CA2542116C - Cell culture methods and devices utilizing gas permeable materials - Google Patents

Cell culture methods and devices utilizing gas permeable materials Download PDF

Info

Publication number
CA2542116C
CA2542116C CA2542116A CA2542116A CA2542116C CA 2542116 C CA2542116 C CA 2542116C CA 2542116 A CA2542116 A CA 2542116A CA 2542116 A CA2542116 A CA 2542116A CA 2542116 C CA2542116 C CA 2542116C
Authority
CA
Canada
Prior art keywords
medium
gas permeable
cell culture
cells
resides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2542116A
Other languages
English (en)
French (fr)
Other versions
CA2542116A1 (en
Inventor
John R. Wilson
Douglas A. Page
Dan Welch
Alison Robeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wilson Wolf Manufacturing LLC
Original Assignee
Wilson Wolf Manufacturing LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34435003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2542116(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wilson Wolf Manufacturing LLC filed Critical Wilson Wolf Manufacturing LLC
Publication of CA2542116A1 publication Critical patent/CA2542116A1/en
Application granted granted Critical
Publication of CA2542116C publication Critical patent/CA2542116C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/08Flask, bottle or test tube
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/24Gas permeable parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06Plates; Walls; Drawers; Multilayer plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2542116A 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials Expired - Lifetime CA2542116C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50965103P 2003-10-08 2003-10-08
US60/509,651 2003-10-08
PCT/US2004/033297 WO2005035728A2 (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials

Publications (2)

Publication Number Publication Date
CA2542116A1 CA2542116A1 (en) 2005-04-21
CA2542116C true CA2542116C (en) 2015-01-27

Family

ID=34435003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2542116A Expired - Lifetime CA2542116C (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials

Country Status (7)

