BRPI0613662A2 - microorganismo recombinante, e, método para produzir metionina - Google Patents
microorganismo recombinante, e, método para produzir metioninaInfo
- Publication number
- BRPI0613662A2 BRPI0613662A2 BRPI0613662A BRPI0613662A BRPI0613662A2 BR PI0613662 A2 BRPI0613662 A2 BR PI0613662A2 BR PI0613662 A BRPI0613662 A BR PI0613662A BR PI0613662 A BRPI0613662 A BR PI0613662A BR PI0613662 A2 BRPI0613662 A2 BR PI0613662A2
- Authority
- BR
- Brazil
- Prior art keywords
- recombinant microorganism
- producing methionine
- methionine
- producing
- microorganism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70069905P | 2005-07-18 | 2005-07-18 | |
US71404205P | 2005-09-01 | 2005-09-01 | |
PCT/US2006/028439 WO2007012078A1 (en) | 2005-07-18 | 2006-07-18 | Methionine producing recombinant microorganisms |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0613662A2 true BRPI0613662A2 (pt) | 2017-05-09 |
Family
ID=37309368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0613662A BRPI0613662A2 (pt) | 2005-07-18 | 2006-07-18 | microorganismo recombinante, e, método para produzir metionina |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090298136A1 (pt) |
EP (1) | EP1907559A1 (pt) |
JP (1) | JP2009501550A (pt) |
KR (1) | KR20080036608A (pt) |
AU (1) | AU2006269864A1 (pt) |
BR (1) | BRPI0613662A2 (pt) |
CA (1) | CA2615416A1 (pt) |
MX (1) | MX2008000480A (pt) |
RU (1) | RU2447146C2 (pt) |
WO (1) | WO2007012078A1 (pt) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2314710T3 (en) * | 2006-01-04 | 2016-06-13 | Metabolic Explorer Sa | A process for the production of methionine by culturing a microorganism modified to enhance the production of cysteine |
KR100905381B1 (ko) | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | L-메치오닌 전구체 생산 균주 및 상기 l-메치오닌전구체로부터의 l-메치오닌 및 유기산의 생산방법 |
EP2082045B1 (en) | 2006-10-24 | 2015-03-18 | Basf Se | Method of reducing gene expression using modified codon usage |
CN101849016A (zh) * | 2007-02-19 | 2010-09-29 | 羸创德固赛有限责任公司 | 具有甲酰基-thf-合成酶和/或甘氨酸切割活性的棒状杆菌 |
WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
US7851180B2 (en) * | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
US9005952B2 (en) | 2008-04-04 | 2015-04-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
US8163532B2 (en) | 2008-05-28 | 2012-04-24 | Evonik Degussa Gmbh | Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase |
WO2010011874A2 (en) * | 2008-07-23 | 2010-01-28 | Opx Biotechnologies, Inc | Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp) |
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
DE102009030342A1 (de) | 2009-06-25 | 2010-12-30 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen |
US8283152B2 (en) * | 2009-08-28 | 2012-10-09 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
AU2010298004B2 (en) | 2009-09-27 | 2016-02-25 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
RU2009136544A (ru) * | 2009-10-05 | 2011-04-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-цистеина с использованием бактерии семейства enterobacteriaceae |
FR2951195B1 (fr) | 2009-10-14 | 2014-01-31 | Roquette Freres | Composition riche en methionine destinee a l'alimentation animale |
DE112010004851T5 (de) | 2009-12-17 | 2012-09-20 | Basf Se | Verfahren und rekombinante Mikroorganismen für die Herstellung von Cadaverin |
