CA2624333A1 - Compounds and methods for inhibiting hepatitis c viral replication - Google Patents
Compounds and methods for inhibiting hepatitis c viral replication Download PDFInfo
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- CA2624333A1 CA2624333A1 CA002624333A CA2624333A CA2624333A1 CA 2624333 A1 CA2624333 A1 CA 2624333A1 CA 002624333 A CA002624333 A CA 002624333A CA 2624333 A CA2624333 A CA 2624333A CA 2624333 A1 CA2624333 A1 CA 2624333A1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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US60/725,564 | 2005-10-11 | ||
PCT/US2006/040049 WO2007044893A2 (en) | 2005-10-11 | 2006-10-10 | Compounds and methods for inhibiting hepatitis c viral replication |
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CA2624333A1 true CA2624333A1 (en) | 2007-04-19 |
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CA002624333A Abandoned CA2624333A1 (en) | 2005-10-11 | 2006-10-10 | Compounds and methods for inhibiting hepatitis c viral replication |
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US (1) | US8119592B2 (lt) |
EP (1) | EP1999129B1 (lt) |
JP (1) | JP2009511595A (lt) |
KR (1) | KR20080056295A (lt) |
CN (1) | CN101415705B (lt) |
AT (1) | ATE493409T1 (lt) |
AU (1) | AU2006301966A1 (lt) |
BR (1) | BRPI0617274A2 (lt) |
CA (1) | CA2624333A1 (lt) |
CU (1) | CU23781B7 (lt) |
DE (1) | DE602006019323D1 (lt) |
DK (1) | DK1999129T3 (lt) |
EA (1) | EA200801050A1 (lt) |
EC (1) | ECSP088437A (lt) |
ES (1) | ES2356776T3 (lt) |
GE (1) | GEP20104956B (lt) |
HK (1) | HK1125360A1 (lt) |
IL (1) | IL190404A0 (lt) |
MA (1) | MA29924B1 (lt) |
MX (1) | MX2008004754A (lt) |
NI (1) | NI200800114A (lt) |
NO (1) | NO20081999L (lt) |
NZ (1) | NZ568135A (lt) |
TN (1) | TNSN08160A1 (lt) |
UA (1) | UA93990C2 (lt) |
WO (1) | WO2007044893A2 (lt) |
ZA (1) | ZA200803797B (lt) |
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JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
EP2305697A3 (en) * | 2005-07-25 | 2011-07-27 | Intermune, Inc. | Macrocyclic inhibitors of Hepatitis C virus replication |
DE602006019323D1 (de) | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
KR101512477B1 (ko) | 2006-07-13 | 2015-04-15 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서 사용되는 4-아미노-4-옥소부타노일 펩티드 |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
AU2008205116A1 (en) * | 2007-01-08 | 2008-07-17 | Phenomix Corporation | Macrocyclic hepatitis C protease inhibitors |
CA2679377A1 (en) | 2007-02-26 | 2008-09-04 | Achillion Pharmaceuticals, Inc. | Tertiary amine substituted peptides useful as inhibitors of hcv replication |
US20090155209A1 (en) * | 2007-05-03 | 2009-06-18 | Blatt Lawrence M | Novel macrocyclic inhibitors of hepatitis c virus replication |
AU2008251425A1 (en) | 2007-05-10 | 2008-11-20 | Array Biopharma, Inc. | Novel peptide inhibitors of hepatitis C virus replication |
RU2523790C2 (ru) | 2007-12-21 | 2014-07-27 | Авила Терапьютикс, Инк. | Ингибиторы протеазы вируса гепатита с и их применение |
US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
RU2515318C2 (ru) | 2007-12-21 | 2014-05-10 | Авила Терапьютикс, Инк. | Ингибиторы протеазы вируса гепатита с и их применение |
US8309685B2 (en) | 2007-12-21 | 2012-11-13 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
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EP2300491B1 (en) | 2008-05-29 | 2016-01-06 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
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ES2356776T3 (es) | 2011-04-13 |
EA200801050A1 (ru) | 2008-12-30 |
EP1999129B1 (en) | 2010-12-29 |
GEP20104956B (en) | 2010-04-12 |
DE602006019323D1 (de) | 2011-02-10 |
MX2008004754A (es) | 2009-03-02 |
ZA200803797B (en) | 2009-03-25 |
CN101415705B (zh) | 2011-10-26 |
CU20080057A7 (es) | 2009-12-01 |
ECSP088437A (es) | 2008-06-30 |
BRPI0617274A2 (pt) | 2011-07-19 |
IL190404A0 (en) | 2008-11-03 |
NO20081999L (no) | 2008-07-11 |
NZ568135A (en) | 2011-06-30 |
CN101415705A (zh) | 2009-04-22 |
US20090093533A1 (en) | 2009-04-09 |
DK1999129T3 (da) | 2011-02-07 |
CU23781B7 (es) | 2012-02-15 |
MA29924B1 (fr) | 2008-11-03 |
WO2007044893A3 (en) | 2008-10-02 |
UA93990C2 (ru) | 2011-03-25 |
WO2007044893A2 (en) | 2007-04-19 |
HK1125360A1 (en) | 2009-08-07 |
NI200800114A (es) | 2010-09-06 |
AU2006301966A1 (en) | 2007-04-19 |
JP2009511595A (ja) | 2009-03-19 |
KR20080056295A (ko) | 2008-06-20 |
US8119592B2 (en) | 2012-02-21 |
TNSN08160A1 (en) | 2009-10-30 |
ATE493409T1 (de) | 2011-01-15 |
EP1999129A2 (en) | 2008-12-10 |
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