MX358883B - Aumentar el rendimiento de particulas similares a virus en plantas. - Google Patents
Aumentar el rendimiento de particulas similares a virus en plantas.Info
- Publication number
- MX358883B MX358883B MX2014003776A MX2014003776A MX358883B MX 358883 B MX358883 B MX 358883B MX 2014003776 A MX2014003776 A MX 2014003776A MX 2014003776 A MX2014003776 A MX 2014003776A MX 358883 B MX358883 B MX 358883B
- Authority
- MX
- Mexico
- Prior art keywords
- plant
- nucleic acid
- plants
- virus
- vlp
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 108091006146 Channels Proteins 0.000 abstract 2
- 102000034573 Channels Human genes 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16223—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un método para producir una partícula similar a virus (VLP). El método comprende introducir un primer ácido nucleico y un segundo ácido nucleico en la planta, o porción de la planta. El primer ácido nucleico comprende una primera región reguladora activa en la planta y enlazada funcionalmente a una secuencia de nucleótidos que codifican para una proteína viral estructural. El segundo el ácido nucleico comprende una segunda región reguladora activa en la planta y enlazada funcionalmente a una secuencia de nucleótidos que codifica para una proteína de canal, por ejemplo de manera enunciativa para una proteína de canal protónico. La planta o porción de la planta se incuban bajo condiciones que permitan la expresión de los ácidos nucleicos, produciendo con esto la VLP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161541780P | 2011-09-30 | 2011-09-30 | |
| PCT/CA2012/050681 WO2013044390A1 (en) | 2011-09-30 | 2012-09-28 | Increasing virus-like particle yield in plants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014003776A MX2014003776A (es) | 2014-08-21 |
| MX358883B true MX358883B (es) | 2018-08-31 |
Family
ID=47994080
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003776A MX358883B (es) | 2011-09-30 | 2012-09-28 | Aumentar el rendimiento de particulas similares a virus en plantas. |
| MX2018006627A MX2018006627A (es) | 2011-09-30 | 2014-03-28 | Aumentar el rendimiento de particulas similares a virus en plantas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018006627A MX2018006627A (es) | 2011-09-30 | 2014-03-28 | Aumentar el rendimiento de particulas similares a virus en plantas. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US11155581B2 (es) |
| EP (2) | EP2760882B1 (es) |
| JP (1) | JP6248040B2 (es) |
| KR (1) | KR101974017B1 (es) |
| CN (2) | CN103930435A (es) |
| AU (1) | AU2012315421C1 (es) |
| BR (1) | BR112014007474A2 (es) |
| CA (1) | CA2850407C (es) |
| DK (1) | DK2760882T3 (es) |
| ES (1) | ES2951259T3 (es) |
| FI (1) | FI2760882T3 (es) |
| HK (1) | HK1200179A1 (es) |
| HR (1) | HRP20230695T1 (es) |
| HU (1) | HUE062759T2 (es) |
| IL (1) | IL231587B (es) |
| IN (1) | IN2014CN03077A (es) |
| MX (2) | MX358883B (es) |
| MY (1) | MY184072A (es) |
| NZ (1) | NZ622731A (es) |
| PL (1) | PL2760882T3 (es) |
| PT (1) | PT2760882T (es) |
| RU (1) | RU2682752C2 (es) |
| SG (2) | SG10201708052XA (es) |
| SI (1) | SI2760882T1 (es) |
| TW (1) | TWI700368B (es) |
| WO (1) | WO2013044390A1 (es) |
| ZA (1) | ZA201403059B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2760882T3 (da) | 2011-09-30 | 2023-07-03 | Medicago Inc | Forøgelse af udbyttet af viruslignende partikler i planter |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| KR102199018B1 (ko) * | 2013-03-28 | 2021-01-07 | 메디카고 인코포레이티드 | 식물에서 인플루엔자 바이러스-유사 입자 생산 |
| ES2864081T3 (es) | 2014-01-10 | 2021-10-13 | Medicago Inc | Elementos potenciadores de CPMV |
| EP3122883B1 (en) * | 2014-03-27 | 2022-03-02 | Medicago Inc. | Modified cpmv enhancer elements |
| MX2020009495A (es) * | 2018-03-14 | 2020-12-07 | Medicago Inc | Potenciador de la expresion en plantas. |
