II)-enolate polymerization initiators
US5510307A (en) 1993-04-08 1996-04-23 Isp Investments Inc. Free radical initiator delivery system
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
PL181380B1 (pl) 1993-08-24 2001-07-31 Ajinomoto Kk zmutowana karboksylaze, zrekombinowany DNA, mikroorganizm zawierajacy DNA kodujacy zmutowana karboksylaze, sposób wytwarzania aminokwasu, sposób selekcji E. coli, oraz sposób wytwarzania zmutowanej karboksylazy PL PL PL PL PL PL
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5558656A (en) 1993-12-20 1996-09-24 The Procter & Gamble Company Sanitary napkin having an internal shaping component
ES2336977T3 (es) 1995-05-18 2010-04-19 University Of Stellenbosch Secuencia de acido nucleico para una malato permeasa de s.pompe y sus usos.
US5723639A (en) 1995-10-16 1998-03-03 University Of Chicago Esterification of fermentation-derived acids via pervaporation
DE19629372A1 (de) 1996-07-20 1998-01-22 Degussa Verfahren zur Herstellung von Malonsäure oder einem Salz derselben
IL129722A0 (en) 1996-11-13 2000-02-29 Du Pont Method for the production of 1,3-propanediol by recombinant organisms
SK285201B6 (sk) 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
EP0977865A1 (en) 1997-02-13 2000-02-09 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6087140A (en) 1997-02-19 2000-07-11 Wisconsin Alumni Research Foundation Microbial production of 1,2-propanediol from sugar
US6143538A (en) 1997-02-20 2000-11-07 The United States Of America As Represented By The United States Department Of Energy Fatty acyl-CoA reductase
US7125938B2 (en) 1997-03-11 2006-10-24 Carnegie Mellon University Atom or group transfer radical polymerization
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
BE1011197A3 (fr) 1997-06-06 1999-06-01 Brussels Biotech En Abrege Bb Procede de purification d'acide lactique.
WO1999014343A1 (en) 1997-09-19 1999-03-25 Ortho-Mcneil Pharmaceutical, Inc. Dna encoding a ras carboxyl-terminal processing protein
US6306636B1 (en) 1997-09-19 2001-10-23 Arch Development Corporation Nucleic acid segments encoding wheat acetyl-CoA carboxylase
US6229046B1 (en) 1997-10-14 2001-05-08 Cargill, Incorported Lactic acid processing methods arrangements and products
EP1291420B1 (en) 1997-12-05 2009-11-25 Europäisches Laboratorium Für Molekularbiologie (Embl) Novel DNA cloning method relying on the E.coli RECE/RECT recombination system
KR100250830B1 (ko) 1997-12-09 2000-04-01 성재갑 자가분해에 의해 폴리하이드록시알킨산으로부터 광학활성을 가진 단량체 하이드록시카르복실산의 제조방법
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
JP4913929B2 (ja) 1998-06-12 2012-04-11 味の素株式会社 核酸系物質の製造法
ES2302386T3 (es) 1998-08-04 2008-07-01 Metabolix, Inc. Produccion de polihidroxialcanoatos a partir de polioles.
DE69930276T2 (de) 1998-08-18 2006-10-05 Metabolix, Inc., Cambridge Transgene polyhydroxyalkanoat produzierende mikroben
WO2000014241A1 (fr) 1998-09-04 2000-03-16 Kyowa Hakko Kogyo Co., Ltd. Nouveau gene
ES2224450T3 (es) 1998-10-30 2005-03-01 Catalytic Distillation Technologies Produccion de amidas y/o acidos a partir de nitrilos.
