CA2634379C - Treatment of type 2 diabetes with a combination of dpiv inhibitor and metformin or thiazolidinedione - Google Patents

Treatment of type 2 diabetes with a combination of dpiv inhibitor and metformin or thiazolidinedione Download PDF

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Publication number
CA2634379C
CA2634379C CA2634379A CA2634379A CA2634379C CA 2634379 C CA2634379 C CA 2634379C CA 2634379 A CA2634379 A CA 2634379A CA 2634379 A CA2634379 A CA 2634379A CA 2634379 C CA2634379 C CA 2634379C
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CA
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Prior art keywords
dpiv inhibitor
metformin
thiazolidinedione
dpiv
diabetes
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CA2634379A
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English (en)
French (fr)
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CA2634379A1 (en
Inventor
Jonathan Rachman
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Royalty Pharma Collection Trust
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Royalty Pharma Collection Trust
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Application filed by Royalty Pharma Collection Trust filed Critical Royalty Pharma Collection Trust
Publication of CA2634379A1 publication Critical patent/CA2634379A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2634379A 2005-12-23 2006-12-22 Treatment of type 2 diabetes with a combination of dpiv inhibitor and metformin or thiazolidinedione Active CA2634379C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0526291.0A GB0526291D0 (en) 2005-12-23 2005-12-23 Therapeutic method
GB0526291.0 2005-12-23
PCT/GB2006/050475 WO2007072083A1 (en) 2005-12-23 2006-12-22 Treatment of type 2 diabetes with a combination of dpiv inhibitor and metformin or thiazolidinedione

Publications (2)

Publication Number Publication Date
CA2634379A1 CA2634379A1 (en) 2007-06-28
CA2634379C true CA2634379C (en) 2014-05-20

Family

ID=35841111

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2634379A Active CA2634379C (en) 2005-12-23 2006-12-22 Treatment of type 2 diabetes with a combination of dpiv inhibitor and metformin or thiazolidinedione

Country Status (27)

Country Link
US (3) US20100216800A1 (cg-RX-API-DMAC10.html)
EP (1) EP1965783B1 (cg-RX-API-DMAC10.html)
JP (2) JP2009520801A (cg-RX-API-DMAC10.html)
KR (1) KR20080080220A (cg-RX-API-DMAC10.html)
CN (1) CN101365434A (cg-RX-API-DMAC10.html)
AU (1) AU2006327974B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0620450A2 (cg-RX-API-DMAC10.html)
CA (1) CA2634379C (cg-RX-API-DMAC10.html)
CY (1) CY1114401T1 (cg-RX-API-DMAC10.html)
DK (1) DK1965783T3 (cg-RX-API-DMAC10.html)
EA (1) EA017084B1 (cg-RX-API-DMAC10.html)
ES (1) ES2427822T3 (cg-RX-API-DMAC10.html)
GB (1) GB0526291D0 (cg-RX-API-DMAC10.html)
HR (1) HRP20130880T1 (cg-RX-API-DMAC10.html)
IL (1) IL192257A0 (cg-RX-API-DMAC10.html)
MA (1) MA30085B1 (cg-RX-API-DMAC10.html)
MX (1) MX2008008250A (cg-RX-API-DMAC10.html)
NO (1) NO20082790L (cg-RX-API-DMAC10.html)
NZ (1) NZ569427A (cg-RX-API-DMAC10.html)
PL (1) PL1965783T3 (cg-RX-API-DMAC10.html)
PT (1) PT1965783E (cg-RX-API-DMAC10.html)
RS (1) RS52942B (cg-RX-API-DMAC10.html)
SG (1) SG186610A1 (cg-RX-API-DMAC10.html)
SI (1) SI1965783T1 (cg-RX-API-DMAC10.html)
UA (1) UA100111C2 (cg-RX-API-DMAC10.html)
WO (1) WO2007072083A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200806200B (cg-RX-API-DMAC10.html)

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US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013148130A1 (en) * 2012-03-29 2013-10-03 Oklahoma Medical Research Foundation Inhibition of memapsin 1 cleavage in the treatment of diabetes
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US20160279105A1 (en) 2016-09-29
US20100216800A1 (en) 2010-08-26
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RS52942B (sr) 2014-02-28
CN101365434A (zh) 2009-02-11
UA100111C2 (ru) 2012-11-26
EA017084B1 (ru) 2012-09-28
WO2007072083A1 (en) 2007-06-28
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US20140051734A1 (en) 2014-02-20
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PT1965783E (pt) 2013-08-27
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