BRPI0719469C1 - vetores de expressão derivados de retrovírus e métodos para produzir um vírus infeccioso de sarampo - Google Patents
vetores de expressão derivados de retrovírus e métodos para produzir um vírus infeccioso de sarampoInfo
- Publication number
- BRPI0719469C1 BRPI0719469C1 BRPI0719469A BRPI0719469A BRPI0719469C1 BR PI0719469 C1 BRPI0719469 C1 BR PI0719469C1 BR PI0719469 A BRPI0719469 A BR PI0719469A BR PI0719469 A BRPI0719469 A BR PI0719469A BR PI0719469 C1 BRPI0719469 C1 BR PI0719469C1
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- producing
- cells
- measles
- recombinant
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 241000712079 Measles morbillivirus Species 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000002458 infectious effect Effects 0.000 title abstract 2
- 241001430294 unidentified retrovirus Species 0.000 title 1
- 201000005505 Measles Diseases 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 241001493065 dsRNA viruses Species 0.000 abstract 2
- 102000053602 DNA Human genes 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 241000711513 Mononegavirales Species 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
- C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06292025.1A EP1939214B1 (en) | 2006-12-22 | 2006-12-22 | Cells and methodology to generate non-segmented negative-strand RNA viruses |
| EP06292025.1 | 2006-12-22 | ||
| PCT/IB2007/004444 WO2008078198A2 (en) | 2006-12-22 | 2007-12-21 | Cells and methodology to generate non-segmented negative-strand rna viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0719469A2 BRPI0719469A2 (pt) | 2014-02-11 |
| BRPI0719469B1 BRPI0719469B1 (pt) | 2019-07-02 |
| BRPI0719469C1 true BRPI0719469C1 (pt) | 2021-05-25 |
Family
ID=37831098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0719469A BRPI0719469C1 (pt) | 2006-12-22 | 2007-12-21 | vetores de expressão derivados de retrovírus e métodos para produzir um vírus infeccioso de sarampo |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8586364B2 (enExample) |
| EP (2) | EP1939214B1 (enExample) |
| JP (2) | JP5902371B2 (enExample) |
| KR (1) | KR101469007B1 (enExample) |
| CN (2) | CN101631798A (enExample) |
| BR (1) | BRPI0719469C1 (enExample) |
| CA (1) | CA2673262C (enExample) |
| DK (2) | DK1939214T3 (enExample) |
| ES (2) | ES2423518T3 (enExample) |
| MX (1) | MX2009006755A (enExample) |
| WO (1) | WO2008078198A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1375670B1 (en) | 2002-06-20 | 2013-06-12 | Institut Pasteur | Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions |
| ES2330309T3 (es) | 2002-06-20 | 2009-12-09 | Institut Pasteur | Adnc infeccioso de una cepa de vacuna aprobada de virus del sarampion. uso para composiciones inmunogenicas. |
| CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
| WO2012038832A2 (en) * | 2010-09-24 | 2012-03-29 | Institut Pasteur | Generation of replicating chimeric measles virus - retrovirus particles |
| CN103906843B (zh) * | 2011-06-08 | 2016-12-07 | 维什瓦斯·乔希 | 双质粒哺乳动物表达系统 |
| FR2994697B1 (fr) * | 2012-08-24 | 2016-05-13 | Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad) | Souche vaccinale marquee du virus de la peste des petits ruminants, et son procede d'obtention |
