CA2735167A1 - Composition of asymmetric rna duplex as microrna mimetic or inhibitor - Google Patents

Composition of asymmetric rna duplex as microrna mimetic or inhibitor Download PDF

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Publication number
CA2735167A1
CA2735167A1 CA2735167A CA2735167A CA2735167A1 CA 2735167 A1 CA2735167 A1 CA 2735167A1 CA 2735167 A CA2735167 A CA 2735167A CA 2735167 A CA2735167 A CA 2735167A CA 2735167 A1 CA2735167 A1 CA 2735167A1
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Prior art keywords
mimetic
strand
inhibitor
nucleotides
mirna
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Abandoned
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CA2735167A
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English (en)
French (fr)
Inventor
Chiang Jia Li
Harry Rogoff
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Sumitomo Pharma Oncology Inc
Original Assignee
Boston Biomedical Inc
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Publication of CA2735167A1 publication Critical patent/CA2735167A1/en
Abandoned legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
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    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C12N2330/51—Specially adapted vectors

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  • Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Obesity (AREA)
CA2735167A 2007-08-27 2008-08-27 Composition of asymmetric rna duplex as microrna mimetic or inhibitor Abandoned CA2735167A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US96825707P 2007-08-27 2007-08-27
US60/968,257 2007-08-27
US2975308P 2008-02-19 2008-02-19
US61/029,753 2008-02-19
US3895408P 2008-03-24 2008-03-24
US61/038,954 2008-03-24
PCT/US2008/074531 WO2009029690A1 (en) 2007-08-27 2008-08-27 Composition of asymmetric rna duplex as microrna mimetic or inhibitor

Publications (1)

Publication Number Publication Date
CA2735167A1 true CA2735167A1 (en) 2009-03-05

Family

ID=40387778

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2735167A Abandoned CA2735167A1 (en) 2007-08-27 2008-08-27 Composition of asymmetric rna duplex as microrna mimetic or inhibitor
CA2735166A Active CA2735166C (en) 2007-08-27 2008-08-27 Compositions of asymmetric interfering rna and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2735166A Active CA2735166C (en) 2007-08-27 2008-08-27 Compositions of asymmetric interfering rna and uses thereof

Country Status (8)

Country Link
US (6) US9328345B2 (https=)
EP (4) EP2193140B1 (https=)
JP (7) JP2010537640A (https=)
CN (3) CN105018492B (https=)
CA (2) CA2735167A1 (https=)
DK (1) DK2193140T3 (https=)
ES (2) ES2617877T3 (https=)
WO (2) WO2009029688A2 (https=)

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