EA032977B1 - Генетически стабильный онколитический рнк вирус, способ его производства и применения - Google Patents
Генетически стабильный онколитический рнк вирус, способ его производства и примененияInfo
- Publication number
- EA032977B1 EA032977B1 EA201690232A EA201690232A EA032977B1 EA 032977 B1 EA032977 B1 EA 032977B1 EA 201690232 A EA201690232 A EA 201690232A EA 201690232 A EA201690232 A EA 201690232A EA 032977 B1 EA032977 B1 EA 032977B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- virus
- human
- manufacture
- rna virus
- modified
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32311—Enterovirus
- C12N2770/32321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32311—Enterovirus
- C12N2770/32332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
В способе производства модифицированного энтеровируса ECHO 7 типа посредством модификации природного ECHO 7 вируса, выделенного известным способом из фекалий человека и идентифицированного по последовательности генома, модификацию осуществляли изначально путем проведения адаптации вируса в раковых клетках, ослабленных противоопухолевым средством дакарбазином, затем пассировали модифицированный вирус в культуре эмбриональных фибробластов человека с последующим репродуцированием в клетках меланомы человека и дальнейшим пассированием в культуре эмбриональных фибробластов человека, затем обрабатывали рибавирином, выделяли и очищали известным способом. Модифицированный вирус является пригодным в лечении ряда опухолей.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13176757.6A EP2826856B9 (en) | 2013-07-16 | 2013-07-16 | Genetically stable oncolytic RNA virus, method of manufacturing and use thereof |
PCT/EP2014/065277 WO2015007788A1 (en) | 2013-07-16 | 2014-07-16 | Genetically stable oncolytic rna virus, method of manufacturing and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201690232A1 EA201690232A1 (ru) | 2016-05-31 |
EA032977B1 true EA032977B1 (ru) | 2019-08-30 |
Family
ID=48790285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690232A EA032977B1 (ru) | 2013-07-16 | 2014-07-16 | Генетически стабильный онколитический рнк вирус, способ его производства и применения |
Country Status (16)
Country | Link |
---|---|
US (2) | US10174291B2 (ru) |
EP (2) | EP2826856B9 (ru) |
JP (1) | JP6293882B2 (ru) |
CN (2) | CN105518128B (ru) |
AU (1) | AU2014292114B2 (ru) |
BR (1) | BR112016000874B1 (ru) |
CA (1) | CA2917584C (ru) |
EA (1) | EA032977B1 (ru) |
ES (1) | ES2566146T3 (ru) |
GE (1) | GEP201706763B (ru) |
HK (1) | HK1219500A1 (ru) |
MD (1) | MD4480C1 (ru) |
MX (1) | MX365075B (ru) |
PL (2) | PL2826856T3 (ru) |
UA (1) | UA116387C2 (ru) |
WO (1) | WO2015007788A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109276580B (zh) * | 2017-07-21 | 2021-08-24 | 厦门大学 | 一种用于治疗肿瘤的病毒 |
CN109419818B (zh) * | 2017-08-24 | 2021-08-10 | 厦门大学 | 一种用于治疗肿瘤的埃可病毒 |
CN107669707A (zh) * | 2017-11-16 | 2018-02-09 | 邹罡 | 埃可病毒作为溶瘤病毒在抗肿瘤中的应用 |
CN110064044B (zh) * | 2018-01-20 | 2022-09-09 | 中国科学院武汉病毒研究所 | 一种肠道病毒71型的抑制剂及应用 |
GB201808500D0 (en) | 2018-05-23 | 2018-07-11 | Ditesan Ltd | Virus and virus use |
WO2020035423A1 (en) | 2018-08-13 | 2020-02-20 | Ditesan Ltd. | Combination therapy of cancer by administrating echo-7 virus and a pharmaceutically effective anti-cancer drug |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1537872A1 (en) * | 2002-06-14 | 2005-06-08 | Venskus, Dite | Immunostimulator having antineoplastic action and method for producing said immunostimulator |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4987101A (en) | 1988-12-16 | 1991-01-22 | International Business Machines Corporation | Method for providing improved insulation in VLSI and ULSI circuits |
