CA2376285C - Dispositif a jeu de microaiguilles intradermiques - Google Patents

Dispositif a jeu de microaiguilles intradermiques Download PDF

Info

Publication number
CA2376285C
CA2376285C CA002376285A CA2376285A CA2376285C CA 2376285 C CA2376285 C CA 2376285C CA 002376285 A CA002376285 A CA 002376285A CA 2376285 A CA2376285 A CA 2376285A CA 2376285 C CA2376285 C CA 2376285C
Authority
CA
Canada
Prior art keywords
microneedles
base element
microneedle
reservoir
openings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002376285A
Other languages
English (en)
Other versions
CA2376285A1 (fr
Inventor
Vadim Vladimirovich Yuzhakov
Faiz F. Sherman
Grover David Owens
Vladimir Gartstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium Inc
Original Assignee
Corium International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corium International Inc filed Critical Corium International Inc
Publication of CA2376285A1 publication Critical patent/CA2376285A1/fr
Application granted granted Critical
Publication of CA2376285C publication Critical patent/CA2376285C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/0085—Manufacture of substrate-free structures using moulds and master templates, e.g. for hot-embossing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne, d'une manière générale, les dispositifs médicaux et, plus particulièrement un dispositif d'administration de fluide et un dispositif de prélèvement de fluide du même type. Dans un mode de réalisation, ledit dispositif pénètre dans la stratum corneum et dans l'épiderme, mais il ne touche pas le derme de la peau. Dans un autre mode de réalisation, le dispositif pénètre dans le derme de manière entrer en contact avec le sang ou avec d'autres fluides biologiques. L'invention concerne tout particulièrement un jeu de microaiguilles permettant de transférer des fluides dans le corps, tel qu'un dispositif d'administration ou de prélever des fluides dans le corps afin de prélever un échantillon de fluide organique, ceci sans douleur et sans trauma pour la peau.
CA002376285A 1999-06-09 2000-06-07 Dispositif a jeu de microaiguilles intradermiques Expired - Fee Related CA2376285C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/329,025 1999-06-09
US09/329,025 US6256533B1 (en) 1999-06-09 1999-06-09 Apparatus and method for using an intracutaneous microneedle array
PCT/US2000/015613 WO2000074765A1 (fr) 1999-06-09 2000-06-07 Dispositif a jeu de microaiguilles intradermiques

Publications (2)

Publication Number Publication Date
CA2376285A1 CA2376285A1 (fr) 2000-12-14
CA2376285C true CA2376285C (fr) 2006-05-09

Family

ID=23283537

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376285A Expired - Fee Related CA2376285C (fr) 1999-06-09 2000-06-07 Dispositif a jeu de microaiguilles intradermiques

Country Status (7)

Country Link
US (3) US6256533B1 (fr)
EP (1) EP1183065B1 (fr)
JP (1) JP2003501162A (fr)
AU (1) AU5728000A (fr)
CA (1) CA2376285C (fr)
TW (1) TW458791B (fr)
WO (1) WO2000074765A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914480B2 (en) 2004-03-24 2011-03-29 Corium International, Inc. Transdermal delivery device
US8216190B2 (en) 2000-10-16 2012-07-10 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US8702726B2 (en) 2000-10-16 2014-04-22 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

