CA1340994C - Treatment of conditions and disease - Google Patents

Treatment of conditions and disease

Info

Publication number
CA1340994C
CA1340994C CA000612307A CA612307A CA1340994C CA 1340994 C CA1340994 C CA 1340994C CA 000612307 A CA000612307 A CA 000612307A CA 612307 A CA612307 A CA 612307A CA 1340994 C CA1340994 C CA 1340994C
Authority
CA
Canada
Prior art keywords
dosage
agent
component
disease
condition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000612307A
Other languages
English (en)
French (fr)
Inventor
Rudolf Edgar Dr. Falk
Samuel Simon Asculai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Original Assignee
Hyal Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4140639&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1340994(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hyal Pharmaceutical Corp filed Critical Hyal Pharmaceutical Corp
Priority to CA000612307A priority Critical patent/CA1340994C/en
Priority to EP90914108A priority patent/EP0445255B2/en
Priority to HU9007339A priority patent/HU220758B1/hu
Priority to AT90914108T priority patent/ATE131068T1/de
Priority to JP51320490A priority patent/JP3256761B2/ja
Priority to SG1996002961A priority patent/SG49658A1/en
Priority to AT95100186T priority patent/ATE227587T1/de
Priority to AU64330/90A priority patent/AU6433090A/en
Priority to DE69024039T priority patent/DE69024039T3/de
Priority to PCT/CA1990/000306 priority patent/WO1991004058A2/en
Priority to RO148511A priority patent/RO112812B1/ro
Priority to US07/675,908 priority patent/US6069135A/en
Priority to DE69034018T priority patent/DE69034018T2/de
Priority to KR1019910700514A priority patent/KR920700697A/ko
Priority to EP95100186A priority patent/EP0656213B1/en
Priority to DK90914108T priority patent/DK0445255T4/da
Priority to CA002042034A priority patent/CA2042034A1/en
Priority to DK95100186T priority patent/DK0656213T3/da
Priority to BR909006924A priority patent/BR9006924A/pt
Priority to ES95100186T priority patent/ES2186693T3/es
Priority to ES90914108T priority patent/ES2080837T5/es
Priority to SU4895848/A priority patent/RU2146139C1/ru
Priority to FI912470A priority patent/FI912470A0/fi
Priority to IL9574590A priority patent/IL95745A/en
Priority to APAP/P/1990/000206A priority patent/AP175A/en
Priority to ZA907564A priority patent/ZA907564B/xx
Priority to SK4598-90A priority patent/SK459890A3/sk
Priority to IN821/CAL/90A priority patent/IN171745B/en
Priority to CN90108840A priority patent/CN1101228C/zh
Priority to NO91911952A priority patent/NO911952L/no
Priority to AU52274/93A priority patent/AU674894C/en
Priority to LTIP1582A priority patent/LT3545B/lt
Priority to US08/286,263 priority patent/US5827834A/en
Priority to US08/462,147 priority patent/US5852002A/en
Priority to US08/462,614 priority patent/US5914314A/en
Priority to US08/461,124 priority patent/US5932560A/en
Priority to US08/462,615 priority patent/US5830882A/en
Priority to US08/462,154 priority patent/US5985850A/en
Priority to US08/465,335 priority patent/US5811410A/en
Priority to US08/461,565 priority patent/US6048844A/en
Priority to US08/462,148 priority patent/US5929048A/en
Priority to HU95P/P00656P priority patent/HU211953A9/hu
Priority to US08/460,978 priority patent/US6194392B1/en
Priority to US08/744,852 priority patent/US5985851A/en
Priority to AU14850/97A priority patent/AU1485097A/en
Priority to HK44797A priority patent/HK44797A/en
Priority to HK98105089.4A priority patent/HK1005985B/en
Application granted granted Critical
Publication of CA1340994C publication Critical patent/CA1340994C/en
Priority to US10/628,999 priority patent/US20040019011A1/en
Priority to US11/245,816 priority patent/US20060128655A1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CA000612307A 1989-09-21 1989-09-21 Treatment of conditions and disease Expired - Lifetime CA1340994C (en)