US6297319B1 (en) 1998-11-05 2001-10-02 Nippon Shokubai Co., Ltd. Water-absorbing agent and production process therefor
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
AU2392200A (en) 1998-12-31 2000-07-31 Millennium Pharmaceuticals, Inc. A. fumigatus acetyl coenzyme-a carboxylase genes and polypeptides and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
ATE276994T1 (de) 1999-03-22 2004-10-15 Purac Biochem Bv Verfahren zur reinigung von milchsäure auf industrieller basis
KR20010111577A (ko) 1999-03-23 2001-12-19 보드 오브 트러스티즈 오퍼래이팅 미시건 스태이트 유니버시티 미오-이노시톨-1-포스페이트 신타아제 및미오-이노시톨-2-디히드로게나아제를 사용한1,2,3-트리히드록시벤젠 및 1,2,3,4-테트라히드록시벤젠의합성
AU4211600A (en) 1999-04-10 2000-11-14 Maxygen, Inc. Modified lipid production
US6355412B1 (en) 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
DE60030403D1 (de) 1999-08-30 2006-10-12 Wisconsin Alumni Res Found Herstellung von 3-hydroxypropionsäure in rekombinanten organismen
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US20020102672A1 (en) 1999-10-04 2002-08-01 Joseph Mizrahi Process for producing a purified lactic acid solution
ATE319848T1 (de) 1999-10-25 2006-03-15 Kosan Biosciences Inc Herstellung von polyketiden
US6531291B1 (en) 1999-11-10 2003-03-11 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof
AU1661901A (en) 1999-11-24 2001-06-04 Cargill Dow Llc Improved lactic acid processing; methods; arrangements; and, products
NL1013682C2 (nl) 1999-11-26 2001-05-30 Purac Biochem Bv Werkwijze en inrichting voor het zuiveren van een waterige oplossing van melkzuur.
US6613553B1 (en) 2000-02-04 2003-09-02 St. Jude Children's Research Hospital Enoyl reductases and methods of use thereof
RU2212447C2 (ru) 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US6586229B1 (en) 2000-06-01 2003-07-01 North Carolina State University Method for the production of ρ-Hydroxybenzoate in species of pseudomonas and agrobacterium
US20020164729A1 (en) 2000-07-21 2002-11-07 Skraly Frank A. Production of polyhydroxyalkanoates from polyols
CA2322105A1 (en) 2000-10-23 2002-04-23 Plant Bioscience Limited Antibiotic production (ii)
AU1981802A (en) 2000-11-20 2002-06-03 Cargill Inc 3-hydroxypropionic acid and other organic compounds
US6623944B2 (en) 2001-03-14 2003-09-23 Degussa Ag Process for preparation of D-pantothenic acid and/or salts thereof
ATE393137T1 (de) 2001-05-07 2008-05-15 Cargill Inc Verfahren zur herstellung von carbonsäuren und deren derivaten
MY146503A (en) 2001-08-13 2012-08-15 Malaysian Palm Oil Board Method and compositions for the production of transgenic plants
US6723799B2 (en) 2001-08-24 2004-04-20 E I. Du Pont De Nemours And Company Acid-dyeable polymer compositions
WO2003035873A1 (en) 2001-10-23 2003-05-01 Ajinomoto Co, Inc Novel glutamic acid receptor and utilization thereof
US7256016B2 (en) 2001-11-02 2007-08-14 Rice University Recycling system for manipulation of intracellular NADH availability
US7230144B2 (en) 2001-12-18 2007-06-12 Metabolix Inc. Methods of making intermediates from polyhydroxyalkanoates
JP4532116B2 (ja) 2002-01-18 2010-08-25 ノボザイムズ エー/エス アラニン2,3−アミノムターゼ
US6709919B2 (en) 2002-05-15 2004-03-23 Taiwan Semiconductor Manufacturing Company Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
WO2003074676A2 (en) 2002-03-01 2003-09-12 Monsanto Technology Llc Wax ester synthase dna sequence, protein and uses thereof
CN100577626C (zh) 2002-03-25 2010-01-06 嘉吉有限公司 制造α,β-不饱和羧酸或其衍生物的方法
EP1654373B1 (en) 2002-05-10 2012-08-15 Metabolix, Inc. Bioabsorbable polymer containing 2-hydroxyacid monomers
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
AU2003256480B2 (en) 2002-07-10 2008-03-06 The Penn State Research Foundation Method for determining gene knockout strategies
AU2003205041A1 (en) 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
GB0218019D0 (en) 2002-08-05 2002-09-11 Ciba Spec Chem Water Treat Ltd Production of a fermentation product
BR0314498A (pt) 2002-10-04 2005-08-16 Du Pont Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol
