CA2273951C - Parasiticidal pyrazoles - Google Patents

Parasiticidal pyrazoles Download PDF

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Publication number
CA2273951C
CA2273951C CA002273951A CA2273951A CA2273951C CA 2273951 C CA2273951 C CA 2273951C CA 002273951 A CA002273951 A CA 002273951A CA 2273951 A CA2273951 A CA 2273951A CA 2273951 C CA2273951 C CA 2273951C
Authority
CA
Canada
Prior art keywords
dichloro
hydrogen
cyano
halo
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002273951A
Other languages
English (en)
French (fr)
Other versions
CA2273951A1 (en
Inventor
Bernard Joseph Banks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625290.3A external-priority patent/GB9625290D0/en
Priority claimed from GBGB9702235.4A external-priority patent/GB9702235D0/en
Priority claimed from GBGB9712045.5A external-priority patent/GB9712045D0/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2273951A1 publication Critical patent/CA2273951A1/en
Application granted granted Critical
Publication of CA2273951C publication Critical patent/CA2273951C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
CA002273951A 1996-12-05 1997-11-25 Parasiticidal pyrazoles Expired - Fee Related CA2273951C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9625290.3 1996-12-05
GBGB9625290.3A GB9625290D0 (en) 1996-12-05 1996-12-05 Parasiticidal agents
GB9702235.4 1997-02-04
GBGB9702235.4A GB9702235D0 (en) 1997-02-04 1997-02-04 Parasiticidal agents
GB9712045 1997-06-10
GBGB9712045.5A GB9712045D0 (en) 1997-06-10 1997-06-10 Parasiticidal agents
PCT/EP1997/006697 WO1998024767A1 (en) 1996-12-05 1997-11-25 Parasiticidal pyrazoles

Publications (2)

Publication Number Publication Date
CA2273951A1 CA2273951A1 (en) 1998-06-11
CA2273951C true CA2273951C (en) 2003-04-01

Family

ID=27268619

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002273951A Expired - Fee Related CA2273951C (en) 1996-12-05 1997-11-25 Parasiticidal pyrazoles

Country Status (40)

Country Link
US (2) US6075043A (ja)
EP (1) EP0946515B1 (ja)
JP (2) JP3950483B2 (ja)
KR (1) KR100354311B1 (ja)
CN (1) CN1106386C (ja)
AR (1) AR013879A1 (ja)
AT (1) ATE233736T1 (ja)
AU (1) AU720705B2 (ja)
BG (1) BG64127B1 (ja)
BR (1) BR9713565A (ja)
CA (1) CA2273951C (ja)
CO (1) CO5031251A1 (ja)
CZ (1) CZ295295B6 (ja)
DE (1) DE69719547T2 (ja)
DK (1) DK0946515T3 (ja)
DZ (1) DZ2360A1 (ja)
EA (1) EA002278B1 (ja)
ES (1) ES2191870T3 (ja)
HK (1) HK1029111A1 (ja)
HR (1) HRP970663B1 (ja)
HU (1) HUP0000544A3 (ja)
ID (1) ID21556A (ja)
IL (1) IL129866A (ja)
IS (1) IS1982B (ja)
MA (1) MA24414A1 (ja)
MY (1) MY117021A (ja)
NO (2) NO313518B1 (ja)
NZ (1) NZ335611A (ja)
OA (1) OA11055A (ja)
PA (1) PA8442101A1 (ja)
PE (1) PE20199A1 (ja)
PL (1) PL190926B1 (ja)
PT (1) PT946515E (ja)
RS (1) RS49720B (ja)
SK (1) SK285203B6 (ja)
TN (1) TNSN97197A1 (ja)
TW (1) TW524667B (ja)
UA (1) UA60321C2 (ja)
UY (2) UY24798A1 (ja)
WO (1) WO1998024767A1 (ja)

