CA2811013C - Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains - Google Patents

Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains Download PDF

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Publication number
CA2811013C
CA2811013C CA2811013A CA2811013A CA2811013C CA 2811013 C CA2811013 C CA 2811013C CA 2811013 A CA2811013 A CA 2811013A CA 2811013 A CA2811013 A CA 2811013A CA 2811013 C CA2811013 C CA 2811013C
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Canada
Prior art keywords
group
acrylamide
propyl
meth
polysiloxane
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Active
Application number
CA2811013A
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English (en)
French (fr)
Other versions
CA2811013A1 (en
Inventor
Selma Kuyu
Dawn Alison Smith
Jinyu Huang
Frank Chang
Robert Scott
Arturo Norberto Medina
Manivakkam J. Shankernarayanan
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Alcon Inc
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Novartis AG
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Publication date
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Publication of CA2811013A1 publication Critical patent/CA2811013A1/en
Application granted granted Critical
Publication of CA2811013C publication Critical patent/CA2811013C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/442—Block-or graft-polymers containing polysiloxane sequences containing vinyl polymer sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B2207/00—Coding scheme for general features or characteristics of optical elements and systems of subclass G02B, but not including elements and systems which would be classified in G02B6/00 and subgroups
    • G02B2207/109—Sols, gels, sol-gel materials

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Eyeglasses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
CA2811013A 2010-10-06 2011-10-05 Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains Active CA2811013C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39046410P 2010-10-06 2010-10-06
US61/390,464 2010-10-06
US42267210P 2010-12-14 2010-12-14
US61/422,672 2010-12-14
PCT/US2011/054870 WO2012047964A1 (en) 2010-10-06 2011-10-05 Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains

Publications (2)

Publication Number Publication Date
CA2811013A1 CA2811013A1 (en) 2012-04-12
CA2811013C true CA2811013C (en) 2016-01-19

Family

ID=45925625

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2811013A Active CA2811013C (en) 2010-10-06 2011-10-05 Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains

Country Status (6)

Country Link
US (2) US8835525B2 (enExample)
EP (1) EP2625217B1 (enExample)
JP (1) JP5640153B2 (enExample)
BR (1) BR112013008221B1 (enExample)
CA (1) CA2811013C (enExample)
WO (1) WO2012047964A1 (enExample)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013008221B1 (pt) 2010-10-06 2020-02-11 Alcon Inc. Pré-polímero processável em água, lente de contato de hidrogel de silicone e seu método de fabricação
SG188507A1 (en) * 2010-10-06 2013-04-30 Novartis Ag Water-processable silicone-containing prepolymers and uses thereof
AU2013220367B2 (en) * 2012-02-15 2016-06-09 Dsm Ip Assets B.V. Polysiloxane based block copolymers
JP6065988B2 (ja) 2012-12-14 2017-01-25 ノバルティス アーゲー トリス（トリメチルシロキシ）シランビニル系モノマー及びその用途
JP6154022B2 (ja) 2012-12-14 2017-06-28 ノバルティス アーゲー 両親媒性シロキサン含有（メタ）アクリルアミド及びこれらの使用
WO2014093756A1 (en) 2012-12-14 2014-06-19 Novartis Ag Actinically-crosslinkable amphiphilic prepolymers
EP2931732B1 (en) 2012-12-14 2020-11-25 Alcon Inc. Amphiphilic siloxane-containing vinylic monomers and uses thereof
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
WO2014152017A1 (en) 2013-03-21 2014-09-25 Shifamed Holdings, Llc Accommodating intraocular lens
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
SG2013035662A (en) * 2013-05-08 2014-12-30 Menicon Singapore Pte Ltd Systems and methods for printing on a contact lens
EP2808707A1 (en) 2013-05-31 2014-12-03 DSM IP Assets B.V. Macromers comprising pendant polyoxazoline groups
SG11201601187VA (en) 2013-09-30 2016-04-28 Novartis Ag Method for making uv-absorbing ophthalmic lenses
US9568645B2 (en) 2013-09-30 2017-02-14 Novartis Ag Silicone hydrogel lenses with relatively-long thermal stability
CN105658391B (zh) 2013-10-31 2019-02-19 诺华股份有限公司 生产眼用透镜的方法
HUE036795T2 (hu) 2013-12-13 2018-07-30 Novartis Ag Eljárás kontaktlencse elõállítására
WO2015164630A1 (en) 2014-04-25 2015-10-29 Novartis Ag Carbosiloxane vinylic monomers
CA2940207C (en) 2014-04-25 2019-09-10 Novartis Ag Hydrophilized carbosiloxane vinylic monomers
US10174233B2 (en) * 2014-07-02 2019-01-08 The Yokohama Rubber Co., Ltd. Reactive hot-melt adhesive composition