| BR112020026537A2 (pt) * | 2018-06-27 | 2021-04-06 | Medicago Inc. | Mutantes de hemaglutinina do vírus influenza |
| WO2020181354A1 (en) * | 2019-03-14 | 2020-09-17 | Mitsubishi Tanabe Pharma Corporation | Endogenous plant expression enhancer |
| WO2021236908A2 (en) * | 2020-05-20 | 2021-11-25 | Biomarin Pharmaceutical Inc. | Use of regulatory proteins for the production of adeno-associated virus |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4962028A (en) | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| US5805417A (en) | 1995-10-13 | 1998-09-08 | Hitachi, Ltd. | Heat dissipation structure in a portable computer including a heat dissipation block extending from a heat dissipation plate through a first circuit board to a CPU on a second circuit board |
| WO2000020557A2 (en) | 1998-10-07 | 2000-04-13 | Boyce Institute For Plant Research At Cornell University | Gemini virus vectors for gene expression in plants |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| RU2164148C1 (ru) * | 2000-08-09 | 2001-03-20 | Петров Рэм Викторович | Вакцина против вируса гриппа и способ ее получения |
| NZ543348A (en) * | 2003-05-05 | 2008-08-29 | Thompson Boyce Plant Res | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| US20040268442A1 (en) | 2003-05-05 | 2004-12-30 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
| US8535930B2 (en) * | 2005-04-29 | 2013-09-17 | University Of Cape Town | Expression of proteins in plants |
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| CN103865892B (zh) | 2005-10-18 | 2017-04-12 | 诺瓦瓦克斯股份有限公司 | 功能性流感病毒样颗粒(vlp) |
| US20090169576A1 (en) * | 2005-10-26 | 2009-07-02 | Roberto Crea | Influenza combinatorial antigen vaccine |
| KR20090034297A (ko) | 2006-02-16 | 2009-04-07 | 더 거번먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 레프리젠티드 바이 더 세크러터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 | 인플루엔자에 대한 항바이러스제 및 백신 |
| EP1991264B1 (en) | 2006-03-07 | 2015-01-07 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| EP1998814A4 (en) | 2006-05-11 | 2010-06-16 | Novavax Inc | NEW VACCINES AGAINST INFLUENZA M2 |
| EP2029755A1 (en) | 2006-05-22 | 2009-03-04 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| CA2654178A1 (en) * | 2006-06-16 | 2007-12-27 | Dow Agrosciences Llc | Novel dna sequences, vectors and proteins of avian influenza hemagglutinin |
| US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
| HUE031698T2 (en) | 2007-06-15 | 2017-07-28 | Medicago Inc | Modification of glycoprotein production in plants |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| PT2610345E (pt) * | 2007-11-27 | 2016-01-11 | Medicago Inc | Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| EA034733B1 (ru) | 2008-01-21 | 2020-03-13 | Медикаго Инк. | Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение |
| CA2730171C (en) | 2008-07-08 | 2016-10-11 | Medicago Inc. | Soluble recombinant influenza antigens |
| WO2010006452A1 (en) | 2008-07-18 | 2010-01-21 | Medicago Inc. | New influenza virus immunizing epitope |
| US8513397B2 (en) | 2008-08-27 | 2013-08-20 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| EP2413962A1 (en) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
| ES2669303T3 (es) | 2009-06-24 | 2018-05-24 | Medicago Inc. | Partículas pseudovíricas quiméricas de influenza que comprenden hemaglutinina |
| FR2947875B1 (fr) | 2009-07-10 | 2011-07-08 | Raymond A & Cie | Dispositif de fixation a elements de fixation multiples dont l'un est flottant |
| WO2011011390A1 (en) * | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| PT3354657T (pt) | 2009-09-22 | 2022-05-06 | Medicago Inc | Método de preparação de proteínas derivadas de plantas |
| US9352031B2 (en) * | 2010-02-18 | 2016-05-31 | Technovax, Inc. | Universal virus-like particle (VLP) influenza vaccines |