CN100381411C (zh) 2002-11-01 2008-04-16 嘉吉有限公司 制备1,3-丙二醇的方法
US20040152159A1 (en) 2002-11-06 2004-08-05 Causey Thomas B. Materials and methods for the efficient production of acetate and other products
AU2003289229A1 (en) 2002-12-06 2004-06-30 Kaneka Corporation Process for producing optically active 3-hydroxypropionic ester derivative
EP1597364B1 (fr) 2003-02-18 2013-07-24 Metabolic Explorer Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques
US7141154B2 (en) 2003-03-06 2006-11-28 Uchicago Argonne Llc Single-stage separation and esterification of cation salt carboxylates using electrodeionization
AU2004225838B2 (en) 2003-03-31 2009-11-05 University Of Bristol Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids
DE10314618A1 (de) 2003-04-01 2004-10-14 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
US20040225116A1 (en) 2003-05-08 2004-11-11 Payne Mark S. Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
ATE437850T1 (de) 2003-06-26 2009-08-15 Novozymes As Verfahren zur trennung und rückgewinnung von 3- hydroxypropionsäure und acrylsäure
AU2004277608A1 (en) 2003-09-29 2005-04-14 The Regents Of The University Of California Methods for identifying a biosynthetic pathway gene product
FR2862068B1 (fr) 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
US7326557B2 (en) 2003-11-14 2008-02-05 Rice University Increasing intracellular NADPH availability in E. coli
ATE543873T1 (de) 2003-12-04 2012-02-15 Novozymes As Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase
US7186214B2 (en) 2004-02-12 2007-03-06 Medtronic, Inc. Instruments and methods for accessing an anatomic space
WO2005093060A1 (ja) 2004-03-26 2005-10-06 Nippon Shokubai Co., Ltd. 1,3−プロパンジオール及び/又は3−ヒドロキシプロピオン酸を製造する方法
EP1732874A1 (en) 2004-04-02 2006-12-20 Ciba Speciality Chemicals Water Treatments Limited Preparation of acrylic acid derivatives from alpha or beta-hydroxy carboxylic acids
AU2005238534A1 (en) 2004-04-28 2005-11-10 Biogen Idec Ma Inc. Arylphenylamino-, arylphenylamide-, and arylphenylether-sulfide derivatives
US20050272135A1 (en) 2004-06-02 2005-12-08 The University Of Chicago Processs for production and purification of fermentation derived organic acids
US7652167B2 (en) 2004-07-19 2010-01-26 Board Of Trustees Of Michigan State University Process for production of organic acid esters
CA2574777C (en) 2004-07-23 2015-09-01 Acceleron Pharma Inc. Actrii receptor polypeptides, methods and compositions
AU2004322803A1 (en) 2004-07-30 2006-03-02 Cargill, Incorporated Alanine 2, 3 aminomutases
US7148051B2 (en) 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
KR20070065870A (ko) 2004-09-17 2007-06-25 라이스 유니버시티 다량의 숙신산염을 생산하는 세균
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
EP1799828B1 (en) 2004-10-12 2013-05-01 Board of Trustees of Michigan State University Biosynthesis of phloroglucinol and preparation of 1,3-dihydroxybenzene therefrom
JP5323356B2 (ja) 2004-10-14 2013-10-23 カーネギー インスチチューション オブ ワシントン 高感度fretセンサーの開発およびその使用方法
US7273746B2 (en) 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DE102004062294A1 (de) 2004-12-23 2006-07-06 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
TWI529181B (zh) 2005-02-28 2016-04-11 贏創德固賽有限責任公司 以可更新原料為基之吸水聚合物結構及其生產的方法
GB2439039B (en) 2005-03-30 2009-12-23 Ca Nat Research Council Use of a sterol acyltransferase gene to alter sterol ester biosynthesis
JP5804666B2 (ja) 2005-04-12 2015-11-04 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company バイオマスの処理および利用における別の供給流れの集中
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
WO2006125000A2 (en) 2005-05-19 2006-11-23 E.I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
BRPI0613662A2 (pt) 2005-07-18 2017-05-09 Basf Ag microorganismo recombinante, e, método para produzir metionina
US20090132178A1 (en) 2005-08-03 2009-05-21 Dharamsi Akil I Crystalline enoyl-(acyl-carrier-protein) Reductase from Heliobacter Pylori
EP1752532A1 (en) * 2005-08-09 2007-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
