KR101469007B1 - 비분절 음성 가닥 ｒｎａ 바이러스 생성하는 세포 및 방법 - Google Patents

비분절 음성 가닥 ｒｎａ 바이러스 생성하는 세포 및 방법 Download PDF

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KR101469007B1
KR101469007B1 KR1020097015426A KR20097015426A KR101469007B1 KR 101469007 B1 KR101469007 B1 KR 101469007B1 KR 1020097015426 A KR1020097015426 A KR 1020097015426A KR 20097015426 A KR20097015426 A KR 20097015426A KR 101469007 B1 KR101469007 B1 KR 101469007B1
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KR20090103922A (ko
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프레데릭 땅지
삐에르 샤르노
이브 자꼬브
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앵스티띠 파스퇴르
상뜨르 나시오날 드 라 리쉐르쉐 샹띠피끄
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KR1020097015426A 2006-12-22 2007-12-21 비분절 음성 가닥 ｒｎａ 바이러스 생성하는 세포 및 방법 Active KR101469007B1 (ko)

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Application Number Priority Date Filing Date Title
EP06292025.1A EP1939214B1 (en) 2006-12-22 2006-12-22 Cells and methodology to generate non-segmented negative-strand RNA viruses
EP06292025.1 2006-12-22
PCT/IB2007/004444 WO2008078198A2 (en) 2006-12-22 2007-12-21 Cells and methodology to generate non-segmented negative-strand rna viruses

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KR20090103922A KR20090103922A (ko) 2009-10-01
KR101469007B1 true KR101469007B1 (ko) 2014-12-05