| CN103328002B (zh) | 2010-10-04 | 2020-01-14 | 麻省理工学院 | 血球凝集素多肽以及与其相关的试剂和方法 |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| DK2760882T3 (da) | 2011-09-30 | 2023-07-03 | Medicago Inc | Forøgelse af udbyttet af viruslignende partikler i planter |
| US9555094B2 (en) | 2012-07-23 | 2017-01-31 | The Institute Of Biological Resources | Isolated nucleic acid for the production of a vaccine against virus |
| KR102199018B1 (ko) | 2013-03-28 | 2021-01-07 | 메디카고 인코포레이티드 | 식물에서 인플루엔자 바이러스-유사 입자 생산 |
-
2012
- 2012-09-28 DK DK12836545.9T patent/DK2760882T3/da active
- 2012-09-28 EP EP12836545.9A patent/EP2760882B1/en active Active
- 2012-09-28 PL PL12836545.9T patent/PL2760882T3/pl unknown
- 2012-09-28 ES ES12836545T patent/ES2951259T3/es active Active
- 2012-09-28 MX MX2014003776A patent/MX358883B/es active IP Right Grant
- 2012-09-28 KR KR1020147011886A patent/KR101974017B1/ko active IP Right Grant
- 2012-09-28 EP EP19205918.6A patent/EP3626733B1/en active Active
- 2012-09-28 CN CN201280047819.2A patent/CN103930435A/zh active Pending
- 2012-09-28 HR HRP20230695TT patent/HRP20230695T1/hr unknown
- 2012-09-28 SI SI201232036T patent/SI2760882T1/sl unknown
- 2012-09-28 RU RU2014116371A patent/RU2682752C2/ru active
- 2012-09-28 NZ NZ622731A patent/NZ622731A/en unknown
- 2012-09-28 TW TW101135891A patent/TWI700368B/zh active
- 2012-09-28 JP JP2014532198A patent/JP6248040B2/ja active Active
- 2012-09-28 FI FIEP12836545.9T patent/FI2760882T3/fi active
- 2012-09-28 SG SG10201708052XA patent/SG10201708052XA/en unknown
- 2012-09-28 CN CN202310130025.2A patent/CN116218900A/zh active Pending
- 2012-09-28 MY MYPI2014700716A patent/MY184072A/en unknown
- 2012-09-28 WO PCT/CA2012/050681 patent/WO2013044390A1/en active Application Filing
- 2012-09-28 CA CA2850407A patent/CA2850407C/en active Active
- 2012-09-28 HU HUE12836545A patent/HUE062759T2/hu unknown
- 2012-09-28 US US14/347,804 patent/US11155581B2/en active Active
- 2012-09-28 AU AU2012315421A patent/AU2012315421C1/en active Active
- 2012-09-28 BR BR112014007474A patent/BR112014007474A2/pt not_active Application Discontinuation
- 2012-09-28 SG SG11201400712VA patent/SG11201400712VA/en unknown
- 2012-09-28 PT PT128365459T patent/PT2760882T/pt unknown
- 2012-09-28 IN IN3077CHN2014 patent/IN2014CN03077A/en unknown
-
2014
- 2014-03-19 IL IL231587A patent/IL231587B/en active IP Right Grant
- 2014-03-28 MX MX2018006627A patent/MX2018006627A/es unknown
- 2014-04-29 ZA ZA2014/03059A patent/ZA201403059B/en unknown
-
2015
- 2015-01-21 HK HK15100674.6A patent/HK1200179A1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2018006627A (es) | Aumentar el rendimiento de particulas similares a virus en plantas. | |
| MX2013014712A (es) | Produccion de particulas tipo virus de la rabia en plantas. | |
| PH12018501452A1 (en) | Rotavirus-like particle production in plants | |
| MY161891A (en) | Virus like particle production in plants | |
| PH12015502217B1 (en) | Influenza virus-like particle production in plants | |
| IN2015DN01606A (es) | ||
| MX2019004568A (es) | Produccion mejorada de derivados de acidos grasos. | |
| WO2012171030A3 (en) | Method and apparatus for antibody production and purification | |
| IN2012DN00650A (es) | ||
| NZ603918A (en) | Improved methods for preparing squalene | |
| WO2014095669A3 (de) | Verfahren und anlage zur herstellung von biogas aus lignocellulosehaltiger biomasse | |
| MY185050A (en) | A pentose sugar fermenting cell | |
| PH12015500459B1 (en) | Picornavirus-like particle production in plants | |
| MY183015A (en) | Solvent production using monophasic clostridia | |
| WO2011037367A3 (ko) | 고효율 유도만능줄기세포 제조방법 및 상기 방법에 의해 제조된 유도만능줄기세포 | |
| TH1401001699A (th) | การเพิ่มผลผลิตอนุภาคคล้ายไวรัสในพืช | |
| TH171332A (th) | การผลิตอนุภาคคล้ายไวรัสโรคพิษสุนัขบ้าในพืช | |
| WO2012173390A3 (ko) | 인유두종바이러스 l1 단백질의 생산 수율을 향상시키는 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |