CA1320732C - Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl)-phenylmethyl|-1-piperazinyl| ethyoxy|-acetic acid and its dihydrochloride - Google Patents

Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl)-phenylmethyl|-1-piperazinyl| ethyoxy|-acetic acid and its dihydrochloride

Info

Publication number
CA1320732C
CA1320732C CA000614708A CA614708A CA1320732C CA 1320732 C CA1320732 C CA 1320732C CA 000614708 A CA000614708 A CA 000614708A CA 614708 A CA614708 A CA 614708A CA 1320732 C CA1320732 C CA 1320732C
Authority
CA
Canada
Prior art keywords
chlorophenyl
alkali metal
phenylmethyl
piperazinyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000614708A
Other languages
English (en)
French (fr)
Inventor
Guy Bodson
Eric Cossement
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Application granted granted Critical
Publication of CA1320732C publication Critical patent/CA1320732C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000614708A 1988-11-23 1989-09-29 Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl)-phenylmethyl|-1-piperazinyl| ethyoxy|-acetic acid and its dihydrochloride Expired - Fee Related CA1320732C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8827390 1988-11-23
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
CA1320732C true CA1320732C (en) 1993-07-27

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000614708A Expired - Fee Related CA1320732C (en) 1988-11-23 1989-09-29 Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl)-phenylmethyl|-1-piperazinyl| ethyoxy|-acetic acid and its dihydrochloride

Country Status (17)

Country Link
KR (1) KR970009727B1 (pl)
AT (1) AT398970B (pl)
CA (1) CA1320732C (pl)
CY (1) CY1696A (pl)
DK (1) DK174289B1 (pl)
ES (1) ES2018967A6 (pl)
FI (1) FI91861C (pl)
GB (2) GB8827390D0 (pl)
GR (1) GR1000576B (pl)
HK (1) HK45493A (pl)
HU (1) HU208002B (pl)
NO (1) NO172287C (pl)
PH (1) PH26334A (pl)
PL (1) PL161374B1 (pl)
PT (1) PT92363B (pl)
RU (1) RU1838306C (pl)
SG (1) SG12793G (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950412A3 (en) * 1992-09-24 2001-05-16 Sepracor, Inc. Compositions for treating allergic disorders using (-) cetirizine
AU5136193A (en) * 1992-09-24 1994-04-12 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003238883A1 (en) * 2002-06-05 2003-12-22 Dr.Reddy's Laboratories Ltd. A novel amorphous form of (2-(4-((4-chlorophenyl)-phenyl methyl)-1- piperazinyl) ethoxy) acetic acid dihydrochloride (cetirizine dihydrochloride)
CN100378086C (zh) * 2003-01-23 2008-04-02 Ucb法奇姆股份有限公司 哌嗪衍生物和它们作为合成中间体的应用
AU2003228011A1 (en) * 2003-05-21 2004-12-13 Wockhardt Limited 2-(2-(4-((4-chlorophenyl) phenylmethyl)-1-piperazinyl)ethoxy)acetic acid monohydrochloride as anti-allergenic compound and process for its production
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
FI75816C (fi) * 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.

Also Published As

Publication number Publication date
ATA266489A (de) 1994-07-15
GR890100771A (en) 1990-12-31
KR900007824A (ko) 1990-06-02
KR970009727B1 (ko) 1997-06-17
CY1696A (en) 1994-01-14
FI91861B (fi) 1994-05-13
ES2018967A6 (es) 1991-05-16
NO894650L (no) 1990-05-25
PT92363B (pt) 1995-07-18
NO894650D0 (no) 1989-11-22
DK586589D0 (da) 1989-11-22
GB8926242D0 (en) 1990-01-10
FI895563A0 (fi) 1989-11-22
FI91861C (fi) 1994-08-25
AT398970B (de) 1995-02-27
NO172287C (no) 1993-06-30
PT92363A (pt) 1990-05-31
DK586589A (da) 1990-05-24
GR1000576B (el) 1992-08-26
HK45493A (en) 1993-05-21
HU208002B (en) 1993-07-28
GB8827390D0 (en) 1988-12-29
SG12793G (en) 1993-04-16
RU1838306C (ru) 1993-08-30
HUT53626A (en) 1990-11-28
GB2225320A (en) 1990-05-30
HU896130D0 (en) 1990-02-28
PL161374B1 (pl) 1993-06-30
NO172287B (no) 1993-03-22
PH26334A (en) 1992-04-29
GB2225320B (en) 1992-09-02
DK174289B1 (da) 2002-11-18

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