Country Link
US (9) US9255243B2 (https=)
EP (4) EP2336293B1 (https=)
JP (5) JP2007511205A (https=)
CN (2) CN101120083B (https=)
AU (4) AU2004280623B2 (https=)
CA (1) CA2542116C (https=)
WO (1) WO2005035728A2 (https=)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101120083B (zh) 2003-10-08 2013-03-27 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
US7323024B2 (en) * 2003-12-10 2008-01-29 Babcock & Wilcox Technical Services Y-12, Llc Vessel with filter and method of use
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9376658B2 (en) 2008-01-03 2016-06-28 Emd Millipore Corporation Cell culture array system for automated assays and methods of operation and manufacture thereof
WO2007008609A2 (en) 2005-07-07 2007-01-18 The Regents Of The University Of California Methods and apparatus for cell culture array
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
JP2007097407A (ja) * 2005-09-30 2007-04-19 Espec Corp 細胞製造方法及び細胞培養装置
DE102006004157A1 (de) * 2006-01-30 2007-08-02 Eppendorf Ag Vorrichtung und Verfahren zum Inkubieren von Zellen
US7745210B2 (en) * 2006-06-30 2010-06-29 Corning Incorporated Fluid flow diverter for cell culture vessel
US9175254B2 (en) * 2006-07-07 2015-11-03 University Of Miami Enhanced oxygen cell culture platforms
EP2044192B1 (en) * 2006-07-07 2017-04-12 University of Miami Enhanced oxygen cell culture platforms
US8486692B2 (en) * 2006-11-14 2013-07-16 Acme Biosystems Llc Cell culture apparatus and associated methods
US20080131959A1 (en) * 2006-11-15 2008-06-05 Millipore Corporation Bioreactor construction
AU2007332869B2 (en) 2006-12-07 2012-10-11 Wilson Wolf Manufacturing, LLC Highly efficient gas permeable devices and methods for culturing cells
US7897379B2 (en) * 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US9309491B2 (en) * 2007-05-29 2016-04-12 Corning Incorporated Cell culture apparatus for co-culture of cells
US8999703B2 (en) 2008-05-05 2015-04-07 Daniel P. Welch Cell container
CA2722907C (en) * 2008-05-05 2016-07-12 Wilson Wolf Manufacturing Corporation Cell container
US8216828B2 (en) * 2008-05-30 2012-07-10 Corning Incorporated Assembly of cell culture vessels
US8518692B2 (en) * 2008-07-08 2013-08-27 Wilson Wolf Manufacturing Corporation Gas permeable cell culture device and method of use
ES2733631T3 (es) * 2008-07-16 2019-12-02 Emd Millipore Corp Un sistema de cultivo celular de múltiples niveles
EP2344622B1 (en) * 2008-10-08 2017-12-20 Agency for Science, Technology And Research Apparatus for culturing anchorage dependent cells
JP2012506257A (ja) * 2008-10-22 2012-03-15 バイオベスト インターナショナル インコーポレイテッド 細胞および細胞由来生成物の産生のための、灌流バイオリアクター、細胞培養システム、および方法
AU2010242985B2 (en) * 2009-04-29 2015-06-18 Biolife Solutions, Inc. Apparatuses and compositions for cryopreservation of cellular monolayers
US10287539B2 (en) * 2009-06-09 2019-05-14 Jtec Corporation Rotating culture vessel and automatic cell culture apparatus using same
US8778669B2 (en) * 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
EP3101122B1 (en) * 2009-08-24 2023-06-14 Baylor College of Medicine Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses
US8809050B2 (en) * 2009-12-08 2014-08-19 Wilson Wolf Manufacturing Methods of cell culture for adoptive cell therapy
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US9554888B2 (en) * 2010-04-20 2017-01-31 University Of Utah Research Foundation Phase separation sprayed scaffold
KR20130109000A (ko) 2010-05-11 2013-10-07 아르텔리스 에스에이 세포 배양 장치 및 방법
EP2627762A4 (en) 2010-10-12 2017-02-15 Nalge Nunc International Corporation Cell culture device
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
US9434924B2 (en) * 2011-04-21 2016-09-06 Nipro Corporation Cell culture method and cell culture kit
AU2012324644B2 (en) * 2011-10-21 2014-08-28 Cell Medica Limited Device for the aseptic expansion of cells
JP6232383B2 (ja) 2011-12-03 2017-11-15 イー・エム・デイー・ミリポア・コーポレイシヨン マイクロ流体の細胞培養のためのマイクロインキュベーションシステムおよび方法
GB201121308D0 (en) * 2011-12-12 2012-01-25 Cell Medica Ltd Process
CN104769104A (zh) 2011-12-12 2015-07-08 细胞药物有限公司 扩大t细胞的方法
JP5662927B2 (ja) * 2011-12-22 2015-02-04 株式会社日立製作所 包装容器
PT2812431T (pt) 2012-02-09 2019-10-18 Baylor College Medicine Pepmixes para gerar ctls multivirais com larga especifidade
CN102643744A (zh) * 2012-04-18 2012-08-22 广州洁特生物过滤制品有限公司 一种高通量细胞培养器及其制造方法
SG11201407226WA (en) * 2012-05-18 2014-12-30 Wolf Wilson Mfg Corp Improved methods of cell culture for adoptive cell therapy
JP5981653B2 (ja) * 2012-08-06 2016-08-31 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 無菌条件下の植物の大規模成長のためのバイオリアクタ容器
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
US9790465B2 (en) 2013-04-30 2017-10-17 Corning Incorporated Spheroid cell culture well article and methods thereof
CN118562610A (zh) * 2013-06-24 2024-08-30 威尔逊沃夫制造公司 用于透气性细胞培养过程的封闭系统装置和方法
CN105593362B (zh) * 2013-09-23 2021-09-10 威尔逊沃夫制造公司 遗传修饰动物细胞的改进方法
WO2015157636A1 (en) 2014-04-10 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy
US11078455B2 (en) * 2014-06-09 2021-08-03 Seiichi YOKOO Closed culture vessel for adherent cells
JP2016077164A (ja) * 2014-10-10 2016-05-16 大日本印刷株式会社 細胞培養容器
EP3212759A1 (en) 2014-10-29 2017-09-06 Corning Incorporated Cell culture insert
WO2016069930A1 (en) 2014-10-29 2016-05-06 Corning Incorporated Microwell design and fabrication for generation of cell culture aggregates
JP6930914B2 (ja) 2014-10-29 2021-09-01 コーニング インコーポレイテッド 灌流バイオリアクタ・プラットフォーム
US10709821B2 (en) * 2014-11-24 2020-07-14 Biotronik Ag Sealing structure for heart valve implants
CA3009153A1 (en) 2015-01-30 2016-08-04 The University Of North Carolina At Chapel Hill Methods to generate gastrointestinal epithelial tissue constructs
WO2016152697A1 (ja) * 2015-03-20 2016-09-29 積水化学工業株式会社 微生物の培養方法及び培養装置
CN108076642A (zh) 2015-05-08 2018-05-25 威尔逊沃夫制造公司 改进的用于测试的培养方法和装置
GB201508752D0 (en) * 2015-05-21 2015-07-01 Mason Christopher And Veraitch Farlan S Cell culture device, system and methods of use thereof
US11802265B2 (en) * 2015-06-25 2023-10-31 Auckland Uniservices Ltd Tissue culture apparatus and method
KR101714010B1 (ko) * 2015-07-13 2017-03-08 재단법인 아산사회복지재단 3차원 조직 재생을 위한 적층 가능한 세포배양용장치 및 이를 이용한 배양방법
US9683208B2 (en) * 2015-07-31 2017-06-20 Ernest Louis Stadler Horizontal single use pressurizable modular multi-agitator microbial fermentator
JP6999941B2 (ja) 2015-09-18 2022-02-10 ベイラー カレッジ オブ メディスン 病原体からの免疫原性抗原同定および臨床的有効性との相関
WO2017100771A1 (en) * 2015-12-11 2017-06-15 The University Of Iowa Research Foundation Methods of producing biosynthetic bacterial cellulose membranes
EP3438236B1 (en) * 2016-03-28 2022-08-24 Sony Group Corporation Cell culture container, cell culture system, cell culture kit and cell culture method
CN109689366B (zh) 2016-05-05 2022-12-02 西南研究院 用于细胞扩增和相关应用的三维生物反应器