Families Citing this family (656)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US7048723B1 (en) * 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US7473244B2 (en) * 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
CA2424520C (fr) * 2000-08-21 2007-01-02 The Cleveland Clinic Foundation Reseau de microaiguilles et procede de fabrication
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
WO2002045771A2 (fr) * 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Adaptateur pour micro-aiguilles
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US7144495B2 (en) 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
JP2004525713A (ja) * 2001-04-13 2004-08-26 ベクトン・ディキンソン・アンド・カンパニー 全身吸収のために皮膚の皮内層中に物質を投与するための方法および装置
MXPA03009603A (es) * 2001-04-20 2004-12-06 Johnson & Johnson Arreglo de microproyeccion que tiene un agente benefico que contiene un recubrimiento.
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
DE60213976T2 (de) * 2001-06-08 2007-04-26 Becton Dickinson And Co. Vorrichtung zur manipulation von nadeln oder polierarray
US20020188310A1 (en) * 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ATE450209T1 (de) 2001-06-12 2009-12-15 Pelikan Technologies Inc Gerät und verfahren zur entnahme von blutproben
US6501976B1 (en) 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
ES2357887T3 (es) 2001-06-12 2011-05-03 Pelikan Technologies Inc. Aparato para mejorar la tasa de éxito de obtención de sangre a partir de una punción capilar.
US6875613B2 (en) 2001-06-12 2005-04-05 Lifescan, Inc. Biological fluid constituent sampling and measurement devices and methods
WO2002100460A2 (fr) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Actionneur electrique de lancette
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US6837988B2 (en) * 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US6721586B2 (en) 2001-06-12 2004-04-13 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US6793632B2 (en) 2001-06-12 2004-09-21 Lifescan, Inc. Percutaneous biological fluid constituent sampling and measurement devices and methods
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US6576416B2 (en) 2001-06-19 2003-06-10 Lifescan, Inc. Analyte measurement device and method of use
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
EP1414632A4 (fr) * 2001-07-10 2006-08-30 Aclara Biosciences Inc Moulage par injection d'une structure microfluidique sans coulure
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002337788A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
AU2002343457A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
EP1446110A2 (fr) * 2001-10-16 2004-08-18 Structural Bioinformatics Inc. Organosulfures inhibiteurs de tyrosine phosphatases
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20030093040A1 (en) * 2001-10-29 2003-05-15 Mikszta John A. Method and device for the delivery of a substance
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20030113813A1 (en) * 2001-11-15 2003-06-19 Heidaran Mohammad A. Methods and devices for the integrated discovery of cell culture environments
WO2003047689A1 (fr) * 2001-11-29 2003-06-12 Microlin Llc Appareil et procedes d'administration de fluide utilisant des aiguilles electroactives et des dispositifs d'administration electrochimiques implantables
US6952604B2 (en) * 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
ES2374042T3 (es) * 2002-02-04 2012-02-13 Becton, Dickinson And Company Dispositivo y método para suministrar o extraer una sustancia a través de la piel.
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3933058B2 (ja) * 2002-02-25 2007-06-20 日立化成工業株式会社 マイクロ流体システム用支持ユニット及びその製造方法
JP4373795B2 (ja) 2002-03-11 2009-11-25 ベクトン・ディキンソン・アンド・カンパニー 外科用ブレードの製造のためのシステム及び方法
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7060192B2 (en) 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
KR101323980B1 (ko) 2002-07-19 2013-10-30 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
ES2617576T3 (es) * 2002-08-29 2017-06-19 Becton, Dickinson And Company Administración de sustancias mediante un sistema microabrasivo giratorio
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
CA2444211C (fr) * 2002-10-11 2013-11-19 Dermal Therapy (Barbados) Inc. Determination des conditions biologiques par mesures d'impedance
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7611482B2 (en) * 2002-11-21 2009-11-03 Boston Scientific Scimed, Inc. Minimally-invasive smart devices
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20050070819A1 (en) * 2003-03-31 2005-03-31 Rosedale Medical, Inc. Body fluid sampling constructions and techniques
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
EP1628666B1 (fr) * 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Composes et leurs utilisations pour la modulation de l'amyloide-beta
CN1321706C (zh) * 2003-05-29 2007-06-20 财团法人工业技术研究院 一种数组式微针软质基材结构及其制造方法
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
DK1633235T3 (da) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparat til udtagelse af legemsvæskeprøver og detektering af analyt
WO2006001797A1 (fr) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Element penetrant peu douloureux
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
ES2437565T3 (es) * 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
US7708544B2 (en) * 2003-07-21 2010-05-04 10X Technology Llc Apparatus and method for manufacturing microneedles
US20050031676A1 (en) * 2003-08-04 2005-02-10 Wong Patrick S.L. Method and device for enhancing transdermal agent flux
WO2005020912A2 (fr) * 2003-08-25 2005-03-10 3M Innovative Properties Company Administration de composes modificateurs de la reponse immunitaire
CN1905835B (zh) 2003-09-11 2011-11-30 赛拉诺斯股份有限公司 分析物监测和药物递送的医疗装置
EP1662970A2 (fr) * 2003-09-17 2006-06-07 Becton, Dickinson and Company Systeme et procede de creation de tranchees lineaires et non lineaires dans des materiaux au silicium et autres materiaux cristallins au moyen d'une toupie
EP1671096A4 (fr) 2003-09-29 2009-09-16 Pelikan Technologies Inc Procede et appareil permettant d'obtenir un dispositif de capture d'echantillons ameliore
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7744738B1 (en) 2003-10-16 2010-06-29 The University Of Notre Dame Method and apparatus for rapid particle manipulation and characterization
US8267914B1 (en) * 2003-10-16 2012-09-18 University Of Notre Dame Du Lac Method and apparatus for AC electrospray
JP2007510445A (ja) * 2003-10-24 2007-04-26 アルザ・コーポレーシヨン 経皮薬剤送達促進用の前処置法及びシステム
USD902408S1 (en) 2003-11-05 2020-11-17 Abbott Diabetes Care Inc. Analyte sensor control unit
US20060036209A1 (en) * 2003-11-13 2006-02-16 Janardhanan Subramony System and method for transdermal delivery
MXPA06006041A (es) * 2003-11-28 2007-01-31 Acrux Dds Pty Ltd Metodo y sistema para administracion transdermica rapida.
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
EP1706171A1 (fr) * 2003-12-29 2006-10-04 3M Innovative Properties Company Dispositifs medicaux et kits comprenant ces dispositifs
EP1706026B1 (fr) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Procédé et appareil permettant d'améliorer le flux fluidique et le prélèvement d'échantillons
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
CN1636505B (zh) * 2004-01-09 2011-11-09 希森美康株式会社 提取器具、提取装置和血糖值测量装置
US7351246B2 (en) * 2004-01-20 2008-04-01 Epley John M Minimally invasive, sustained, intra-tympanic drug delivery system
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005090370A1 (fr) 2004-02-05 2005-09-29 The Regents Of The University Of California Agents pharmacologiquement actifs contenant des phosphonates esterifies, et leurs procedes d'utilisation
ATE448018T1 (de) * 2004-02-18 2009-11-15 Hitachi Chemical Co Ltd Mikrofluidische einheit mit hohlfaser-kanal
EP1718452A1 (fr) * 2004-02-23 2006-11-08 3M Innovative Properties Company Procede de moulage de reseau de micro-aiguilles
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US20050203575A1 (en) * 2004-03-15 2005-09-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin microactivation system and method
US20080082090A1 (en) * 2004-04-01 2008-04-03 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
WO2005096979A1 (fr) 2004-04-01 2005-10-20 The General Hospital Corporation Procede et appareil de traitement dermatologique et remodelage de tissus
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
EP1751546A2 (fr) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Hydrogel imprimable pour biocapteurs
WO2005112913A1 (fr) 2004-05-20 2005-12-01 The Scripps Research Institute Stabilisation de la transthyretine
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (fr) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Procede et appareil pour la fabrication d'un dispositif d'echantillonnage de liquides
ES2650188T3 (es) * 2004-06-10 2018-01-17 3M Innovative Properties Company Dispositivo y kit de aplicación de parches
EP1765332A2 (fr) * 2004-06-17 2007-03-28 Cengent Therapeutics, Inc. Modulateurs a base d'azote trisubstitue de tyrosine phosphatases
US20060135483A1 (en) * 2004-07-09 2006-06-22 Cheruvallath Zacharia S Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases
TWI246929B (en) * 2004-07-16 2006-01-11 Ind Tech Res Inst Microneedle array device and its fabrication method
US7150904B2 (en) * 2004-07-27 2006-12-19 Ut-Battelle, Llc Composite, ordered material having sharp surface features
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
WO2006028970A1 (fr) 2004-09-02 2006-03-16 Cengent Therapeutics, Inc. Derives d'inhibiteurs de thiazole et de thiadiazole de tyrosine phosphatases
NZ584773A (en) 2004-09-17 2012-07-27 Whitehead Biomedical Inst Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
ITPD20040252A1 (it) * 2004-10-14 2005-01-14 Bidoia Sas Di Gianfranco Bidoi Irrigatore chirurgico
AU2005306372B2 (en) 2004-11-18 2011-01-06 Kindeva Drug Delivery L.P. Method of contact coating a microneedle array
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
CN101102809B (zh) * 2004-11-18 2010-05-26 3M创新有限公司 涂敷微针阵列的遮蔽方法
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CA2587386C (fr) 2004-11-18 2013-01-15 3M Innovative Properties Company Attache et applicateur pour jeu de micro-aiguilles
EP1819379B1 (fr) * 2004-11-18 2016-08-31 Nanopass Technologies Ltd. Systeme pour administrer un fluide a une barriere biologique souple