CN107106293B (zh) 2014-08-26 2019-07-12 施菲姆德控股有限责任公司 调节性人工晶状体
NZ728772A (en) 2014-09-26 2018-10-26 Novartis Ag Polymerizable polysiloxanes with hydrophilic substituents
EP3268804B1 (en) 2015-03-11 2020-11-04 University of Florida Research Foundation, Inc. Mesh size control of lubrication in gemini hydrogels
US10266445B2 (en) 2015-05-07 2019-04-23 Novartis Ag Method for producing contact lenses with durable lubricious coatings thereon
CA2992823C (en) 2015-09-04 2019-10-29 Novartis Ag Method for producing contact lenses with durable lubricious coatings thereon
JP6680870B2 (ja) 2015-09-04 2020-04-15 アルコン インク． その上に耐久性潤滑性コーティングを有するソフトシリコーン医療デバイス
US11141263B2 (en) 2015-11-18 2021-10-12 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
AU2016358160B2 (en) 2015-11-18 2021-07-29 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
JP6708737B2 (ja) 2015-12-15 2020-06-10 アルコン インク． 親水性置換基を有する重合性ポリシロキサン
JP6615349B2 (ja) * 2015-12-15 2019-12-04 ノバルティス アーゲー 両親媒性分枝鎖状ポリジオルガノシロキサンマクロマー
US10081142B2 (en) 2015-12-15 2018-09-25 Novartis Ag Method for producing contact lenses with a lubricious surface
MY197430A (en) * 2015-12-15 2023-06-17 Alcon Inc Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
WO2017145023A1 (en) * 2016-02-22 2017-08-31 Novartis Ag Soft silicone medical devices
US10254567B2 (en) 2016-02-22 2019-04-09 Novartis Ag UV-absorbing vinylic monomers and uses thereof
EP3419961B1 (en) 2016-02-22 2020-09-02 Alcon Inc. Uv/visible-absorbing vinylic monomers and uses thereof
WO2018055491A1 (en) 2016-09-20 2018-03-29 Novartis Ag Process for producing contact lenses with durable lubricious coatings thereon
US10301451B2 (en) 2016-10-11 2019-05-28 Novartis Ag Chain-extended polydimethylsiloxane vinylic crosslinkers and uses thereof
JP6839295B2 (ja) 2016-10-11 2021-03-03 アルコン インク． 重合性ポリジメチルシロキサン−ポリオキシアルキレンブロックコポリマー
JP6965703B2 (ja) * 2016-11-28 2021-11-10 東洋インキＳｃホールディングス株式会社 （メタ）アクリル系重合体、（メタ）アクリル系ブロック共重合体、顔料分散体、感光性着色組成物、カラーフィルタ、インキ組成物、複合ブロック共重合体、顔料分散剤。
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
CN120000379A (zh) 2016-12-23 2025-05-16 施菲姆德控股有限责任公司 多片式调节性人工晶状体及其制造和使用方法
US10987214B2 (en) 2017-05-30 2021-04-27 Shifamed Holdings, Llc Surface treatments for accommodating intraocular lenses and associated methods and devices
EP3634309B1 (en) 2017-06-07 2023-05-24 Shifamed Holdings, LLC Adjustable optical power intraocular lenses
US10809181B2 (en) 2017-08-24 2020-10-20 Alcon Inc. Method and apparatus for determining a coefficient of friction at a test site on a surface of a contact lens
EP3676082A1 (en) 2017-08-29 2020-07-08 Alcon Inc. Cast-molding process for producing contact lenses
KR20240169143A (ko) 2017-12-13 2024-12-02 알콘 인코포레이티드 한 주 및 한 달 착용용 워터 그래디언트 콘택트 렌즈
MY199542A (en) 2018-01-22 2023-11-06 Alcon Inc Cast-molding process for producing uv-absorbing contact lenses
JP7019058B2 (ja) 2018-02-26 2022-02-14 アルコン インク． シリコーンヒドロゲルコンタクトレンズ
MY201659A (en) 2018-03-28 2024-03-08 Alcon Inc Method for making silicone hydrogel contact lenses
EP3802081B1 (en) 2018-06-04 2023-03-01 Alcon Inc. Method for producing silicone hydrogel contact lenses
EP3802082A1 (en) 2018-06-04 2021-04-14 Alcon Inc. Method for producing silicone hydrogel contact lenses
HUE063073T2 (hu) 2018-06-04 2023-12-28 Alcon Inc Eljárás szilikon-hidrogél kontaktlencsék elõállítására
CN112513146A (zh) * 2018-08-10 2021-03-16 东丽株式会社 聚硅氧烷-聚亚烷基二醇嵌段共聚物及其制造方法
WO2020100090A1 (en) 2018-11-15 2020-05-22 Alcon Inc. Contact lens with phosphorylcholine-modified polyvinylalcohols therein
WO2020115570A1 (en) 2018-12-03 2020-06-11 Alcon Inc. Method for making coated silicone hydrogel contact lenses
MY208051A (en) 2018-12-03 2025-04-11 Alcon Inc Method for producing coated silicone hydrogel contact lenses
CN113544195B (zh) 2019-03-14 2023-05-02 美国陶氏有机硅公司 具有聚(甲基)丙烯酸酯基团的聚有机硅氧烷及其制备方法和用途
US11648583B2 (en) 2019-04-10 2023-05-16 Alcon Inc. Method for producing coated contact lenses
WO2020230016A1 (en) 2019-05-13 2020-11-19 Alcon Inc. Method for producing photochromic contact lenses
MY206069A (en) 2019-05-28 2024-11-27 Alcon Inc Pad transfer printing method for making colored contact lenses
SG11202111037SA (en) 2019-05-28 2021-12-30 Alcon Inc Method for making opaque colored silicone hydrogel contact lenses
US12072556B2 (en) 2019-11-04 2024-08-27 Alcon Inc. Contact lenses with surfaces having different softness
JP7664244B2 (ja) 2019-12-16 2025-04-17 アルコン インク． 湿潤性シリコーンヒドロゲルコンタクトレンズ
US20210284778A1 (en) 2020-03-11 2021-09-16 Alcon Inc. Photochromic polydiorganosiloxane vinylic crosslinkers
US11833770B2 (en) 2020-03-19 2023-12-05 Alcon Inc. Method for producing embedded or hybrid hydrogel contact lenses
MX2022011570A (es) 2020-03-19 2022-10-18 Alcon Inc Lentes de contacto con hidrogel de silicona embebido.