US10813342B2 (en) 2016-05-10 2020-10-27 Excet Incorporated Methods of using training aid delivery devices (TADD)
CN109843921B (zh) 2016-07-07 2023-05-26 艾欧凡斯生物治疗公司 程序性死亡1配体1(pd-l1)结合蛋白及其应用方法
EP3484997A4 (en) * 2016-07-12 2020-07-29 California Institute of Technology SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
JP2018033387A (ja) * 2016-08-31 2018-03-08 株式会社アステック 細胞培養容器
MX2019004707A (es) 2016-10-26 2019-08-12 Iovance Biotherapeutics Inc Reestimulacion de linfocitos infiltrantes de tumor crioconservados.
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
EP3538640A1 (en) 2016-11-11 2019-09-18 Oribiotech Ltd Cell culture device system and methods of use thereof
US11401507B2 (en) 2016-11-17 2022-08-02 Iovance Biotherapeutics, Inc. Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
CA3049165A1 (en) 2017-01-06 2018-07-12 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
BR112019013940A2 (pt) 2017-01-06 2020-02-11 Iovance Biotherapeutics, Inc. Método de tratar um câncer com uma população de linfócitos infiltrantes de tumor, processo para preparação de uma população de linfócitos infiltrantes de tumor, população de linfócitos infiltrantes de tumor, e, composição farmacêutica.
JP2018143210A (ja) * 2017-03-08 2018-09-20 株式会社アステック 細胞培養容器
US11254913B1 (en) 2017-03-29 2022-02-22 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
JOP20190224A1 (ar) 2017-03-29 2019-09-26 Iovance Biotherapeutics Inc عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي
WO2018195014A1 (en) 2017-04-19 2018-10-25 Neubiser Richard Bioreactor for biological material
US20200377855A1 (en) * 2017-05-05 2020-12-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Rapid method for the culture of tumor infiltrating lymphocytes
US20200224161A1 (en) 2017-05-10 2020-07-16 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
US10821134B2 (en) 2017-05-17 2020-11-03 Board Of Regents, The University Of Texas System BK virus specific T cells
BR112019024556A2 (pt) 2017-05-24 2020-06-23 Novartis Ag Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer
EP3635097A1 (en) 2017-06-05 2020-04-15 Iovance Biotherapeutics, Inc. Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
JP7197557B2 (ja) 2017-07-14 2022-12-27 コーニング インコーポレイテッド 多孔性支持体を有する細胞培養槽
JP7195302B2 (ja) 2017-07-14 2022-12-23 コーニング インコーポレイテッド 3d培養のための細胞培養容器及び3d細胞の培養方法
EP3652290B1 (en) 2017-07-14 2022-05-04 Corning Incorporated 3d cell culture vessels for manual or automatic media exchange
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
EP4501408A3 (en) 2017-11-17 2025-04-09 Iovance Biotherapeutics, Inc. Til expansion from fine needle aspirates and small biopsies
EP3714041A1 (en) 2017-11-22 2020-09-30 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
EP3724885A2 (en) 2017-12-15 2020-10-21 Iovance Biotherapeutics, Inc. Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof
WO2019136459A1 (en) 2018-01-08 2019-07-11 Iovance Biotherapeutics, Inc. Processes for generating til products enriched for tumor antigen-specific t-cells
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
SG11202006541UA (en) 2018-01-08 2020-08-28 Iovance Biotherapeutics Inc Processes for generating til products enriched for tumor antigen-specific t-cells
US20190233787A1 (en) * 2018-01-30 2019-08-01 The Trustees Of Indiana University Bioreactor
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
CN112055744A (zh) 2018-02-09 2020-12-08 环球生命科技咨询美国有限责任公司 用于在生物处理系统中的流体管线管理的装置
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US20210087511A1 (en) * 2018-02-09 2021-03-25 Global Life Sciences Solutions Usa Llc Bioprocessing methods for cell therapy
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
MA52667B1 (fr) 2018-03-29 2024-07-31 Iovance Biotherapeutics, Inc. Procédés de production de lymphocytes infiltrant les tumeurs et leurs utilisations en immunothérapie
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
US20210130779A1 (en) 2018-04-27 2021-05-06 Iovance Biotherapeutics, Inc. Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2019217753A1 (en) 2018-05-10 2019-11-14 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
CA3093581A1 (en) * 2018-05-15 2019-11-21 The University Of North Carolina At Chapel Hill Devices, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and non-gaseous chemical gradients for in vitro cell culture
EP3802848A4 (en) 2018-05-25 2022-03-09 The University of North Carolina at Chapel Hill FORMATION OF ARRAYS OF PLANAR INTESTINAL CRYPTS WITH A STEM CELL/PROLIFERATIVE CELL COMPARTMENT AND A DIFFERENTIATED CELL ZONE
WO2020013845A1 (en) 2018-07-13 2020-01-16 Corning Incorporated Cell culture vessels with stabilizer devices
CN111065725B (zh) 2018-07-13 2024-03-29 康宁股份有限公司 包括具有互联的壁的微板的流体装置
WO2020013847A1 (en) 2018-07-13 2020-01-16 Corning Incorporated Microcavity dishes with sidewall including liquid medium delivery surface
TW202031273A (zh) 2018-08-31 2020-09-01 美商艾歐凡斯生物治療公司 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療
CA3112599A1 (en) 2018-09-20 2020-03-26 Iovance Biotherapeutics, Inc. Expansion of tils from cryopreserved tumor samples
SG11202102986XA (en) 2018-09-24 2021-04-29 Southwest Res Inst Three-dimensional bioreactors
CN113015429A (zh) * 2018-10-02 2021-06-22 学校法人同志社 用于保存角膜内皮细胞的方法和容器
CA3118493A1 (en) 2018-11-05 2020-05-14 Iovance Biotherapeutics, Inc. Expansion of tils utilizing akt pathway inhibitors
TW202039830A (zh) 2018-11-05 2020-11-01 美商艾歐凡斯生物治療公司 用於製造腫瘤浸潤性淋巴細胞之方法及其在免疫療法中之用途
TW202039831A (zh) 2018-11-05 2020-11-01 美商艾歐凡斯生物治療公司 對抗pd-1抗體呈現難治性之非小細胞肺癌(nsclc)病患之治療
US20230039976A1 (en) 2018-11-05 2023-02-09 Iovance Biotherapeutics, Inc. Selection of improved tumor reactive t-cells
KR20210111746A (ko) * 2018-11-08 2021-09-13 감마델타 테라퓨틱스 리미티드 세포를 단리 및 증식하는 방법
GB201818243D0 (en) * 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
US12410391B2 (en) 2018-11-16 2025-09-09 The University Of North Carolina At Chapel Hill In vitro cell culture mucus systems
JP7710372B2 (ja) 2018-12-19 2025-07-18 アイオバンス バイオセラピューティクス,インコーポレイテッド 操作されたサイトカイン受容体対を使用して腫瘍浸潤リンパ球を拡大培養する方法及びその使用
US11447729B2 (en) 2018-12-21 2022-09-20 Global Life Sciences Solutions Usa Llc Apparatus and method for bioprocessing
US12024699B2 (en) 2019-01-04 2024-07-02 Oribiotech Ltd. Systems, devices, and methods for cell processing
AU2020204795A1 (en) 2019-01-04 2021-08-12 Oribiotech Ltd Cell processing platform cell processing system and methods of use thereof
US11692161B2 (en) 2019-02-05 2023-07-04 Corning Incorporated Packed-bed bioreactor systems and methods of using the same
US20200308532A1 (en) 2019-03-29 2020-10-01 Fenwal, Inc. Automated Systems and Methods for Cell Culturing
WO2020203713A1 (ja) 2019-03-29 2020-10-08 公立大学法人横浜市立大学 マトリックス組成物
US10772914B1 (en) 2019-04-18 2020-09-15 Baylor College Of Medicine EBV-specific immune cells