WO2012087039A2 (ko) * | 2010-12-21 | 2012-06-28 | 씨제이제일제당 (주) | 호모세린 아세틸 트랜스퍼라제 활성을 가지는 변이형 폴리펩티드 및 이를 발현하는 미생물 |
BR112013016810B1 (pt) * | 2010-12-29 | 2020-12-29 | Cj Cheiljedang Corporation | métodos para produção de l-metionina e produtos correlatos |
WO2012090021A1 (en) | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
EP2678421B1 (en) | 2011-02-22 | 2018-04-11 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
WO2012137689A1 (ja) | 2011-04-01 | 2012-10-11 | 味の素株式会社 | L-システインの製造法 |
US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
DE102011006716A1 (de) | 2011-04-04 | 2012-10-04 | Evonik Degussa Gmbh | Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung |
US20120264902A1 (en) * | 2011-04-18 | 2012-10-18 | The Regents Of The University Of Colorado, A Body Corporate | Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP) |
DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
FR2983870B1 (fr) | 2011-12-08 | 2015-07-17 | Roquette Freres | Composition en methionine destinee a l'alimentation animale |
BR112014021439B1 (pt) | 2012-04-27 | 2021-12-21 | Evonik Technochemie Gmbh | Polipeptídeo de isopropilmalato sintase e a sequência de nucleotídeos que o codifica, vetor, microrganismo do gênero corynebacterium e uso do mesmo, bem como processo fermentativo para a produção de kic ou l-leucina |
JP2012196222A (ja) * | 2012-06-11 | 2012-10-18 | Metabolic Explorer | 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法 |
JP6100370B2 (ja) | 2012-06-18 | 2017-03-22 | メタボリック エクスプローラー | メチオニンの発酵生産のための組換え微生物 |
CN109182238A (zh) | 2012-08-10 | 2019-01-11 | 嘉吉有限公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
WO2014064244A2 (en) * | 2012-10-26 | 2014-05-01 | Adisseo France S.A.S. | Means and methods for the enzymatic production of l-methionine from o-phospho-l-homoserine and methanethiol |
DE102012024435A1 (de) | 2012-12-14 | 2014-07-10 | Forschungszentrum Jülich GmbH | Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren |
EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
US9512057B2 (en) | 2013-03-15 | 2016-12-06 | Cargill, Incorporated | 3-hydroxypropionic acid compositions |
US20150119601A1 (en) | 2013-03-15 | 2015-04-30 | Opx Biotechnologies, Inc. | Monofunctional mcr + 3-hp dehydrogenase |
PL2811028T3 (pl) | 2013-06-03 | 2017-07-31 | Evonik Degussa Gmbh | Sposób wytwarzania L-waliny z zastosowaniem zrekombinowanych bakterii maczugowatych zawierających operon ilvBN indukowany propionianem |
BR112016001026A2 (pt) | 2013-07-19 | 2017-10-24 | Cargill Inc | organismo geneticamente modificado |
US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
ES2693789T3 (es) | 2013-08-30 | 2018-12-13 | Evonik Degussa Gmbh | Microorganismo para la producción de metionina con mejor actividad de metionina sintasa y flujo de metionina |
EP3039120B1 (en) * | 2013-08-30 | 2019-02-27 | Evonik Degussa GmbH | A microorganism for methionine production with enhanced methionine efflux |
KR101555749B1 (ko) * | 2013-10-23 | 2015-09-25 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
EP3095868A1 (en) | 2015-05-19 | 2016-11-23 | Evonik Degussa GmbH | Methionine production |
CN107787368A (zh) | 2015-07-10 | 2018-03-09 | 赢创德固赛有限公司 | 氨基酸生产 |
WO2017089077A1 (en) * | 2015-11-27 | 2017-06-01 | Evonik Degussa Gmbh | Method for producing l-methionine |