TWI788804B (zh) 2020-03-19 2023-01-01 瑞士商愛爾康公司 用於嵌入式接觸鏡片之高折射率矽氧烷插入物材料
AU2021236973B2 (en) 2020-03-19 2024-05-09 Alcon Inc. Insert materials with high oxygen permeability and high refractive index
EP4139412A1 (en) 2020-04-20 2023-03-01 Dow Silicones Corporation Polyorganosiloxane hybrid pressure sensitive adhesive and methods for the preparation and use thereof
US12116442B2 (en) 2020-05-07 2024-10-15 Alcon Inc. Method for producing silicone hydrogel contact lenses
WO2021245551A1 (en) 2020-06-02 2021-12-09 Alcon Inc. Method for making photochromic contact lenses
TWI803920B (zh) 2020-07-28 2023-06-01 瑞士商愛爾康公司 塗層接觸鏡片及其製備方法
HUE069854T2 (hu) 2020-10-28 2025-04-28 Alcon Inc Eljárás fotokróm kontaktlencsék elõállítására
HUE069913T2 (hu) 2020-11-04 2025-04-28 Alcon Inc Eljárás fotokróm kontaktlencsék elõállítására
WO2022097048A1 (en) 2020-11-04 2022-05-12 Alcon Inc. Method for making photochromic contact lenses
WO2022172154A1 (en) 2021-02-09 2022-08-18 Alcon Inc. Hydrophilized polydiorganosiloxane vinylic crosslinkers
WO2022189941A1 (en) 2021-03-08 2022-09-15 Alcon Inc. Method for making photochromic contact lenses
WO2022201013A1 (en) 2021-03-23 2022-09-29 Alcon Inc. Polysiloxane vinylic crosslinkers with high refractive index
KR20230132841A (ko) 2021-03-24 2023-09-18 알콘 인코포레이티드 안구내장형 하이드로겔 콘택트렌즈의 제조 방법
WO2022208447A1 (en) 2021-04-01 2022-10-06 Alcon Inc. Embedded hydrogel contact lenses
EP4313569A1 (en) 2021-04-01 2024-02-07 Alcon Inc. Method for making embedded hydrogel contact lenses
HUE070670T2 (hu) 2021-04-01 2025-06-28 Alcon Inc Eljárás fotokróm kontaktlencsék elõállítására
TW202307527A (zh) 2021-06-14 2023-02-16 瑞士商愛爾康公司 繞射接觸鏡片
CN114369190B (zh) * 2022-01-24 2023-09-22 西南石油大学 一种高弹性超疏水聚苯乙烯基多孔材料的制备方法
WO2023209569A1 (en) 2022-04-26 2023-11-02 Alcon Inc. Method for making embedded hydrogel contact lenses
KR20240168389A (ko) 2022-04-26 2024-11-29 알콘 인코포레이티드 내장형 히드로겔 콘택트 렌즈의 제조 방법
KR20240153593A (ko) 2022-04-28 2024-10-23 알콘 인코포레이티드 Uv- 및 hevl-흡수 안과용 렌즈의 제조 방법
EP4514596A1 (en) 2022-04-29 2025-03-05 Alcon Inc. Method for making silicone hydrogel contact lenses
WO2023218324A1 (en) 2022-05-09 2023-11-16 Alcon Inc. Method for making embedded hydrogel contact lenses
TW202411352A (zh) 2022-05-23 2024-03-16 瑞士商愛爾康公司 Ｕｖ／ｈｅｖｌ過濾性接觸鏡片
WO2023228054A1 (en) 2022-05-23 2023-11-30 Alcon Inc. Method for making hevl-filtering contact lenses
TW202413071A (zh) 2022-05-25 2024-04-01 瑞士商愛爾康公司 用於製造嵌入式水凝膠接觸鏡片之方法
JP2025525733A (ja) 2022-08-17 2025-08-07 アルコン インク． ハイドロゲルコーティングをその上に有するコンタクトレンズ
TWI828345B (zh) * 2022-09-30 2024-01-01 晶碩光學股份有限公司 矽氧烷單體、隱形眼鏡組成物及隱形眼鏡
US20240280834A1 (en) 2023-02-02 2024-08-22 Alcon Inc. Water gradient silicone hydrogel contact lenses
TW202441215A (zh) 2023-02-27 2024-10-16 瑞士商愛爾康公司 用於生產可潤濕矽酮水凝膠接觸鏡片之方法
CN116218461B (zh) * 2023-02-27 2023-10-27 广东德聚技术股份有限公司 一种密封防水的单组份硅胶及其制备方法
WO2024194826A1 (en) 2023-03-22 2024-09-26 Alcon Inc. Method for making embedded hydrogel contact lenses
US20240383865A1 (en) 2023-05-18 2024-11-21 Alcon Inc. High-energy-violet-absorbing vinylic monomers
CN121039534A (zh) 2023-05-18 2025-11-28 爱尔康公司 Uv/hevl过滤性硅氧烷水凝胶隐形眼镜
WO2024241239A1 (en) 2023-05-25 2024-11-28 Alcon Inc. Coated silicone hydrogel contact lenses and method for making the same
WO2024246817A1 (en) 2023-06-01 2024-12-05 Alcon Inc. Embedded hydrogel contact lenses
WO2025032504A2 (en) 2023-08-07 2025-02-13 Alcon Inc. Uv/hevl-filtering silicone hydrogel contact lenses
CN117209677B (zh) * 2023-10-23 2024-04-05 山东辰星医疗科技有限公司 一种具有互穿网络的有机硅水凝胶及其制备方法
WO2025109468A1 (en) 2023-11-20 2025-05-30 Alcon Inc. Embedded contact lens with a high refractive index insert therein
WO2025243221A1 (en) 2024-05-22 2025-11-27 Alcon Inc. Reactive hevl-absorbing dyes
US20250361401A1 (en) 2024-05-22 2025-11-27 Alcon Inc. Reactive dyes
US20250362530A1 (en) 2024-05-22 2025-11-27 Alcon Inc. Method for making centrally colored contact lenses
CN119798359A (zh) * 2025-01-06 2025-04-11 兰州大学 一种基于巯基-烯烃光点击化学的环肽构建方法及其应用

Family Cites Families (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042552A (en) 1972-09-19 1977-08-16 Warner-Lambert Company Composition for hydrophilic lens blank and method of casting
US4045547A (en) 1974-11-21 1977-08-30 Warner-Lambert Company Fabrication of soft contact lens and composition therefor
US4245069A (en) 1978-12-28 1981-01-13 Permavision Polysiloxane composition
US4343927A (en) 1976-11-08 1982-08-10 Chang Sing Hsiung Hydrophilic, soft and oxygen permeable copolymer compositions
US4182822A (en) 1976-11-08 1980-01-08 Chang Sing Hsiung Hydrophilic, soft and oxygen permeable copolymer composition
US4136250A (en) 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4189546A (en) 1977-07-25 1980-02-19 Bausch & Lomb Incorporated Polysiloxane shaped article for use in biomedical applications
US4153641A (en) 1977-07-25 1979-05-08 Bausch & Lomb Incorporated Polysiloxane composition and contact lens
US4261875A (en) 1979-01-31 1981-04-14 American Optical Corporation Contact lenses containing hydrophilic silicone polymers
US4276402A (en) 1979-09-13 1981-06-30 Bausch & Lomb Incorporated Polysiloxane/acrylic acid/polcyclic esters of methacrylic acid polymer contact lens