JP4728631B2 (ja) * 2004-11-30 2011-07-20 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
JP2008522875A (ja) 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルの成形方法
CN100367906C (zh) * 2004-12-08 2008-02-13 圣美迪诺医疗科技(湖州)有限公司 皮下植入式生物传感器
EP1832339A1 (fr) * 2004-12-09 2007-09-12 Hitachi Chemical Co., Ltd. Unité support pour système micro fluide et procédé de fabrication idoine
US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US8613703B2 (en) 2007-05-31 2013-12-24 Abbott Diabetes Care Inc. Insertion devices and methods
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US8545403B2 (en) 2005-12-28 2013-10-01 Abbott Diabetes Care Inc. Medical device insertion
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US7883464B2 (en) * 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP4731931B2 (ja) * 2005-02-03 2011-07-27 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
EP1869414A4 (fr) * 2005-03-29 2010-07-28 Arkal Medical Inc Dispositifs, systemes, procedes et outils pour la surveillance continue du glucose
WO2006130217A2 (fr) * 2005-04-01 2006-12-07 The Regents Of The University Of California Esters de phosphate de phosphonates de nucleosides substitues
US8222257B2 (en) 2005-04-01 2012-07-17 The Regents Of The University Of California Phosphono-pent-2-en-1-yl nucleosides and analogs
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
KR101637140B1 (ko) * 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20080269666A1 (en) * 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
CA2612005C (fr) * 2005-06-17 2013-10-29 Georgia Tech Research Corporation Microstructures revetues et procede de fabrication de celles-ci
WO2007002109A2 (fr) * 2005-06-20 2007-01-04 The Regents Of The University Of California Chelateurs multicoordinants derives de pyrone destines a l'imagerie medicale et a la chelation
WO2007002523A2 (fr) * 2005-06-24 2007-01-04 3M Innovative Properties Company Timbre repliable et son procede d'application
EP1896115B2 (fr) * 2005-06-27 2020-01-22 3M Innovative Properties Company Ensemble de cartouches a micro-aiguilles
JP5144510B2 (ja) 2005-06-27 2013-02-13 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイ適用装置
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
US20070088332A1 (en) * 2005-08-22 2007-04-19 Transcutaneous Technologies Inc. Iontophoresis device
DE102005040251A1 (de) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
JP4519037B2 (ja) * 2005-08-31 2010-08-04 東京エレクトロン株式会社 加熱装置及び塗布、現像装置
US20090035446A1 (en) * 2005-09-06 2009-02-05 Theraject, Inc. Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7967763B2 (en) * 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
JP2009506873A (ja) * 2005-09-07 2009-02-19 ザ ファウンドリー， インコーポレイテッド 皮下構造を破壊するための装置および方法
KR20080047600A (ko) 2005-09-15 2008-05-29 티티아이 엘뷰 가부시키가이샤 로드형 이온토포레시스 장치
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US8492428B2 (en) * 2005-09-20 2013-07-23 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
CA2664589A1 (fr) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Dispositif d'iontophorese et methode d'administration d'agents actifs a une interface biologique
EP2989981B8 (fr) 2005-09-30 2018-09-05 Intuity Medical, Inc. Cartouche d'échantillonnage et d'analyse de fluide corporel multi-sites
WO2007041526A2 (fr) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Appareil de ionophorese et procede d'apport d'antibiotiques vers des interfaces biologiques
WO2007040938A1 (fr) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Systemes, dispositifs et procedes d'apport de medicament transdermique a micro-aiguilles fonctionnalisees
WO2007041322A2 (fr) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Apport ionophoretique d'agents actifs conjugues a des nanoparticules
WO2007041434A2 (fr) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Appareil de ionophorese et procede d'apport de facteurs angiogeniques de façon a renforcer la guerison de tissus endommages
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
JP2009509677A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 小胞封入活性物質のイオントフォレーシス送達
CA2629193C (fr) * 2005-11-18 2016-03-29 3M Innovative Properties Company Compositions pouvant etre revetues, revetements derives de celles-ci et micro-reseaux comprenant de tels revetements
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
US7618429B2 (en) * 2005-12-22 2009-11-17 Spamedica International Srl Skin rejuvination resurfacing method
US10799285B2 (en) * 2005-12-22 2020-10-13 Inmode Ltd. Skin rejuvenation resurfacing device and method of use
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
WO2007079193A2 (fr) 2005-12-30 2007-07-12 Tti Ellebeau, Inc. Systèmes iontophorétiques, dispositifs et procédés d'administration de principes actifs dans une interface biologique
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
WO2011053607A1 (fr) 2009-10-26 2011-05-05 Emkinetics, Inc. Procédé et appareil pour la stimulation électromagnétique d'un nerf, d'un muscle, et de tissus de l'organisme
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
EP2007373A4 (fr) * 2006-03-29 2012-12-19 Foldrx Pharmaceuticals Inc Inhibition de la toxicité de l'alpha-synucléine
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US7918814B2 (en) * 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276211A1 (en) * 2006-05-26 2007-11-29 Jose Mir Compact minimally invasive biomedical monitor
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
WO2007147043A2 (fr) * 2006-06-16 2007-12-21 Transport Pharmaceutical, Inc. Formulations pharmaceutiques destinées à l'administration iontophorétique d'antibiotique de tétracycline
US20080008745A1 (en) * 2006-06-21 2008-01-10 University Of Kentucky Research Foundation Transdermal delivery of naltrexone hydrochloride, naltrexol hydrochloride, and bis(hydroxy-methyl)propionyl-3-0 ester naltrexone using microneedles
EP2036586B1 (fr) * 2006-07-04 2015-09-09 Toppan Printing Co., Ltd. Procédé de fabrication d'une micro-aiguille
JP5338021B2 (ja) * 2006-07-04 2013-11-13 凸版印刷株式会社 針状体の製造方法
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
US20100100005A1 (en) * 2006-07-11 2010-04-22 Infotonics Technology Center, Inc. Minimally invasive allergy testing system with coated allergens
KR100781702B1 (ko) * 2006-07-21 2007-12-03 연세대학교 산학협력단 중공형 마이크로니들 및 이의 제조방법
KR100793615B1 (ko) 2006-07-21 2008-01-10 연세대학교 산학협력단 생분해성 솔리드 마이크로니들 및 이의 제조방법
JPWO2008020632A1 (ja) * 2006-08-18 2010-01-07 凸版印刷株式会社 マイクロニードル及びマイクロニードルパッチ
ES2439994T3 (es) 2006-08-28 2014-01-27 Kyowa Hakko Kirin Co., Ltd. Anticuerpos antagonistas monoclonales humanos específicos de LIGHT humano
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
WO2008042902A2 (fr) 2006-10-02 2008-04-10 Emkinetics, Inc. Procédé et appareil de thérapie par induction magnétique
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
WO2008048632A1 (fr) * 2006-10-17 2008-04-24 Vgx Pharmaceuticals, Inc. Dispositifs d'électroporation et leurs procédés d'utilisation pour l'électroporation de cellules de mammifères
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008062832A1 (fr) * 2006-11-22 2008-05-29 Toppan Printing Co., Ltd. Matrice à micro-aiguilles et son procédé de production
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
JP5383497B2 (ja) * 2006-12-01 2014-01-08 Ｔｔｉ・エルビュー株式会社 装置、例として経皮送達装置に給電し且つ／又は当該装置を制御するシステム及び装置
WO2008073806A1 (fr) * 2006-12-08 2008-06-19 Sabic Innovative Plastics Ip B.V. Système actif d'administration d'un médicament par voie transdermique
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US8409185B2 (en) * 2007-02-16 2013-04-02 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
EP2125073A1 (fr) * 2007-03-02 2009-12-02 TecPharma Licensing AG Système d'administration modulaire
US8560059B2 (en) * 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
US7713196B2 (en) 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
US20100210932A1 (en) * 2007-03-20 2010-08-19 Bayer Healthcare Llc Method of analyzing an analyte
US8439861B2 (en) 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
EP2173370B1 (fr) 2007-06-27 2015-10-21 The Board of Trustees of the Leland Stanford Junior University Inhibiteurs oligopeptidiques de tyrosinase et leurs utilisations
JP5568008B2 (ja) * 2007-06-27 2014-08-06 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ペプチドチロシナーゼインヒビターおよびその使用
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
US20100196446A1 (en) 2007-07-10 2010-08-05 Morteza Gharib Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
JP2010535591A (ja) * 2007-08-06 2010-11-25 トランスダーム， インコーポレイテッド ポリマー膜から形成される微小針アレイ
US8328720B2 (en) * 2007-08-10 2012-12-11 Infotonics Technology Center, Inc. MEMS interstitial prothrombin time test
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
WO2009029572A1 (fr) * 2007-08-24 2009-03-05 Deka Products Limited Partnership Système et appareil à micro-aiguille
US20100121307A1 (en) * 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
EP2197541A4 (fr) * 2007-09-20 2011-06-01 Nitric Biotherapeutics Inc Procédé d'augmentation de la fourniture iontophorétique d'un peptide
JP5559054B2 (ja) * 2007-09-28 2014-07-23 ザ クイーンズ ユニヴァーシティ オブ ベルファスト 送達装置および方法
US20090264421A1 (en) * 2007-10-05 2009-10-22 Bible Keith C Methods and Compositions for Treating Cancer
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
WO2009065061A1 (fr) 2007-11-14 2009-05-22 Myoscience, Inc. Gestion de la douleur à l'aide du remodelage cryogénique
WO2009067463A1 (fr) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Dispositifs d'évaluation de structures de transport de fluides associées au corps
US8426587B2 (en) 2007-11-21 2013-04-23 Pharmaxis Ltd. Haloallylamine inhibitors of SSAO/VAP-1 and uses therefor
JP5461427B2 (ja) * 2007-12-17 2014-04-02 ニューワールド ファーマシューティカルズ，エルエルシー 統合的な皮内送達、診断、及び、情報伝達システム
WO2009079712A1 (fr) 2007-12-24 2009-07-02 The University Of Queensland Procédé d'application
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
WO2009097660A1 (fr) 2008-02-07 2009-08-13 The University Of Queensland Fabrication de timbre transdermique
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8591481B2 (en) 2008-03-21 2013-11-26 Ut-Battelle, Llc Microfabricated instruments and methods to treat recurrent corneal erosion
