HU896130D0 - Process for the preparation of 2-2-[4- /(4- chloro- phenyl)- phenyl- methyl/- 1- piperazynil]- ethoxi- acetic acid and salts thereof - Google Patents

Process for the preparation of 2-2-[4- /(4- chloro- phenyl)- phenyl- methyl/- 1- piperazynil]- ethoxi- acetic acid and salts thereof

Info

Publication number
HU896130D0
HU896130D0 HU896130A HU613089A HU896130D0 HU 896130 D0 HU896130 D0 HU 896130D0 HU 896130 A HU896130 A HU 896130A HU 613089 A HU613089 A HU 613089A HU 896130 D0 HU896130 D0 HU 896130D0
Authority
HU
Hungary
Prior art keywords
phenyl
piperazynil
ethoxi
chloro
salts
Prior art date
Application number
HU896130A
Other languages
Hungarian (hu)
Other versions
HU208002B (en
HUT53626A (en
Inventor
Guy Bodson
Eric Cossement
Jean Gobert
Original Assignee
Guy Bodson
Eric Cossement
Jean Gobert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guy Bodson, Eric Cossement, Jean Gobert filed Critical Guy Bodson
Publication of HU896130D0 publication Critical patent/HU896130D0/en
Publication of HUT53626A publication Critical patent/HUT53626A/en
Publication of HU208002B publication Critical patent/HU208002B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU896130A 1988-11-23 1989-11-22 Process for producing 2-/2-/4-//4-chloro-phenyl/-phenyl-methyl/-1-piperazinyl/-ethoxy/- -aceticacid and dihydrochloride salt of them HU208002B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (3)

Publication Number Publication Date
HU896130D0 true HU896130D0 (en) 1990-02-28
HUT53626A HUT53626A (en) 1990-11-28
HU208002B HU208002B (en) 1993-07-28

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
HU896130A HU208002B (en) 1988-11-23 1989-11-22 Process for producing 2-/2-/4-//4-chloro-phenyl/-phenyl-methyl/-1-piperazinyl/-ethoxy/- -aceticacid and dihydrochloride salt of them

Country Status (17)

Country Link
KR (1) KR970009727B1 (en)
AT (1) AT398970B (en)
CA (1) CA1320732C (en)
CY (1) CY1696A (en)
DK (1) DK174289B1 (en)
ES (1) ES2018967A6 (en)
FI (1) FI91861C (en)
GB (2) GB8827390D0 (en)
GR (1) GR1000576B (en)
HK (1) HK45493A (en)
HU (1) HU208002B (en)
NO (1) NO172287C (en)
PH (1) PH26334A (en)
PL (1) PL161374B1 (en)
PT (1) PT92363B (en)
RU (1) RU1838306C (en)
SG (1) SG12793G (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10199031I2 (en) * 1992-09-24 2004-09-23 Sepracor Inc Use of (-) cetrizine to treat allergic rhinitis and asthma.
ATE177636T1 (en) * 1992-09-24 1999-04-15 Sepracor Inc TRANSDERMAL TREATMENT OF HURTS WITH OPTICALLY PURE (+)-CETIRIZINE
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (en) * 1999-03-04 2009-03-30 Sandoz As Process for the preparation of 2- {2- [4- (diphenylmethyl) -1-piperazinyl] ethoxy} -acetic acid compounds or salts thereof
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003238883A1 (en) * 2002-06-05 2003-12-22 Dr.Reddy's Laboratories Ltd. A novel amorphous form of (2-(4-((4-chlorophenyl)-phenyl methyl)-1- piperazinyl) ethoxy) acetic acid dihydrochloride (cetirizine dihydrochloride)
CN100378086C (en) 2003-01-23 2008-04-02 Ucb法奇姆股份有限公司 piperazine derivatives and their use as synthesis intermediates
US20060258684A1 (en) * 2003-05-21 2006-11-16 Singh Prasad S 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
NO155805C (en) * 1981-02-06 1987-06-10 Ucb Sa ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2- (4- (DIPHENYLMETHYL) -1-PIPERAZINYL) -ACDIC ACIDS AND THEIR AMIDS AND NON-TOXIC SALTS.

Also Published As

Publication number Publication date
FI91861C (en) 1994-08-25
PH26334A (en) 1992-04-29
PL161374B1 (en) 1993-06-30
DK586589A (en) 1990-05-24
CY1696A (en) 1994-01-14
HK45493A (en) 1993-05-21
NO894650L (en) 1990-05-25
NO172287C (en) 1993-06-30
GR890100771A (en) 1990-12-31
NO894650D0 (en) 1989-11-22
PT92363B (en) 1995-07-18
AT398970B (en) 1995-02-27
DK586589D0 (en) 1989-11-22
SG12793G (en) 1993-04-16
NO172287B (en) 1993-03-22
CA1320732C (en) 1993-07-27
RU1838306C (en) 1993-08-30
FI91861B (en) 1994-05-13
HU208002B (en) 1993-07-28
HUT53626A (en) 1990-11-28
FI895563A0 (en) 1989-11-22
GB2225320A (en) 1990-05-30
GB8926242D0 (en) 1990-01-10
ES2018967A6 (en) 1991-05-16
KR900007824A (en) 1990-06-02
ATA266489A (en) 1994-07-15
PT92363A (en) 1990-05-31
DK174289B1 (en) 2002-11-18
GB8827390D0 (en) 1988-12-29
KR970009727B1 (en) 1997-06-17
GR1000576B (en) 1992-08-26
GB2225320B (en) 1992-09-02

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees