CA2702257C - Broad spectrum beta-lactamase inhibitors - Google Patents

Broad spectrum beta-lactamase inhibitors Download PDF

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Publication number
CA2702257C
CA2702257C CA2702257A CA2702257A CA2702257C CA 2702257 C CA2702257 C CA 2702257C CA 2702257 A CA2702257 A CA 2702257A CA 2702257 A CA2702257 A CA 2702257A CA 2702257 C CA2702257 C CA 2702257C
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CA
Canada
Prior art keywords
group
beta
groups
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2702257A
Other languages
English (en)
French (fr)
Other versions
CA2702257A1 (en
Inventor
Larry Sutton
Sophia Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GLADIUS PHARMACEUTICALS Corp
Original Assignee
GLADIUS PHARMACEUTICALS Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GLADIUS PHARMACEUTICALS Corp filed Critical GLADIUS PHARMACEUTICALS Corp
Priority to CA2935651A priority Critical patent/CA2935651A1/en
Publication of CA2702257A1 publication Critical patent/CA2702257A1/en
Application granted granted Critical
Publication of CA2702257C publication Critical patent/CA2702257C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CA2702257A 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors Expired - Fee Related CA2702257C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2935651A CA2935651A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99789807P 2007-10-09 2007-10-09
US99794107P 2007-10-09 2007-10-09
US60/997,898 2007-10-09
US60/997,941 2007-10-09
PCT/US2008/079410 WO2009049086A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2935651A Division CA2935651A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Publications (2)

Publication Number Publication Date
CA2702257A1 CA2702257A1 (en) 2009-04-16
CA2702257C true CA2702257C (en) 2016-07-12

Family

ID=40549565

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2702257A Expired - Fee Related CA2702257C (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors
CA2935651A Abandoned CA2935651A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2935651A Abandoned CA2935651A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Country Status (5)

Country Link
US (6) US8883772B2 (enExample)
EP (1) EP2209474A4 (enExample)
JP (4) JP5733856B2 (enExample)
CA (2) CA2702257C (enExample)
WO (1) WO2009049086A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
CA2702257C (en) 2007-10-09 2016-07-12 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
HK1200096A1 (en) 2011-09-09 2015-07-31 Merck Sharp & Dohme Corp. Methods for treating intrapulmonary infections
ES2700575T3 (es) * 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
US20190100534A1 (en) * 2017-10-04 2019-04-04 Gladius Pharmaceuticals, Inc. Cephem Compounds with Latent Reactive Groups
EP3795149A4 (en) 2018-05-14 2022-01-05 National University Corporation Tokai National Higher Education and Research System BETA-LACTAMASE INHIBITOR
US11957690B2 (en) 2018-07-16 2024-04-16 Brown University Chromogenic beta-lactamase substrate
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
KR20250134233A (ko) * 2023-02-02 2025-09-10 에보포인트 바이오사이언시스 컴퍼니 리미티드 β-락타마제 억제제를 함유하는 약제학적 조성물 및 이의 용도

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WO2013051597A1 (ja) 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas

Also Published As

Publication number Publication date
CA2935651A1 (en) 2009-04-16
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US10000509B2 (en) 2018-06-19
US20160362422A1 (en) 2016-12-15
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US20170327515A1 (en) 2017-11-16
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CA2702257A1 (en) 2009-04-16
US9862729B2 (en) 2018-01-09
US9453032B2 (en) 2016-09-27
US20090131394A1 (en) 2009-05-21
EP2209474A1 (en) 2010-07-28
US20150011524A1 (en) 2015-01-08
US8883772B2 (en) 2014-11-11
US20180065989A1 (en) 2018-03-08
US20180273549A1 (en) 2018-09-27
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US10239890B2 (en) 2019-03-26

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