Priority Applications (49)

Application Number Priority Date Filing Date Title
CA000612307A CA1340994C (en) 1989-09-21 1989-09-21 Treatment of conditions and disease
EP90914108A EP0445255B2 (en) 1989-09-21 1990-09-18 USE OF HYALURONIC ACID IN COMBINATION WITH ASCORBIC ACID, ANTITUMOUR AGENTS AND/OR NSAIDs FOR TREATING CANCER
HU9007339A HU220758B1 (hu) 1989-09-21 1990-09-18 Eljárás hialuronsavat és nem szteroid gyulladásgátlót tartalmazó, rák kezelésére alkalmas gyógyászati készítmények előállítására
AT90914108T ATE131068T1 (de) 1989-09-21 1990-09-18 Behandlung von pathologischen zuständen und krankheiten.
JP51320490A JP3256761B2 (ja) 1989-09-21 1990-09-18 症状及び疾病の治療
SG1996002961A SG49658A1 (en) 1989-09-21 1990-09-18 Treatment of condition and disease
AT95100186T ATE227587T1 (de) 1989-09-21 1990-09-18 Kombinierte verwendung von hyaluronsäure und therapeutischen wirkstoffen zur verbesserung des therapeutischen effekts
AU64330/90A AU6433090A (en) 1989-09-21 1990-09-18 Treatment of conditions and disease
DE69024039T DE69024039T3 (de) 1989-09-21 1990-09-18 VERWENDUNG VON HYALURONSÄURE IN KOMBINATION MIT ASCORBINSÄURE, ANTITUMORMITTELN UND/ODER NSAIDs ZUR BEHANDLUNG VON KREBS
PCT/CA1990/000306 WO1991004058A2 (en) 1989-09-21 1990-09-18 Treatment of conditions and disease
RO148511A RO112812B1 (ro) 1989-09-21 1990-09-18 Metoda de tratament al unor stari sau boli si compozitie pentru aceasta
US07/675,908 US6069135A (en) 1989-09-21 1990-09-18 Use of hyaluronic acid or its derivatives to enhance delivery of therapeutic agents
DE69034018T DE69034018T2 (de) 1989-09-21 1990-09-18 Kombinierte verwendung von hyaluronsäure und therapeutischen wirkstoffen zur verbesserung des therapeutischen effekts
KR1019910700514A KR920700697A (ko) 1989-09-21 1990-09-18 질병치료용 약물과 히알루론산으로 구성된 복합물을 이용한 포유류의 종양관련성 질병 치료방법 및 이용된 복합물
EP95100186A EP0656213B1 (en) 1989-09-21 1990-09-18 Combined use of hyaluronic acid and therapeutic agents to improve the therapeutic effect
DK90914108T DK0445255T4 (da) 1989-09-21 1990-09-18 Anvendelse af hyaluronsyre i kombination med ascorbinsyre, antitumormidler og/eller NSAID's til behandling af cancer
CA002042034A CA2042034A1 (en) 1989-09-21 1990-09-18 Treatment of conditions and disease
DK95100186T DK0656213T3 (da) 1989-09-21 1990-09-18 Kombineret anvendelse af hyaluronsyre og terapeutiske aktivstoffer til forbedring af den terapeutiske effekt
BR909006924A BR9006924A (pt) 1989-09-21 1990-09-18 Formulacao para tratamento de sintomas e doencas,uso de formulacao para o tratamento de sintomas e doencas,metodo para o tratamento de sintomas e doencas,distribuicao de agentes medicinais e terapeuticos para o tratamento de sintomas e doencas e combinacao para administracao em mamiferos
ES95100186T ES2186693T3 (es) 1989-09-21 1990-09-18 Uso combinado del acido hialuronico y de agentes terapeuticos para mejorar el efecto terapeutico.
ES90914108T ES2080837T5 (es) 1989-09-21 1990-09-18 Uso de acido hialuronico en combinacion con acido ascorbico, agentes antitumorales y/o faine para el tratamiento del cancer.
SU4895848/A RU2146139C1 (ru) 1989-09-21 1990-09-18 Лечение состояний и заболеваний, комбинации и композиции, предназначенные для лечения, способ повышения активности макрофагов и комбинации для его осуществления