CN100579599C (zh) * 2008-04-09 2010-01-13 南京大学 微针阵列注射器的制备方法
EP2265324B1 (fr) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Système intégré de mesure d'analytes
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
EP2294415A4 (fr) * 2008-05-23 2011-10-05 Univ Queensland Détection de substances à analyser par un timbre à micro-aiguilles avec des réactifs sélectifs
JP5816080B2 (ja) 2008-05-30 2015-11-17 インテュイティ メディカル インコーポレイテッド 体液採取装置及び採取部位インターフェイス
CA2726067C (fr) 2008-06-06 2020-10-20 Intuity Medical, Inc. Dispositif de mesure et mode de fonctionnement
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US9913806B2 (en) * 2008-06-25 2018-03-13 Fe3 Medical, Inc. Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
ES2732453T3 (es) 2008-07-01 2019-11-22 Curemark Llc Métodos y composiciones para el tratamiento de síntomas de trastornos neurológicos y de salud mental
KR101013581B1 (ko) * 2008-08-06 2011-02-14 라종주 전기 피부 미용기
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
CN105999538A (zh) * 2008-11-18 2016-10-12 3M创新有限公司 空心微针阵列和方法
US20110301628A1 (en) * 2008-12-05 2011-12-08 Yossi Gross Techniques for use with a nail penetration device
KR101004014B1 (ko) 2008-12-18 2010-12-31 (주)마이티시스템 측면에 유로가 형성된 미세바늘의 구조 및 그 제작방법
US20110021996A1 (en) * 2008-12-18 2011-01-27 Miti Systems Inc. Structure of micro-needle with side channel and manufacturing method thereof
CA2748043A1 (fr) 2008-12-22 2010-07-01 Myoscience, Inc. Systeme de cryochirurgie integre avec fluide frigorigene et source d'energie electrique
WO2010078323A1 (fr) * 2008-12-29 2010-07-08 Sung-Yun Kwon Procédé de fabrication de timbres de perforateur à solution solide et leurs utilisations
WO2010080835A1 (fr) 2009-01-06 2010-07-15 Curemark Llc Compositions et procédés pour le traitement ou la prévention d'infections orales par e. coli
AU2010203709B2 (en) 2009-01-06 2014-05-22 Galenagen, Llc Compositions and methods for the treatment or prevention of Staphylococcus Aureus infections and for the Eradication or reduction of Staphylococcus Aureus on surfaces
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100198034A1 (en) 2009-02-03 2010-08-05 Abbott Diabetes Care Inc. Compact On-Body Physiological Monitoring Devices and Methods Thereof
US8190252B2 (en) 2009-02-12 2012-05-29 Incube Labs, Llc Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
US8961492B2 (en) 2009-02-12 2015-02-24 Incube Labs, Llc System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US8348922B2 (en) * 2009-02-12 2013-01-08 Incube Labs, Llc Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent
AU2010217957B2 (en) 2009-02-26 2015-08-13 Liquidia Technologies, Inc. Interventional drug delivery system and associated methods
WO2010101620A2 (fr) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systèmes et procédés permettant de créer et d'utiliser des bulles de succion ou d'autres régions groupées de fluide dans la peau
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
JP5563652B2 (ja) * 2009-03-17 2014-07-30 カーディオスライヴ インコーポレイテッド 体外除細動器
CN101829396B (zh) * 2009-03-27 2013-01-30 清华大学 微针阵列芯片及利用其的经皮给药贴剂及其制备方法
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US8399443B2 (en) 2009-04-22 2013-03-19 Mercator Medsystems, Inc. Treatment of hypertension by renal vascular delivery of guanethidine
US8821945B2 (en) 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
US8888757B2 (en) * 2009-05-27 2014-11-18 Wisconsin Alumni Research Foundation Active microneedle array
US8417330B2 (en) * 2009-06-26 2013-04-09 Incube Labs, Llc Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
KR101213223B1 (ko) * 2009-07-07 2013-01-09 한국전자통신연구원 할로우를 가지는 미세 바늘 및 미세 바늘 구조체의 제조 방법
US8404728B2 (en) 2009-07-30 2013-03-26 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
AU2010278894B2 (en) 2009-07-30 2014-01-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8903485B2 (en) * 2009-08-06 2014-12-02 Incube Labs, Llc Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
JP2011045565A (ja) * 2009-08-27 2011-03-10 Nanbu Plastics Co Ltd 薬液注入装置
EP3001194B1 (fr) 2009-08-31 2019-04-17 Abbott Diabetes Care, Inc. Dispositifs médicaux et procédés
SG10201502531SA (en) 2009-10-19 2015-05-28 Theranos Inc Integrated Health Data Capture And Analysis System
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US8871460B2 (en) 2009-11-09 2014-10-28 Neurogenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor
WO2011065981A1 (fr) 2009-11-30 2011-06-03 Intuity Medical, Inc. Dispositif et procédé de fourniture de matériau d'étalonnage
US20110301235A1 (en) 2009-12-02 2011-12-08 Alquest Therapeutics, Inc. Organoselenium compounds and uses thereof
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
KR101224939B1 (ko) * 2009-12-07 2013-01-22 가천대학교 산학협력단 활성 성분의 흡수 속도가 개선된 마이크로니들
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
SG181896A1 (en) * 2009-12-23 2012-07-30 Map Pharmaceuticals Inc Novel ergoline analogs
US8454975B1 (en) 2010-01-11 2013-06-04 Elizabeth VanderVeer Method for enhancing skin appearance
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
JP5841951B2 (ja) 2010-02-01 2016-01-13 プロテウス デジタル ヘルス， インコーポレイテッド データ収集システム
CN102905612A (zh) 2010-02-01 2013-01-30 普罗秋斯数字健康公司 双腕式数据采集系统
US8986279B2 (en) 2010-02-10 2015-03-24 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
US9265453B2 (en) 2010-03-24 2016-02-23 Abbott Diabetes Care Inc. Medical device inserters and processes of inserting and using medical devices
WO2011127207A2 (fr) 2010-04-07 2011-10-13 California Institute Of Technology Procédé simple pour la production d'un réseau de nanotubes de carbone superhydrophobe
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2011246880B2 (en) 2010-04-28 2015-10-29 Sorrento Therapeutics, Inc. Medical devices for delivery of siRNA
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
JP5871907B2 (ja) 2010-04-28 2016-03-01 キンバリー クラーク ワールドワイド インコーポレイテッド 細胞間相互作用を強化させたナノパターンド医療デバイス
DK2563450T3 (da) 2010-04-28 2017-11-13 Kimberly Clark Co Apparat til administration af rheumatoid-arthritis-medikament
CA2798145C (fr) 2010-05-04 2022-10-18 Corium International, Inc. Methode et dispositif permettant l'administration transdermique d'hormone parathyroidienne au moyen d'un reseau de microprojections
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
TWI578997B (zh) 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
EP2593014B1 (fr) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Environnement basse pression pour dispositifs à transfert de fluide
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
ES2353181B1 (es) * 2010-09-01 2012-02-17 Francisco Javier García Saban Dispositivo de medición secuencial de un analito.
BR112013009205A2 (pt) 2010-10-15 2016-07-26 Iscience Interventional Corp dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho.
TWI450707B (zh) * 2010-11-09 2014-09-01 Univ Chung Hua 生物阻抗量測儀及生物阻抗量測儀組合
WO2012064802A1 (fr) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systèmes et interfaces pour prélèvement sanguin
US8609458B2 (en) 2010-12-10 2013-12-17 California Institute Of Technology Method for producing graphene oxide with tunable gap
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
CN106955415B (zh) 2011-03-24 2019-06-18 因卡伯实验室有限责任公司 用于治疗剂的两阶段经皮离子电渗递送的系统及方法
WO2012135238A1 (fr) 2011-03-29 2012-10-04 California Institute Of Technology Procédé pour augmenter la capacité des capacités électrochimiques à base de nanotubes de carbone par dépôt conforme de nanoparticules
US10244981B2 (en) * 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
DK2701733T3 (da) 2011-04-21 2019-05-27 Curemark Llc Forbindelser til behandling af neuropsykiatriske forstyrrelser
EP3236259A1 (fr) 2011-04-29 2017-10-25 Seventh Sense Biosystems, Inc. Production de plasma ou de sérum et élimination de fluides sous pression réduite
WO2012149143A1 (fr) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Acheminement et/ou réception de fluides
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
WO2012154704A2 (fr) 2011-05-06 2012-11-15 Incube Labs, Llc Système et procédé d'administration transdermique iontophorétique biphasique d'agents thérapeutiques, dans la régulation des états de manque dus à l'accoutumance
MX343603B (es) 2011-06-14 2016-11-11 Jeong Gu Gwak Aparato y método para mejoramiento de la piel usando un efecto ra o efecto ra plus.
US8604035B2 (en) 2011-06-23 2013-12-10 Map Pharmaceuticals, Inc. Fluoroergoline analogs
KR102599318B1 (ko) * 2011-06-28 2023-11-07 이노비오 파마수티컬즈, 인크. 최소 침습 피부 전기천공 장치
EP3750480B1 (fr) 2011-08-03 2022-02-02 Intuity Medical, Inc. Dispositifs de prélèvement de fluide corporel
WO2013037482A1 (fr) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Agonistes du récepteur du farnésoïde x pour le traitement et la prévention du cancer
EP3881781B1 (fr) * 2011-10-12 2023-03-29 Vaxxas Pty Limited Dispositif de distribution
JP6069336B2 (ja) 2011-10-19 2017-02-01 マーケイター メドシステムズ， インコーポレイテッド 腎の脱神経を包含する治療効果を増強するための組織および細胞の局所的調節
CN104039382B (zh) 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
DK3542851T3 (da) 2011-10-27 2022-03-14 Sorrento Therapeutics Inc Implanterbare indretninger til levering af bioaktive midler
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
JP2013106831A (ja) * 2011-11-22 2013-06-06 Toppan Printing Co Ltd 針状体の製造方法および針状体の転写版
ES2967952T3 (es) 2011-12-11 2024-05-06 Abbott Diabetes Care Inc Dispositivos sensores de analitos
US8764681B2 (en) 2011-12-14 2014-07-01 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
SG11201403434YA (en) 2011-12-19 2014-09-26 Map Pharmaceuticals Inc Novel iso-ergoline derivatives
EP2793583A4 (fr) 2011-12-21 2015-08-12 Map Pharmaceuticals Inc Nouveaux composés neuromodulateurs
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
CA2860893A1 (fr) 2012-01-13 2013-07-18 Myoscience, Inc. Protection de la peau pour le remodelage sous-cutane cryogenique dans le cadre de soins cosmetiques et autres traitements
EP2802279B1 (fr) 2012-01-13 2017-08-16 Myoscience, Inc. Aiguille cryogénique avec régulation de la zone de congélation
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US11460430B2 (en) 2012-04-04 2022-10-04 University Of Cincinnati Sweat simulation, collecting and sensing systems
US9681836B2 (en) 2012-04-23 2017-06-20 Cyberonics, Inc. Methods, systems and apparatuses for detecting seizure and non-seizure states
