CA2703946A1 - Nouvelle classe d'agents therapeutiques qui ameliorent la diffusion des petites molecules - Google Patents
Nouvelle classe d'agents therapeutiques qui ameliorent la diffusion des petites molecules Download PDFInfo
- Publication number
- CA2703946A1 CA2703946A1 CA2703946A CA2703946A CA2703946A1 CA 2703946 A1 CA2703946 A1 CA 2703946A1 CA 2703946 A CA2703946 A CA 2703946A CA 2703946 A CA2703946 A CA 2703946A CA 2703946 A1 CA2703946 A1 CA 2703946A1
- Authority
- CA
- Canada
- Prior art keywords
- mammal
- enhancing compound
- diffusion enhancing
- diffusion
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US109507P | 2007-10-31 | 2007-10-31 | |
US61/001,095 | 2007-10-31 | ||
PCT/US2008/012440 WO2009058399A1 (fr) | 2007-10-31 | 2008-10-31 | Nouvelle classe d'agents thérapeutiques qui améliorent la diffusion des petites molécules |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2703946A1 true CA2703946A1 (fr) | 2009-05-07 |
Family
ID=40583148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2703946A Abandoned CA2703946A1 (fr) | 2007-10-31 | 2008-10-31 | Nouvelle classe d'agents therapeutiques qui ameliorent la diffusion des petites molecules |
Country Status (13)
Country | Link |
---|---|
US (2) | US8206751B2 (fr) |
EP (1) | EP2214714A4 (fr) |
JP (2) | JP2011502125A (fr) |
KR (1) | KR20100083820A (fr) |
CN (1) | CN101878040A (fr) |
AU (1) | AU2008319225B2 (fr) |
BR (1) | BRPI0818119A2 (fr) |
CA (1) | CA2703946A1 (fr) |
EA (1) | EA201070544A1 (fr) |
IL (1) | IL205417A0 (fr) |
MX (1) | MX2010004803A (fr) |
WO (1) | WO2009058399A1 (fr) |
ZA (1) | ZA201003475B (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
PL373780A1 (en) * | 2002-02-25 | 2005-09-19 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
EP1853544A4 (fr) | 2005-02-24 | 2010-06-16 | Diffusion Pharmaceuticals Llc | Transcarotenoides et leur synthese, leur preparation et leurs utilisations |
US8283337B2 (en) * | 2007-02-23 | 2012-10-09 | Next21 K.K. | Therapeutic or prophylactic agent for vasoconstriction |
AU2008246305B2 (en) | 2007-04-13 | 2013-03-21 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease |
US8206751B2 (en) | 2007-10-31 | 2012-06-26 | Diffusion Pharmaceuticals Llc | Class of therapeutics that enhance small molecule diffusion |
JP6076597B2 (ja) | 2008-08-09 | 2017-02-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 化粧品としてのインドール化合物の使用 |
EP2445339B1 (fr) | 2009-06-22 | 2019-08-07 | Diffusion Pharmaceuticals LLC | Composé améliorant la diffusion et son utilisation avec un thrombolytique |
ES2654945T3 (es) * | 2010-06-02 | 2018-02-15 | Diffusion Pharmaceuticals Llc | Formulaciones orales de carotenoides trans bipolares |
CN102372623A (zh) * | 2010-08-27 | 2012-03-14 | 江苏天晟药业有限公司 | 藏红花酸二铵盐 |
US20130323166A1 (en) * | 2010-09-10 | 2013-12-05 | William Beaumont Hospital | Radiation Therapy for Treating Alzheimer's Disease |
US20120171184A1 (en) * | 2010-12-31 | 2012-07-05 | Lajos Szente | Cellular hydration compositions |
CN103491981B (zh) | 2010-12-31 | 2017-11-10 | 东塘实验室有限公司 | 含有环糊精的细胞水合组合物 |
CN102210869B (zh) * | 2011-04-29 | 2012-07-25 | 山东弘立医学动物实验研究有限公司 | 四氢嘧啶及其衍生物在制备透皮吸收促进剂中的应用 |
CN102210868A (zh) * | 2011-04-29 | 2011-10-12 | 济南环肽医药科技有限公司 | 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用 |
CN102210685B (zh) * | 2011-04-29 | 2013-01-30 | 济南环肽医药科技有限公司 | 四氢嘧啶及其衍生物在制备预防和治疗化疗药物引发的口腔粘膜炎药物中的应用 |
CN102274238B (zh) * | 2011-06-30 | 2012-10-03 | 山东弘立医学动物实验研究有限公司 | 一种治疗胰腺癌的药物组合物 |
CN102847161A (zh) * | 2011-06-30 | 2013-01-02 | 山东弘立医学动物实验研究有限公司 | 四氢嘧啶及其衍生物在制备药物肺部收促进剂中的应用 |
CN102302498B (zh) * | 2011-08-22 | 2012-10-03 | 济南环肽医药科技有限公司 | 一种治疗肾炎的药物 |
GB201120772D0 (en) * | 2011-12-02 | 2012-01-11 | Ip Science Ltd | Cocoa-based food products |
US9084720B2 (en) | 2013-05-07 | 2015-07-21 | BioBlast Pharma Ltd. | Compositions and methods for treating oculopharyngeal muscular dystrophy |
AU2014264228A1 (en) | 2013-05-07 | 2015-11-12 | Bio Blast Pharma Ltd. | Treatment of protein aggregation myopathic and neurodegenerative diseases by parenteral administration of trehalose |