US20220249559A1 (en) 2019-05-13 2022-08-11 Iovance Biotherapeutics, Inc. Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
CN110283725A (zh) * 2019-07-02 2019-09-27 英诺维尔智能科技(苏州)有限公司 一种新型多层贴壁细胞培养容器结构
CN110218649A (zh) * 2019-07-02 2019-09-10 英诺维尔智能科技(苏州)有限公司 一种新型两侧透气多层贴壁细胞培养容器结构
CN114729292A (zh) * 2019-10-24 2022-07-08 奥克泰生物科技股份有限公司 具有经改进的细胞接触表面的细胞培养室
JP2022553389A (ja) 2019-10-25 2022-12-22 アイオバンス バイオセラピューティクス,インコーポレイテッド 腫瘍浸潤リンパ球の遺伝子編集及び免疫療法におけるその使用
WO2021097366A1 (en) 2019-11-15 2021-05-20 City Of Hope System, device and method for production of bioproduct including high density cell respirator for intensified production of adeno-associated viruses
CN114945661A (zh) * 2019-11-27 2022-08-26 康宁股份有限公司 径向流固定床生物反应器及其使用方法
KR102417445B1 (ko) * 2019-11-29 2022-07-06 주식회사 아모그린텍 세포배양장치
FR3104611B1 (fr) * 2019-12-11 2022-10-07 Air Liquide Digesteur comprenant une paroi interne présentant des expansions et/ou des creux
US12516291B2 (en) 2019-12-11 2026-01-06 Iovance Biotherapeutics, Inc. Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same
WO2021163501A1 (en) * 2020-02-14 2021-08-19 Xcell Biosciences, Inc. Gas and liquid flow regulation system for cell culture
CA3172354A1 (en) * 2020-03-09 2021-09-16 Oribiotech Ltd Cell culture container
GB202003406D0 (en) 2020-03-09 2020-04-22 Oribiotech Ltd A bioreactor having sensors therin
CA3175039A1 (en) 2020-03-10 2021-09-16 Cellares Corporation Systems, devices, and methods for cell processing
KR20230013022A (ko) 2020-03-20 2023-01-26 감마델타 테라퓨틱스 엘티디 골수성 악성종양의 치료를 위한 v 델타1+ t 세포
US20210290674A1 (en) * 2020-03-20 2021-09-23 GammaDelta Therapeutics Ltd. Methods for treating myeloid malignancies
US12159700B2 (en) 2020-04-22 2024-12-03 Iovance Biotherapeutics, Inc. Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
EP4146794A1 (en) 2020-05-04 2023-03-15 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
TW202208616A (zh) 2020-05-04 2022-03-01 美商艾歐凡斯生物治療公司 改良之腫瘤反應性t細胞的選擇
GB202006989D0 (en) 2020-05-12 2020-06-24 Gammadelta Therapeutics Ltd Methods for isolating gamma delta t cells
US20230372397A1 (en) 2020-10-06 2023-11-23 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022076606A1 (en) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
TW202241468A (zh) 2020-12-11 2022-11-01 美商艾歐凡斯生物治療公司 用腫瘤浸潤性淋巴球療法與braf抑制劑及/或mek抑制劑組合治療癌症患者
CA3202483A1 (en) 2020-12-17 2022-06-23 Maria Fardis Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
US20240123067A1 (en) 2020-12-17 2024-04-18 Iovance Biotherapeutics, Inc. Treatment of cancers with tumor infiltrating lymphocyte therapies
CN112682606B (zh) * 2021-01-21 2022-01-07 江苏丰禾机械制造股份有限公司 内置弹性连接结构的波纹管补偿器
AU2022246174A1 (en) 2021-03-25 2023-09-14 Iovance Biotherapeutics, Inc. Methods and compositions for t-cell coculture potency assays and use with cell therapy products
EP4326287A2 (en) 2021-04-19 2024-02-28 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
US20240342285A1 (en) 2021-07-28 2024-10-17 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
GB2609490B (en) 2021-08-05 2025-03-19 Oribiotech Ltd Outlet valve for a container
WO2023015293A2 (en) * 2021-08-06 2023-02-09 The Regents Of The University Of California Devices for growing cultures of microorganisms
WO2023077015A2 (en) 2021-10-27 2023-05-04 Iovance Biotherapeutics, Inc. Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
US12539515B2 (en) 2021-10-28 2026-02-03 Southwest Research Institute Devices for cell separation
EP4430167A1 (en) 2021-11-10 2024-09-18 Iovance Biotherapeutics, Inc. Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
US20250101380A1 (en) 2022-01-28 2025-03-27 Iovance Biotherapeutics, Inc. Tumor infiltrating lymphocytes engineered to express payloads
US20250179409A1 (en) * 2022-02-25 2025-06-05 Duogenic StemCells Corporation Cell proliferation apparatuses and uses thereof
GB202204926D0 (en) 2022-04-04 2022-05-18 Gammadelta Therapeutics Ltd Method for expanding gammadelta T cells
CA3248034A1 (en) 2022-04-15 2023-10-19 Iovance Biotherapeutics, Inc. METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT
EP4565683A1 (en) 2022-08-01 2025-06-11 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
WO2024118836A1 (en) 2022-11-30 2024-06-06 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes with shortened rep step
US12522792B2 (en) 2022-12-28 2026-01-13 Industrial Technology Research Institute Cell culture device
WO2024151885A1 (en) 2023-01-13 2024-07-18 Iovance Biotherapeutics, Inc. Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
CN120897988A (zh) 2023-03-21 2025-11-04 赛阿瑞斯公司 用于在细胞处理系统内的电穿孔的系统、设备和方法
EP4687923A1 (en) 2023-04-07 2026-02-11 Takeda Pharmaceutical Company Limited T cells for use in treating relapsed or refractory acute myeloid leukemia
EP4704933A1 (en) 2023-05-03 2026-03-11 Volumina Medical SA Devices and methods for preparing and conditioning biological assemblies for minimally invasive delivery for tissue engineering, cell therapies and other therapeutic applications
US12399193B2 (en) 2023-05-05 2025-08-26 Cellares Corporation Systems, devices, and methods for combined cell processes
WO2024249958A1 (en) * 2023-05-31 2024-12-05 Wilson Wolf Manufacturing Long term potency assays for cell and gene-modified cell therapy
EP4720307A1 (en) 2023-06-01 2026-04-08 Kamau Therapeutics, Inc. Methods for clinical-scale production of genetically modified primary cells
CN121752711A (zh) 2023-06-30 2026-03-27 赛阿瑞斯公司 用于自动化细胞处理系统内的流体转移的系统、装置和方法
WO2025017531A1 (en) 2023-07-20 2025-01-23 Takeda Pharmaceutical Company Limited Grid-free methods for making gamma delta t cells
WO2025041064A2 (en) 2023-08-21 2025-02-27 Cellares Corporation Systems, devices, and methods for automatic cell sorting
US12305156B2 (en) 2023-08-21 2025-05-20 Cellares Corporation Systems, devices, and methods for fluid control in a cell processing system
US12497587B2 (en) 2023-08-21 2025-12-16 Cellares Corporation Bioreactors and methods of their use in automatic cell processing systems
US20250075161A1 (en) * 2023-08-29 2025-03-06 Suzhou Cellpro Biotechnology Co., Ltd. Highly-breathable Closed Cell Culture Device and Method
WO2025101484A1 (en) 2023-11-06 2025-05-15 Iovance Biotherapeutics, Inc. Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
WO2025189164A1 (en) * 2024-03-08 2025-09-12 Appraiseye, Inc. Adeno-associated virus and cell maintenance and transfection
US12492368B2 (en) 2024-03-11 2025-12-09 Cellares Corporation Monitoring air pressure within a cell processing system
US12559710B2 (en) 2024-03-27 2026-02-24 Cellares Corporation Liquid level and flow rate detection within a cell processing system
USD1109621S1 (en) 2024-04-15 2026-01-20 Cellares Corporation Analytical platform for biological material testing