EP2841147A4 (fr) 2012-05-01 2016-04-13 Univ Pittsburgh Réseaux de micro-aiguilles à extrémité chargée pour l'insertion transdermique
SG10201707020TA (en) 2012-05-02 2017-10-30 Boehringer Ingelheim Int Substituted 3-haloallylamine inhibitors of ssao and uses thereof
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
DE102012010262B4 (de) * 2012-05-25 2014-07-03 Albrecht Molsberger Therapeutisch anwendbare Gleichstromabgabevorrichtung
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
WO2013187965A1 (fr) 2012-06-14 2013-12-19 Mayo Foundation For Medical Education And Research Dérivés de pyrazole en tant qu'inhibiteurs de stat3
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
WO2014022314A1 (fr) 2012-07-30 2014-02-06 California Institute Of Technology Systèmes composites de nano tri-carbone et fabrication
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CA2879939A1 (fr) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Procede pour eliciter une reponse immunitaire contre le vrs et b. pertussis chez les nourrissons
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
AU2013342275B2 (en) 2012-11-08 2017-11-09 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
WO2014088492A1 (fr) * 2012-12-07 2014-06-12 Ascilion Ab Capteur microfabriqué et procédé de détection du niveau d'un constituant dans un fluide corporel
US10821276B2 (en) 2012-12-14 2020-11-03 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
KR102378235B1 (ko) 2012-12-14 2022-03-25 민데라 코포레이션 바이오마커의 검출 및 취득을 위한 방법 및 디바이스
WO2014093875A1 (fr) * 2012-12-14 2014-06-19 The Trustees Of Columbia University In The City Of New York Système et méthode pour l'administration locale d'un agent thérapeutique dans l'oreille interne
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
WO2014100354A1 (fr) 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Nouveaux dérivés de méthysergide
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014120114A1 (fr) * 2013-01-29 2014-08-07 Empire Technology Development Llc Capteur de natrémie fondé sur des micro-aiguilles et procédés d'utilisation
BR112015022253B1 (pt) 2013-03-12 2022-03-15 Corium, Inc Aplicador de microprojeções
WO2014153002A1 (fr) 2013-03-14 2014-09-25 The California Institute For Biomedical Research Anticorps bispécifiques et leurs utilisations
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
WO2014152717A2 (fr) 2013-03-14 2014-09-25 Sano Intelligence, Inc. Microcapteur porté sur le corps destiné à une biosurveillance
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
JP2016512754A (ja) 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
WO2014146126A1 (fr) 2013-03-15 2014-09-18 Myoscience, Inc. Méthodes et dispositifs cryogéniques de dissection par extrémité émoussée
JP2016514133A (ja) 2013-03-15 2016-05-19 コリウム インターナショナル， インコーポレイテッド ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
KR102341601B1 (ko) 2013-03-15 2021-12-21 코리움, 인크. 치료제를 전달하기 위한 마이크로어레이 및 사용 방법
CA2903459C (fr) 2013-03-15 2024-02-20 Corium International, Inc. Applicateurs de microprojection d'impacts multiples et procedes d'utilisation
US10016229B2 (en) 2013-03-15 2018-07-10 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
CA3121759C (fr) 2013-05-03 2024-01-02 Clearside Biomedical, Inc. Appareil et methodes d'injection oculaire
WO2014197317A1 (fr) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Appareil et procédés pour une administration de médicament à l'aide de multiples réservoirs
SG10201708143QA (en) 2013-06-06 2017-11-29 Pierre Fabre Médicament Anti-c10orf54 antibodies and uses thereof
WO2014197995A1 (fr) * 2013-06-13 2014-12-18 Microdermics Inc. Micro-aiguilles métalliques
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
CN103330562B (zh) * 2013-07-11 2015-01-28 无锡交大联云科技有限公司 一种仿生柔性干电极及其制作方法
CA2919773A1 (fr) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Compositions immunogenes en combinaison
US11185271B2 (en) 2013-09-13 2021-11-30 University Of Utah Research Foundation Methods of making micro-molded electrodes and arrays
DE102013219432A1 (de) * 2013-09-26 2015-03-26 Peter Röhr Blutentnahmevorrichtung und Verfahren zum Entnehmen von Blut
US10888244B2 (en) 2013-10-18 2021-01-12 University Of Cincinnati Sweat sensing with chronological assurance
AU2014337151A1 (en) 2013-10-18 2016-05-05 University Of Cincinnati Sweat sensing with chronological assurance
US10182795B2 (en) 2013-10-18 2019-01-22 University Of Cincinnati Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing
WO2015069792A1 (fr) 2013-11-05 2015-05-14 Myoscience, Inc. Système de traitement cryochirurgical sécurisé
WO2015095772A2 (fr) 2013-12-20 2015-06-25 Emory University Préparations et procédés servant à introduire de manière ciblée des agents thérapeutiques dans l'œil
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
CN108064242B (zh) 2014-05-28 2022-10-21 阿吉纳斯公司 抗gitr抗体和其使用方法
AU2015266956A1 (en) 2014-05-28 2016-12-15 University Of Cincinnati Devices with reduced sweat volumes between sensors and sweat glands
US10932761B2 (en) 2014-05-28 2021-03-02 University Of Cincinnati Advanced sweat sensor adhesion, sealing, and fluidic strategies
WO2015184084A2 (fr) * 2014-05-28 2015-12-03 University Of Cincinnati Surveillance de la sueur et régulation de l'administration de médicaments
CA2951430A1 (fr) 2014-06-13 2015-12-17 Glaxosmithkline Biologicals Sa Combinaisons immunogenes
RU2710491C2 (ru) 2014-06-20 2019-12-26 Клиасайд Байомедикал, Инк. Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань
WO2016025129A1 (fr) 2014-08-14 2016-02-18 Alhamadsheh Mamoun M Conjugaison d'agents pharmaceutiquement actifs avec des ligands de transthyrétine par des liants réglables pour augmenter la demi-vie de sérum
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
EP3183346A4 (fr) 2014-08-22 2018-10-24 Auckland Uniservices Limited Modulateurs de canaux
WO2016036866A1 (fr) 2014-09-04 2016-03-10 Corium International, Inc. Matrice de microstructures, procédé de production et procédés d'utilisation
CA2962340A1 (fr) 2014-09-22 2016-03-31 University Of Cincinnati Detection de transpiration avec assurance analytique
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
JP6126658B2 (ja) * 2015-08-17 2017-05-10 花王株式会社 微細中空突起物の製造方法
WO2016060020A1 (fr) * 2014-10-17 2016-04-21 花王株式会社 Procédé de fabrication d'une fine protubérance creuse
JP6586329B2 (ja) * 2015-08-17 2019-10-02 花王株式会社 微細中空突起物の製造方法
US10632653B2 (en) 2014-10-17 2020-04-28 Kao Corporation Fine hollow protrusion manufacturing method
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
PL3333191T3 (pl) 2014-12-11 2021-05-04 Pierre Fabre Médicament Przeciwciała przeciwko c10orf54 i ich zastosowania
WO2016106221A1 (fr) 2014-12-22 2016-06-30 The Rockefeller University Anticorps agonistes anti-mertk et leurs utilisations
EP3253753A4 (fr) 2015-01-20 2018-06-27 Xoc Pharmaceuticals, Inc Composés d'ergoline et leurs utilisations
US9676776B2 (en) 2015-01-20 2017-06-13 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
WO2016130905A1 (fr) 2015-02-13 2016-08-18 University Of Cincinnati Dispositifs de stimulation et de détection de sueur intégrées et indirectes
FI3265123T3 (fi) 2015-03-03 2023-01-31 Vasta-aineita, käyttöjä & menetelmiä
WO2016149673A1 (fr) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Composés bioactifs conjugués à des substrats de réseaux de micro-aiguilles
WO2016176617A2 (fr) 2015-04-29 2016-11-03 New York University Procédé pour le traitement de gliomes de haut grade
AU2016260547B2 (en) 2015-05-14 2020-09-03 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
PT3303394T (pt) 2015-05-29 2020-07-01 Ludwig Inst For Cancer Res Ltd Anticorpos anti-ctla-4 e métodos de uso dos mesmos
US10646142B2 (en) 2015-06-29 2020-05-12 Eccrine Systems, Inc. Smart sweat stimulation and sensing devices
WO2017004067A1 (fr) 2015-06-29 2017-01-05 Corium International, Inc. Micro-réseau pour l'administration d'un agent thérapeutique, procédés d'utilisation, et procédés de fabrication
JP6586317B2 (ja) * 2015-08-19 2019-10-02 花王株式会社 微細突起具及びその製造方法
KR20220131277A (ko) 2015-09-01 2022-09-27 아게누스 인코포레이티드 항-pd-1 항체 및 이를 이용하는 방법
WO2017045031A1 (fr) 2015-09-18 2017-03-23 Vaxxas Pty Limited Réseaux de micro-saillies comportant des micro-saillies ayant des profils à surface élevée
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US20180317833A1 (en) 2015-10-23 2018-11-08 Eccrine Systems, Inc. Devices capable of fluid sample concentration for extended sensing of analytes
AU2015249138A1 (en) * 2015-10-29 2017-05-18 Winter, Paul Nicholas MR A system delivering medications of providing drainage along tubes linked to central container using arrays of special fenestrated hypodermic needles.
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
US10674946B2 (en) 2015-12-18 2020-06-09 Eccrine Systems, Inc. Sweat sensing devices with sensor abrasion protection
WO2017120322A1 (fr) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Administration ciblant le microenvironnement cutané et visant à renforcer les réponses immunitaires et autres
JP2017131397A (ja) * 2016-01-27 2017-08-03 花王株式会社 微細中空突起具の製造方法
WO2017139375A1 (fr) 2016-02-10 2017-08-17 Clearside Biomedical, Inc. Kit d'injection oculaire, conditionnement et procédés d'utilisation
EP3416621B1 (fr) 2016-02-19 2023-12-20 North Carolina State University Systèmes d'administration à micro-aiguilles physiologiquement sensibles
CN109069155B (zh) 2016-03-01 2022-06-24 基托泰克医疗股份有限公司 用于伤口闭合的基于微观结构的系统、装置和方法
KR102376176B1 (ko) 2016-03-01 2022-03-17 조지아 테크 리서치 코오포레이션 마이크로니들 입자, 조성물, 및 치료방법 및 관심물질 전달방법
US10960013B2 (en) 2016-03-04 2021-03-30 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
EP3426352A4 (fr) 2016-03-08 2019-11-13 Los Gatos Pharmaceuticals, Inc. Dérivés de camptothécine et leurs utilisations
EP3426301A4 (fr) 2016-03-08 2019-11-06 Los Gatos Pharmaceuticals, Inc. Nanoparticules composites et utilisations desdites nanoparticules
JP2017176652A (ja) 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
CA3062845A1 (fr) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systemes et methodes pour l'administration de medicaments par voie ophtalmique
WO2017194789A1 (fr) 2016-05-13 2017-11-16 Institut Pasteur Inhibition de récepteurs nicotinique bêta-2 de l'acétylcholine pour traiter une pathologie de la maladie d'alzheimer