US7846688B2 (en) 2005-08-15 2010-12-07 The Regents Of The University Of Colorado Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
WO2007030830A2 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
WO2007047680A2 (en) 2005-10-14 2007-04-26 Cargill, Incorporated Increasing the activity of radical s-adenosyl methionine (sam) enzymes
US7851188B2 (en) 2005-10-26 2010-12-14 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
JP5064761B2 (ja) 2005-12-21 2012-10-31 富士フイルム株式会社 ジエチレントリアミン型金属キレート構造を有する高級脂肪酸トリエステル及びアミド誘導体
US8535916B2 (en) 2006-02-13 2013-09-17 Ls9, Inc. Modified microorganisms and uses therefor
US20070219390A1 (en) 2006-03-15 2007-09-20 Battelle Memorial Institute Method and apparatus for conversion of beta-hydroxy carbonyl compounds
JP2009529891A (ja) 2006-03-15 2009-08-27 マーテック バイオサイエンシーズ コーポレーション 多価不飽和脂肪酸を含む植物種子油
US7687661B2 (en) 2006-03-15 2010-03-30 Battelle Memorial Institute Method for conversion of β-hydroxy carbonyl compounds
CN101473038B (zh) 2006-03-15 2014-05-28 Dsmip资产公司 含有多不饱和脂肪酸的植物种子油
US7842485B2 (en) 2006-03-15 2010-11-30 The Regents Of The University Of Colorado Enhanced alcohol tolerant microorganism and methods of use thereof
KR20070096348A (ko) 2006-03-23 2007-10-02 주식회사 엘지화학 1,4―butanediol〔1,4―BDO〕생성능을가지는 변이체 및 이를 이용한 1,4―BDO의 제조방법
CN101490241A (zh) * 2006-05-19 2009-07-22 Ls9公司 脂肪酸及其衍生物的制备
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
CA2650773C (en) 2006-05-19 2014-12-02 Jay D. Keasling Microorganisms transformed with acetyl-coa carboxylase and wax synthase for production of fatty acid derivatives
KR20120053088A (ko) 2006-05-26 2012-05-24 아미리스 인코퍼레이티드 이소프레노이드의 생산 방법
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US20080103060A1 (en) 2006-08-08 2008-05-01 Regents Of The University Of Colorado Compositions and methods for chemical reporter vectors
DE102006039203B4 (de) 2006-08-22 2014-06-18 Evonik Degussa Gmbh Verfahren zur Herstellung von durch Kristallisation gereinigter Acrylsäure aus Hydroxypropionsäure sowie Vorrichtung dazu
WO2008028002A1 (en) 2006-08-29 2008-03-06 Rice University Increasing nadph-dependent products
EP2064321B1 (en) 2006-08-30 2016-03-09 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
WO2008036654A2 (en) 2006-09-18 2008-03-27 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Algal medium chain length fatty acids and hydrocarbons
BRPI0719792A2 (pt) 2006-10-04 2015-04-07 Cargill Inc Ácidos carboxílicos preparados usando um processo de divisão da molécula de sal
EP2087096A4 (en) 2006-10-20 2009-11-25 Univ Arizona MODIFIED CYANOBACTERIA
WO2008072920A1 (en) 2006-12-15 2008-06-19 Biofuelchem Co., Ltd. Method for preparing butanol through butyryl-coa as an intermediate using bacteria
WO2008089102A2 (en) 2007-01-12 2008-07-24 Regents Of The University Of Colorado Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
AU2008212826A1 (en) 2007-02-09 2008-08-14 Zeachem Inc. Energy efficient methods to produce products
WO2008113041A2 (en) 2007-03-14 2008-09-18 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
CA2679987A1 (en) 2007-03-23 2008-10-02 Metabolic Explorer Metabolically engineered microorganism useful for the production of 1,2-propanediol
EP2149608A4 (en) 2007-04-16 2013-02-20 Ajinomoto Kk PROCESS FOR PREPARING AN ORGANIC ACID
EP2160460B1 (en) * 2007-05-22 2017-08-02 REG Life Sciences, LLC Hydrocarbon-producing genes and methods of their use
EP2152659B1 (de) 2007-06-01 2013-04-24 Evonik Röhm GmbH Ein verfahren zur herstellung von methacrylsäure oder methacrylsäureestern
WO2008149951A1 (ja) 2007-06-06 2008-12-11 Kao Corporation 透明固形石鹸
US8198055B2 (en) 2007-06-08 2012-06-12 Coskata, Inc. Process for converting syngas to liquid products with microorganisms on two-layer membrane
WO2009006430A1 (en) * 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing fatty acid derived compounds
JP2010263790A (ja) 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
KR20090026230A (ko) 2007-09-09 2009-03-12 김건 임베디드 시스템의 범용 고속 실시간 모니터링 장치