WO2017100376A2 (en) | 2015-12-07 | 2017-06-15 | Zymergen, Inc. | Promoters from corynebacterium glutamicum |
US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
CN108603207A (zh) | 2016-01-08 | 2018-09-28 | 赢创德固赛有限公司 | 通过发酵生产来生产l-甲硫氨酸的方法 |
CN105671074B (zh) * | 2016-03-04 | 2019-06-14 | 四川省农业科学院生物技术核技术研究所 | 一种提高植物甲硫氨酸含量的载体及其构建方法和用途 |
EP3478833A4 (en) | 2016-06-30 | 2019-10-02 | Zymergen, Inc. | METHODS OF GENERATING A BACTERIAL HEMOGLOBIN LIBRARY AND USES THEREOF |
JP2019519241A (ja) | 2016-06-30 | 2019-07-11 | ザイマージェン インコーポレイテッド | グルコース透過酵素ライブラリーを生成するための方法およびその使用 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
CA3048992A1 (en) | 2016-12-30 | 2018-07-05 | Quidel Corporation | Phage-mediated immunoassay and methods for determining susceptibility of bacteria to antibiotic or probiotic agents |
JP2020506702A (ja) | 2017-02-02 | 2020-03-05 | カーギル インコーポレイテッド | C6−c10脂肪酸誘導体を生成する遺伝子組み換え細胞 |
CN108504613B (zh) * | 2017-02-27 | 2021-03-30 | 四川利尔生物科技有限公司 | 一种l-高丝氨酸生产菌株及其构建方法和应用 |
JP2020524492A (ja) | 2017-06-07 | 2020-08-20 | ザイマージェン インコーポレイテッド | Corynebacterium glutamicum由来のプロモーターおよび補助遺伝子発現の制御におけるその使用 |
SG11201913899UA (en) * | 2017-06-30 | 2020-01-30 | Cj Cheiljedang Corp | Novel o-succinyl homoserine transferase mutant and method for producing o-succinyl homoserine using same |
KR102605543B1 (ko) * | 2017-07-11 | 2023-11-22 | 아디쎄오 프랑스 에스에이에스 | 메티오닌-생산 효모 |
AU2018301214B2 (en) * | 2017-07-14 | 2024-08-08 | Chrysea Limited | Microbial cells for spermidine production |
EP3692160A1 (en) | 2017-10-02 | 2020-08-12 | Quidel Corporation | Phage-based detection method for antimicrobial susceptibility testing and identification of bacterial species |
US11680279B2 (en) * | 2017-11-29 | 2023-06-20 | Ajinomoto Co., Inc. | Method for producing objective substance |
KR101947959B1 (ko) | 2018-05-28 | 2019-02-13 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
KR101996769B1 (ko) * | 2018-12-21 | 2019-10-01 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
KR102221040B1 (ko) * | 2019-05-09 | 2021-03-03 | 씨제이제일제당 주식회사 | L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법 |
WO2020264061A1 (en) * | 2019-06-25 | 2020-12-30 | Zymergen Inc. | Engineered biosynthetic pathways for production of cystathionine by fermentation |
KR102377500B1 (ko) * | 2019-10-28 | 2022-03-23 | 씨제이제일제당 주식회사 | 외래 metZ 유전자에 의해 코딩되는 단백질이 도입된 L-메티오닌 생산 미생물 및 이를 이용한 L-메티오닌 생산방법 |
US20230340428A1 (en) | 2020-07-15 | 2023-10-26 | Evonik Operations Gmbh | Polynucleotide encoding an amino acid sequence, encoding an oxidoreductase |
CN113088503B (zh) * | 2021-04-27 | 2023-01-10 | 浙江工业大学 | 一种o-琥珀酰巯基转移酶突变体及其在l-甲硫氨酸合成中的应用 |
CN117813315A (zh) | 2021-08-09 | 2024-04-02 | 赢创运营有限公司 | 用于生产重组细菌胶原样蛋白(clp)的方法 |
EP4384539A1 (en) | 2021-08-09 | 2024-06-19 | Evonik Operations GmbH | Polynucleotide encoding a bacterial collagen-like protein |
US20240336948A1 (en) | 2021-08-09 | 2024-10-10 | Evonik Operations Gmbh | Method for producing a recombinant bacterial collagen-like protein (clp) |
CN117999103A (zh) | 2021-09-20 | 2024-05-07 | 赢创运营有限公司 | 非粘附性胶原蛋白样水凝胶 |
CN118742338A (zh) | 2022-02-25 | 2024-10-01 | 赢创运营有限公司 | 基于胶原样蛋白的海绵 |