WO2017197323A1 (fr) 2016-05-13 2017-11-16 Lee Ann S Procédés et systèmes de localisation et de traitement par une thérapie à froid
MA45123A (fr) 2016-05-27 2019-04-10 Agenus Inc Anticorps anti-tim-3 et leurs méthodes d'utilisation
US10471249B2 (en) 2016-06-08 2019-11-12 University Of Cincinnati Enhanced analyte access through epithelial tissue
EP3472210A1 (fr) 2016-06-17 2019-04-24 Life Technologies Corporation Réticulation spécifique à un site d'anticorps
US11253190B2 (en) 2016-07-01 2022-02-22 University Of Cincinnati Devices with reduced microfluidic volume between sensors and sweat glands
AU2017292184A1 (en) 2016-07-08 2019-02-07 Staten Biotechnology B.V. Anti-Apoc3 antibodies and methods of use thereof
EP3487390A4 (fr) 2016-07-19 2020-03-11 Eccrine Systems, Inc. Conductivité de la sueur, taux de sudation volumétrique et dispositifs de réponse galvanique de la peau et applications
US11103703B2 (en) * 2016-08-11 2021-08-31 Advanced Bionics Ag Cochlear implants including electrode arrays and methods of making the same
CA3072847A1 (fr) 2016-08-12 2018-02-15 Clearside Biomedical, Inc. Dispositifs et procedes de reglage de la profondeur d'insertion d'une aiguille pour administration de medicament
WO2018035281A1 (fr) 2016-08-17 2018-02-22 North Carolina State University Voie nord-sud pour la synthèse de bactériochlorines
CN110023337B (zh) 2016-10-11 2024-01-05 艾吉纳斯公司 抗lag-3抗体及其使用方法
US10736565B2 (en) 2016-10-14 2020-08-11 Eccrine Systems, Inc. Sweat electrolyte loss monitoring devices
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
US11332521B2 (en) 2016-11-07 2022-05-17 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
WO2018089692A1 (fr) 2016-11-09 2018-05-17 Phloronol, Inc. Dérivés d'eckol, procédés de synthèse et utilisations associées
KR102487144B1 (ko) * 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
WO2018102252A1 (fr) 2016-11-30 2018-06-07 North Carolina State University Procédés de fabrication de macrocycles bactériochlorines comprenant un noyau isocyclique annelé et des composés apparentés
CA3046082A1 (fr) 2016-12-07 2018-06-14 Agenus Inc. Anticorps et procedes d'utilisation de ceux-ci
AU2017373944B2 (en) 2016-12-07 2022-02-03 Agenus Inc. Anti-CTLA-4 antibodies and methods of use thereof
CA3050721A1 (fr) 2017-01-23 2018-07-26 Abbott Diabetes Care Inc. Systemes, dispositifs et procedes pour l'insertion de capteur d'analyte
EP3576833A1 (fr) * 2017-01-31 2019-12-11 SABIC Global Technologies B.V. Utilisation d'un film destiné à préparer une préforme pour un procédé de moulage par micro-injection
AU2018220515B2 (en) 2017-02-17 2022-06-30 DayLife LLC Universal antivenom
MA47511A (fr) 2017-02-17 2019-12-25 Eidos Therapeutics Inc Procédés de préparation d'ag-10, de ses intermédiaires et de sels correspondants
WO2018151832A1 (fr) 2017-02-17 2018-08-23 Allergan, Inc. Réseau de micro-aiguilles avec principe actif
CN107007927A (zh) * 2017-02-21 2017-08-04 中山大学 一种基于电场驱动给药的微针阵列药贴及制备方法
US10952654B2 (en) 2017-03-14 2021-03-23 International Business Machines Corporation PH sensitive surgical tool
JP7152787B2 (ja) 2017-03-31 2022-10-13 ヴァクザス ピーティーワイ リミテッド 表面をコーティングするための装置および方法
BR112019017241A2 (pt) 2017-04-13 2020-04-14 Agenus Inc anticorpos anti-cd137 e métodos de uso dos mesmos
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
US10406358B1 (en) * 2017-04-24 2019-09-10 Todd M. Bertoch Chronic pain treatment device
EP3618863B1 (fr) 2017-05-01 2023-07-26 Agenus Inc. Anticorps anti-tigit et leurs utilisations
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
AU2018275672A1 (en) 2017-05-31 2020-01-16 Texas Tech University System Methods and devices for the treatment of food allergies
AU2018275873A1 (en) 2017-06-01 2019-12-19 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
CA3065371A1 (fr) 2017-06-13 2018-12-20 Vaxxas Pty Limited Controle de la qualite de revetements de substrats
EP3645029B1 (fr) 2017-06-26 2023-01-18 Institut Pasteur Traitements pour éliminer des réservoirs de vih et réduire la charge virale
KR102340352B1 (ko) 2017-06-27 2021-12-21 주식회사 뉴라클사이언스 섬유증의 치료를 위한 항-fam19a5 항체의 용도
BR112019027729A2 (pt) 2017-06-27 2020-08-18 Neuracle Science Co., Ltd anticorpos anti-fam19a5 e seus usos
KR102454460B1 (ko) 2017-06-27 2022-10-17 주식회사 뉴라클사이언스 암 치료를 위한 항-fam19a5 항체의 용도
CN110972463B (zh) 2017-06-27 2024-05-28 纽洛可科学有限公司 抗序列相似家族19成员a5抗体在治疗青光眼中的用途
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
KR102333037B1 (ko) * 2017-08-17 2021-12-01 코스메드 파마소티컬 씨오 쩜 엘티디 입술용 마이크로니들 어레이
US11571401B2 (en) 2017-09-01 2023-02-07 East Carolina University Compounds, compositions, kits, and methods for activating immune cells and/or an immune system response
US11185674B2 (en) * 2017-10-12 2021-11-30 Northwestern University Targeted delivery of biologic therapeutic agents
CN111315772A (zh) 2017-10-31 2020-06-19 斯塔顿生物技术有限公司 抗apoc3抗体及其使用方法
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
CA3083743C (fr) 2017-11-29 2023-09-26 Copernicus Therapeutics, Inc. Therapie genique pour l'amelioration des fonctions oculaires
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
WO2019136133A1 (fr) 2018-01-03 2019-07-11 The Trustees Of Columbia University In The City Of New York Micro-aiguille pour l'administration locale d'un agent thérapeutique
KR20200135996A (ko) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법
KR20200118913A (ko) 2018-04-24 2020-10-16 주식회사 뉴라클사이언스 신경병성 통증의 치료를 위한 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리의 용도
KR20240056644A (ko) 2018-05-10 2024-04-30 주식회사 뉴라클사이언스 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리 및 그의 사용 방법
US11460411B2 (en) * 2018-06-18 2022-10-04 Kindeva Drug Delivery L.P. Process and apparatus for inspecting microneedle arrays
CN112740043A (zh) 2018-07-20 2021-04-30 皮埃尔法布雷医药公司 Vista受体
WO2020037189A1 (fr) 2018-08-17 2020-02-20 Eidos Therapeutics, Inc. Formules d'ag10
JP2022508576A (ja) * 2018-10-02 2022-01-19 ウェアオプティモ ピーティーワイ リミテッド 電極装備
KR20210070300A (ko) 2018-10-03 2021-06-14 스태튼 바이오테크놀로지 비.브이. 사람 및 시노몰구스 ApoC3에 대해 특이적인 항체 및 이의 사용 방법
US20220008515A1 (en) 2018-11-16 2022-01-13 Neoimmunetech, Inc. Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor
WO2020128033A1 (fr) 2018-12-20 2020-06-25 Institut Pasteur Métabolisme cellulaire de l'ensemencement d'un réservoir de vih-1 dans des lymphocytes t cd4+
EP3921038A1 (fr) 2019-02-06 2021-12-15 Dice Alpha, Inc. Modulateurs d'il-17a et leurs utilisations
US11464908B2 (en) 2019-02-18 2022-10-11 Tandem Diabetes Care, Inc. Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps
EP4378958A2 (fr) 2019-02-26 2024-06-05 Inspirna, Inc. Anticorps anti-mertk à affinité élevée et utilisations associées
CN111939452A (zh) * 2019-05-15 2020-11-17 微邦科技股份有限公司 微针结构及其生物可降解微针
TWI687247B (zh) 2019-05-15 2020-03-11 微邦科技股份有限公司 微針結構及其生物可降解微針
CA3138403A1 (fr) 2019-05-20 2020-11-26 Christopher J. MACNEVIN Colorants a emission etroite, compositions contenant ces derniers, et methodes de production et d'utilisation correspondantes
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
WO2021010879A1 (fr) * 2019-07-12 2021-01-21 Ascilion Ab Unité d'assemblage de capteur intégré
CN110478613B (zh) * 2019-08-22 2022-08-09 京东方科技集团股份有限公司 递送制剂的器件、设备及器件中针头阵列的制备方法
WO2021042019A1 (fr) 2019-08-30 2021-03-04 Agenus Inc. Anticorps anti-cd96 et procédés d'utilisation de ces derniers
JP2022547617A (ja) 2019-09-16 2022-11-14 ダイス アルファ，インク． Ｉｌ－１７ａモジュレーターおよびその使用
IL294663A (en) 2020-01-13 2022-09-01 Neoimmunetech Inc A method for tumor treatment with a combination of il-7 protein and a bispecific antibody
EP4100045A1 (fr) 2020-02-05 2022-12-14 Washington University Procédé de traitement d'une tumeur solide avec une combinaison d'une protéine d'il-7 et de cellules immunitaires porteuses de car
WO2021168345A1 (fr) 2020-02-19 2021-08-26 Kitotech Medical, Inc. Systèmes à microstructure et méthodes de traitement de la douleur
US11202753B1 (en) 2020-03-06 2021-12-21 Aquavit Pharmaceuticals, Inc. Systems and methods for generating immune responses in subjects using microchannel delivery devices
WO2021225826A1 (fr) * 2020-05-06 2021-11-11 The Regents Of The University Of California Patch catalytique bioorthogonal et ses procédés d'utilisation
US11911595B2 (en) 2020-05-18 2024-02-27 Tandem Diabetes Care, Inc. Systems and methods for automated insulin delivery response to meal announcements
JP6846560B2 (ja) * 2020-06-04 2021-03-24 花王株式会社 微細中空突起具
CN111729189B (zh) * 2020-06-29 2023-01-06 嘉兴尚牧智能装备有限公司 硅基贴片及其制备方法
KR20230043779A (ko) 2020-07-29 2023-03-31 바이오링크 인코포레이티드 미세 바늘 어레이를 갖는 지속 분석물 모니터링 시스템
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
WO2022093718A1 (fr) 2020-10-26 2022-05-05 Neoimmunetech, Inc. Procédés d'induction de la mobilisation de cellules souches
WO2022094475A1 (fr) 2020-11-02 2022-05-05 Neoimmunetech, Inc. Utilisation de l'interleukine-7 pour le traitement du coronavirus
JP2023549112A (ja) 2020-11-05 2023-11-22 ネオイミューンテック， インコーポレイテッド Ｉｌ－７タンパク質とヌクレオチドワクチンの組み合わせで腫瘍を治療する方法
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
IL305752A (en) 2021-03-10 2023-11-01 Dice Molecules Sv Inc INTEGRIN INHIBITORS OF ALPHA V BETA 6 AND ALPHA V BETA 1 AND THEIR USES
SE2330048A1 (en) 2021-05-08 2023-01-25 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
CA3218481A1 (fr) 2021-06-14 2022-12-22 argenx BV Anticorps anti-il-9 et leurs procedes d'utilisation
CA3237696A1 (fr) 2021-11-08 2023-05-11 Progentos Therapeutics, Inc. Inhibiteurs du recepteur du facteur de croissance derive des plaquettes (pdgfr) alpha et leurs utilisations
WO2023130081A1 (fr) 2021-12-30 2023-07-06 Neoimmunetech, Inc. Procédé de traitement d'une tumeur avec une combinaison d'une protéine il-7 et d'un antagoniste du vegf
US11981694B2 (en) 2022-01-03 2024-05-14 Lilac Therapeutics, Inc. Acyclic thiol prodrugs
WO2023129577A1 (fr) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Promédicaments à base de thiol cyclique
WO2023159181A1 (fr) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Agrafes et instruments pour peau profonde à modulation de force
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine
WO2024086852A1 (fr) 2022-10-21 2024-04-25 Diagonal Therapeutics Inc. Anticorps agonistes hétéromères dirigés contre récepteur de l'il-18
WO2024102722A1 (fr) 2022-11-07 2024-05-16 Neoimmunetech, Inc. Procédés de traitement d'une tumeur avec un promoteur mgmt non méthylé

