GB2225320B - A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride - Google Patents

A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Info

Publication number
GB2225320B
GB2225320B GB8926242A GB8926242A GB2225320B GB 2225320 B GB2225320 B GB 2225320B GB 8926242 A GB8926242 A GB 8926242A GB 8926242 A GB8926242 A GB 8926242A GB 2225320 B GB2225320 B GB 2225320B
Authority
GB
United Kingdom
Prior art keywords
phenylmethyl
dihydrochloride
piperazinyl
chlorophenyl
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8926242A
Other versions
GB2225320A (en
GB8926242D0 (en
Inventor
Eric Cossement
Jean Gobert
Guy Bodson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of GB8926242D0 publication Critical patent/GB8926242D0/en
Publication of GB2225320A publication Critical patent/GB2225320A/en
Application granted granted Critical
Publication of GB2225320B publication Critical patent/GB2225320B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8926242A 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride Expired - Lifetime GB2225320B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (3)

Publication Number Publication Date
GB8926242D0 GB8926242D0 (en) 1990-01-10
GB2225320A GB2225320A (en) 1990-05-30
GB2225320B true GB2225320B (en) 1992-09-02

Family

ID=10647346

Family Applications (2)

Application Number Title Priority Date Filing Date
GB888827390A Pending GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8926242A Expired - Lifetime GB2225320B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB888827390A Pending GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Country Status (17)

Country Link
KR (1) KR970009727B1 (en)
AT (1) AT398970B (en)
CA (1) CA1320732C (en)
CY (1) CY1696A (en)
DK (1) DK174289B1 (en)
ES (1) ES2018967A6 (en)
FI (1) FI91861C (en)
GB (2) GB8827390D0 (en)
GR (1) GR1000576B (en)
HK (1) HK45493A (en)
HU (1) HU208002B (en)
NO (1) NO172287C (en)
PH (1) PH26334A (en)
PL (1) PL161374B1 (en)
PT (1) PT92363B (en)
RU (1) RU1838306C (en)
SG (1) SG12793G (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10199031I2 (en) * 1992-09-24 2004-09-23 Sepracor Inc Use of (-) cetrizine to treat allergic rhinitis and asthma.
ATE177636T1 (en) * 1992-09-24 1999-04-15 Sepracor Inc TRANSDERMAL TREATMENT OF HURTS WITH OPTICALLY PURE (+)-CETIRIZINE
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (en) * 1999-03-04 2009-03-30 Sandoz As Process for the preparation of 2- {2- [4- (diphenylmethyl) -1-piperazinyl] ethoxy} -acetic acid compounds or salts thereof
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003238883A1 (en) * 2002-06-05 2003-12-22 Dr.Reddy's Laboratories Ltd. A novel amorphous form of (2-(4-((4-chlorophenyl)-phenyl methyl)-1- piperazinyl) ethoxy) acetic acid dihydrochloride (cetirizine dihydrochloride)
CN100378086C (en) 2003-01-23 2008-04-02 Ucb法奇姆股份有限公司 piperazine derivatives and their use as synthesis intermediates
US20060258684A1 (en) * 2003-05-21 2006-11-16 Singh Prasad S 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
EP0058146A1 (en) * 1981-02-06 1982-08-18 U C B, S.A. 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
EP0058146A1 (en) * 1981-02-06 1982-08-18 U C B, S.A. 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
I.L.Finar, Advanced organic chemistry:volume 1:The fundamental principles, (London, 1959) p. 131 *
Ind. chim. belge 22 409-20 (1957) *

Also Published As

Publication number Publication date
FI91861C (en) 1994-08-25
PH26334A (en) 1992-04-29
PL161374B1 (en) 1993-06-30
DK586589A (en) 1990-05-24
CY1696A (en) 1994-01-14
HK45493A (en) 1993-05-21
NO894650L (en) 1990-05-25
NO172287C (en) 1993-06-30
GR890100771A (en) 1990-12-31
NO894650D0 (en) 1989-11-22
PT92363B (en) 1995-07-18
AT398970B (en) 1995-02-27
DK586589D0 (en) 1989-11-22
HU896130D0 (en) 1990-02-28
SG12793G (en) 1993-04-16
NO172287B (en) 1993-03-22
CA1320732C (en) 1993-07-27
RU1838306C (en) 1993-08-30
FI91861B (en) 1994-05-13
HU208002B (en) 1993-07-28
HUT53626A (en) 1990-11-28
FI895563A0 (en) 1989-11-22
GB2225320A (en) 1990-05-30
GB8926242D0 (en) 1990-01-10
ES2018967A6 (en) 1991-05-16
KR900007824A (en) 1990-06-02
ATA266489A (en) 1994-07-15
PT92363A (en) 1990-05-31
DK174289B1 (en) 2002-11-18
GB8827390D0 (en) 1988-12-29
KR970009727B1 (en) 1997-06-17
GR1000576B (en) 1992-08-26

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20081121