MX358883B - Aumentar el rendimiento de particulas similares a virus en plantas. - Google Patents

Aumentar el rendimiento de particulas similares a virus en plantas.

Info

Publication number
MX358883B
MX358883B MX2014003776A MX2014003776A MX358883B MX 358883 B MX358883 B MX 358883B MX 2014003776 A MX2014003776 A MX 2014003776A MX 2014003776 A MX2014003776 A MX 2014003776A MX 358883 B MX358883 B MX 358883B
Authority
MX
Mexico
Prior art keywords
plant
nucleic acid
plants
performance
increase
Prior art date
Application number
MX2014003776A
Other languages
English (en)
Other versions
MX2014003776A (es
Inventor
Andre D´Aoust Marc-
Couture Manon
Vezina Louis-Philippe
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of MX2014003776A publication Critical patent/MX2014003776A/es
Publication of MX358883B publication Critical patent/MX358883B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16223—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16251—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un método para producir una partícula similar a virus (VLP). El método comprende introducir un primer ácido nucleico y un segundo ácido nucleico en la planta, o porción de la planta. El primer ácido nucleico comprende una primera región reguladora activa en la planta y enlazada funcionalmente a una secuencia de nucleótidos que codifican para una proteína viral estructural. El segundo el ácido nucleico comprende una segunda región reguladora activa en la planta y enlazada funcionalmente a una secuencia de nucleótidos que codifica para una proteína de canal, por ejemplo de manera enunciativa para una proteína de canal protónico. La planta o porción de la planta se incuban bajo condiciones que permitan la expresión de los ácidos nucleicos, produciendo con esto la VLP.
MX2014003776A 2011-09-30 2012-09-28 Aumentar el rendimiento de particulas similares a virus en plantas. MX358883B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161541780P 2011-09-30 2011-09-30
PCT/CA2012/050681 WO2013044390A1 (en) 2011-09-30 2012-09-28 Increasing virus-like particle yield in plants

Publications (2)

Publication Number Publication Date
MX2014003776A MX2014003776A (es) 2014-08-21
MX358883B true MX358883B (es) 2018-08-31

Family

ID=47994080

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014003776A MX358883B (es) 2011-09-30 2012-09-28 Aumentar el rendimiento de particulas similares a virus en plantas.
MX2018006627A MX2018006627A (es) 2011-09-30 2014-03-28 Aumentar el rendimiento de particulas similares a virus en plantas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018006627A MX2018006627A (es) 2011-09-30 2014-03-28 Aumentar el rendimiento de particulas similares a virus en plantas.

Country Status (27)

Country Link
US (1) US11155581B2 (es)
EP (2) EP2760882B1 (es)
JP (1) JP6248040B2 (es)
KR (1) KR101974017B1 (es)
CN (2) CN116218900A (es)
AU (1) AU2012315421C1 (es)
BR (1) BR112014007474A2 (es)
CA (1) CA2850407C (es)
DK (1) DK2760882T5 (es)
ES (1) ES2951259T3 (es)
FI (1) FI2760882T3 (es)
HR (1) HRP20230695T1 (es)
HU (1) HUE062759T2 (es)
IL (1) IL231587B (es)
IN (1) IN2014CN03077A (es)
MX (2) MX358883B (es)
MY (1) MY184072A (es)
NZ (1) NZ622731A (es)
PH (1) PH12014500640A1 (es)
PL (1) PL2760882T3 (es)
PT (1) PT2760882T (es)
RU (1) RU2682752C2 (es)
SG (2) SG10201708052XA (es)
SI (1) SI2760882T1 (es)
TW (1) TWI700368B (es)
WO (1) WO2013044390A1 (es)
ZA (1) ZA201403059B (es)

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Also Published As

Publication number Publication date
TWI700368B (zh) 2020-08-01
BR112014007474A2 (pt) 2017-04-04
WO2013044390A1 (en) 2013-04-04
CA2850407C (en) 2021-11-23
HUE062759T2 (hu) 2023-12-28
EP2760882A1 (en) 2014-08-06
DK2760882T3 (da) 2023-07-03
MX2014003776A (es) 2014-08-21
AU2012315421A1 (en) 2014-04-10
MX2018006627A (es) 2020-11-12
AU2012315421B2 (en) 2017-10-19
HK1200179A1 (en) 2015-07-31
DK2760882T5 (da) 2024-06-24
CN116218900A (zh) 2023-06-06
PL2760882T3 (pl) 2023-09-11
MY184072A (en) 2021-03-17
KR20140068260A (ko) 2014-06-05
RU2014116371A (ru) 2015-11-10
CA2850407A1 (en) 2013-04-04
KR101974017B1 (ko) 2019-04-30
ES2951259T3 (es) 2023-10-19
SI2760882T1 (sl) 2023-10-30
EP2760882B1 (en) 2023-05-24
SG10201708052XA (en) 2017-11-29
FI2760882T3 (fi) 2023-07-17
PH12014500640A1 (en) 2014-05-05
CN103930435A (zh) 2014-07-16
SG11201400712VA (en) 2014-04-28
HRP20230695T1 (hr) 2023-12-22
IL231587B (en) 2020-06-30
ZA201403059B (en) 2019-07-31
US20150104480A1 (en) 2015-04-16
PT2760882T (pt) 2023-08-07
JP6248040B2 (ja) 2017-12-13
IL231587A0 (en) 2014-05-28
TW201329235A (zh) 2013-07-16
EP3626733B1 (en) 2024-01-24
JP2014530006A (ja) 2014-11-17
AU2012315421C1 (en) 2019-12-05
US11155581B2 (en) 2021-10-26
RU2682752C2 (ru) 2019-03-21
EP2760882A4 (en) 2015-06-10
IN2014CN03077A (es) 2015-07-03
NZ622731A (en) 2016-04-29
EP3626733A1 (en) 2020-03-25

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