WO2009036095A1 (en) 2007-09-10 2009-03-19 Joule Biotechnologies, Inc. Engineered light-harvesting organisms
JP2009067775A (ja) 2007-09-17 2009-04-02 Rohm & Haas Co ヒドロキシカルボン酸、またはその塩を、不飽和カルボン酸および/またはそのエステルに変換する方法
US8313934B2 (en) 2007-09-27 2012-11-20 Ls9, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
JP2011516029A (ja) 2007-11-10 2011-05-26 ジュール アンリミテッド インコーポレイテッド 高光合成生物
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
WO2009085278A1 (en) 2007-12-21 2009-07-09 Ls9, Inc. Methods and compositions for producing olefins
US8518678B2 (en) 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
WO2009089457A1 (en) 2008-01-11 2009-07-16 Novozymes A/S Methods for producing 3-hydroxypropionic acid and compounds thereof
JP2011509691A (ja) 2008-01-22 2011-03-31 ジェノマティカ, インコーポレイテッド 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体
WO2009111513A1 (en) 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
CA2717586C (en) 2008-03-05 2020-08-11 Genomatica, Inc. Primary alcohol producing organisms
US8598378B2 (en) 2008-03-14 2013-12-03 University Of Hawaii Methods and compositions for extraction and transesterification of biomass components
WO2009121066A1 (en) 2008-03-28 2009-10-01 The Regents Of The University Of California Producing dicarboxylic acids using polyketide synthases
TWI456949B (zh) 2008-04-30 2014-10-11 Thomson Licensing 閘口裝置及其使用方法
EP3483265B1 (en) 2008-05-16 2021-07-21 Genomatica, Inc. Methods and compositions for producing fatty acids and fatty alcohols
WO2009143401A2 (en) 2008-05-23 2009-11-26 E. I. Du Pont De Nemours And Company Dgat genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in in oilseed plants
EP2283135A1 (en) 2008-06-04 2011-02-16 ButamaxTM Advanced Biofuels LLC Deletion mutants for the production of isobutanol
NZ589632A (en) 2008-06-09 2013-03-28 Lanzatech New Zealand Ltd Production of butanediol by anaerobic microbial fermentation
DE102008002309A1 (de) 2008-06-09 2009-12-10 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102008002715A1 (de) 2008-06-27 2009-12-31 Evonik Röhm Gmbh 2-Hydroxyisobuttersäure produzierende rekombinante Zelle
BRPI0915749A2 (pt) 2008-07-08 2018-07-10 Opx Biotechnologies Inc métodos, composições e sistemas para produção biossintética de 1,4-butanodiol
MX2011000793A (es) 2008-07-23 2011-09-06 Opx Biotechnologies Inc Metodos, sistemas y composiciones para incrementada tolerancia de microorganismos a y produccion de acido 3-hidroxipropionico (3-hp).
US20100021978A1 (en) 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
WO2010017230A2 (en) 2008-08-04 2010-02-11 The Regents Of The University Of Colorado Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol
US20160362710A9 (en) 2008-08-18 2016-12-15 REG Life Sciences, LLC Systems and methods for production of mixed fatty esters
US20130189787A1 (en) 2008-09-15 2013-07-25 Opx Biotechnologies ,Inc. Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxyproplonic Acid (3-HP) To Aldehyde Metabolites
NZ591972A (en) 2008-10-03 2013-04-26 Agrisoma Biosciences Inc Production of modified fatty acids in plants
WO2010042664A2 (en) 2008-10-07 2010-04-15 Ls9, Inc. Method and compositions for producing fatty aldehydes
BRPI0922944A2 (pt) 2008-12-12 2015-08-25 Celexion Llc Célula hospedeira projetada metabolicamente para a produção de um alcano, contendo uma ou mais sequências de ácido nucleico exógeno e método para produzir um alcano
JP5670346B2 (ja) 2008-12-23 2015-02-18 マトリックス ジェネティクス, エルエルシー グリコーゲンが低減した、改変された光合成微生物および炭素ベースの生成物を生成することにおけるその使用
CN102325864B (zh) 2008-12-23 2016-01-27 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
WO2010105095A1 (en) 2009-03-11 2010-09-16 Sapphire Energy, Inc. Engineering salt tolerance in photosynthetic microorganisms
US20120058530A1 (en) 2009-04-02 2012-03-08 University Of Florida Research Foundation Inc. Engineering the pathway for succinate production
CA2758298A1 (en) 2009-04-10 2010-10-14 Ls9, Inc. Production of commercial biodiesel from genetically modified microorganisms