| EP2712871A1 (en) | 2012-09-27 | 2014-04-02 | Institut Pasteur | Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications |
| EP2759301A1 (en) | 2013-01-24 | 2014-07-30 | Institut Pasteur | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus) |
| US20140255447A1 (en) * | 2013-03-05 | 2014-09-11 | Biomune Company | Production of avian embryo cells |
| WO2015092710A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Biologicals, S.A. | Contralateral co-administration of vaccines |
| US11535864B2 (en) | 2015-01-05 | 2022-12-27 | Vishwas Dattatraya JOSHI | DNA molecules producing custom designed replicating and non-replicating negative stranded RNA viruses and uses there of |
| EP3184119A1 (en) | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
| EP3255056A1 (en) * | 2016-06-06 | 2017-12-13 | Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives | Method for producing self-assemblying paramyxoviral nucleocapsid-like particles and their uses |
| US11351246B2 (en) | 2017-05-09 | 2022-06-07 | Invectys SAS | Recombinant measles vaccine expressing hTERT |
| EP3412307A1 (en) | 2017-06-07 | 2018-12-12 | Institut Pasteur | Recombinant measles virus expressing zika virus proteins and their applications |
| CN107557340A (zh) * | 2017-09-26 | 2018-01-09 | 南京普菲科医药科技有限公司 | 一种可诱导性拯救弹状病毒的细胞系及其构建方法与应用 |
| JP7225254B2 (ja) | 2017-11-09 | 2023-02-20 | アンスティテュ・パストゥール | 非構造タンパク質を含むジカウイルスキメラポリエピトープ、及び免疫原性組成物におけるその使用 |
| CA3085224A1 (en) | 2017-12-21 | 2019-06-27 | Institut Pasteur | Measles-vectored lassa vaccine |
| WO2020012037A1 (en) * | 2018-07-13 | 2020-01-16 | Valneva Se | Method for rescuing and producing a virus in avian cells |
| CN109355301A (zh) * | 2018-08-22 | 2019-02-19 | 深圳大学 | 一种石斑鱼重组NNVcp的密码子优化的核酸序列、融合表达载体、制备方法及其本身 |
| CN111218474A (zh) * | 2018-11-23 | 2020-06-02 | 成都生物制品研究所有限责任公司 | 一种副粘病毒的拯救系统和副粘病毒拯救方法 |
| EP3673917A1 (en) | 2018-12-28 | 2020-07-01 | Themis Bioscience GmbH | Norovirus vaccines |
| CN109913423A (zh) * | 2019-03-27 | 2019-06-21 | 扬州大学 | 一种稳定表达猪德尔塔冠状病毒N蛋白的重组Vero细胞系及应用 |
| EP3865180A1 (en) | 2020-02-13 | 2021-08-18 | Institut Pasteur | Live recombinant measles virus expressing coronavirus antigens - its use in eliciting immunity against coronaviruses |
| JP2023513913A (ja) | 2020-02-13 | 2023-04-04 | アンスティテュ・パストゥール | 麻疹ベクターを用いたｃｏｖｉｄ－１９免疫原性組成物及びワクチン |
| US20230310581A1 (en) * | 2020-04-27 | 2023-10-05 | Ohio State Innovation Foundation | A live attenuated measles virus vectored vaccine for sars-cov-2 |
| EP3936517A1 (en) * | 2020-07-08 | 2022-01-12 | Institut Pasteur | An improved measles virus vaccine vector based on multiple tandem additional transcription units |
| CA3204201A1 (en) | 2021-01-13 | 2022-07-21 | Thierry Heidmann | Measles-hiv or measles-htlv vaccine |
| US20250304921A1 (en) * | 2022-05-27 | 2025-10-02 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Reverse genetics system for feline morbillivirus |
| EP4501946A1 (en) | 2023-07-31 | 2025-02-05 | LoopLab Bio GmbH | Self-amplifying biologics for targeted therapy |