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459176A (en) * 1966-06-24 1969-08-05 Beckman Instruments Inc Apparatus and method of sampling a dialyzable component of blood
GB1376131A (en) 1971-02-09 1974-12-04 Nat Res Dev Improvements in and relating to cell culture systems
DE2128744C3 (de) 1971-06-09 1979-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Verfahren zur Massenkultivation von Zellen und Geweben
US3839155A (en) 1972-07-27 1974-10-01 Merck & Co Inc Cell and vaccine production
US3870602A (en) * 1973-04-30 1975-03-11 California Lab Ind Inc Gas permeable sterile culture bottle
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
US3941661A (en) * 1974-01-16 1976-03-02 The Curators Of The University Of Missouri Roller culture bottle insert
US4096577A (en) * 1975-03-03 1978-06-20 Ferber Leon A Thin flexible electronic calculator
JPS5238082A (en) 1975-09-13 1977-03-24 Heraeus Gmbh W C Cultivating container for microorganism * bacterium and tissue
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
JPS564989A (en) 1979-06-27 1981-01-19 Sony Corp Writing method for horizontal linearity corrected signal in horizontal llnearity correcting memory of beam index type color television receiver
US4296205A (en) * 1980-02-22 1981-10-20 Verma Dharmvir S Cell culture and continuous dialysis flask and method
US4321330A (en) * 1980-04-04 1982-03-23 Baker Fraser L Tissue culture device
US4317886A (en) * 1980-08-11 1982-03-02 Becton, Dickinson And Company Multiple interior surface roller bottle
JPS5876792U (ja) 1981-11-18 1983-05-24 東洋リノリユ−ム株式会社 デスクトツプ
US4435508A (en) 1981-11-20 1984-03-06 Gabridge Michael G Tissue culture vessel
JPS59220182A (ja) * 1983-05-27 1984-12-11 Ishikawa Seisakusho:Kk 培養槽
DE3322004A1 (de) 1983-06-18 1984-12-20 Robert Bosch Gmbh, 7000 Stuttgart Induktives element, insbesondere uebertrager
US4578588A (en) * 1983-08-12 1986-03-25 Galkin Benjamin M Volume reduction in liquid scintillation counting
DE3409501A1 (de) 1984-03-15 1985-10-24 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur kultivierung von zellen
US4748124A (en) 1984-10-30 1988-05-31 E. I. Du Pont De Nemours And Company Compartmentalized cell-culture device and method
NZ214417A (en) * 1984-12-21 1988-06-30 Univ Texas Microbially produced cellulose
US4668632A (en) * 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
JPH053724Y2 (https=) 1985-04-15 1993-01-28
US4654308A (en) * 1985-06-19 1987-03-31 La Corporation De L'ecole Polytechnique Bioreactor
JPS6232875A (ja) 1985-08-06 1987-02-12 Toyo Eng Corp
EP0264464B1 (en) * 1985-10-19 1992-05-13 Daikin Industries, Limited Culture vessel
US4661455A (en) * 1986-01-16 1987-04-28 Dorr-Oliver Incorporated Membrane cell culturing device
US4829002A (en) 1986-05-12 1989-05-09 Baxter International Inc. System for metering nutrient media to cell culture containers and method
US4937194A (en) 1986-05-12 1990-06-26 Baxter International Inc. Method for metering nutrient media to cell culture containers
US4734373A (en) * 1986-06-24 1988-03-29 Bartal Arie H Apparatus for enhancing cell growth, preservation and transport
US4945203A (en) 1986-11-06 1990-07-31 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4847462A (en) 1986-11-06 1989-07-11 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4717668A (en) * 1986-12-12 1988-01-05 Baxter Travenol Laboratories, Inc. Plastic roller bottle for suspension cultures
US5786215A (en) 1987-05-20 1998-07-28 Baxter International Inc. Method for culturing animal cells
JP2509630B2 (ja) * 1987-07-29 1996-06-26 三井石油化学工業株式会社 培養方法及び培養装置
US5047347A (en) * 1987-08-17 1991-09-10 Cline Martin J Gas permeable culture flask and method for culturing mammalian cells
US4839292B1 (en) * 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
US4829004A (en) * 1987-11-24 1989-05-09 The University Of Michigan Roller bottle system
US4824787A (en) * 1987-12-09 1989-04-25 In Vitro Scientific Products, Inc. Roller bottle for tissue culture growth
US5026650A (en) 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
US5153131A (en) * 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
CA1307225C (en) * 1988-07-19 1992-09-08 David W. Armstrong Cell culture bioreactor
DE68926421T2 (de) * 1988-08-20 1996-09-12 Nitto Denko Corp Verfahren zur Entfernung von gelösten Gasen aus einer Flüssigkeit
US4939151A (en) 1988-10-31 1990-07-03 Baxter International Inc. Adherent cell culture flask
US5068195A (en) 1988-11-02 1991-11-26 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion and maintenance vessel
US4960706A (en) * 1989-03-27 1990-10-02 Baxter International, Inc. Static oxygenator for suspension culture of animal cells
US4912058A (en) * 1989-04-27 1990-03-27 Becton, Dickinson And Company Roller bottle
CA2015294A1 (en) 1989-04-28 1990-10-28 John J. Rinehart Generation and expansion of lak cells
US5240854A (en) * 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
US4937196A (en) * 1989-08-18 1990-06-26 Brunswick Corporation Membrane bioreactor system
JPH0734699Y2 (ja) 1990-01-22 1995-08-09 東洋ガラス株式会社 カレンダー
US5173225A (en) 1990-05-07 1992-12-22 Bowolfe, Inc. Method for making ultra-thin dense skin membrane