US20150345882A1 (en) * | 2014-06-03 | 2015-12-03 | Magpul Industries Corp | Compact anti-tilt follower for an ammunition magazine |
CN104069110A (zh) * | 2014-07-14 | 2014-10-01 | 济南环肽医药科技有限公司 | 四氢嘧啶及其衍生物在制备血容量扩充药物中的应用 |
CN109152839A (zh) * | 2016-03-24 | 2019-01-04 | 扩散药品有限公司 | 双极性反式类胡萝卜素连同化疗和放射治疗在治疗癌症中的用途 |
WO2018176098A1 (fr) | 2017-03-31 | 2018-10-04 | The Florey Institute Of Neuroscience And Mental Health | Prophylaxie et traitement d'un dysfonctionnement et d'un déclin cognitifs |
JP2017155046A (ja) * | 2017-04-05 | 2017-09-07 | イーストポンド・ラボラトリーズ・リミテッド | シクロデキストリンを含有する細胞水和組成物 |
EP3709975A4 (fr) | 2017-11-16 | 2021-09-22 | Aivita Biomedical, Inc. | Utilisation de facteurs de signalisation liés à une membrane cellulaire |
JP2019178154A (ja) * | 2019-06-18 | 2019-10-17 | イーストポンド・ラボラトリーズ・リミテッド | シクロデキストリンを含有する細胞水和組成物 |
CA3174816A1 (fr) | 2020-04-06 | 2021-10-14 | Lajos Szente | Compositions favorisant l'hydratation cellulaire |
KR102453320B1 (ko) | 2022-04-29 | 2022-10-11 | 장세진 | 유속 증가 기능을 갖는 수류터빈 및 이를 활용한 수류발전 시스템 |
WO2024006901A1 (fr) * | 2022-06-29 | 2024-01-04 | Diffusion Pharmaceuticals Llc | Utilisations de caroténoïdes trans bipolaires dans le traitement du cancer |
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CH522572A (de) | 1969-10-31 | 1972-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von Polyenverbindungen |
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IT1233303B (it) | 1989-06-07 | 1992-03-26 | Azionaria Costruzioni Acma Spa | Apparecchiatura per il convogliamento di prodotti |
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GB2353934A (en) * | 1999-09-09 | 2001-03-14 | British Sugar Plc | Nutritional compositions comprising trehalose for persons suffering from diabetes |
JP2001302517A (ja) * | 2000-04-24 | 2001-10-31 | Tokyo Univ Of Pharmacy & Life Science | 脳浮腫の予防治療薬 |
CA2355814C (fr) | 2000-09-14 | 2010-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Composition pharmaceutique pour utilisation ophthalmologique |
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-
2008
- 2008-10-31 US US12/289,713 patent/US8206751B2/en active Active
- 2008-10-31 BR BRPI0818119-5A patent/BRPI0818119A2/pt not_active IP Right Cessation
- 2008-10-31 CA CA2703946A patent/CA2703946A1/fr not_active Abandoned
- 2008-10-31 AU AU2008319225A patent/AU2008319225B2/en not_active Expired - Fee Related
- 2008-10-31 MX MX2010004803A patent/MX2010004803A/es not_active Application Discontinuation
- 2008-10-31 EP EP08844993A patent/EP2214714A4/fr not_active Withdrawn
- 2008-10-31 KR KR1020107010445A patent/KR20100083820A/ko active IP Right Grant
- 2008-10-31 EA EA201070544A patent/EA201070544A1/ru unknown
- 2008-10-31 CN CN2008801143109A patent/CN101878040A/zh active Pending
- 2008-10-31 JP JP2010531078A patent/JP2011502125A/ja not_active Ceased
- 2008-10-31 WO PCT/US2008/012440 patent/WO2009058399A1/fr active Application Filing
-
2010
- 2010-04-28 IL IL205417A patent/IL205417A0/en unknown
- 2010-05-17 ZA ZA2010/03475A patent/ZA201003475B/en unknown
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2012
- 2012-06-22 US US13/507,365 patent/US20130018014A1/en not_active Abandoned
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2015
- 2015-08-13 JP JP2015159872A patent/JP2016026156A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2011502125A (ja) | 2011-01-20 |
JP2016026156A (ja) | 2016-02-12 |
MX2010004803A (es) | 2010-09-09 |
EP2214714A1 (fr) | 2010-08-11 |
KR20100083820A (ko) | 2010-07-22 |
AU2008319225A1 (en) | 2009-05-07 |
US20090110746A1 (en) | 2009-04-30 |
ZA201003475B (en) | 2011-10-26 |
AU2008319225B2 (en) | 2016-09-29 |
US20130018014A1 (en) | 2013-01-17 |
BRPI0818119A2 (pt) | 2015-08-04 |
WO2009058399A1 (fr) | 2009-05-07 |
IL205417A0 (en) | 2010-12-30 |
EP2214714A4 (fr) | 2011-01-12 |
EA201070544A1 (ru) | 2010-12-30 |
CN101878040A (zh) | 2010-11-03 |
US8206751B2 (en) | 2012-06-26 |
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