| CN120648655A (zh) * | 2025-08-21 | 2025-09-16 | 内蒙古自治区农牧业科学院 | 一株t7-293t细胞及其在牛副流感病毒3型感染性克隆拯救病毒中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE181112T1 (de) * | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| HK1050210B (en) | 1999-10-12 | 2007-08-24 | Institut Pasteur | Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna |
| JP2004503233A (ja) | 2000-06-16 | 2004-02-05 | インスティティ・パスツール | デング熱ウイルスエンベロープ糖タンパク質のプロ−アポトーシスフラグメント |
| EP1375670B1 (en) | 2002-06-20 | 2013-06-12 | Institut Pasteur | Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions |
| DE10234579A1 (de) * | 2002-07-30 | 2004-02-12 | Zf Friedrichshafen Ag | Getriebe |
| KR100999316B1 (ko) * | 2003-06-09 | 2010-12-10 | 와이어쓰 엘엘씨 | ｃＤＮＡ로부터의 비분절 네가티브 쇄 ＲＮＡ 바이러스의회수를 위한 개선된 방법 |
| CA2549188A1 (fr) | 2003-12-02 | 2005-06-23 | Universite Paris 7 | Utilisation des proteines et des peptides codes par le genome d'une nouvelle souche de coronavirus associe au sras |
| FR2870126B1 (fr) | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
| CN101198353A (zh) * | 2005-04-14 | 2008-06-11 | 昆士兰大学 | 免疫调节组合物和其应用 |
-
2006
- 2006-12-22 ES ES06292025T patent/ES2423518T3/es active Active
- 2006-12-22 EP EP06292025.1A patent/EP1939214B1/en active Active
- 2006-12-22 DK DK06292025.1T patent/DK1939214T3/da active
-
2007
- 2007-12-21 MX MX2009006755A patent/MX2009006755A/es active IP Right Grant
- 2007-12-21 CN CN200780047473A patent/CN101631798A/zh active Pending
- 2007-12-21 ES ES07870468.1T patent/ES2686168T3/es active Active
- 2007-12-21 JP JP2009542273A patent/JP5902371B2/ja active Active
- 2007-12-21 DK DK07870468.1T patent/DK2091962T3/en active
- 2007-12-21 CA CA2673262A patent/CA2673262C/en active Active
- 2007-12-21 US US12/448,468 patent/US8586364B2/en active Active
- 2007-12-21 WO PCT/IB2007/004444 patent/WO2008078198A2/en not_active Ceased
- 2007-12-21 CN CN201510019183.6A patent/CN104745533A/zh active Pending
- 2007-12-21 BR BRPI0719469A patent/BRPI0719469C1/pt active IP Right Grant
- 2007-12-21 KR KR1020097015426A patent/KR101469007B1/ko active Active
- 2007-12-21 EP EP07870468.1A patent/EP2091962B1/en active Active
-
2013
- 2013-10-15 US US14/054,748 patent/US9499799B2/en active Active
-
2014
- 2014-08-22 JP JP2014169418A patent/JP2015015955A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2686168T3 (es) | 2018-10-16 |
| CA2673262A1 (en) | 2008-07-03 |
| CN101631798A (zh) | 2010-01-20 |
| KR101469007B1 (ko) | 2014-12-05 |
| BRPI0719469B1 (pt) | 2019-07-02 |
| EP2091962A2 (en) | 2009-08-26 |
| ES2423518T3 (es) | 2013-09-20 |
| KR20090103922A (ko) | 2009-10-01 |
| US8586364B2 (en) | 2013-11-19 |
| US20140051148A1 (en) | 2014-02-20 |
| JP5902371B2 (ja) | 2016-04-13 |
| BRPI0719469A2 (pt) | 2014-02-11 |
| DK2091962T3 (en) | 2018-10-08 |
| JP2015015955A (ja) | 2015-01-29 |
| JP2010512779A (ja) | 2010-04-30 |
| US20100144040A1 (en) | 2010-06-10 |
| DK1939214T3 (da) | 2013-10-14 |
| EP1939214B1 (en) | 2013-07-10 |
| WO2008078198A3 (en) | 2008-10-30 |
| US9499799B2 (en) | 2016-11-22 |
| WO2008078198A2 (en) | 2008-07-03 |
| EP1939214A1 (en) | 2008-07-02 |
| MX2009006755A (es) | 2009-07-31 |
| EP2091962B1 (en) | 2018-07-04 |
| CN104745533A (zh) | 2015-07-01 |
| CA2673262C (en) | 2019-03-05 |
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