WO2010126891A1 (en) * 2009-04-27 2010-11-04 Ls9, Inc. Production of fatty acid esters
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
US20110144377A1 (en) 2009-06-16 2011-06-16 E. I. Du Pont Nemours And Company Process for the biological production of 3-hydroxypropionic acid with high yield
EP2448955B1 (en) 2009-06-29 2015-09-30 Synthetic Genomics, Inc. Acyl-acp thioesterase genes and uses therefor
WO2011002892A2 (en) 2009-07-01 2011-01-06 Novozymes North America, Inc. Process for separating and recovering 3-hydroxypropionic acid
ES2707747T3 (es) 2009-09-25 2019-04-04 Reg Life Sciences Llc Producción de derivados de ácidos grasos
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CN102762735B (zh) 2009-10-13 2016-08-03 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
EP2491119B1 (en) 2009-10-20 2016-06-08 Bayer CropScience NV Methods and means to alter lipid biosynthesis by targeting multiple enzymes to suborganelle domains
CA2781443A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Methods, systems, and compositions for microbial bio-production of biomolecules using syngas components, or sugars, as feedstocks
CA2781400A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
US8617861B2 (en) 2009-11-23 2013-12-31 Butamax Advanced Biofuels Llc Method for producing butanol using extractive fermentation with electrolyte addition
BR112012013158A2 (pt) 2009-12-02 2016-03-01 Univ Michigan State método de produção de um éster alquílico de um ácido carboxílico e método para o isolamento de succinato de dietila
US20110183382A1 (en) 2009-12-15 2011-07-28 Qteros, Inc. Methods and compositions for producing chemical products from c. phytofermentans
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
EP2529023A4 (en) 2010-01-27 2015-06-10 Opx Biotechnologies Inc MICRO-ORGANISM MANUFACTURE FROM HIGH-FLOW CHEMICAL PRODUCTS AND CORRESPONDING COMPOSITIONS, METHODS AND SYSTEMS
CN101745245B (zh) 2010-02-05 2012-05-23 北京化工大学 一种多级逆流式旋转床反应精馏装置及其应用
US8859259B2 (en) 2010-02-14 2014-10-14 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
WO2012017083A1 (en) * 2010-08-06 2012-02-09 Jens Nielsen Methods and products for production of wax esters
BR112013003003A2 (pt) 2010-08-06 2016-06-14 Mascoma Corp produção de produtos malonil-coa derivados através de rotas anaeróbicas
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
JP2013544500A (ja) 2010-09-28 2013-12-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ポリケチドシンターゼを用いたα−オレフィンの生成
WO2012054400A1 (en) 2010-10-18 2012-04-26 Zeachem, Inc. Recovery of organic acid using a complex extraction solvent
WO2012071392A2 (en) 2010-11-22 2012-05-31 University Of Florida Research Engineering of thermotolerant bacillus coagulans for production of d(-)-lactic acid
CA2818499A1 (en) 2010-11-22 2012-06-07 Novozymes, Inc. Compositions and methods for 3-hydroxypropionic acid production
US20140121118A1 (en) 2010-11-23 2014-05-01 Opx Biotechnologies, Inc. Methods, systems and compositions regarding multiplex construction protein amino-acid substitutions and identification of sequence-activity relationships, to provide gene replacement such as with tagged mutant genes, such as via efficient homologous recombination
CN103492560B (zh) * 2011-02-07 2016-09-28 威廉马什莱斯大学 逆向β氧化途径
EP3385388A1 (en) * 2011-03-22 2018-10-10 OPX Biotechnologies Inc. Microbial production of chemical products and related compositions, methods and systems
KR20120108538A (ko) 2011-03-24 2012-10-05 삼성전자주식회사 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법
CA2869144A1 (en) 2011-03-30 2012-10-04 Ls9, Inc. Compositions comprising and methods for producing beta-hydroxy fatty acid esters
US20120264902A1 (en) 2011-04-18 2012-10-18 The Regents Of The University Of Colorado, A Body Corporate Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP)
WO2012177726A1 (en) 2011-06-22 2012-12-27 Genomatica, Inc. Microorganism for producing primary alcohols and related compounds and methods related thereto
