AR069885A1 - Metodos para producir el virus de estomatitis vesicular (vsv) atenuado en un cultivo celular y para mejorar el empaque del vsv de propagacion defectuosa, composicion inmunogenica, celula aislada y secuencia de control transcripcional - Google Patents

Metodos para producir el virus de estomatitis vesicular (vsv) atenuado en un cultivo celular y para mejorar el empaque del vsv de propagacion defectuosa, composicion inmunogenica, celula aislada y secuencia de control transcripcional

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Publication number
AR069885A1
AR069885A1 ARP080105638A ARP080105638A AR069885A1 AR 069885 A1 AR069885 A1 AR 069885A1 AR P080105638 A ARP080105638 A AR P080105638A AR P080105638 A ARP080105638 A AR P080105638A AR 069885 A1 AR069885 A1 AR 069885A1
Authority
AR
Argentina
Prior art keywords
vsv
cell
produce
pack
vesicular stomatitis
Prior art date
Application number
ARP080105638A
Other languages
English (en)
Inventor
Christopher Parks
Maninder K Sidhu
Susan Witko
J Erik Johnson
Roger Michael Hendry
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR069885A1 publication Critical patent/AR069885A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20251—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20251—Methods of production or purification of viral material
    • C12N2760/20252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un método para producir el virus de estomatitis vesicular de propagacion defectuosa (VSV). El método involucra proporcionar una célula que incluye un gen G VSV optimizado, en donde la expresion de la proteína G VSV del gen G VSV optimizado es inducible; e inducir la célula para expresar la proteína G VSV del gen G VSV optimizado. El método también involucra infectar la célula inducida con un VSV atenuado; hacer crecer las células en el cultivo; y recuperar el VSV atenuado del cultivo.
ARP080105638A 2007-12-20 2008-12-19 Metodos para producir el virus de estomatitis vesicular (vsv) atenuado en un cultivo celular y para mejorar el empaque del vsv de propagacion defectuosa, composicion inmunogenica, celula aislada y secuencia de control transcripcional AR069885A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1535307P 2007-12-20 2007-12-20

Publications (1)

Publication Number Publication Date
AR069885A1 true AR069885A1 (es) 2010-02-24

Family

ID=40418917

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105638A AR069885A1 (es) 2007-12-20 2008-12-19 Metodos para producir el virus de estomatitis vesicular (vsv) atenuado en un cultivo celular y para mejorar el empaque del vsv de propagacion defectuosa, composicion inmunogenica, celula aislada y secuencia de control transcripcional

Country Status (8)

Country Link
US (1) US20090162321A1 (es)
EP (1) EP2225264A1 (es)
JP (1) JP2011507514A (es)
AR (1) AR069885A1 (es)
AU (1) AU2008343919B2 (es)
CA (1) CA2710166A1 (es)
CL (1) CL2008003821A1 (es)
WO (1) WO2009085172A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101723900B1 (ko) 2009-06-08 2017-04-07 더 유니버시티 오브 웨스트 온타리오 면역화 요법용 발현 벡터로서의 수포성 구내염 바이러스의 상이한 혈청형
US9610346B2 (en) * 2012-03-23 2017-04-04 International Aids Vaccine Initiative Recombinant viral vectors
JP2020534284A (ja) * 2017-09-15 2020-11-26 オハイオ ステート イノベーション ファウンデーション ワクチン、並びに、呼吸器合胞体ウイルス（ｒｓｖ）感染症を予防するためのワクチンの作製方法及び使用方法
WO2019070704A1 (en) * 2017-10-02 2019-04-11 Georgia Tech Research Corporation METHODS AND COMPOSITIONS FOR ENGINEERING SYNTHESIS BIOLOGICAL SWITCHES FOR REMOTE CONTROL OF BIOLOGICAL ACTIVITY
CN109750006A (zh) * 2019-01-14 2019-05-14 青岛农业大学 一种犬瘟热病毒复制缺陷毒株及其构建方法
CN115725657A (zh) * 2022-09-16 2023-03-03 中国科学院广州生物医药与健康研究院 一种节段化的水泡性口炎病毒载体及其制备方法和应用
CN117051040A (zh) * 2023-08-15 2023-11-14 北京百普赛斯生物科技股份有限公司 Vsv△g复制缺陷型病毒制备及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) * 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
AU739597B2 (en) * 1997-05-02 2001-10-18 Uab Research Foundation, The Attenuation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
US6596529B1 (en) * 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
WO2001038488A2 (en) * 1999-11-23 2001-05-31 Mayo Foundation For Medical Education And Research Gene expression by positive feedback activation of a cell type-specific promoter
EP1633860A2 (en) * 2003-06-09 2006-03-15 Wyeth IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA
US8008268B2 (en) * 2006-07-25 2011-08-30 Merial Limited Vaccines against vesicular stomatitis

Also Published As

Publication number Publication date
AU2008343919B2 (en) 2013-01-17
CA2710166A1 (en) 2009-07-09
JP2011507514A (ja) 2011-03-10
CL2008003821A1 (es) 2009-04-03
US20090162321A1 (en) 2009-06-25
AU2008343919A1 (en) 2009-07-09
WO2009085172A1 (en) 2009-07-09
EP2225264A1 (en) 2010-09-08

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