CN1244583A (zh) * | 1998-08-12 | 2000-02-16 | 财团法人生物技术开发中心 | 本土性猪水泡病病毒与其变异株的制备方法及用途 |
IL148621A0 (en) * | 1999-09-17 | 2002-09-12 | Pro Virus Inc | Oncolytic virus |
AUPQ425699A0 (en) * | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
US6602862B1 (en) * | 2000-09-19 | 2003-08-05 | Merz Pharma Gmbh & Co., Kgaa | 1-Amino-alkylcyclohexanes as trypanocidal agents |
WO2002072027A2 (en) * | 2001-03-14 | 2002-09-19 | University Of Alabama Research Foundation | Oncolytic rna replicons |
AU2002953436A0 (en) * | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
WO2004094454A2 (en) * | 2003-04-18 | 2004-11-04 | Idm Pharma, Inc. | Hla-a2 tumor associated antigen peptides and compositions |
CN101132798B (zh) * | 2005-01-17 | 2011-04-27 | 溶瘤病毒有限公司 | 核酸分子在制备用于治疗黑色素瘤的药物中的应用及其组合物 |
JP5448840B2 (ja) * | 2006-12-22 | 2014-03-19 | プシオクサス・セラピューティクス・リミテッド | 腫瘍退縮アデノウイルスの作出およびその使用 |
WO2010009735A2 (en) * | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
CA2689707A1 (en) * | 2009-11-16 | 2011-05-16 | Jean-Simon Diallo | Identification of the novel small molecule viral sensitizer vse1 using high-throughput screening |
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2013
- 2013-07-16 EP EP13176757.6A patent/EP2826856B9/en active Active
- 2013-07-16 PL PL13176757T patent/PL2826856T3/pl unknown
- 2013-07-16 ES ES13176757.6T patent/ES2566146T3/es active Active
-
2014
- 2014-07-16 MD MDA20160014A patent/MD4480C1/ru not_active IP Right Cessation
- 2014-07-16 WO PCT/EP2014/065277 patent/WO2015007788A1/en active Application Filing
- 2014-07-16 PL PL14747317.7T patent/PL3022297T3/pl unknown
- 2014-07-16 CA CA2917584A patent/CA2917584C/en active Active
- 2014-07-16 BR BR112016000874-0A patent/BR112016000874B1/pt active IP Right Grant
- 2014-07-16 UA UAA201601267A patent/UA116387C2/uk unknown
- 2014-07-16 CN CN201480040030.3A patent/CN105518128B/zh active Active
- 2014-07-16 CN CN201910453901.9A patent/CN110129284A/zh active Pending
- 2014-07-16 EA EA201690232A patent/EA032977B1/ru unknown
- 2014-07-16 EP EP14747317.7A patent/EP3022297B1/en active Active
- 2014-07-16 GE GEAP201414061A patent/GEP201706763B/en unknown
- 2014-07-16 JP JP2016526607A patent/JP6293882B2/ja active Active
- 2014-07-16 US US14/904,837 patent/US10174291B2/en active Active
- 2014-07-16 MX MX2016000462A patent/MX365075B/es active IP Right Grant
- 2014-07-16 AU AU2014292114A patent/AU2014292114B2/en active Active
-
2016
- 2016-06-24 HK HK16107401.0A patent/HK1219500A1/zh unknown
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2018
- 2018-09-27 US US16/144,102 patent/US10435672B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1537872A1 (en) * | 2002-06-14 | 2005-06-08 | Venskus, Dite | Immunostimulator having antineoplastic action and method for producing said immunostimulator |
Non-Patent Citations (2)
Title |
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CHUA B H, MCMINN P C, LAM S K, CHUA K B: "Comparison of the complete nucleotide sequences of echovirus 7 strain UMMC", JOURNAL OF GENERAL VIROLOGY., SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD., GB, vol. 82, no. 11, 1 November 2001 (2001-11-01), GB, pages 2629 - 2639, XP002717948, ISSN: 0022-1317, DOI: 10.1099/0022-1317-82-11-2629 * |
FERDAT A K,: "IMMUNOMODULATION MECHANICS IN THE ANTI-TUMOUR EFFECT OF THE ECHO-7 ENTEROVIRUS", EKSPERIMENTAL NAA ONKOLOGIA - EXPERIMENTAL ONCOLOGY., KIEV, UU, vol. 11, no. 05, 1 January 1989 (1989-01-01), UU, pages 43 - 48, XP008054566, ISSN: 0204-3564 * |
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