GB1376131A - Hydrostatic power transmission system - Google Patents

Hydrostatic power transmission system

Info

Publication number
GB1376131A
GB1376131A GB426671A GB426671A GB1376131A GB 1376131 A GB1376131 A GB 1376131A GB 426671 A GB426671 A GB 426671A GB 426671 A GB426671 A GB 426671A GB 1376131 A GB1376131 A GB 1376131A
Authority
GB
United Kingdom
Prior art keywords
support
roll
vessel
cell
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB426671A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to GB426671A priority Critical patent/GB1376131A/en
Priority to US00224527A priority patent/US3853712A/en
Publication of GB1376131A publication Critical patent/GB1376131A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C12M27/12—Roller bottles; Roller tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

1376131 Mixing apparatus NATIONAL RESEARCH DEVELOPMENT CORP 4 Feb 1972 [9 Feb 1971 4 Nov 1971] 4266/71 and 51343/71 Heading B1C [Also in Division C6] Tissue-cell culture apparatus includes a container for culture medium which encloses a compact cell support of a flexible strip material formed into turns which are spaced one from another to provide a passageway through which cells and medium can travel progressively on rotary movement of the support during inoculation. The strip material may be of polypropylene, oriented polystyrene treated by corona discharge to give a hydrophilic surface, unplasticised polyesters, aluminised polymers, stainless steel or aluminium, being materials exhibiting good cell adhesion, low toxicity, high strength, low weight, low cost, ready availability and a specified minimum surface tension. The support 10, Figs. 1 and 2, may take the form of a roll of polymeric material, the turns of which are spaced apart by two narrow corrugated strips 11, 12 one at each end of the roll. Spacing of the ends of the film from the surface of the neighbouring layer is assisted by the inclusion of two corrugated strips 13, 14 arranged along the length of the roll. The limbs of four L-shaped ribs 8, 9, serve to space the cell support within the culture vessel 1. The vessel is formed from two generally cylindrical portions 6, 7 of polystyrene joined at their rims by waterproof tape. The ports 2, 3 and 4 for culture medium, gas (CO 2 /air mixture) and exhaust, respectively, are closed by screw-threaded caps. The gas inlet port 3 communicates with a sparge tube 5. In a further construction, the vessel is enclosed with a gaspermeable plastics (specified) membrane 28, Fig. 9, protected by a ¥-inch plastics mesh work 35 and includes an elastomeric septum (34 on Fig. 8, not shown) through which cells grown on the support may be inoculated with virus.
GB426671A 1971-02-09 1971-02-09 Hydrostatic power transmission system Expired GB1376131A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB426671A GB1376131A (en) 1971-02-09 1971-02-09 Hydrostatic power transmission system
US00224527A US3853712A (en) 1971-02-09 1972-02-08 Cell culture systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB426671A GB1376131A (en) 1971-02-09 1971-02-09 Hydrostatic power transmission system
GB5134371 1971-11-04

Publications (1)

Publication Number Publication Date
GB1376131A true GB1376131A (en) 1974-12-04

Family

ID=26239006

Family Applications (1)

Application Number Title Priority Date Filing Date
GB426671A Expired GB1376131A (en) 1971-02-09 1971-02-09 Hydrostatic power transmission system

Country Status (2)

Country Link
US (1) US3853712A (en)
GB (1) GB1376131A (en)

Cited By (7)

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EP0156652A2 (en) * 1984-04-02 1985-10-02 FMC Corporation Spiral designed reactor
GB2207148A (en) * 1987-07-18 1989-01-25 Sterilin Ltd Bulk cell culture vessel
JPH02303479A (en) * 1989-04-27 1990-12-17 Becton Dickinson & Co Roller bottle and liner thereof
FR2666094A1 (en) * 1990-08-22 1992-02-28 Cyclopore Sa Cell mass-culture bottle and method for its assembly
WO2008104587A2 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system with filler
WO2008104586A3 (en) * 2007-02-28 2009-01-08 Cinv Ag High surface cultivation system with surface increasing substrate
US10876090B2 (en) 2016-11-09 2020-12-29 Univercells Technologies S.A. Cell growth matrix