US4254248A (en) 1979-09-13 1981-03-03 Bausch & Lomb Incorporated Contact lens made from polymers of polysiloxane and polycyclic esters of acrylic acid or methacrylic acid
US4312575A (en) 1979-09-18 1982-01-26 Peyman Gholam A Soft corneal contact lens with tightly cross-linked polymer coating and method of making same
US4260725A (en) 1979-12-10 1981-04-07 Bausch & Lomb Incorporated Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hydrophilic sidechains
US4259467A (en) 1979-12-10 1981-03-31 Bausch & Lomb Incorporated Hydrophilic contact lens made from polysiloxanes containing hydrophilic sidechains
US4341889A (en) 1981-02-26 1982-07-27 Bausch & Lomb Incorporated Polysiloxane composition and biomedical devices
US4355147A (en) 1981-02-26 1982-10-19 Bausch & Lomb Incorporated Polysiloxane with polycyclic modifier composition and biomedical devices
US4327203A (en) 1981-02-26 1982-04-27 Bausch & Lomb Incorporated Polysiloxane with cycloalkyl modifier composition and biomedical devices
US4444711A (en) 1981-12-21 1984-04-24 Husky Injection Molding Systems Ltd. Method of operating a two-shot injection-molding machine
US4661575A (en) 1982-01-25 1987-04-28 Hercules Incorporated Dicyclopentadiene polymer product
US4467082A (en) 1982-03-15 1984-08-21 Dow Corning Corporation Organopolysiloxane photosensitizers and methods for their preparation
US4460534A (en) 1982-09-07 1984-07-17 International Business Machines Corporation Two-shot injection molding
US4485236A (en) 1982-09-27 1984-11-27 Minnesota Mining And Manufacturing Company Azlactone-functional compounds
US4486577A (en) 1982-10-12 1984-12-04 Ciba-Geigy Corporation Strong, silicone containing polymers with high oxygen permeability
US4543398A (en) 1983-04-28 1985-09-24 Minnesota Mining And Manufacturing Company Ophthalmic devices fabricated from urethane acrylates of polysiloxane alcohols
JPS60163901A (ja) 1984-02-04 1985-08-26 Japan Synthetic Rubber Co Ltd プラズマ重合処理方法
US4605712A (en) 1984-09-24 1986-08-12 Ciba-Geigy Corporation Unsaturated polysiloxanes and polymers thereof
US4833218A (en) 1984-12-18 1989-05-23 Dow Corning Corporation Hydrophilic silicone-organic copolymer elastomers containing bioactine agent
US4666953A (en) 1985-03-28 1987-05-19 Loctite Corporation Silicone polyphotoinitiators
JPH0690826B2 (ja) 1985-04-05 1994-11-14 ソニー株式会社 信号再生装置
US4711943A (en) 1985-04-26 1987-12-08 Sola U.S.A. Inc. Hydrophilic siloxane monomers and dimers for contact lens materials, and contact lenses fabricated therefrom
US4684538A (en) 1986-02-21 1987-08-04 Loctite Corporation Polysiloxane urethane compounds and adhesive compositions, and method of making and using the same
DE3708308A1 (de) 1986-04-10 1987-10-22 Bayer Ag Kontaktoptische gegenstaende
DE3710343A1 (de) 1987-03-28 1988-10-06 Basf Lacke & Farben Verzweigtes acrylatcopolymerisat mit polisierbaren doppelbindungen und verfahren zur herstellung des acrylatcopolymerisats
US4837289A (en) 1987-04-30 1989-06-06 Ciba-Geigy Corporation UV- and heat curable terminal polyvinyl functional macromers and polymers thereof
US5070169A (en) 1988-02-26 1991-12-03 Ciba-Geigy Corporation Wettable, flexible, oxygen permeable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units and use thereof
US5070170A (en) 1988-02-26 1991-12-03 Ciba-Geigy Corporation Wettable, rigid gas permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units, and use thereof
US4954587A (en) 1988-07-05 1990-09-04 Ciba-Geigy Corporation Dimethylacrylamide-copolymer hydrogels with high oxygen permeability
JPH0651795B2 (ja) 1988-09-16 1994-07-06 信越化学工業株式会社 メタクリル官能性ジメチルポリシロキサン
US4983702A (en) 1988-09-28 1991-01-08 Ciba-Geigy Corporation Crosslinked siloxane-urethane polymer contact lens
US4954586A (en) 1989-01-17 1990-09-04 Menicon Co., Ltd Soft ocular lens material
AU637361B2 (en) * 1989-04-24 1993-05-27 Novartis Ag Polysiloxane-polyoxyalkylene block copolymers and ophthalmic devices containing them
US5070215A (en) 1989-05-02 1991-12-03 Bausch & Lomb Incorporated Novel vinyl carbonate and vinyl carbamate contact lens material monomers
US5034461A (en) 1989-06-07 1991-07-23 Bausch & Lomb Incorporated Novel prepolymers useful in biomedical devices
DE3927667A1 (de) 1989-08-22 1991-02-28 Espe Stiftung Verwendung von photopolymerisierbaren massen als introkularlinsen-fuellmaterial bei der bekaempfung von katarakt und anderen augenkrankheiten
US5010141A (en) 1989-10-25 1991-04-23 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5079319A (en) 1989-10-25 1992-01-07 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5244981A (en) 1990-04-10 1993-09-14 Permeable Technologies, Inc. Silicone-containing contact lens polymers, oxygen permeable contact lenses and methods for making these lenses and treating patients with visual impairment
US5314960A (en) 1990-04-10 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, oxygen permeable hydrophilic contact lenses and methods for making these lenses and treating patients with visual impairment
US5480946A (en) 1990-04-26 1996-01-02 Ciba Geigy Corporation Unsaturated urea polysiloxanes
DE69101464T2 (de) * 1990-04-26 1994-07-14 Ciba Geigy Ungesättigte Harnstoff-Polysiloxane.
US5314961A (en) 1990-10-11 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, compositions and improved oxygen permeable hydrophilic contact lenses
US5219965A (en) 1990-11-27 1993-06-15 Bausch & Lomb Incorporated Surface modification of polymer objects
US5194556A (en) 1991-01-09 1993-03-16 Ciba-Geigy Corporation Rigid contact lenses with improved oxygen permeability
US5559163A (en) 1991-01-28 1996-09-24 The Sherwin-Williams Company UV curable coatings having improved weatherability
AU647880B2 (en) 1991-02-28 1994-03-31 Ciba-Geigy Ag Contact lenses made from thermoformable material
JPH05238950A (ja) 1991-04-22 1993-09-17 Sanwa Kagaku Kenkyusho Co Ltd 易吸収性ｖｉｐ製剤
US5352753A (en) 1991-04-25 1994-10-04 Allergan, Inc. Ultraviolet light absorbing compounds, silicone compositions and methods for making same
US5164462A (en) 1991-04-25 1992-11-17 Allergan, Inc. Ultraviolet light absorbing compounds and silicone compositions
WO1993005085A1 (en) 1991-09-12 1993-03-18 Bausch & Lomb Incorporated Wettable silicone hydrogel compositions and methods
US5310779A (en) 1991-11-05 1994-05-10 Bausch & Lomb Incorporated UV curable crosslinking agents useful in copolymerization
JP3354571B2 (ja) 1991-11-05 2002-12-09 ボシュ・アンド・ロム・インコーポレイテッド ぬれ性のシリコーンヒドロゲル組成物およびその製造方法
US5358995A (en) 1992-05-15 1994-10-25 Bausch & Lomb Incorporated Surface wettable silicone hydrogels
JP3195662B2 (ja) 1992-08-24 2001-08-06 株式会社メニコン 眼用レンズ材料
JP2774233B2 (ja) 1992-08-26 1998-07-09 株式会社メニコン 眼用レンズ材料
KR100209818B1 (ko) 1992-09-04 1999-07-15 사또 아끼오 분해성점착필름 및 분해성수지조성물
US5423158A (en) 1993-04-02 1995-06-13 Continental Emsco Company Vertically erected mast
EP0695298B1 (en) 1993-04-22 1997-11-19 Wesley Jessen Corporation Uv-absorbing benzotriazoles having a styrene group
TW328535B (en) 1993-07-02 1998-03-21 Novartis Ag Functional photoinitiators and their manufacture
US6800225B1 (en) 1994-07-14 2004-10-05 Novartis Ag Process and device for the manufacture of mouldings and mouldings manufactured in accordance with that process
TW272976B (enExample) 1993-08-06 1996-03-21 Ciba Geigy Ag
GB9321714D0 (en) 1993-10-21 1993-12-15 Sandoz Ltd Improvements in or relating to organic compounds
US5712356A (en) 1993-11-26 1998-01-27 Ciba Vision Corporation Cross-linkable copolymers and hydrogels
US5894002A (en) 1993-12-13 1999-04-13 Ciba Vision Corporation Process and apparatus for the manufacture of a contact lens
TW303379B (enExample) 1994-03-02 1997-04-21 Ciba Sc Holding Ag
US5480927A (en) 1994-05-20 1996-01-02 Ciba Geigy Corporation Method of increasing the concentration of radiation-absorbing agents in optical and ophthalmic lenses
US5843346A (en) 1994-06-30 1998-12-01 Polymer Technology Corporation Method of cast molding contact lenses
TW381106B (en) 1994-09-02 2000-02-01 Ciba Sc Holding Ag Alkoxyphenyl-substituted bisacylphosphine oxides
US5760100B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
US6342570B1 (en) 1994-11-14 2002-01-29 Novartis Ag Cross-linkable copolymers and hydrogels
US5665840A (en) 1994-11-18 1997-09-09 Novartis Corporation Polymeric networks from water-soluble prepolymers
TW434456B (en) 1994-12-30 2001-05-16 Novartis Ag A compound as functionalized photoinitiator, its production process, its corresponding oligomers or polymers and its application in coating a substrate
TW349967B (en) 1995-02-03 1999-01-11 Novartis Ag Process for producing contact lenses and a cross-linkable polyvinylalcohol used therefor
AU4620596A (en) 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers containing ester or amide groups
GB9504996D0 (en) 1995-03-11 1995-04-26 Zeneca Ltd Compositions
DE29624309U1 (de) 1995-04-04 2002-01-03 Commonwealth Scientific And Industrial Research Organisation, Campbell Dauertraglinsen
US5681871A (en) 1995-05-24 1997-10-28 Johnson & Johnson Vision Products, Inc. Method for preparing ultraviolet radiation absorbing contact lenses
AUPN354595A0 (en) 1995-06-14 1995-07-06 Ciba-Geigy Ag Novel materials
CH691970A5 (de) 1996-03-04 2001-12-14 Ciba Sc Holding Ag Alkylphenylbisacylphosphinoxide und Photoinitiatormischungen.
