CA2607276C - Sclerostin fragments and anti-sclerostin antibodies - Google Patents
Sclerostin fragments and anti-sclerostin antibodies Download PDFInfo
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- CA2607276C CA2607276C CA2607276A CA2607276A CA2607276C CA 2607276 C CA2607276 C CA 2607276C CA 2607276 A CA2607276 A CA 2607276A CA 2607276 A CA2607276 A CA 2607276A CA 2607276 C CA2607276 C CA 2607276C
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
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- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Jellies, Jams, And Syrups (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
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| US67758305P | 2005-05-03 | 2005-05-03 | |
| US60/677,583 | 2005-05-03 | ||
| US77684706P | 2006-02-24 | 2006-02-24 | |
| US60/776,847 | 2006-02-24 | ||
| US78224406P | 2006-03-13 | 2006-03-13 | |
| US60/782,244 | 2006-03-13 | ||
| US79264506P | 2006-04-17 | 2006-04-17 | |
| US60/792,645 | 2006-04-17 | ||
| US11/410,540 | 2006-04-25 | ||
| US11/410,540 US8003108B2 (en) | 2005-05-03 | 2006-04-25 | Sclerostin epitopes |
| PCT/US2006/016345 WO2006119062A2 (en) | 2005-05-03 | 2006-04-28 | Sclerostin epitopes |
Publications (2)
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| CA2607276A1 CA2607276A1 (en) | 2006-11-09 |
| CA2607276C true CA2607276C (en) | 2016-08-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2607276A Active CA2607276C (en) | 2005-05-03 | 2006-04-28 | Sclerostin fragments and anti-sclerostin antibodies |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8003108B2 (member.php) |
| EP (6) | EP1891100A2 (member.php) |
| JP (7) | JP5680823B2 (member.php) |
| CA (1) | CA2607276C (member.php) |
| CY (2) | CY1118977T1 (member.php) |
| DK (2) | DK2301961T4 (member.php) |
| ES (5) | ES2624643T5 (member.php) |
| FI (2) | FI2301961T4 (member.php) |
| HR (2) | HRP20170679T4 (member.php) |
| HU (2) | HUE032092T2 (member.php) |
| LT (2) | LT2301961T (member.php) |
| MX (1) | MX348432B (member.php) |
| MY (1) | MY174493A (member.php) |
| PL (2) | PL2301961T5 (member.php) |
| PT (2) | PT2251351T (member.php) |
| SI (2) | SI2251351T2 (member.php) |
| WO (1) | WO2006119062A2 (member.php) |
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| HK1044171B (zh) | 1998-11-27 | 2016-03-24 | Ucb Pharma S.A. | 增加骨矿化的组合物和方法 |
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| US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
| US7585501B2 (en) | 2002-06-14 | 2009-09-08 | Stowers Institute For Medical Research | Compositions and methods for treating kidney disease |
| AU2004262640B2 (en) | 2003-06-16 | 2010-12-23 | Ucb Manufacturing, Inc. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
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| US8883162B2 (en) | 2005-10-19 | 2014-11-11 | Ibc Pharmaceuticals, Inc. | Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors |
| US9862770B2 (en) | 2005-10-19 | 2018-01-09 | Ibc Pharmaceuticals, Inc. | Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors |
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| EP4176884A1 (en) * | 2006-12-29 | 2023-05-10 | Ossifi-Mab LLC | Methods of altering bone growth by administration of sost or wise antagonist or agonist |
| WO2008101234A2 (en) * | 2007-02-16 | 2008-08-21 | Sloan-Kettering Institute For Cancer Research | Anti ganglioside gd3 antibodies and uses thereof |
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