JP2012516900A - ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ - Google Patents

ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ Download PDF

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Publication number
JP2012516900A
JP2012516900A JP2011549296A JP2011549296A JP2012516900A JP 2012516900 A JP2012516900 A JP 2012516900A JP 2011549296 A JP2011549296 A JP 2011549296A JP 2011549296 A JP2011549296 A JP 2011549296A JP 2012516900 A JP2012516900 A JP 2012516900A
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Prior art keywords
alkyl
compound
cancer
group
alkylaryl
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JP2011549296A
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Japanese (ja)
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JP2012516900A5 (enExample
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カセビア，デービッド
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トーカイ ファーマシューティカルズ，インク．
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Publication of JP2012516900A publication Critical patent/JP2012516900A/ja
Publication of JP2012516900A5 publication Critical patent/JP2012516900A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
JP2011549296A 2009-02-05 2010-02-05 ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ Pending JP2012516900A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15003109P 2009-02-05 2009-02-05
US61/150,031 2009-02-05
PCT/US2010/023391 WO2010091306A1 (en) 2009-02-05 2010-02-05 Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015159619A Division JP2016034946A (ja) 2009-02-05 2015-08-12 ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ

Publications (2)

Publication Number Publication Date
JP2012516900A true JP2012516900A (ja) 2012-07-26
JP2012516900A5 JP2012516900A5 (enExample) 2013-03-21

Family

ID=42115803

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011549296A Pending JP2012516900A (ja) 2009-02-05 2010-02-05 ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ
JP2015159619A Pending JP2016034946A (ja) 2009-02-05 2015-08-12 ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ

Family Applications After (1)

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JP2015159619A Pending JP2016034946A (ja) 2009-02-05 2015-08-12 ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ

Country Status (9)

Country Link
US (2) US20110312916A1 (enExample)
EP (2) EP2393827B1 (enExample)
JP (2) JP2012516900A (enExample)
CN (1) CN102686600A (enExample)
AU (1) AU2010210422A1 (enExample)
BR (1) BRPI1008745A2 (enExample)
CA (1) CA2761389A1 (enExample)
ES (1) ES2552087T3 (enExample)
WO (1) WO2010091306A1 (enExample)

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US20100048913A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US8785423B2 (en) * 2008-04-14 2014-07-22 University Of Maryland, Baltimore Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases
US20110312916A1 (en) 2009-02-05 2011-12-22 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
JP2014523445A (ja) * 2011-07-18 2014-09-11 トーカイ ファーマシューティカルズ，インク． 前立腺癌を処置するための新規な組成物及び方法
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WO2013096907A1 (en) * 2011-12-22 2013-06-27 Tokai Pharmaceuticals, Inc. Methods and compositions for combination therapy using p13k/mtor inhibitors
WO2014102833A2 (en) * 2012-12-31 2014-07-03 Hetero Research Foundation Process for abiraterone acetate
CA2898573A1 (en) * 2013-01-18 2014-07-24 Cortendo Ab (Publ) Abiraterone and analogs thereof for the treatment of diseases associated with cortisol overproduction
US9714266B2 (en) 2013-02-21 2017-07-25 Bayer Pharma Aktiengesellschaft Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3)
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
EP3514147B1 (en) * 2013-04-04 2022-08-03 University of Maryland, Baltimore Steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
EP3033088A4 (en) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CN104017045B (zh) * 2014-06-23 2016-01-13 广州艾格生物科技有限公司 甾体cyp17抑制剂的新型药物前体及其应用、制备方法
CN105646637B (zh) * 2014-11-28 2018-12-14 四川海思科制药有限公司 一种阿比特龙衍生物及其制备方法和医药用途
CN107188922B (zh) * 2016-03-14 2019-12-20 四川海思科制药有限公司 一种阿比特龙衍生物的盐及其制备方法和医药用途
CN107188921A (zh) * 2016-03-15 2017-09-22 四川海思科制药有限公司 阿比特龙衍生物的制备方法及其新固态形式和用途
CN107365343A (zh) * 2016-05-12 2017-11-21 四川海思科制药有限公司 一种苯并咪唑雄甾衍生物及其制备方法和医药用途
ES2697706R1 (es) * 2016-06-01 2019-02-08 Ind Chimica Srl Proceso Para La Preparación De Galeterona.
ITUA20164043A1 (it) * 2016-06-01 2017-12-01 Ind Chimica Srl Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene
CN106220705A (zh) * 2016-07-25 2016-12-14 厦门市瑞思医药科技有限公司 一种2’‑(n,n,n‑三甲基氯化铵基)乙酸阿比特龙酯的合成方法
CN109846826A (zh) * 2019-01-25 2019-06-07 湖南华腾制药有限公司 醋酸阿比特龙柔性脂质体及其制备方法
JP7644713B2 (ja) 2019-03-06 2025-03-12 プロペラ セラピューティクス インコーポレイテッド アビラテロンプロドラッグ
WO2021100019A1 (en) 2019-11-22 2021-05-27 Suven Life Sciences Limited Prodrugs of abiraterone
WO2022122042A1 (zh) * 2020-12-12 2022-06-16 上海喀露蓝科技有限公司 阿比特龙衍生物及其制备方法
JP2024506382A (ja) 2021-02-15 2024-02-13 プロペラ セラピューティクス インコーポレイテッド アビラテロンプロドラッグ
EP4294513A1 (en) 2021-02-19 2023-12-27 Mevion Medical Systems, Inc. Gantry for a particle therapy system
CN113061154B (zh) * 2021-03-25 2022-07-08 天津海润家和创新医药研究有限责任公司 新型注射用阿比特龙衍生物的制备方法和用途

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