US6361925B1 (en) 1996-03-04 2002-03-26 Ciba Specialty Chemicals Corporation Photoinitiator mixtures and compositions with alkylphenylbisacylphosphine oxides
AR008108A1 (es) 1996-08-01 1999-12-09 Novartis Ag Un metodo para formar un articulo polimerico absorbente de radiacion, un articulo polimerico asi formado, y un metodo para formar un tintepolimerico
IL129393A0 (en) 1996-10-21 2000-02-17 Novartis Ag Crosslinkable polymers
CA2223905C (en) * 1996-12-06 2008-08-26 Toray Industries, Inc. Plastic articles for medical use
JP4061664B2 (ja) * 1996-12-06 2008-03-19 東レ株式会社 プラスチック成形品
TW425403B (en) 1997-02-04 2001-03-11 Novartis Ag Branched polyurethane (meth)acrylate prepolymers, opthal-mic mouldings derived therefrom and processes for their manufacture
EP0867456A1 (de) 1997-02-04 1998-09-30 Novartis AG Ophthalmischer Formkörper
ES2175698T3 (es) 1997-02-21 2002-11-16 Novartis Ag Articulos de moldeo oftalmicos.
BR9808960B1 (pt) 1997-04-22 2008-11-18 composiÇço de revestimento de fibra àtica curÁvel por radiaÇço, composiÇço de revestimento lÍquida, de revestimento primÁrio interno e externo, material de matriz ou de acondicionamento, fribra àtica de vidro e dispositivo de transmissço de luz.
US6359025B1 (en) 1997-05-16 2002-03-19 Dsm N.V. Radiation-curable liquid resin composition for coating optical fibers
US5989462A (en) 1997-07-31 1999-11-23 Q2100, Inc. Method and composition for producing ultraviolent blocking lenses
US6015842A (en) 1997-08-07 2000-01-18 Alcon Laboratories, Inc. Method of preparing foldable hydrophilic ophthalmic device materials
JP3722986B2 (ja) 1997-08-29 2005-11-30 株式会社ニデック 紫外線吸収性基材
JP4616473B2 (ja) 1997-09-16 2011-01-19 ノバルティス アーゲー 架橋結合可能なポリ尿素ポリマー類
US6020445A (en) 1997-10-09 2000-02-01 Johnson & Johnson Vision Products, Inc. Silicone hydrogel polymers
TW429327B (en) 1997-10-21 2001-04-11 Novartis Ag Single mould alignment
JPH11130744A (ja) 1997-10-29 1999-05-18 Menicon Co Ltd 架橋性化合物およびそれを用いてなる光学材料
US5981669A (en) 1997-12-29 1999-11-09 Bausch & Lomb Incorporated Silicone-containing prepolymers and low water materials
US6451871B1 (en) 1998-11-25 2002-09-17 Novartis Ag Methods of modifying surface characteristics
JP4125426B2 (ja) 1998-02-06 2008-07-30 三井化学ポリウレタン株式会社 低反発性ウレタンフォーム
US6822016B2 (en) 2001-09-10 2004-11-23 Johnson & Johnson Vision Care, Inc. Biomedical devices containing internal wetting agents
US5962548A (en) 1998-03-02 1999-10-05 Johnson & Johnson Vision Products, Inc. Silicone hydrogel polymers
US6849671B2 (en) 1998-03-02 2005-02-01 Johnson & Johnson Vision Care, Inc. Contact lenses
US7052131B2 (en) 2001-09-10 2006-05-30 J&J Vision Care, Inc. Biomedical devices containing internal wetting agents
US20070043140A1 (en) 1998-03-02 2007-02-22 Lorenz Kathrine O Method for the mitigation of symptoms of contact lens related dry eye
US6367929B1 (en) 1998-03-02 2002-04-09 Johnson & Johnson Vision Care, Inc. Hydrogel with internal wetting agent
US5998498A (en) 1998-03-02 1999-12-07 Johnson & Johnson Vision Products, Inc. Soft contact lenses
US6943203B2 (en) 1998-03-02 2005-09-13 Johnson & Johnson Vision Care, Inc. Soft contact lenses
US7461937B2 (en) 2001-09-10 2008-12-09 Johnson & Johnson Vision Care, Inc. Soft contact lenses displaying superior on-eye comfort
US6218463B1 (en) 1998-04-20 2001-04-17 Johnson & Johnson Vision Care, Inc. Ocular devices manufactured with free radical-polymerizable latent ultra-violet absorbers
US6036891A (en) 1998-05-11 2000-03-14 Pharmacia & Upjohn Polymerizable hydrophilic ultraviolet light absorbing monomers
US6359024B2 (en) 1998-05-15 2002-03-19 Bausch & Lomb Incorporated Method for polymerizing contact lenses
US5914355A (en) 1998-05-15 1999-06-22 Bausch & Lomb Incorporated Method for making contact lenses having UV absorbing properties
US5989117A (en) 1998-07-01 1999-11-23 Lin; Kuei-Chou Shellfish wash device
AU4980199A (en) 1998-07-08 2000-02-01 Sunsoft Corporation Interpenetrating polymer network hydrophilic hydrogels for contact lens
US5959117A (en) 1998-08-10 1999-09-28 Bausch & Lomb Monomers useful for contact lens materials
US6039913A (en) 1998-08-27 2000-03-21 Novartis Ag Process for the manufacture of an ophthalmic molding
US6149692A (en) 1998-08-27 2000-11-21 Novartis Ag Method and composition for incorporating radiation-absorbing agents into polymers
US6241766B1 (en) 1998-10-29 2001-06-05 Allergan Sales, Inc. Intraocular lenses made from polymeric compositions
EP1002807A1 (en) 1998-11-20 2000-05-24 Novartis AG Functionalized resin derived from polyallylamine
US5981675A (en) 1998-12-07 1999-11-09 Bausch & Lomb Incorporated Silicone-containing macromonomers and low water materials