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US3948732A (en) * 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
GB1490586A (en) * 1974-08-22 1977-11-02 Instrumentation Labor Inc Apparatus for culturing cells
US4144136A (en) * 1977-06-06 1979-03-13 Institut Armand-Frappier Apparatus for cellular culture
CH635868A5 (en) * 1977-08-16 1983-04-29 Chemap Ag DEVICE FOR TISSUE TISSUE CELLS.
US4184922A (en) * 1977-11-11 1980-01-22 The Government Of The United States Dual circuit, woven artificial capillary bundle for cell culture
US4296204A (en) * 1978-01-25 1981-10-20 Merck & Co., Inc. Use of motionless mixer as cell culture propagator
US4264739A (en) * 1979-01-05 1981-04-28 Merck & Co., Inc. Sparger for cell culture system
US4415670A (en) * 1980-07-07 1983-11-15 Merck & Co., Inc. Motionless mixer as cell culture propagator
US4317886A (en) * 1980-08-11 1982-03-02 Becton, Dickinson And Company Multiple interior surface roller bottle
US4514499A (en) * 1983-02-04 1985-04-30 Corning Glass Works Cell culture using a monolithic support
US4937187A (en) * 1983-02-04 1990-06-26 Brown University Research Foundation Methods for separating malignant cells from clinical specimens
US4559299A (en) * 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices
DE3413707C2 (en) * 1984-04-12 1986-11-06 Rastislav Dr.Med.Vet. 7958 Laupheim Skoda Method for mass growth of cells in lamellar chambers
US4919659A (en) * 1985-12-16 1990-04-24 The Board Of Regents For The University Of Washington Radio frequency plasma deposited polymers that enhance cell growth
EP0289666B1 (en) * 1987-04-03 1992-06-17 Yeda Research And Development Company Limited Cell culture carriers etc.
US4810652A (en) * 1988-01-13 1989-03-07 Becton, Dickinson And Company Cell growth harvester for roller bottles
US5094955A (en) * 1988-03-15 1992-03-10 Akzo N.V. Device and method for detecting microorganisms
US5164796A (en) * 1988-03-15 1992-11-17 Akzo N.V. Apparatus and method for detection of microorganisms
US5518895A (en) * 1990-02-15 1996-05-21 Akzo N.V. Device for detecting microorganisms using piezoelectric means
US5217876A (en) * 1988-03-15 1993-06-08 Akzo N.V. Method for detecting microorganisms
US5162229A (en) * 1988-03-15 1992-11-10 Akzo N.V. Device and method for enhanced recovery and detection of microbial growth in the presence of antimicrobial substances
US4861725A (en) * 1988-03-29 1989-08-29 Liau Ming Y Mammalian cell culture apparatus
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
ATE91148T1 (en) * 1988-06-10 1993-07-15 Becton Dickinson Co ROLLER BOTTLE WITH ENLARGED SURFACE.
US5084393A (en) * 1988-09-01 1992-01-28 Alena Rogalsky Container for a biological culture
US5858769A (en) * 1989-05-15 1999-01-12 Akzo Nobel N.V. Device for detecting microorganisms
US5240854A (en) * 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
US5798261A (en) * 1989-10-31 1998-08-25 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Distributed pore chemistry in porous organic polymers
JPH0728722B2 (en) * 1990-06-29 1995-04-05 富士写真フイルム株式会社 Bioreactor equipment
US5217899A (en) * 1990-08-24 1993-06-08 The General Hospital Corporation Cell stretching apparatus
DE69026954T2 (en) * 1990-09-19 1996-09-05 Scott Berry E CONTINUOUS CELL CULTURE SYSTEM OF HIGH TIGHTNESS
JP2585866B2 (en) * 1990-09-19 1997-02-26 ベリー，エリック・スコット Continuous high density cell culture system
JPH04262775A (en) * 1990-10-18 1992-09-18 Costar Corp Continuous cell cultivating device
US5272084A (en) * 1991-12-18 1993-12-21 Corning Incorporated Cell culture vessels having interior ridges and method for cultivating cells in same
US5512480A (en) * 1994-03-11 1996-04-30 Baxter International Inc. Flow-through bioreactor with grooves for cell retention
US6107085A (en) * 1997-07-11 2000-08-22 Corning Incorporated Self contained cell growth system
US5869329A (en) * 1997-08-25 1999-02-09 Becton Dickinson And Company Blood culture vial or bottle having an agitation paddle
US6245557B1 (en) 1999-06-30 2001-06-12 Robert P. Fouts Cell and protein harvesting assemblies and methods
US6569675B2 (en) 2000-06-16 2003-05-27 Corning Incorporated Cell cultivating flask and method for using the cell cultivating flask
CA2353307A1 (en) * 2001-07-13 2003-01-13 Carmen Parent Device and procedure for processing gaseous effluents
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
US7449331B2 (en) * 2002-09-20 2008-11-11 Whitley Kenneth W Roller bottle
CA2405635A1 (en) * 2002-09-27 2004-03-27 C02 Solution Inc. A process and a plant for the production of useful carbonated species and for the recycling of carbon dioxide emissions from power plants
ES2295275T3 (en) 2002-10-04 2008-04-16 Becton Dickinson And Company CROP FLASK.
CN103173354B (en) 2003-10-08 2017-07-14 威尔森沃尔夫制造公司 The method and device of cell culture is carried out using poromeric material
US6987019B1 (en) 2004-09-03 2006-01-17 Vitaly Rogalsky Device for growing cells
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
CA2544997A1 (en) * 2005-04-28 2006-10-28 Carmen Parent Immobilized biological material with improved functionality and method for producing the same
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
AU2007332869B2 (en) 2006-12-07 2012-10-11 Wilson Wolf Manufacturing, LLC Highly efficient gas permeable devices and methods for culturing cells
EP2297295A4 (en) 2008-07-08 2013-11-27 Wolf Wilson Mfg Corp Improved gas permeable cell culture device and method of use
TW201043691A (en) * 2009-06-11 2010-12-16 Food Industry Res & Dev Inst Biological reactor and method for producing microbial cellulose product
US8871485B2 (en) 2010-06-23 2014-10-28 University Of Florida Research Foundation, Inc. Modified carbonic anhydrase enzymes and their use in carbon dioxide sequestration and elimination
US9683208B2 (en) * 2015-07-31 2017-06-20 Ernest Louis Stadler Horizontal single use pressurizable modular multi-agitator microbial fermentator
EP3728549A1 (en) 2017-12-20 2020-10-28 Univercells Technologies S.A. Bioreactor and related methods
US20240034976A1 (en) * 2018-01-25 2024-02-01 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Rolled scaffold for large scale cell culture in monolayer
CN112088210A (en) * 2018-06-08 2020-12-15 株式会社岛津制作所 Cell culture apparatus and cell culture method
JP2019208474A (en) * 2018-06-08 2019-12-12 株式会社島津製作所 Cell culture device
JP2019213519A (en) 2018-06-08 2019-12-19 株式会社島津製作所 Cell culture device
CN113728085A (en) 2019-02-05 2021-11-30 康宁股份有限公司 Woven cell culture substrate
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same

