EP3253753A4 - Composés d'ergoline et leurs utilisations - Google Patents
Composés d'ergoline et leurs utilisations Download PDFInfo
- Publication number
- EP3253753A4 EP3253753A4 EP16740618.0A EP16740618A EP3253753A4 EP 3253753 A4 EP3253753 A4 EP 3253753A4 EP 16740618 A EP16740618 A EP 16740618A EP 3253753 A4 EP3253753 A4 EP 3253753A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- ergoline compounds
- ergoline
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562105208P | 2015-01-20 | 2015-01-20 | |
PCT/US2016/013980 WO2016118541A1 (fr) | 2015-01-20 | 2016-01-20 | Composés d'ergoline et leurs utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3253753A1 EP3253753A1 (fr) | 2017-12-13 |
EP3253753A4 true EP3253753A4 (fr) | 2018-06-27 |
Family
ID=56407317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16740618.0A Withdrawn EP3253753A4 (fr) | 2015-01-20 | 2016-01-20 | Composés d'ergoline et leurs utilisations |
Country Status (11)
Country | Link |
---|---|
US (8) | US9657020B2 (fr) |
EP (1) | EP3253753A4 (fr) |
JP (1) | JP6856532B2 (fr) |
CN (2) | CN113149982A (fr) |
AU (2) | AU2016209492B2 (fr) |
BR (1) | BR112017015487A2 (fr) |
CA (1) | CA2974117A1 (fr) |
HK (1) | HK1248215A1 (fr) |
IL (2) | IL253466B (fr) |
MX (1) | MX2017009405A (fr) |
WO (1) | WO2016118541A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112017015487A2 (pt) | 2015-01-20 | 2018-01-30 | Xoc Pharmaceuticals Inc | Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo |
MX2017009406A (es) | 2015-01-20 | 2018-01-18 | Xoc Pharmaceuticals Inc | Compuestos de tipo isoergolina y usos de estos. |
CN106866656A (zh) * | 2017-02-28 | 2017-06-20 | 西南交通大学 | 一类麦角碱衍生物及其在预防和治疗精神疾病的用途 |
BR112019025420A2 (pt) | 2017-06-01 | 2020-06-16 | Xoc Pharmaceuticals, Inc. | Compostos policíclicos e usos destes |
WO2020183011A1 (fr) | 2019-03-14 | 2020-09-17 | Institut Curie | Inhibiteurs de htr1d et leurs utilisations dans le traitement du cancer |
WO2021127391A1 (fr) * | 2019-12-20 | 2021-06-24 | The Jackson Laboratory | Cibles moléculaires pour la dépendance |
WO2022008627A2 (fr) * | 2020-07-07 | 2022-01-13 | Compass Pathfinder Limited | Procédé amélioré pour la production de diéthylamide d'acide lysergique (lsd) et nouveaux dérivés associés |
CA3232050A1 (fr) * | 2021-10-26 | 2023-05-04 | Methvin Isaac | Agonistes derives d'ergoline du recepteur 5-ht2a |
WO2023182288A1 (fr) * | 2022-03-22 | 2023-09-28 | 国立大学法人京都大学 | Médicament pour le traitement ou la prévention de la maladie de charcot-marie-tooth |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US705519A (en) * | 1902-04-28 | 1902-07-22 | Louis Roser Jr | Hose-supporter. |
US4005089A (en) * | 1974-05-28 | 1977-01-25 | Richter Gedeon Vegyeszeti Gyar Rt. | Compounds with ergoline skeleton |
EP0816364A1 (fr) * | 1996-07-02 | 1998-01-07 | F. Hoffmann-La Roche Ag | Réactifs pour le dosage immunologique du diéthylamide de l'acide lysergique |
WO2013095708A1 (fr) * | 2011-12-21 | 2013-06-27 | Map Pharmaceuticals, Inc. | Nouveaux composés neuromodulateurs |
WO2014078857A1 (fr) * | 2012-11-19 | 2014-05-22 | Regents Of The University Of Minnesota | Dérivés d'ergoline en tant que modulateurs d'un récepteur de la dopamine |
WO2014100354A1 (fr) * | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | Nouveaux dérivés de méthysergide |
Family Cites Families (153)
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CA470573A (fr) | 1951-01-02 | Stoll Arthur | Fabrication de dihydro-derives sympathicolytiquement actifs d'amides d'acide lysergique | |
US3085092A (en) | 1963-04-09 | Preparation of lysergic acid deriva- | ||
US1046493A (en) | 1911-12-07 | 1912-12-10 | Daniel J Ring | Garter. |
US2086559A (en) | 1936-01-30 | 1937-07-13 | Lilly Co Eli | Hydrogenated ergotocin |
DE1770227A1 (de) * | 1967-04-20 | 1972-03-30 | Richter Gedeon Vegyeszet | Lysergsaeureamide und Verfahren zu deren Herstellung |
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
SE396753B (sv) * | 1970-05-18 | 1977-10-03 | Richter Gedeon Vegyeszet | Analogiforfarande for framstellning av en forening tillhorande dihydrolysergsyraserien |
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AU2021200381A1 (en) | 2021-03-18 |
US20180298001A1 (en) | 2018-10-18 |
JP6856532B2 (ja) | 2021-04-07 |
US10703753B2 (en) | 2020-07-07 |
US20170174684A1 (en) | 2017-06-22 |
IL253466B (en) | 2021-04-29 |
US10308651B2 (en) | 2019-06-04 |
US10464936B2 (en) | 2019-11-05 |
EP3253753A1 (fr) | 2017-12-13 |
US9938277B2 (en) | 2018-04-10 |
IL282088A (en) | 2021-05-31 |
US20190337947A1 (en) | 2019-11-07 |
MX2017009405A (es) | 2018-01-18 |
WO2016118541A1 (fr) | 2016-07-28 |
CA2974117A1 (fr) | 2016-07-28 |
AU2016209492A1 (en) | 2017-08-31 |
HK1248215A1 (zh) | 2018-10-12 |
BR112017015487A2 (pt) | 2018-01-30 |
AU2016209492B2 (en) | 2020-10-22 |
JP2018502888A (ja) | 2018-02-01 |
US20170174685A1 (en) | 2017-06-22 |
CN107428745A (zh) | 2017-12-01 |
US20180327404A1 (en) | 2018-11-15 |
US20190169188A1 (en) | 2019-06-06 |
US9657020B2 (en) | 2017-05-23 |
US10246458B2 (en) | 2019-04-02 |
US9951070B2 (en) | 2018-04-24 |
CN113149982A (zh) | 2021-07-23 |
IL253466A0 (en) | 2017-09-28 |
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