FI912470A FI912470A0 (fi) 1989-09-21 1990-09-18 Behandling av haelsotillstaond och sjukdomar.
IL9574590A IL95745A (en) 1989-09-21 1990-09-19 Pharmaceutical compositions containing a therapeutic agent and hyaluronic acid or its derivatives for facilitating the transport of the active agent
APAP/P/1990/000206A AP175A (en) 1989-09-21 1990-09-21 Combination and formulations and the administration thereof to a mammal for the treatment of conditions and disease.
ZA907564A ZA907564B (en) 1989-09-21 1990-09-21 Treatment of conditions and disease
SK4598-90A SK459890A3 (en) 1989-09-21 1990-09-21 USE OF HYALURONIC ACID, THE SALTS THEREOF AND ANALOGUES FORì (54) PRODUCING A THERAPEUTIC AGENT TO TREAT DISEASES OR CONDIT
IN821/CAL/90A IN171745B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-09-21 1990-09-21
CN90108840A CN1101228C (zh) 1989-09-21 1990-09-21 病症与疾病的治疗
NO91911952A NO911952L (no) 1989-09-21 1991-05-21 Behandling av tilstander og sykdommer samt midler derfor.
AU52274/93A AU674894C (en) 1989-09-21 1993-12-09 Treatment of conditions and disease
LTIP1582A LT3545B (en) 1989-09-21 1993-12-10 Compositions of medicinal preparation and hyaluronic acid for treatment of conditions and disease
US08/286,263 US5827834A (en) 1989-09-21 1994-08-05 Method of using hyaluronic acid or its pharmaceutically acceptable salts for the treatment of disease
US08/462,147 US5852002A (en) 1989-09-21 1995-06-05 Treatment of conditions and disease
US08/462,614 US5914314A (en) 1989-09-21 1995-06-05 Use of a form of hyaluronic acid and a medicinal agent for reducing rejection of organs transplantation in mammals
US08/461,124 US5932560A (en) 1989-09-21 1995-06-05 Treatment of conditions and disease
US08/462,615 US5830882A (en) 1989-09-21 1995-06-05 Compositions containing a form of hyaluronic acid and a medicinal agent for treating acne in mammals and methods for administration of such composition
US08/462,154 US5985850A (en) 1989-09-21 1995-06-05 Compositions comprising hyaluronic acid and drugs
US08/465,335 US5811410A (en) 1989-09-21 1995-06-05 Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID
US08/461,565 US6048844A (en) 1989-09-21 1995-06-05 Treatment of conditions and disease
US08/462,148 US5929048A (en) 1989-09-21 1995-06-05 Treatment of conditions and disease
HU95P/P00656P HU211953A9 (en) 1989-09-21 1995-06-30 Treatment of conditions and disease
US08/460,978 US6194392B1 (en) 1989-09-21 1995-08-07 Treatment of conditions and disease
US08/744,852 US5985851A (en) 1989-09-21 1996-11-18 Use of hyaluronic acid or its derivatives in peritoneal dialysis and formulations thereof
AU14850/97A AU1485097A (en) 1989-09-21 1997-02-21 Treatment of conditions and disease
HK44797A HK44797A (en) 1989-09-21 1997-04-10 USE OF HYALURONIC ACID IN COMBINATION WITH ASCORBIC ACID, ANTITUMOUR AGENTS AND/OR NSAIDs FOR TREATING CANCER
HK98105089.4A HK1005985B (en) 1989-09-21 1998-06-10 Combined use of hyaluronic acid and therapeutic agents to improve the therapeutic effect
US10/628,999 US20040019011A1 (en) 1989-09-21 2003-07-28 Treatment of conitions and disease
US11/245,816 US20060128655A1 (en) 1989-09-21 2005-10-07 Use of hyaluronic acid or its derivatives to enhance delivery of antineoplastic agents

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