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US2522947A (en) * 1945-05-16 1950-09-19 Weyerhaeuser Timber Co Apparatus for growing aerobic organisms
US3102082A (en) * 1961-07-17 1963-08-27 John H Brewer Apparatus and method for culturing micro-organisms
US3281307A (en) * 1962-11-05 1966-10-25 Dow Chemical Co Packing
US3740321A (en) * 1970-04-15 1973-06-19 Smith Kline French Lab Cell propagator

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156652A2 (en) * 1984-04-02 1985-10-02 FMC Corporation Spiral designed reactor
EP0156652A3 (en) * 1984-04-02 1988-05-04 Amerace Corporation Spiral designed reactor
GB2207148A (en) * 1987-07-18 1989-01-25 Sterilin Ltd Bulk cell culture vessel
EP0300666A1 (en) * 1987-07-18 1989-01-25 Sterilin Limited Bulk cell culture vessel
JPH02303479A (en) * 1989-04-27 1990-12-17 Becton Dickinson & Co Roller bottle and liner thereof
JPH0728721B2 (en) 1989-04-27 1995-04-05 ベクトン・ディッキンソン・アンド・カンパニー Roller bottle and its liner
FR2666094A1 (en) * 1990-08-22 1992-02-28 Cyclopore Sa Cell mass-culture bottle and method for its assembly
WO2008104587A2 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system with filler
WO2008104587A3 (en) * 2007-02-28 2008-12-24 Cinv Ag High surface cultivation system with filler
WO2008104586A3 (en) * 2007-02-28 2009-01-08 Cinv Ag High surface cultivation system with surface increasing substrate
US10876090B2 (en) 2016-11-09 2020-12-29 Univercells Technologies S.A. Cell growth matrix

Also Published As

Publication number Publication date
US3853712A (en) 1974-12-10

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years