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL200971A (fr) 1954-10-04
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
DE2319591C2 (de) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medizinischer Apparat
FR2232331B1 (fr) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (de) 1975-03-07 1978-12-27 Collo Gmbh Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl.
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
SU1667864A1 (ru) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Электростимул тор
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5531675A (en) * 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (fr) 1989-07-06 1991-01-06 Ronald J. Filipski Applicateur clinique en forme de fourchette
EP0429842B1 (fr) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5162043A (en) * 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
TW279133B (fr) 1990-12-13 1996-06-21 Elan Med Tech
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5158073A (en) 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5250067A (en) 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
US5728089A (en) 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) * 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (fr) 1993-10-22 2005-05-10 Giorgio Cirelli Dispositif d'injection
CA2149836C (fr) 1994-05-23 1999-07-06 Sang Bae Choi Dispositif perforant pour administration transdermique
JP2551742B2 (ja) 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
KR0134151B1 (ko) 1994-05-23 1998-04-14 이형도 인슐린 패치
US5512219A (en) 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
JPH10510175A (ja) 1994-12-09 1998-10-06 ノバルティス アクチェンゲゼルシャフト 経皮システム
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (fr) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Dispositif micromecanique et procede pour ameliorer l'administration percutanee de composes
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
JP2713255B2 (ja) 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
JPH09215755A (ja) * 1996-02-09 1997-08-19 Poritoronikusu:Kk 皮接治療具
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
WO1997048440A1 (fr) 1996-06-18 1997-12-24 Alza Corporation Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques
DE19624578A1 (de) 1996-06-20 1998-01-08 Nancy L Divers Vorrichtung zur Hautpflege
ATE241405T1 (de) 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5904712A (en) * 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) * 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6047208A (en) * 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5938684A (en) 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
KR100557261B1 (ko) 1997-12-11 2006-03-07 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
KR100561892B1 (ko) 1997-12-11 2006-03-16 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
KR100572539B1 (ko) * 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
US6135990A (en) * 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
AU767122B2 (en) * 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1109594B1 (fr) * 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Dispositif d'electrotransport comprenant des lames
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) * 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6689103B1 (en) * 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6355054B1 (en) * 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
DE60022540T2 (de) * 1999-11-15 2006-06-14 Velcro Ind Befestigungselement für die haut
US6511463B1 (en) * 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
HU225467B1 (en) * 1999-12-10 2006-12-28 Alza Corp Skin treatment apparatus for sustained transdermal drug delivery
ATE310561T1 (de) * 1999-12-10 2005-12-15 Alza Corp Vorrichtung und verfahren zur verbesserung des mikronadel-haut-piercing
WO2001043643A1 (fr) * 1999-12-16 2001-06-21 Alza Corporation Dispositif destine a augmenter le flux transdermique de substances echantillonnees
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6533884B1 (en) 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8216190B2 (en) 2000-10-16 2012-07-10 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US8702726B2 (en) 2000-10-16 2014-04-22 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7914480B2 (en) 2004-03-24 2011-03-29 Corium International, Inc. Transdermal delivery device
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays

Also Published As

Publication number Publication date
CA2376285A1 (fr) 2000-12-14
US6256533B1 (en) 2001-07-03
WO2000074765A1 (fr) 2000-12-14
EP1183065A1 (fr) 2002-03-06
US7416541B2 (en) 2008-08-26
JP2003501162A (ja) 2003-01-14
US20050209565A1 (en) 2005-09-22
TW458791B (en) 2001-10-11
AU5728000A (en) 2000-12-28
US6931277B1 (en) 2005-08-16
EP1183065B1 (fr) 2016-03-23

Similar Documents

Publication Publication Date Title
CA2376285C (fr) Dispositif a jeu de microaiguilles intradermiques
EP1183064B1 (fr) Procede de fabrication d'un jeu de microaiguilles intradermiques
EP1183066B1 (fr) Structure intracutanee de micro-aiguille a bords effiles
US6565532B1 (en) Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
EP1086214B1 (fr) Dispositifs a microaiguilles et procedes de leur fabrication
JP4778669B2 (ja) ソフトリソグラフィ及びフォトリソグラフィを使用して微小針（ｍｉｃｒｏｎｅｅｄｌｅｓ）構造を製造する方法
US6334856B1 (en) Microneedle devices and methods of manufacture and use thereof
AU2007202052B2 (en) Microneedle devices and production thereof
WO2001091846A2 (fr) Appareil a micro-aiguilles pour le marquage de la peau et l'administration d'un maquillage sous-cutane semi-permanent
AU2005200910B2 (en) Devices and methods for enhanced microneedle penetration of biological barriers
CA2591168C (fr) Procede de fabrication d'un jeu de microaiguilles intradermiques
CA2510389A1 (fr) Dispositifs a microaiguilles et procedes de fabrication et d'utilisation correspondants
AU2008200252A1 (en) Microneedle devices and methods of manufacture and use thereof

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190607