EP0471947A1 (en) 1990-06-29 1992-02-26 Sekisui Chemical Co., Ltd. Culture bag
FR2666094A1 (fr) 1990-08-22 1992-02-28 Cyclopore Sa Bouteille de culture en masse de cellules et procede pour son assemblage.
US5139951A (en) * 1990-10-10 1992-08-18 Costar Corporation Culture device having a detachable cell or tissue growth surface
US5650325A (en) 1990-11-29 1997-07-22 Spielmann; Richard Apparatus having a rotatable stack of parallel trays with culturing surfaces on opposite sides for liquid/gas exchange
CA2055966C (en) * 1990-12-19 1995-08-01 Oresta Natalia Fedun Cell culture insert
CA2062100C (en) * 1991-03-05 2000-10-31 Hirotoshi Fujisawa Disc cartridge
JPH0734699B2 (ja) 1991-03-14 1995-04-19 アース製薬株式会社 屋内ダニ防除用エアゾール剤およびそれを用いた屋内ダニ防除方法
GB9112836D0 (en) * 1991-06-14 1991-07-31 Medical Res Council Production of monoclonal antibodies
JPH053724A (ja) * 1991-06-27 1993-01-14 Kiriyuu Kogyo Kk きのこ栽培容器
JPH05123182A (ja) * 1991-10-30 1993-05-21 Nakano Vinegar Co Ltd 静置培養による微生物セルロースの製造法及びその装置
US5310676A (en) * 1991-11-15 1994-05-10 A/S Nunc Cell cultivating device
DE4206585C2 (de) 1992-03-03 1994-11-24 Augustinus Dr Med Bader Vorrichtung zur Massenkultur von Zellen
DE4214157C1 (https=) * 1992-04-29 1993-08-05 Degussa Ag, 6000 Frankfurt, De
GB2268187A (en) 1992-07-01 1994-01-05 Univ Hull Cell culture vessels
DE4229325C2 (de) 1992-09-02 1995-12-21 Heraeus Instr Gmbh Kulturgefäß für Zellkulturen
DE4229334C2 (de) 1992-09-02 1995-12-21 Heraeus Instr Gmbh Rollflaschenähnliches Kulturgefäß für Zellkulturen
US5330908A (en) 1992-12-23 1994-07-19 The United States Of America As Represented By The Administrator, National Aeronautics And Space Administration High density cell culture system
JP2749245B2 (ja) * 1993-06-25 1998-05-13 鹿島建設株式会社 付着微細藻類の培養方法
US5324428A (en) * 1993-07-19 1994-06-28 Spectrum Medical Industries, Inc. Disposable dialysis apparatus
JPH0734699A (ja) 1993-07-21 1995-02-03 Ishikawajima Harima Heavy Ind Co Ltd エレベータ式駐車装置
AT401476B (de) 1993-08-20 1996-09-25 Sy Lab Vertriebsges M B H Thermokammer
US5686301A (en) 1993-09-02 1997-11-11 Heraeus Instruments Gmbh Culture vessel for cell cultures
US5437998A (en) * 1993-09-09 1995-08-01 Synthecon, Inc. Gas permeable bioreactor and method of use
US5702941A (en) 1993-09-09 1997-12-30 Synthecon, Inc. Gas permeable bioreactor and method of use
AU7839294A (en) * 1993-09-22 1995-04-10 Pierce Chemical Company Device and method for dialyzing samples
FR2710492B1 (fr) * 1993-09-29 1997-08-01 Compac Int Inc Sac pour la culture de blanc de champignon.
US5534423A (en) * 1993-10-08 1996-07-09 Regents Of The University Of Michigan Methods of increasing rates of infection by directing motion of vectors
JPH0734699U (ja) * 1993-12-07 1995-06-27 信越ポリマー株式会社 好気培養容器
EP0700900B1 (en) 1994-02-10 1999-11-03 Kao Corporation Process for producing acyloxybenzenesulfonic acid or salt thereof
JP2766182B2 (ja) * 1994-04-14 1998-06-18 株式会社バイオポリマー・リサーチ バクテリアセルロースの製造方法
US6169169B1 (en) * 1994-05-19 2001-01-02 Dako A/S PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis
US5565353A (en) * 1994-06-22 1996-10-15 Board Of Regents, The University Of Texas System Perfusable culture device
DE69534132T2 (de) 1994-06-28 2005-09-29 Wilson Wolf Corp., New Brighton Zellkulturflasche mit mehreren kammern
US5714384A (en) * 1994-06-28 1998-02-03 Wilson; John R. Compartmentalized tissue culture bag
US5693537A (en) * 1994-06-28 1997-12-02 Wilson; John R. Compartmentalized tissue culture flask
US5707869A (en) 1994-06-28 1998-01-13 Wolf; Martin L. Compartmentalized multiple well tissue culture plate
JPH0834802A (ja) * 1994-07-21 1996-02-06 Gun Ei Chem Ind Co Ltd バクテリアセルロース、その製造方法及び該バクテリアセルロースを用いた加工物
US5527705A (en) * 1994-09-12 1996-06-18 Becton, Dickinson And Company Roller bottle for trans-membrane co-culture of cells and method for its use
US5935847A (en) 1994-10-28 1999-08-10 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
US6297046B1 (en) 1994-10-28 2001-10-02 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
DE19504958C1 (de) 1995-02-15 1995-11-02 Heraeus Instr Gmbh Verfahren für die Kultivierung von Zellen auf einem Träger, Vorrichtung zur Durchführung des Verfahrens und Verwendung der Vorrichtung
BE1009306A5 (fr) * 1995-04-28 1997-02-04 Baxter Int Bioreacteur.
CA2175626C (en) * 1995-05-18 1999-08-03 Timothy A. Stevens Tissue culture flask
US5985653A (en) 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
DE19529099C2 (de) 1995-08-08 1997-12-04 Forschungszentrum Juelich Gmbh Vorrichtung zur Serien-Kultivierung von Mikroorganismen bzw. Zellen in begasten Flüssigkeitssäulen
US6130080A (en) * 1995-08-31 2000-10-10 Ashby Scientific, Inc. Roller bottle having pitted or cratered inner surface for cell growth
US5614412A (en) * 1995-09-08 1997-03-25 Smith; Stephen L. Apparatus for carrying flexible containers and method of transferring fluids to containers
US5686304A (en) 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
US6145688A (en) * 1996-07-17 2000-11-14 Smith; James C. Closure device for containers
US5866419A (en) * 1996-09-16 1999-02-02 Meder; Martin G. Roller bottle
US5876604A (en) * 1996-10-24 1999-03-02 Compact Membrane Systems, Inc Method of gasifying or degasifying a liquid
