HRP20170679T4 - Epitopi sklerostina - Google Patents
Epitopi sklerostina Download PDFInfo
- Publication number
- HRP20170679T4 HRP20170679T4 HRP20170679TT HRP20170679T HRP20170679T4 HR P20170679 T4 HRP20170679 T4 HR P20170679T4 HR P20170679T T HRP20170679T T HR P20170679TT HR P20170679 T HRP20170679 T HR P20170679T HR P20170679 T4 HRP20170679 T4 HR P20170679T4
- Authority
- HR
- Croatia
- Prior art keywords
- polypeptide
- monoclonal antibody
- segments
- bone
- antibody according
- Prior art date
Links
- 102000019307 Sclerostin Human genes 0.000 title 1
- 108050006698 Sclerostin Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 210000000988 bone and bone Anatomy 0.000 claims 6
- 101000711796 Homo sapiens Sclerostin Proteins 0.000 claims 5
- 102000058171 human SOST Human genes 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 230000035876 healing Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 2
- 239000011707 mineral Substances 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 230000037118 bone strength Effects 0.000 claims 1
- 229940096384 chicken egg white lysozyme Drugs 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 238000000132 electrospray ionisation Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000004007 reversed phase HPLC Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Claims (8)
1. Monoklonsko protutijelo veže se za humani sklerostin s disocijacijskom konstantom manjom ili jednakom od 1 x 10-9 M kako je izmjereno površinskom plazmonskom rezonancijom; povećava barem jednu formaciju kosti, mineralnu gustoću kosti, mineralni sastav kosti, koštanu masu, kvalitetu kosti i jačinu kosti kod sisavca; i veže se za polipeptid koji je imunogeni dio humanog sklerostina koji se može dobiti metodom koja obuhvaća sljedeće korake:
a) tretiranje ljudskog sklerostina da se postigne potpuna triptička digestija;
b) prikupljanje uzorka triptičke digestije prosječne molekularne težine 7,122.0 Daltona (teorijska masa 7121.5 Daltona) kako je određeno masenom spektrometrijom tekućinske kromatografije s ionizacijom u elektrospreju ili retencijskim vremenom od oko 20.6 minuta kako je određeno eluiranjem s reverzno-fazne HPLC kolone s linearnim gradijentom od 0.05% trifluoroctetne kiseline (TFO) do 90% acetonitrila u 0.05% TFK pri brzini protoka od 0.2 ml/min; i
c) pročišćavanje imunogenog dijela.
2. Monoklonsko protutijelo prema patentnom zahtjevu 1, naznačeno time, da se veže na polipeptide T20, T20.6, T21-22 i N22.7-23.5 te ima minimalno detektabilno vezanje za polipeptide T19.2, N14.6 i N18.6,
pri čemu polipeptid T20 ima odsječke DVSEYSCREL HFTRYVTDGP CRSAKPVTEL VCSGQCGPAR i PSGPDFR CIPDRYRAQR VQLLCPGGEA PRARKVRLVA SCKCKRLT R;
pri čemu polipeptid T20.6 ima odsječke DVSEYSCREL HFTR, WWRPSGPPFR CIPDRYR, SAKPVTELVC SGQCGPAR i LVASCKCKRL TR;
pri čemu polipeptid T21-22 ima odsječke DVSEYSCREL HFTRYVTDGP CRSAKPVTEL VCSGQCGPAR i WWRPSGPDFR CIPDRYRAQR VQLLCPGGEA PRARKVRLVA SCKCKRLTR;
pri čemu polipeptid N22.7-23.5 ima odsječke DVSEYSCREL HFTRYVTDGP CRSAKPVTEL VCSGQCGPAR LLPNAIGRGK WWRPSGPDFR CIPDRYRAQR VQLLCPGGEA PRARKVRLVA SCKCKRLTRF HNQS;
pri čemu polipeptid T19.2 ima odsječke YVTDGP CR i VQLLCPGGEA PR;
pri čemu polipeptid N14.6 ima odsječke ENGGRPPHHPF, EIIPELGFYP EPPP i DFGTEAARPQ KGRKPRPRAR SAKANQA; i
pri čemu polipeptid N18.6 ima odsječke DATEIIPELG EYPEPPPELE NNKTMNRAEN GGRPPHHPFE TK.
3. Monoklonsko protutijelo prema patentnom zahtjevu 1 ili 2, naznačeno time, da je fragment F(ab')2, Fab, Fab' ili Fv.
4. Monoklonsko protutijelo prema bilo kojem od patentnih zahtjeva 1 do 3, naznačeno time, daje humanizirano protutijelo ili humano protutijelo.