KR101860442B1 (ko) 2011-06-27 2018-05-24 삼성전자주식회사 3-하이드록시프로피온산의 생산을 위한 유전자 조작
CA2840525A1 (en) 2011-06-28 2013-01-03 Brookhaven Science Associates, Llc Modified plants with increased oil content
CA2844064A1 (en) 2011-08-04 2013-02-07 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
AU2012290942B2 (en) * 2011-08-04 2014-09-25 Suntory Holdings Limited Protein exhibiting fatty acid elongation promoting activity, gene encoding same and use thereof
EP2753701B1 (en) 2011-09-27 2018-05-02 ExxonMobil Research and Engineering Company Acyl-acp wax ester synthases
US8790901B2 (en) 2011-12-14 2014-07-29 Pronutria, Inc. Microorganisms and methods for producing unsaturated fatty acids
WO2013126855A1 (en) 2012-02-23 2013-08-29 The Regents Of The University Of California Atp driven direct photosynthetic production of fuels and chemicals
SI3385374T1 (sl) 2012-04-02 2020-09-30 Genomatica, Inc. Encimi CAR in izboljšana proizvodnja maščobnih alkoholov
KR102166271B1 (ko) 2012-04-02 2020-10-16 알이지 라이프 사이언시스, 엘엘씨 지방산 유도체들의 개선된 생산
US20130345470A1 (en) 2012-06-20 2013-12-26 Opx Biotechnologies, Inc. Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide
EP2864282A4 (en) 2012-06-20 2016-01-20 Opx Biotechnologies Inc CLEANING OF 3-HYDROXYPROPIONIC ACID FROM RAW CELLBOUILLON AND DEHYDRATION TO ACRYLIC ACID
CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
KR20230020007A (ko) 2012-09-14 2023-02-09 게노마티카 인코포레이티드 개선된 에스테르 신타아제 특성을 갖는 효소 변이체
EP2946009B1 (en) 2013-01-16 2016-07-27 REG Life Sciences, LLC Acyl-acp reductase with improved properties
WO2014116754A1 (en) 2013-01-23 2014-07-31 Iowa State University Research Foundation, Inc. Materials and methods for characterizing and using kasiii for production of bi-functional fatty acids
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
US9512057B2 (en) 2013-03-15 2016-12-06 Cargill, Incorporated 3-hydroxypropionic acid compositions
US20150044746A1 (en) 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction
EP2970982B1 (en) 2013-03-15 2020-10-28 Cargill, Incorporated Acetyl-coa carboxylase mutations
WO2014198831A1 (en) 2013-06-14 2014-12-18 Technical University Of Denmark Microbial production of 3-hydroxypropionic acid
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters

Also Published As

Publication number Publication date
CN104718282A (zh) 2015-06-17
CN109182238A (zh) 2019-01-11
SG11201501013PA (en) 2015-04-29
AU2013299414A1 (en) 2015-03-26
EP2882843A1 (en) 2015-06-17
KR20150040359A (ko) 2015-04-14
MX2015001780A (es) 2015-09-28
US20160340700A1 (en) 2016-11-24
EP2882843A4 (en) 2016-04-06
BR112015002940A2 (pt) 2018-04-24
WO2014026162A1 (en) 2014-02-13
JP2015524283A (ja) 2015-08-24
IN2015DN01858A (cg-RX-API-DMAC10.html) 2015-05-29
US20140051136A1 (en) 2014-02-20
US10465213B2 (en) 2019-11-05

Similar Documents

Publication Publication Date Title
US10465213B2 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP3022310B1 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2689020B1 (en) Microbial production of chemical products and related compositions, methods and systems
US20150072399A1 (en) Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxypropionic Acid (3-HP) To Aldehyde Metabolites
JP2020103304A (ja) 合成代謝弁を用いた迅速かつ動的なフラックス制御のための組成物及び方法
US20110190513A1 (en) Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
US12129506B2 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
US20180312886A1 (en) Microbial production of chemical products and related compositions, methods and systems
EP2993228A2 (en) Production of fatty acid esters
JP7594536B2 (ja) 逆グリオキシル酸短絡を通じたグリコール酸およびグリシンの生成のための微生物および方法
WO2014165763A1 (en) Microorganisms for the conversion of methane and methanol to higher value chemicals and fuels
US8993281B2 (en) Genetically modified Acinetobacter hosts for lipid production
WO2018203076A1 (en) Modified microorganisms and methods for production of branched c5 carbon compounds
WO2018187389A2 (en) Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180730

FZDE Dead

Effective date: 20201104