US6306491B1 (en) * 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
US5736398A (en) * 1997-01-16 1998-04-07 Board Of Regents, The University Of Texas System Gas permeable pouches for growing cultures
US5817509A (en) 1997-03-19 1998-10-06 Becton Dickinson And Company Culture vessel assembly
US5928936A (en) * 1997-04-09 1999-07-27 Huntington Medical Research Institutes Cell culture container that self-seals after cannula penetration made of porous sheets
DE19719751A1 (de) 1997-05-10 1998-11-12 Augustinus Dr Med Bader Vorrichtung zum Züchten und/oder Behandeln von Zellen
US5914154A (en) 1997-05-30 1999-06-22 Compact Membrane Systems, Inc. Non-porous gas permeable membrane
US5783075A (en) * 1997-06-23 1998-07-21 Spectrum Medical Laboratories, Inc. Disposable dialyzer apparatus
JP3761676B2 (ja) 1997-07-11 2006-03-29 株式会社メニコン 細胞培養用容器
US6190913B1 (en) * 1997-08-12 2001-02-20 Vijay Singh Method for culturing cells using wave-induced agitation
US6596532B1 (en) 1997-12-12 2003-07-22 BIOMéRIEUX, INC. Device for isolation and surface culture of microorganisms from bulk fluids
GB9803362D0 (en) 1998-02-17 1998-04-15 Cellon Sa A cell culture vessel
US5989913A (en) * 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
DE29817223U1 (de) 1998-09-24 1998-11-19 Marotzki, Stefan, Dr., 25436 Tornesch Vorrichtung zur Aufnahme einer Zellkultur
EP1183187A4 (en) * 1998-10-21 2004-03-17 Wei K Hsu STERILIZED CULTURE SYSTEM WITH MICROFILTRATION MEMBRANE CAPABLE OF FIXABLE RELEASE
GB9912641D0 (en) 1999-05-28 1999-07-28 Ashby Scient Ltd Textured and porous silicone rubber
ATE328618T1 (de) * 1998-10-28 2006-06-15 Cellon S A Strukturierter und poröser silikonkautschuk
US6455310B1 (en) 1999-03-23 2002-09-24 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
US6410309B1 (en) * 1999-03-23 2002-06-25 Biocrystal Ltd Cell culture apparatus and methods of use
DE19915611A1 (de) * 1999-04-07 2000-11-16 Augustinus Bader Rollhalterung
US7560274B1 (en) * 1999-05-28 2009-07-14 Cellon S.A. Culture chamber
WO2000078920A1 (en) 1999-06-21 2000-12-28 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
IL147207A0 (en) * 1999-06-21 2002-08-14 Gen Hospital Corp Methods and devices for culturing cells
US6569675B2 (en) 2000-06-16 2003-05-27 Corning Incorporated Cell cultivating flask and method for using the cell cultivating flask
US20030077816A1 (en) 2000-12-27 2003-04-24 Richard Kronenthal Bioreactor and method for using
DE10109706B4 (de) 2001-02-11 2006-03-09 In Vitro Systems & Services Gmbh Verfahren zur Herstellung von Kulturgefäßen
US20020155594A1 (en) 2001-03-27 2002-10-24 Hsieh Helen V. Method and apparatus for culturing cells
KR20020088848A (ko) 2001-05-21 2002-11-29 (주)코아바이오텍 세포배양관 및 이를 이용한 대량 세포배양기
JP2003018365A (ja) * 2001-07-05 2003-01-17 Nisca Corp 画像読取装置及び画像読取方法
US20040072347A1 (en) * 2001-07-27 2004-04-15 Gerold Schuler Generation of fully mature and stable dendritic cells from leukaphereses products for clinical applications
EP1465979A4 (en) * 2001-12-21 2007-11-14 Organogenesis Inc CHAMBER WITH ADJUSTABLE VOLUME FOR CELL CULTURE AND ORGAN SUPPORT
TW547111U (en) * 2002-01-10 2003-08-11 Dcd Inc Exercise apparatus
US7033823B2 (en) * 2002-01-31 2006-04-25 Cesco Bioengineering, Inc. Cell-cultivating device
DE10204531A1 (de) 2002-02-01 2003-08-21 Inst Chemo Biosensorik Deckelelement
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7229820B2 (en) * 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
WO2004020065A2 (en) * 2002-08-28 2004-03-11 Mt Technologies, Inc. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
US20040067585A1 (en) * 2002-10-07 2004-04-08 Yu-Chi Wang Cell cultivation surface and method of making the same
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
CN101120083B (zh) * 2003-10-08 2013-03-27 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
US7078228B2 (en) * 2003-12-31 2006-07-18 Corning Incorporated Cell cultivating flask
BRPI0405989A (pt) 2004-12-22 2006-09-05 Unilever Nv artigo plastificado para tratamento da pele
JP4649224B2 (ja) 2005-02-09 2011-03-09 株式会社カネカ 付着性細胞の培養方法および培養装置
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
JP5123182B2 (ja) 2005-08-17 2013-01-16 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 臨床作業ワークフローによるシンプルクリックスタイルインタラクションを特徴とする方法及び装置
JP4878195B2 (ja) 2006-03-30 2012-02-15 株式会社 ジャパン・ティッシュ・エンジニアリング 培養組織の包装容器
JP5659448B2 (ja) 2006-08-23 2015-01-28 株式会社フコク 培養容器及び同容器を用いた細胞培養方法
AU2007332869B2 (en) 2006-12-07 2012-10-11 Wilson Wolf Manufacturing, LLC Highly efficient gas permeable devices and methods for culturing cells
US7897379B2 (en) * 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US20090160975A1 (en) * 2007-12-19 2009-06-25 Ncr Corporation Methods and Apparatus for Improved Image Processing to Provide Retroactive Image Focusing and Improved Depth of Field in Retail Imaging Systems
US8518692B2 (en) * 2008-07-08 2013-08-27 Wilson Wolf Manufacturing Corporation Gas permeable cell culture device and method of use
JP6232875B2 (ja) 2013-09-19 2017-11-22 コベルコ建機株式会社 ハイブリッド建設機械の動力制御装置
US10183132B2 (en) 2014-09-11 2019-01-22 Ethicon Llc Methods and devices for co-delivery of liquid and powdered hemostats and sealants
JP6434283B2 (ja) 2014-11-18 2018-12-05 株式会社栗本鐵工所 ラジオコントロール用送信機

