MX2020002301A - Terapia de combinacion de anticuerpos anti receptor del factor estimulante de colonias 1 (csf1r) y anti proteina de muerte programada 1 (pd-1) combinados para cancer pancreatico. - Google Patents
Terapia de combinacion de anticuerpos anti receptor del factor estimulante de colonias 1 (csf1r) y anti proteina de muerte programada 1 (pd-1) combinados para cancer pancreatico.Info
- Publication number
- MX2020002301A MX2020002301A MX2020002301A MX2020002301A MX2020002301A MX 2020002301 A MX2020002301 A MX 2020002301A MX 2020002301 A MX2020002301 A MX 2020002301A MX 2020002301 A MX2020002301 A MX 2020002301A MX 2020002301 A MX2020002301 A MX 2020002301A
- Authority
- MX
- Mexico
- Prior art keywords
- combination
- csf1r
- pancreatic cancer
- antibody
- combination therapy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C07K2317/565—Complementarity determining region [CDR]
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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Abstract
La presente invención se refiere a métodos para tratar el cáncer de páncreas con regímenes de dosificación particulares de anticuerpos que se unen al receptor del factor estimulante de colonias 1 (CSF1R) (por ejemplo, cabiralizumab) en combinación con anticuerpos que se unen a la muerte celular programada 1 (PD-1) (por ejemplo, nivolumab).
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762558161P | 2017-09-13 | 2017-09-13 | |
US201762580154P | 2017-11-01 | 2017-11-01 | |
US201762581962P | 2017-11-06 | 2017-11-06 | |
US201862671887P | 2018-05-15 | 2018-05-15 | |
US201862679612P | 2018-06-01 | 2018-06-01 | |
PCT/US2018/050711 WO2019055537A1 (en) | 2017-09-13 | 2018-09-12 | ANTI-CSF1R AND ANTI-PD -1 ANTIBODY POLYTHERAPY FOR PANCREATIC CANCER |
Publications (1)
Publication Number | Publication Date |
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MX2020002301A true MX2020002301A (es) | 2020-07-13 |
Family
ID=63708492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020002301A MX2020002301A (es) | 2017-09-13 | 2018-09-12 | Terapia de combinacion de anticuerpos anti receptor del factor estimulante de colonias 1 (csf1r) y anti proteina de muerte programada 1 (pd-1) combinados para cancer pancreatico. |
Country Status (12)
Country | Link |
---|---|
US (2) | US11421034B2 (es) |
EP (1) | EP3681535A1 (es) |
JP (2) | JP2020535119A (es) |
KR (1) | KR20200051024A (es) |
CN (1) | CN111479586A (es) |
AU (1) | AU2018334171A1 (es) |
BR (1) | BR112020004879A2 (es) |
CA (1) | CA3073531A1 (es) |
IL (1) | IL272669A (es) |
MX (1) | MX2020002301A (es) |
SG (1) | SG11202001606XA (es) |
WO (1) | WO2019055537A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022534982A (ja) * | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
KR20210100457A (ko) * | 2020-02-06 | 2021-08-17 | 아주대학교산학협력단 | 케모카인 억제제, 콜로니 자극 인자 억제제 및 면역항암제를 포함하는 암의 예방 또는 치료용 조성물 및 병용 요법 |
US20230184771A1 (en) * | 2020-04-21 | 2023-06-15 | Board Of Regents, The University Of Texas System | Methods for treating bladder cancer |
EP4112746A1 (en) * | 2021-07-02 | 2023-01-04 | STRATIFYER Molecular Pathology GmbH | Method for predicting a clinical response towards an immune checkpoint inhibitor based on pretreatment therewith |
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2018
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- 2018-09-12 MX MX2020002301A patent/MX2020002301A/es unknown
- 2018-09-12 CN CN201880058749.8A patent/CN111479586A/zh active Pending
- 2018-09-12 EP EP18779538.0A patent/EP3681535A1/en active Pending
- 2018-09-12 KR KR1020207010187A patent/KR20200051024A/ko not_active Application Discontinuation
- 2018-09-12 CA CA3073531A patent/CA3073531A1/en active Pending
- 2018-09-12 BR BR112020004879-8A patent/BR112020004879A2/pt unknown
- 2018-09-12 WO PCT/US2018/050711 patent/WO2019055537A1/en unknown
- 2018-09-12 SG SG11202001606XA patent/SG11202001606XA/en unknown
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2020
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JP2020535119A (ja) | 2020-12-03 |
US20210009697A1 (en) | 2021-01-14 |
US20230192870A1 (en) | 2023-06-22 |
KR20200051024A (ko) | 2020-05-12 |
CN111479586A (zh) | 2020-07-31 |
WO2019055537A1 (en) | 2019-03-21 |
IL272669A (en) | 2020-03-31 |
CA3073531A1 (en) | 2019-03-21 |
EP3681535A1 (en) | 2020-07-22 |
JP2023093514A (ja) | 2023-07-04 |
BR112020004879A2 (pt) | 2020-09-15 |
US11421034B2 (en) | 2022-08-23 |
SG11202001606XA (en) | 2020-03-30 |
AU2018334171A1 (en) | 2020-03-05 |
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