WO2023165952A1 (en) | 2022-03-01 | 2023-09-07 | Evonik Operations Gmbh | Biotechnological production of collagen proteins and bacterial collagen-like proteins by recombinant microorganisms |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS5540240B1 (pt) * | 1970-02-06 | 1980-10-16 | ||
RU2207376C2 (ru) * | 1999-10-14 | 2003-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислоты методом ферментации, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты) |
US20020049305A1 (en) * | 2000-08-02 | 2002-04-25 | Degussa Ag | Nucleotide sequences which code for the metF gene |
US6958228B2 (en) * | 2000-08-02 | 2005-10-25 | Degussa Ag | Nucleotide sequence which code for the metH gene |
US6942996B2 (en) * | 2000-08-02 | 2005-09-13 | Degussa Ag | Isolated polynucleotide from Corynebacterium encoding a homocysteine methyltransferase |
US6815196B2 (en) * | 2000-09-02 | 2004-11-09 | Degussa Ag | Nucleotide sequences encoding o-succinylhomoserine sulfhydrylase |
US6812016B2 (en) * | 2000-09-02 | 2004-11-02 | Degussa Ag | Nucleotide sequences which code for the metY gene |
US6822085B2 (en) * | 2000-09-03 | 2004-11-23 | Degussa Ag | Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes |
DE10126164A1 (de) * | 2001-05-30 | 2002-12-05 | Degussa | Für das metD-gen kodierende Nukleotidsequenzen |
DE10144493A1 (de) * | 2001-09-11 | 2003-07-03 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coyneformer Bakterien |
DE10154292A1 (de) * | 2001-11-05 | 2003-05-15 | Basf Ag | Gene die für Stoffwechselweg-Proteine codieren |
DE10217058A1 (de) * | 2002-04-17 | 2003-11-27 | Basf Ag | Verfahren zur Herstellung von schwefelhaltigen Feinchemikalien |
DE10239082A1 (de) * | 2002-08-26 | 2004-03-04 | Basf Ag | Verfahren zur fermentativen Herstellung schwefelhaltiger Feinchemikalien |
DE10239308A1 (de) * | 2002-08-27 | 2004-03-11 | Basf Ag | Verfahren zur fermentativen Herstellung von schwefelhaltigen Feinchemikalien |
US20040154305A1 (en) * | 2002-09-26 | 2004-08-12 | Ramgen Power Systems, Inc. | Gas turbine power plant with supersonic gas compressor |
DE102004009453A1 (de) * | 2004-02-27 | 2005-09-15 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von coryneformen Bakterien |
-
2006
- 2006-07-18 AU AU2006269864A patent/AU2006269864A1/en not_active Abandoned
- 2006-07-18 BR BRPI0613662A patent/BRPI0613662A2/pt not_active IP Right Cessation
- 2006-07-18 JP JP2008523003A patent/JP2009501550A/ja active Pending
- 2006-07-18 CA CA002615416A patent/CA2615416A1/en not_active Abandoned
- 2006-07-18 US US11/988,962 patent/US20090298136A1/en not_active Abandoned
- 2006-07-18 EP EP06800212A patent/EP1907559A1/en not_active Withdrawn
- 2006-07-18 RU RU2008105480/10A patent/RU2447146C2/ru not_active IP Right Cessation
- 2006-07-18 KR KR1020087003737A patent/KR20080036608A/ko not_active Application Discontinuation
- 2006-07-18 MX MX2008000480A patent/MX2008000480A/es not_active Application Discontinuation
- 2006-07-18 WO PCT/US2006/028439 patent/WO2007012078A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2007012078A1 (en) | 2007-01-25 |
RU2447146C2 (ru) | 2012-04-10 |
KR20080036608A (ko) | 2008-04-28 |
RU2008105480A (ru) | 2009-08-27 |
US20090298136A1 (en) | 2009-12-03 |
AU2006269864A1 (en) | 2007-01-25 |
EP1907559A1 (en) | 2008-04-09 |
CA2615416A1 (en) | 2007-01-25 |
MX2008000480A (es) | 2008-03-07 |
JP2009501550A (ja) | 2009-01-22 |
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