Also Published As

Publication number Publication date
US9410114B2 (en) 2016-08-09
AU2004280623B2 (en) 2010-12-02
AU2011200410A1 (en) 2011-02-24
EP2336293A2 (en) 2011-06-22
AU2019240734B2 (en) 2022-05-05
AU2019240734A1 (en) 2019-10-31
US20100255576A1 (en) 2010-10-07
US20110287543A1 (en) 2011-11-24
JP2011147460A (ja) 2011-08-04
AU2004280623A1 (en) 2005-04-21
CN101120083B (zh) 2013-03-27
US20150329815A1 (en) 2015-11-19
JP2007511205A (ja) 2007-05-10
EP2336293A3 (en) 2012-01-25
JP2014236753A (ja) 2014-12-18
US20070254356A1 (en) 2007-11-01
US20160024465A1 (en) 2016-01-28
EP1687400A2 (en) 2006-08-09
WO2005035728A2 (en) 2005-04-21
US8415144B2 (en) 2013-04-09
US8697443B2 (en) 2014-04-15
EP3943591A1 (en) 2022-01-26
JP2012040033A (ja) 2012-03-01
CN101120083A (zh) 2008-02-06
WO2005035728A3 (en) 2007-02-22
EP3450538A1 (en) 2019-03-06
AU2022209247A1 (en) 2022-08-18
US9441192B2 (en) 2016-09-13
EP1687400A4 (en) 2009-01-07
AU2011200410B2 (en) 2012-09-13
EP2336293B1 (en) 2016-02-10
US8158427B2 (en) 2012-04-17
EP3450538B1 (en) 2021-08-25
US9255243B2 (en) 2016-02-09
CA2542116A1 (en) 2005-04-21
CN103173354B (zh) 2017-07-14
US8158426B2 (en) 2012-04-17
CN103173354A (zh) 2013-06-26
USRE49293E1 (en) 2022-11-15
US20110129923A1 (en) 2011-06-02
US20050106717A1 (en) 2005-05-19
US8168432B2 (en) 2012-05-01
US20110287542A1 (en) 2011-11-24
JP2016174614A (ja) 2016-10-06

Similar Documents

Publication Publication Date Title
AU2019240734B2 (en) Cell culture methods and devices utilizing gas permeable materials
EP2092052B1 (en) Highly efficient gas permeable devices for culturing cells
AU2012254908B2 (en) Cell culture methods and devices utilizing gas permeable materials
AU2017203120B2 (en) Cell culture methods and devices utilizing gas permeable materials

Legal Events

Date Code Title Description
EEER Examination request