US6329485B1 (en) 1998-12-11 2001-12-11 Bausch & Lomb Incorporated High refractive index hydrogel compositions for ophthalmic implants
US6422794B1 (en) 1998-12-16 2002-07-23 Holland Company Cargo snugger strap and hook mechanism
ATE278721T1 (de) 1999-03-30 2004-10-15 Novartis Pharma Gmbh Organische verbindungen
JP3449406B2 (ja) 1999-04-07 2003-09-22 Ｈｏｙａヘルスケア株式会社 新規ピラゾロン化合物およびそれを用いた眼用プラスチックレンズ
US6252032B1 (en) 1999-07-07 2001-06-26 Minimed Inc. UV absorbing polymer
CA2379244C (en) 1999-07-27 2007-09-18 Jay F. Kunzler Contact lens material
US6376568B1 (en) 1999-07-29 2002-04-23 Ciba Specialty Chemicals Corporation Surface-active photoinitiators
EP1754728B1 (en) 1999-10-07 2010-02-24 Johson & Johnson Vision Care Inc. Soft contact lenses
US6719929B2 (en) 2000-02-04 2004-04-13 Novartis Ag Method for modifying a surface
US6793973B2 (en) 2000-02-04 2004-09-21 Novartis Ag Single-dip process for achieving a layer-by-layer-like coating
US7521519B1 (en) 2000-03-14 2009-04-21 Novartis Ag Organic compounds
WO2001071415A1 (en) * 2000-03-22 2001-09-27 Menicon Co., Ltd. Material for ocular lens
WO2001071392A1 (en) 2000-03-24 2001-09-27 Novartis Ag Crosslinkable or polymerizable prepolymers
US6881269B2 (en) 2000-08-17 2005-04-19 Novartis Ag Lens plasma coating system
US6852353B2 (en) 2000-08-24 2005-02-08 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
US20030044447A1 (en) 2000-12-21 2003-03-06 Diana Zanini Antimicrobial contact lenses and methods for their production
US20050260249A1 (en) 2000-12-21 2005-11-24 Neely Frank L Antimicrobial contact lenses and methods for their production
US20040151755A1 (en) 2000-12-21 2004-08-05 Osman Rathore Antimicrobial lenses displaying extended efficacy, processes to prepare them and methods of their use
US20040213827A1 (en) 2000-12-21 2004-10-28 Enns John B. Antimicrobial contact lenses and methods for their production
US20040115242A1 (en) 2001-12-20 2004-06-17 Meyers Ann-Marie W. Antimicrobial contact lenses and methods for their production
WO2002081485A1 (en) 2001-03-30 2002-10-17 Johnson & Johnson Vision Care, Inc. Monomer, polymer, and ocular lens and contact lens each obtained therefrom
ES2305205T3 (es) 2001-03-30 2008-11-01 JOHNSON & JOHNSON VISION CARE, INC. Monomeros, polimeros, lentes oftalmicas de contacto fabricadas con ayuda de los mismos.
JP2003066381A (ja) 2001-05-23 2003-03-05 Novartis Ag 流体で物品を処理するためのシステム及び方法
US6811805B2 (en) 2001-05-30 2004-11-02 Novatis Ag Method for applying a coating
US6811804B2 (en) 2001-06-07 2004-11-02 Abbott Laboratories Juice and soy protein beverage and uses thereof
US6776934B2 (en) 2001-11-02 2004-08-17 Bausch & Lomb Incorporated Method for polymerizing lenses
TWI255224B (en) 2002-01-09 2006-05-21 Novartis Ag Polymeric articles having a lubricious coating and method for making the same
US6846892B2 (en) 2002-03-11 2005-01-25 Johnson & Johnson Vision Care, Inc. Low polydispersity poly-HEMA compositions
US6852793B2 (en) 2002-06-19 2005-02-08 Bausch & Lomb Incorporated Low water content, high refractive index, flexible, polymeric compositions
DE60317797T2 (de) 2002-08-14 2008-10-30 Novartis Ag Strahlungshärtbare prepolymere
JP2004085655A (ja) * 2002-08-23 2004-03-18 Asahi Kasei Aimii Kk 耐汚染性の含水ソフトコンタクトレンズ
US20070138692A1 (en) 2002-09-06 2007-06-21 Ford James D Process for forming clear, wettable silicone hydrogel articles
US20080299179A1 (en) 2002-09-06 2008-12-04 Osman Rathore Solutions for ophthalmic lenses containing at least one silicone containing component
US20040150788A1 (en) 2002-11-22 2004-08-05 Ann-Margret Andersson Antimicrobial lenses, processes to prepare them and methods of their use
US6896926B2 (en) 2002-09-11 2005-05-24 Novartis Ag Method for applying an LbL coating onto a medical device
US6926965B2 (en) 2002-09-11 2005-08-09 Novartis Ag LbL-coated medical device and method for making the same
US7387759B2 (en) 2002-12-17 2008-06-17 Novartis Ag System and method for curing polymeric moldings having a masking collar
US7384590B2 (en) 2002-12-17 2008-06-10 Novartis Ag System and method for curing polymeric moldings
CN100529842C (zh) 2003-01-10 2009-08-19 株式会社美你康 含有有机硅的高安全性眼用透镜材料及其制造方法
US7276544B2 (en) 2003-09-08 2007-10-02 Bausch & Lomb Incorporated Process for manufacturing intraocular lenses with blue light absorption characteristics
US7416737B2 (en) 2003-11-18 2008-08-26 Johnson & Johnson Vision Care, Inc. Antimicrobial lenses, processes to prepare them and methods of their use
US7977430B2 (en) 2003-11-25 2011-07-12 Novartis Ag Crosslinkable polyurea prepolymers
US7214809B2 (en) 2004-02-11 2007-05-08 Johnson & Johnson Vision Care, Inc. (Meth)acrylamide monomers containing hydroxy and silicone functionalities