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TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
GB9801851D0 (en) * 1998-01-29 1998-03-25 Pfizer Ltd Parasiticidal agents
GB9811050D0 (en) * 1998-05-22 1998-07-22 Pfizer Ltd Pyrazoles
AR021608A1 (es) * 1998-12-11 2002-07-31 Merial Ltd Represion de artropodos en animales
US6531501B1 (en) 1998-12-11 2003-03-11 Aventis Cropscience, S.A. Control of arthropods in animals
GB9916052D0 (en) * 1999-07-08 1999-09-08 Pfizer Ltd Anthelmintic compositions
PL364874A1 (en) 1999-12-02 2004-12-27 Bayer Cropscience S.A. Control of arthropods in animals
AU2003218758A1 (en) * 2002-03-14 2003-09-22 Syngenta Participations Ag Derivatives of 1-phenyl-3-phenylpyrazole as herbicides
CH697663B1 (de) * 2003-01-07 2009-01-15 Lanxess Deutschland Gmbh Pyrazolylalkine.
WO2005023773A1 (en) * 2003-09-04 2005-03-17 Pfizer Limited Process for the preparation of substituted aryl pyrazoles
GB0329314D0 (en) * 2003-12-18 2004-01-21 Pfizer Ltd Substituted arylpyrazoles
US7514464B2 (en) * 2003-12-18 2009-04-07 Pfizer Limited Substituted arylpyrazoles
AU2005223483B2 (en) 2004-03-18 2009-04-23 Zoetis Llc N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
US20080146643A1 (en) * 2005-06-15 2008-06-19 Pfizer Limited Combination
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
AU2006257647A1 (en) 2005-06-15 2006-12-21 Pfizer Limited Substituted arylpyrazoles for use against parasites
US20080176865A1 (en) * 2005-06-15 2008-07-24 Pfizer Limited Substituted arylpyrazoles
US20070149464A1 (en) * 2005-06-15 2007-06-28 Pfizer Inc. Combination
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP1783114A1 (en) * 2005-11-03 2007-05-09 Novartis AG N-(hetero)aryl indole derivatives as pesticides
DE102006061537A1 (de) * 2006-12-27 2008-07-03 Bayer Healthcare Ag Mittel zur Bekämpfung von Parasiten an Tieren
DE102006061538A1 (de) 2006-12-27 2008-07-03 Bayer Healthcare Ag Kombinationsprodukt zur Bekämpfung von Parasiten an Tieren
AU2011236510A1 (en) 2010-04-08 2012-10-11 Zoetis Llc Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
RU2551354C2 (ru) 2010-08-05 2015-05-20 Зоетис ЭлЭлСи Производные изоксазолина в качестве противопаразитарных агентов
AU2011306489B2 (en) 2010-09-24 2015-11-05 Zoetis Services Llc Isoxazoline oximes as antiparasitic agents
WO2012120399A1 (en) 2011-03-10 2012-09-13 Pfizer Inc. Spirocyclic isoxazoline derivatives as antiparasitic agents
CA2829179C (en) 2011-03-22 2016-07-05 Zoetis Llc Isoxazoline derivatives as antiparasitic agents
EP2725899B1 (de) 2011-06-30 2016-09-28 Hansen-AB GmbH Mittel zur bekämpfung von parasiten an tieren
PL2814825T3 (pl) 2012-02-03 2016-08-31 Zoetis Services Llc Dihydrofuranowe pochodne azetydyny jako środki przeciwpasożytnicze
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
BR112014027805A2 (pt) 2012-05-09 2017-06-27 Zoetis Llc derivados de azetidina como agentes antiparasitários
US20150297565A1 (en) 2012-12-12 2015-10-22 Zoetis Services Llc Phenylpyrazole injectable compositions
SG11202000940XA (en) 2017-08-24 2020-02-27 Novo Nordisk As Glp-1 compositions and uses thereof
CN111116478B (zh) * 2019-12-18 2021-10-26 浙江金伯士药业有限公司 一种兽用抗生素维吉霉素中间体的制备方法
CA3165359A1 (en) 2020-02-18 2021-07-22 Dorthe Kot Engelund Glp-1 compositions and uses thereof
CN115894374A (zh) * 2023-02-16 2023-04-04 广州佳途科技股份有限公司 一种氟甲腈的制备方法及其应用

