BRPI1008745A2 - pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios - Google Patents
pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios Download PDFInfo
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- BRPI1008745A2 BRPI1008745A2 BRPI1008745A BRPI1008745A BRPI1008745A2 BR PI1008745 A2 BRPI1008745 A2 BR PI1008745A2 BR PI1008745 A BRPI1008745 A BR PI1008745A BR PI1008745 A BRPI1008745 A BR PI1008745A BR PI1008745 A2 BRPI1008745 A2 BR PI1008745A2
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- Brazil
- Prior art keywords
- alkyl
- compound
- cancer
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- fact
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Classifications
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- C07J—STEROIDS
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- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15003109P | 2009-02-05 | 2009-02-05 | |
| PCT/US2010/023391 WO2010091306A1 (en) | 2009-02-05 | 2010-02-05 | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1008745A2 true BRPI1008745A2 (pt) | 2019-09-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1008745A BRPI1008745A2 (pt) | 2009-02-05 | 2010-02-05 | pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20110312916A1 (enExample) |
| EP (2) | EP2393827B1 (enExample) |
| JP (2) | JP2012516900A (enExample) |
| CN (1) | CN102686600A (enExample) |
| AU (1) | AU2010210422A1 (enExample) |
| BR (1) | BRPI1008745A2 (enExample) |
| CA (1) | CA2761389A1 (enExample) |
| ES (1) | ES2552087T3 (enExample) |
| WO (1) | WO2010091306A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US8785423B2 (en) * | 2008-04-14 | 2014-07-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases |
| US20110312916A1 (en) | 2009-02-05 | 2011-12-22 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| JP2014523445A (ja) * | 2011-07-18 | 2014-09-11 | トーカイ ファーマシューティカルズ，インク． | 前立腺癌を処置するための新規な組成物及び方法 |
| DE102011083725A1 (de) | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| SG11201401471PA (en) * | 2011-11-30 | 2014-08-28 | Astrazeneca Ab | Combination treatment of cancer |
| WO2013096907A1 (en) * | 2011-12-22 | 2013-06-27 | Tokai Pharmaceuticals, Inc. | Methods and compositions for combination therapy using p13k/mtor inhibitors |
| WO2014102833A2 (en) * | 2012-12-31 | 2014-07-03 | Hetero Research Foundation | Process for abiraterone acetate |
| CA2898573A1 (en) * | 2013-01-18 | 2014-07-24 | Cortendo Ab (Publ) | Abiraterone and analogs thereof for the treatment of diseases associated with cortisol overproduction |
| US9714266B2 (en) | 2013-02-21 | 2017-07-25 | Bayer Pharma Aktiengesellschaft | Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3) |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| EP3514147B1 (en) * | 2013-04-04 | 2022-08-03 | University of Maryland, Baltimore | Steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
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2010
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- 2010-02-05 EP EP10704283.0A patent/EP2393827B1/en not_active Not-in-force
- 2010-02-05 WO PCT/US2010/023391 patent/WO2010091306A1/en not_active Ceased
- 2010-02-05 AU AU2010210422A patent/AU2010210422A1/en not_active Abandoned
- 2010-02-05 BR BRPI1008745A patent/BRPI1008745A2/pt not_active IP Right Cessation
- 2010-02-05 ES ES10704283.0T patent/ES2552087T3/es active Active
- 2010-02-05 CA CA2761389A patent/CA2761389A1/en not_active Abandoned
- 2010-02-05 JP JP2011549296A patent/JP2012516900A/ja active Pending
- 2010-02-05 CN CN2010800071882A patent/CN102686600A/zh active Pending
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2014
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2015
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| JP2016034946A (ja) | 2016-03-17 |
| AU2010210422A8 (en) | 2011-08-25 |
| WO2010091306A1 (en) | 2010-08-12 |
| JP2012516900A (ja) | 2012-07-26 |
| US20140371181A1 (en) | 2014-12-18 |
| AU2010210422A1 (en) | 2011-08-18 |
| ES2552087T3 (es) | 2015-11-25 |
| EP2393827B1 (en) | 2015-10-07 |
| CA2761389A1 (en) | 2010-08-12 |
| CN102686600A (zh) | 2012-09-19 |
| US20110312916A1 (en) | 2011-12-22 |
| EP3023433A1 (en) | 2016-05-25 |
| US9359395B2 (en) | 2016-06-07 |
| EP2393827A1 (en) | 2011-12-14 |
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