5. Monoklonsko protutijelo prema bilo kojem od patentnih zahtjeva 1 do 4, naznačeno time, da se veže za humani sklerostin s disocijacijskom konstantom manjom od ili jednakom 1 x 10-10 M, manjom od ili jednakom 1 x 10~11 M ili koja je manja od ili jednaka 1 x 10-12 M.
6. Monoklonsko protutijelo prema bilo kojem od patentnih zahtjeva 1 do 5, naznačeno time, da se veže za humani sklerostin s afinitetom, kako je izmjereno površinskom plazmonskom rezonancijom, koja je najmanje 50, 100, 250, 500, 1000 ili 10,000 puta veća od afiniteta za lizozim kokošjeg bjelanjka.
7. Monoklonsko protutijelo prema bilo kojem od patentnih zahtjeva 1 do 6, naznačeno time, da je za uporabu u liječenju osteoporoze ili osteopenije.
8. Monoklonsko protutijelo prema bilo kojem od patentnih zahtjeva 1 do 6, naznačeno time, da je za uporabu u poboljšavanju ishoda kod ortopedskih procedura, zubnih procedura, operacija usadka, zamjene zglobova, presađivanja kosti, kozmetičke operacije kosti ili reparacije poput liječenja loma, zacjeljivanja bez srastanja, zakašnjelog zacjeljivanja ili rekonstrukcije lica.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67758305P | 2005-05-03 | 2005-05-03 | |
US77684706P | 2006-02-24 | 2006-02-24 | |
US78224406P | 2006-03-13 | 2006-03-13 | |
US79264506P | 2006-04-17 | 2006-04-17 | |
US11/410,540 US8003108B2 (en) | 2005-05-03 | 2006-04-25 | Sclerostin epitopes |
EP10014373.4A EP2301961B9 (en) | 2005-05-03 | 2006-04-28 | Sclerostin epitopes |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20170679T1 HRP20170679T1 (hr) | 2017-07-14 |
HRP20170679T4 true HRP20170679T4 (hr) | 2023-10-13 |
Family
ID=36956127
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170514TT HRP20170514T4 (hr) | 2005-05-03 | 2006-04-28 | Epitopi sklerostina |
HRP20170679TT HRP20170679T4 (hr) | 2005-05-03 | 2006-04-28 | Epitopi sklerostina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170514TT HRP20170514T4 (hr) | 2005-05-03 | 2006-04-28 | Epitopi sklerostina |
Country Status (17)
Country | Link |
---|---|
US (3) | US8003108B2 (hr) |
EP (6) | EP2251351B2 (hr) |
JP (7) | JP5680823B2 (hr) |
CA (1) | CA2607276C (hr) |
CY (2) | CY1118977T1 (hr) |
DK (2) | DK2251351T4 (hr) |
ES (5) | ES2624643T5 (hr) |
FI (2) | FI2251351T4 (hr) |
HR (2) | HRP20170514T4 (hr) |
HU (2) | HUE033718T2 (hr) |
LT (2) | LT2251351T (hr) |
MX (1) | MX348432B (hr) |
MY (1) | MY174493A (hr) |
PL (2) | PL2301961T5 (hr) |
PT (2) | PT2301961T (hr) |
SI (2) | SI2251351T2 (hr) |
WO (1) | WO2006119062A2 (hr) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
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IL143266A0 (en) | 1998-11-27 | 2002-04-21 | Darwin Discovery Ltd | Transforming growth factor-beta binding proteins and pharmaceutical compositions for increasing bone mineral content utilizing the same |
US7585501B2 (en) | 2002-06-14 | 2009-09-08 | Stowers Institute For Medical Research | Compositions and methods for treating kidney disease |
US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
WO2003106657A2 (en) | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
WO2005014650A2 (en) * | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
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US8883162B2 (en) | 2005-10-19 | 2014-11-11 | Ibc Pharmaceuticals, Inc. | Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors |
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EP2241332A4 (en) | 2007-12-05 | 2011-01-26 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT AGAINST PRITURE |
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MY195714A (en) | 2008-04-11 | 2023-02-07 | Chugai Pharmaceutical Co Ltd | Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly |
JP2012501178A (ja) * | 2008-08-26 | 2012-01-19 | マクロジェニクス,インコーポレーテッド | T細胞受容体抗体およびその使用方法 |
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