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DE3771318D1 (de) * 1986-12-05 1991-08-14 Ciba Geigy Ag Ektoparasitizide nicht-waessrige pour-on-fluessigformulierung.
DE3706993A1 (de) * 1987-03-05 1988-09-15 Bayer Ag 5-amino-3-halogenalkyl-1-aryl-pyrazole
SE455750B (sv) 1987-06-11 1988-08-01 Ericsson Telefon Ab L M Digitalt tidsmultiplext mobiltelefonisystem med ett effektivt utnyttjande av varje tidsram
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ZA94170B (en) * 1993-01-20 1995-03-15 Soltec Res Pty Ltd Ectoparasiticidal formulation
AUPM437194A0 (en) * 1994-03-11 1994-03-31 Commonwealth Scientific And Industrial Research Organisation Pesticide formulation
EP0851913B1 (en) 1995-08-11 2004-05-19 Novozymes A/S Novel lipolytic enzymes
GB9601128D0 (en) * 1995-08-11 1996-03-20 Pfizer Ltd Parasiticidal compounds
JPH0987111A (ja) * 1995-09-27 1997-03-31 Sumitomo Chem Co Ltd 害虫駆除用毒餌剤
FR2739255B1 (fr) * 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
ATE236883T1 (de) * 1995-12-19 2003-04-15 Bayer Cropscience Sa Neue 1-aryl pyrazol derivate und ihre verwendung als schädlingsbekämpfungsmittel
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GR1002899B (el) * 1996-03-29 1998-05-11 Rhone Merieux Περιλαιμιο κατα ψυλλων και κροτωνων για σκυλους και γατες, με βαση ν-φαινυλπυραζολη
IE970215A1 (en) * 1996-03-29 1997-10-08 Rhone Merieux Direct pour-on skin solution for antiparasitic use in cattle¹and sheep
GR970100096A (el) * 1996-03-29 1997-11-28 Merial Εξωτερικη διαταξη κατα των παρασιτων για βοοειδη με βαση τη ν-φαινυλπυραζολη, ειδικα σκουλαρικια.
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
US7100379B2 (en) * 2003-08-14 2006-09-05 Samsung Electronics Co., Ltd. Water supply control apparatus and method for ice maker

Also Published As

Publication number Publication date
CN1106386C (zh) 2003-04-23
DE69719547T2 (de) 2003-10-02
IS5050A (is) 1999-05-11
PE20199A1 (es) 1999-03-05
UY24923A1 (es) 1998-09-01
PL190926B1 (pl) 2006-02-28
HUP0000544A3 (en) 2002-01-28
UY24798A1 (es) 2000-09-29
NZ335611A (en) 2001-01-26
CO5031251A1 (es) 2001-04-27
BR9713565A (pt) 2000-03-14
AR013879A1 (es) 2001-01-31
HRP970663A2 (en) 1998-10-31
NO992732L (no) 1999-08-05
HRP970663B1 (en) 2003-10-31
DK0946515T3 (da) 2003-07-14
KR20000057432A (ko) 2000-09-15
CZ295295B6 (cs) 2005-06-15
PL333922A1 (en) 2000-01-31
JP2000505812A (ja) 2000-05-16
JP3950483B2 (ja) 2007-08-01
BG64127B1 (bg) 2004-01-30
KR100354311B1 (ko) 2002-09-28
PT946515E (pt) 2003-06-30
MA24414A1 (fr) 1998-07-01
PA8442101A1 (es) 2000-05-24
YU25299A (sh) 2002-10-18
CN1258282A (zh) 2000-06-28
IL129866A0 (en) 2000-02-29
JP2007211016A (ja) 2007-08-23
BG103454A (en) 2000-01-31
EA199900447A1 (ru) 2000-02-28
SK74099A3 (en) 2001-02-12
EP0946515A1 (en) 1999-10-06
NO992736D0 (no) 1999-06-04
NO992732D0 (no) 1999-06-04
NO313518B1 (no) 2002-10-14
AU720705B2 (en) 2000-06-08
EA002278B1 (ru) 2002-02-28
AU5485998A (en) 1998-06-29
HK1029111A1 (en) 2001-03-23
IL129866A (en) 2004-05-12
RS49720B (sr) 2007-12-31
ID21556A (id) 1999-06-24
UA60321C2 (uk) 2003-10-15
MY117021A (en) 2004-04-30
ATE233736T1 (de) 2003-03-15
DZ2360A1 (fr) 2002-12-28
SK285203B6 (sk) 2006-08-03
HUP0000544A2 (hu) 2000-06-28
TW524667B (en) 2003-03-21
WO1998024767A1 (en) 1998-06-11
EP0946515B1 (en) 2003-03-05
US6268509B1 (en) 2001-07-31
TNSN97197A1 (fr) 2005-03-15
DE69719547D1 (de) 2003-04-10
ES2191870T3 (es) 2003-09-16
IS1982B (is) 2005-01-14
CZ195199A3 (cs) 2000-08-16
US6075043A (en) 2000-06-13
CA2273951A1 (en) 1998-06-11
OA11055A (en) 2002-03-07

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