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US (2) US8586364B2 (enExample)
EP (2) EP1939214B1 (enExample)
JP (2) JP5902371B2 (enExample)
KR (1) KR101469007B1 (enExample)
CN (2) CN101631798A (enExample)
BR (1) BRPI0719469C1 (enExample)
CA (1) CA2673262C (enExample)
DK (2) DK1939214T3 (enExample)
ES (2) ES2423518T3 (enExample)
MX (1) MX2009006755A (enExample)
WO (1) WO2008078198A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1375512T3 (da) 2002-06-20 2009-10-26 Pasteur Institut Infektiös cDNA af en godkendt vaccinestamme af mæslingevirus. Anvendelse til immunogene sammensætninger
DK1375670T3 (da) 2002-06-20 2013-09-23 Pasteur Institut Rekombinante mæslingevira, der udtrykker epitoper af RNA-viras antigener, samt anvendelse af de rekombinante vira til fremstilling af vaccinesammensætninger
CA2432738A1 (en) 2003-02-26 2004-08-26 Philippe Despres New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications
WO2012038832A2 (en) * 2010-09-24 2012-03-29 Institut Pasteur Generation of replicating chimeric measles virus - retrovirus particles
CN103906843B (zh) * 2011-06-08 2016-12-07 维什瓦斯·乔希 双质粒哺乳动物表达系统
FR2994697B1 (fr) * 2012-08-24 2016-05-13 Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad) Souche vaccinale marquee du virus de la peste des petits ruminants, et son procede d'obtention
EP2712871A1 (en) 2012-09-27 2014-04-02 Institut Pasteur Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications
EP2759301A1 (en) 2013-01-24 2014-07-30 Institut Pasteur Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus)
US20140255447A1 (en) * 2013-03-05 2014-09-11 Biomune Company Production of avian embryo cells
WO2015092710A1 (en) 2013-12-19 2015-06-25 Glaxosmithkline Biologicals, S.A. Contralateral co-administration of vaccines
GB2583296A (en) 2015-01-05 2020-10-21 Seagull Biosolutions Pvt Ltd Dna molecules producing custom designed replicating and non-replicating negative stranded rna viruses and uses there of
EP3184119A1 (en) 2015-12-23 2017-06-28 Themis Bioscience GmbH Chromatography based purification strategies for measles scaffold based viruses
EP3255056A1 (en) * 2016-06-06 2017-12-13 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives Method for producing self-assemblying paramyxoviral nucleocapsid-like particles and their uses
EP3622078A1 (en) 2017-05-09 2020-03-18 Invectys Recombinant measles vaccine expressing htert
EP3412307A1 (en) 2017-06-07 2018-12-12 Institut Pasteur Recombinant measles virus expressing zika virus proteins and their applications
CN107557340A (zh) * 2017-09-26 2018-01-09 南京普菲科医药科技有限公司 一种可诱导性拯救弹状病毒的细胞系及其构建方法与应用
BR112020009157A2 (pt) 2017-11-09 2020-10-27 Institut Pasteur poliepítopo quimérico, polinucleotídeo, vetor, célula hospedeira e composição imunogênica
EP3727411A2 (en) 2017-12-21 2020-10-28 Institut Pasteur Lassa vaccine
WO2020012037A1 (en) * 2018-07-13 2020-01-16 Valneva Se Method for rescuing and producing a virus in avian cells
CN109355301A (zh) * 2018-08-22 2019-02-19 深圳大学 一种石斑鱼重组NNVcp的密码子优化的核酸序列、融合表达载体、制备方法及其本身
CN111218474A (zh) * 2018-11-23 2020-06-02 成都生物制品研究所有限责任公司 一种副粘病毒的拯救系统和副粘病毒拯救方法
EP3673917A1 (en) 2018-12-28 2020-07-01 Themis Bioscience GmbH Norovirus vaccines
CN109913423A (zh) * 2019-03-27 2019-06-21 扬州大学 一种稳定表达猪德尔塔冠状病毒N蛋白的重组Vero细胞系及应用
EP3865180A1 (en) 2020-02-13 2021-08-18 Institut Pasteur Live recombinant measles virus expressing coronavirus antigens - its use in eliciting immunity against coronaviruses
MX2022009989A (es) 2020-02-13 2022-11-08 Pasteur Institut Composiciones inmunogenicas y vacunas para covid-19 vectorizadas por sarampion.
US20230310581A1 (en) * 2020-04-27 2023-10-05 Ohio State Innovation Foundation A live attenuated measles virus vectored vaccine for sars-cov-2
EP3936517A1 (en) * 2020-07-08 2022-01-12 Institut Pasteur An improved measles virus vaccine vector based on multiple tandem additional transcription units
AU2022208199A1 (en) 2021-01-13 2023-07-13 Centre National De La Recherche Scientifique Measles-hiv or measles-htlv vaccine
WO2023230598A2 (en) * 2022-05-27 2023-11-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Reverse genetics system for feline morbillivirus
EP4501946A1 (en) 2023-07-31 2025-02-05 LoopLab Bio GmbH Self-amplifying biologics for targeted therapy
WO2026013289A1 (en) 2024-07-12 2026-01-15 Institut Pasteur Measles-mumps-rubella (mmr) vaccines
CN120648655B (zh) * 2025-08-21 2026-02-13 内蒙古自治区农牧业科学院 一株t7-293t细胞及其在牛副流感病毒3型感染性克隆拯救病毒中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006270A1 (en) * 1995-08-09 1997-02-20 Schweiz. Serum- & Impfinstitut Bern cDNA CORRESPONDING TO THE ANTIGENOME OF NONSEGMENTED NEGATIVE STRAND RNA VIRUSES, AND PROCESS FOR THE PRODUCTION OF SUCH VIRUSES ENCODING ADDITIONAL ANTIGENICALLY ACTIVE PROTEINS
WO2004013517A1 (de) * 2002-07-30 2004-02-12 Zf Friedrichshafen Ag Getriebe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60033045T2 (de) 1999-10-12 2007-11-08 Institut Pasteur Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten
JP2004503233A (ja) 2000-06-16 2004-02-05 インスティティ・パスツール デング熱ウイルスエンベロープ糖タンパク質のプロ−アポトーシスフラグメント
DK1375670T3 (da) 2002-06-20 2013-09-23 Pasteur Institut Rekombinante mæslingevira, der udtrykker epitoper af RNA-viras antigener, samt anvendelse af de rekombinante vira til fremstilling af vaccinesammensætninger
KR101020532B1 (ko) * 2003-06-09 2011-03-09 와이어쓰 엘엘씨 ｃＤＮＡ로부터의 비분절 네가티브 쇄 ＲＮＡ 바이러스의 회수를 위한 개선된 방법
EP2361974A1 (fr) 2003-12-02 2011-08-31 Institut Pasteur Utilisation des proteines et des peptides codés par le genome d'une nouvelle souche de coronavirus associé au SRAS
FR2870126B1 (fr) 2004-05-17 2009-07-17 Pasteur Institut Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
US20080248067A1 (en) * 2005-04-14 2008-10-09 The University Of Queensland Immunomodulating Compositions and Uses Therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006270A1 (en) * 1995-08-09 1997-02-20 Schweiz. Serum- & Impfinstitut Bern cDNA CORRESPONDING TO THE ANTIGENOME OF NONSEGMENTED NEGATIVE STRAND RNA VIRUSES, AND PROCESS FOR THE PRODUCTION OF SUCH VIRUSES ENCODING ADDITIONAL ANTIGENICALLY ACTIVE PROTEINS
WO2004013517A1 (de) * 2002-07-30 2004-02-12 Zf Friedrichshafen Ag Getriebe

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUMAN GENE THERAPY. 2001, vol. 12, no. 9, pages 1103-1108. *
THE JOURNAL OF GENE MEDICINE. 2003, vol. 5, no. 8, pages 654-667. *

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EP1939214A1 (en) 2008-07-02
CN104745533A (zh) 2015-07-01
US20100144040A1 (en) 2010-06-10
JP2010512779A (ja) 2010-04-30
WO2008078198A3 (en) 2008-10-30
BRPI0719469A2 (pt) 2014-02-11
ES2423518T3 (es) 2013-09-20
US9499799B2 (en) 2016-11-22
EP2091962B1 (en) 2018-07-04
ES2686168T3 (es) 2018-10-16
DK1939214T3 (da) 2013-10-14
US8586364B2 (en) 2013-11-19
US20140051148A1 (en) 2014-02-20
KR20090103922A (ko) 2009-10-01
BRPI0719469B1 (pt) 2019-07-02
MX2009006755A (es) 2009-07-31
CN101631798A (zh) 2010-01-20
EP1939214B1 (en) 2013-07-10
DK2091962T3 (en) 2018-10-08
JP2015015955A (ja) 2015-01-29
JP5902371B2 (ja) 2016-04-13
WO2008078198A2 (en) 2008-07-03
BRPI0719469C1 (pt) 2021-05-25
CA2673262C (en) 2019-03-05
CA2673262A1 (en) 2008-07-03
EP2091962A2 (en) 2009-08-26

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