US7550519B2 (en) 2004-04-21 2009-06-23 Novartis Ag Curable colored inks for making colored silicone hydrogel lenses
US20060069178A1 (en) 2004-09-24 2006-03-30 Bausch & Lomb Incorporated Method for polymerizing ophthalmic devices
US7249848B2 (en) 2004-09-30 2007-07-31 Johnson & Johnson Vision Care, Inc. Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents
US7247692B2 (en) 2004-09-30 2007-07-24 Johnson & Johnson Vision Care, Inc. Biomedical devices containing amphiphilic block copolymers
US20060252850A1 (en) 2005-05-04 2006-11-09 Bausch & Lomb Incorporated Radiation-absorbing polymeric materials and ophthalmic devices comprising same
US20070092830A1 (en) 2005-10-24 2007-04-26 Bausch & Lomb Incorporated Polymeric radiation-absorbing materials and ophthalmic devices comprising same
US20070092831A1 (en) 2005-10-24 2007-04-26 Bausch & Lomb Incorporated Radiation-absorbing polymeric materials and ophthalmic devices comprising same
US7423108B2 (en) 2005-12-16 2008-09-09 Bausch & Lomb Incorporated High refractive-index siloxy-containing monomers and polymers, and ophthalmic devices comprising such polymers
US7759408B2 (en) 2005-12-21 2010-07-20 Bausch & Lomb Incorporated Silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups
US8828420B2 (en) 2006-01-06 2014-09-09 Bausch & Lomb Incorporated Siloxane prepolymer containing pendant cationic and polymerizable groups
US7825273B2 (en) 2006-01-06 2010-11-02 Bausch & Lomb Incorporated Process for making cationic hydrophilic siloxanyl monomers
US7528208B2 (en) 2006-01-06 2009-05-05 Bausch & Lomb Incorporated Siloxane prepolymer containing pendant and end-capping cationic and polymerizable groups
US7960447B2 (en) 2006-04-13 2011-06-14 Bausch & Lomb Incorporated Cationic end-capped siloxane prepolymer for reduced cross-link density
JP2009535464A (ja) 2006-05-03 2009-10-01 ビジョン シーアールシー リミティド 生物系ポリシロキサン
US7858000B2 (en) 2006-06-08 2010-12-28 Novartis Ag Method of making silicone hydrogel contact lenses
US7572841B2 (en) 2006-06-15 2009-08-11 Coopervision International Holding Company, Lp Wettable silicone hydrogel contact lenses and related compositions and methods
US8231218B2 (en) 2006-06-15 2012-07-31 Coopervision International Holding Company, Lp Wettable silicone hydrogel contact lenses and related compositions and methods
US7601766B2 (en) 2006-06-30 2009-10-13 Bausch & Lomb Incorporated Carboxylic siloxanyl monomers with pendant polymerizable groups
US7557231B2 (en) 2006-06-30 2009-07-07 Bausch & Lomb Incorporated Carboxylic tris-like siloxanyl monomers
US7468397B2 (en) * 2006-06-30 2008-12-23 Bausch & Lomb Incorporated Polymerizable siloxane-quaternary amine copolymers
US20080004413A1 (en) 2006-06-30 2008-01-03 Derek Schorzman Carboxylic M2Dx-like siloxanyl monomers
ATE470681T1 (de) 2006-07-12 2010-06-15 Novartis Ag Aktinisch vernetzbare copolymere zur herstellung von kontaktlinsen
US20080076897A1 (en) 2006-09-27 2008-03-27 Kunzler Jay F Pendant end-capped low modulus cationic siloxanyls
JP5669396B2 (ja) 2006-12-13 2015-02-12 ノバルティス アーゲー 化学線硬化性シリコーンヒドロゲルコポリマーおよびその使用
AR064286A1 (es) 2006-12-13 2009-03-25 Quiceno Gomez Alexandra Lorena Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida
BRPI0809271A2 (pt) 2007-03-22 2014-10-14 Novartis Ag Pré-polímeros com cadeias pendentes de polímero contendo polissiloxano
MX2009010109A (es) 2007-03-22 2009-10-12 Novartis Ag Prepolimeros que contienen silicona con cadenas polimericas hidrofilicas.
US8080622B2 (en) 2007-06-29 2011-12-20 Johnson & Johnson Vision Care, Inc. Soluble silicone prepolymers
ATE516940T1 (de) 2008-03-12 2011-08-15 Novartis Ag Gussformverfahren und gussform für kontaktlinsen
JP5460728B2 (ja) * 2008-11-13 2014-04-02 ノバルティス アーゲー 末端親水性ポリマー鎖を有するポリシロキサン共重合体
AU2009333223B2 (en) 2008-12-30 2012-02-23 Novartis Ag Tri-functional UV-absorbing compounds and use thereof
JP5784131B2 (ja) * 2010-10-06 2015-09-24 ノバルティス アーゲー ペンダント親水性基を持つ重合しうる鎖延長ポリシロキサン
BR112013008221B1 (pt) 2010-10-06 2020-02-11 Alcon Inc. Pré-polímero processável em água, lente de contato de hidrogel de silicone e seu método de fabricação
SG188507A1 (en) * 2010-10-06 2013-04-30 Novartis Ag Water-processable silicone-containing prepolymers and uses thereof

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US8835525B2 (en) 2014-09-16
US9052440B2 (en) 2015-06-09
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EP2625217A1 (en) 2013-08-14
EP2625217B1 (en) 2018-07-04
JP5640153B2 (ja) 2014-12-10
US20120088844A1 (en) 2012-04-12
CA2811013A1 (en) 2012-04-12
BR112013008221A2 (pt) 2016-06-21
BR112013008221B1 (pt) 2020-02-11
WO2012047964A1 (en) 2012-04-12

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